Background
Social phobia, also called social anxiety disorder, is the third most common mental health disorder after depression and substance abuse, affecting as many as 10 million Americans. Social phobia is an anxiety disorder involving intense distress in response to public situations.[1, 2] Individuals with social phobia typically experience symptoms resembling panic during a social encounter. These situations may include speaking in public, using public restrooms, eating with other people, or engaging in social contact in general.
Persons with this disorder fear being humiliated or embarrassed in social and/or performance situations by their actions and may become intensely anxious, with an increased heart rate, diaphoresis, and other signs of autonomic arousal. These physical symptoms may cause additional anxiety, often leading to a conditioned fear response that reinforces their anxiety in public situations.[1]
The onset of social phobia may or may not be abrupt, often manifesting after a stressor or humiliating social experience in an individual with a childhood history of excessive shyness or social inhibition. Social phobia is considered a disorder if it is severe enough to adversely affect social or occupational functioning.[3] That is, individuals with true social phobia go to great lengths to avoid social situations, usually to their own detriment. The fear of embarrassment is egodystonic, and persons with social phobia are distressed by their symptoms.
The median delay from onset to seeking treatment can be as long as 28 years.[4, 5]
Case presentation
The chief complaint of a 9-year-old boy is, "No one likes me or wants to play with me, and I hate it when the teacher asks me to read aloud." He has difficulties with functioning at school, his teacher reports that he rarely raises his hand to be called on, and his mother reports that he has frequent stomachaches, especially the night before he is supposed to take standardized tests. At home, he seems content to play his clarinet by himself, and he tells the clinician that he dreads concerts because he is expected to play in front of others.
Pathophysiology
The pathophysiology of social phobia is unclear. However, theories have arisen based on the efficacy of pharmacologic agents used to treat social phobia. Thus, serotonergic functioning might be involved, as serotonergic reuptake inhibitors help alleviate symptoms. Similarly, some researchers believe in an adrenergic etiology because of the success of propranolol therapy. Neurocircuitry involving the amygdala, a structure involved in fear, may be involved, as studies have found an exaggerated reactivity of the amygdala to aversive social stimuli in social anxiety.[6, 7]
Very low weight (600-1250 g) premature babies may also be at higher risk for later development of social anxiety disorder, possibly owing to abnormalities in the uncinate fasciculus, the major white matter tract connecting the frontal cortex to the amygdala, and other limbic temporal regions.[8]
Approaches to prevention of social phobia in school children include universal emotional health interventions using computer programs such as FRIENDS or COPING CAT to decrease anxiety symptoms and to improve self-esteem, which may be helpful as long as the interventions specifically target social phobia.[9, 10, 11, 12, 13, 14]
Epidemiology
Frequency
United States
Nine percent of youth in the United States experience social phobia at some point in their lifetime — a slightly lower rate than the 12.1% rate observed among US adults in the National Comorbidity Survey (NCS)-Replication study. This social phobia was associated with marked levels of impairment and persistence. However, adolescents did not have significant associations, when compared with adults, between social phobia and mood or alcohol use disorders, after controlling for comorbid disorders; this suggests these relationships may be due, in part, to other psychopathology.
The US NCS-Adolescent Supplement is the first study of social phobia in adolescents with a large community-based sample and was done from 2001-2004.[15] . This study of 10,123 adolescents aged 13-18 years in the continental United States had a very good overall response rate of 83.3% of parents/parental surrogates, who responded to a self-administered questionnaire. Additional scales of excellent quality were used, such as the modified version of the World Health Organization Composite International Diagnostic Interview (CIDI) Version 3.0 and the Sheehan Disability Scale, to determine the impact of the disorder on the adolescents’ general functioning.
The study used the new Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM5) proposed criteria for social phobia and found no sex differences in incidence; data were statistically very reliable (P = .001-.01) that 4.8% of all adolescents, representing more than half (55.8%) of all adolescents with social phobia, had fear of most social situations — generalized social phobia (7 or more of the 12 types of social fears) — as follows:
- Meeting new people their own age
- Talking to people in authority (eg, coaches, other adults they do not know very well)
- Being with a group of people their own age (eg, at a party, in the lunchroom at school)
- Going into a room that already has people in it
- Talking with people they do not know very well
- Going out with/dating someone they are interested in
- Any other situation in which they could be the center of attention or something embarrassing might happen (eg, working/doing homework while someone watches; writing/eating/drinking while someone watches; speaking in class when a teacher asks a question/when a teacher calls on them; acting/performing/giving a talk in front of a group of people; taking an important test/examination or interviewing for a job, although they are well prepared)
A smaller percentage (3.8%) of all adolescents, representing 44.2% of all those adolescents with social phobia, had nongeneralized type of social phobia — fewer than 7 types of fears.
A very much smaller percentage of all adolescents (0.7%) had performance social phobia, representing only 0.8% of all adolescents with social phobia. This is perhaps due to the fact that public speaking and performance fears may only become clinically significant with the greater opportunity for avoidance that characterizes adulthood, as youth are required, because of school, to participate in such situations. Thus, they have more occasions for exposure resulting in performance anxiety, habituation, and lower prevalence rates than occur in adults, who are able to avoid such situations.
Disability from social phobia of the generalized type was moderate to severe and highly persistent; 87.03% of adolescents experienced at least 7 fears for 4 days of the previous calendar year, and there was a high comorbidity with social phobia. About one third to one fifth of adolescents with generalized social phobia had another disorder, most often anxiety due to agoraphobia (27%), followed by panic disorder (20.5%), separation anxiety disorder (18.1%), posttraumatic stress disorder (17.1%), and specific phobia (12.8%).
Lifetime incidence of comorbid oppositional defiant disorder occurred in a significant number of adolescents, more so in those with generalized social phobia (12.5% compared with adolescents who had the nongeneralized type of social phobia). That group had lower rates of comorbid disorders, and there was a statistically significant rate (P = .05) of significant comorbid drug-use disorders in 13% of those with generalized social phobia, as compared with only 7.2% of those with nongeneralized social phobia.
A unique pattern was found — an association between generalized social phobia with agoraphobia and panic disorder. Nongeneralized social phobia had an association with posttraumatic stress disorder and a unique negative association with alcohol use disorders. Although overall 18.6% of adolescents with social phobia presented with a lifetime mood disorder, adjusted odds ratios indicated that these associations were primarily due to other anxiety or behavior disorder.
International
The lifetime prevalence of social phobia is estimated at 7%-12%.[3] Some community samples of adolescents show an incidence of 1.6%.[1, 2]
Social phobia often goes undiagnosed in patients with other coexisting acute psychiatric conditions such as depression or suicidality but should not be overlooked, as it can contribute to a lack of symptom remission. In some situations, social phobia may be the root cause of depressive or suicidal symptoms.[4, 5]
Mortality/Morbidity
Social phobia is often comorbid with other anxiety disorders; in one study, 60% of children with social phobia had another disorder (generally an anxiety disorder); 10% had generalized anxiety disorder, attention deficit/hyperactivity disorder (ADHD), or specific phobia. In other studies, children with social phobia were found to have comorbid separation anxiety disorder (in younger children), as well as selective mutism. Social phobia often leads to extreme social isolation in children and can be accompanied by selective mutism and/or can be a precursor to depression.
In adults with social phobia, academic and occupational functioning may be affected; often, people with social phobia have significant trouble forming relationships with others.[7]
Social phobia is also commonly comorbid with autistic spectrum disorder. Longstanding social phobia increases the lifetime risk of depression later in adulthood, potentially leading to an increased risk of substance abuse, including alcoholism. This thereby confers a higher risk for cardiovascular morbidity and mortality.[16, 3, 17, 18]
Race
Social phobia occurs in many cultures. Persons of Asian descent in North America may not receive treatment as early in the course of the disorder as persons of European descent. In addition, persons of Asian descent have significant cultural differences involving emotional responses in social interactions compared with persons of other cultures.[19, 20]
Sex
In the general population, more females than males develop social phobia, with a female-to-male ratio of 1.5-2:1; however, in clinical samples, cases involving males are more prevalent. The reasons for this prevalence are unknown.[21]
Age
Social phobia typically manifests in middle childhood, at approximately age 10 years. Adolescents (aged 11-12 y) with social phobia may avoid age-appropriate social activities, such as attending parties and dating. Symptoms of social phobia in younger children include crying, temper tantrums, fidgeting, somatic complaints, and avoidance and withdrawal from social situations. Untreated childhood social phobia typically continues into adulthood.[1, 16]
Beidel DC. Social anxiety disorder: etiology and early clinical presentation. J Clin Psychiatry. 1998;59 Suppl 17:27-32. [Medline].
Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. Jan 1994;51(1):8-19. [Medline].
Heimberg RG, Stein MB, Hiripi E, Kessler RC. Trends in the prevalence of social phobia in the United States: a synthetic cohort analysis of changes over four decades. Eur Psychiatry. Feb 2000;15(1):29-37. [Medline].
Wiltink J, Haselbacher A, Knebel A, Tschan R, Zwerenz R, Michal M, et al. Social Phobia - An Anxiety Disorder Underdiagnosed in Outpatient and Consultation-Liaison Service?. Psychother Psychosom Med Psychol. May 18 2009;[Medline].
Pöhlmann K, Döbbel S, Löffler S, Israel M, Joraschky P. [Social phobia - the blind spot: infrequently diagnosed, highly complex, and a predictor for unfavourable therapy outcomes?]. Z Psychosom Med Psychother. 2009;55(2):180-8. [Medline].
Phan KL, Orlichenko A, Boyd E, Angstadt M, Coccaro EF, Liberzon I, et al. Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder. Biol Psychiatry. Oct 1 2009;66(7):691-4. [Medline].
Stein MB. Neurobiological perspectives on social phobia: from affiliation to zoology. Biol Psychiatry. Dec 15 1998;44(12):1277-85. [Medline].
Constable RT, Ment LR, Vohr BR, Kesler SR, Fulbright RK, Lacadie C, et al. Prematurely born children demonstrate white matter microstructural differences at 12 years of age, relative to term control subjects: an investigation of group and gender effects. Pediatrics. Feb 2008;121(2):306-16. [Medline].
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Text Revision. 4th ed. Washington, DC: American Psychiatric Association; 2000.
Amir N, Beard C, Burns M, Bomyea J. Attention modification program in individuals with generalized anxiety disorder. J Abnorm Psychol. Feb 2009;118(1):28-33. [Medline].
Suveg C, Hudson JL, Brewer G, Flannery-Schroeder E, Gosch E, Kendall PC. Cognitive-behavioral therapy for anxiety-disordered youth: secondary outcomes from a randomized clinical trial evaluating child and family modalities. J Anxiety Disord. Apr 2009;23(3):341-9. [Medline].
Titov N, Andrews G, Johnston L, Schwencke G, Choi I. Shyness programme: longer term benefits, cost-effectiveness, and acceptability. Aust N Z J Psychiatry. Jan 2009;43(1):36-44. [Medline].
Suveg C, Sood E, Comer JS, Kendall PC. Changes in emotion regulation following cognitive-behavioral therapy for anxious youth. J Clin Child Adolesc Psychol. May 2009;38(3):390-401. [Medline].
Berger T, Hohl E, Caspar F. Internet-based treatment for social phobia: a randomized controlled trial. J Clin Psychol. Oct 2009;65(10):1021-35. [Medline].
Burstein M, He JP, Kattan G, Albano AM, Avenevoli S, Merikangas KR. Social phobia and subtypes in the national comorbidity survey-adolescent supplement: prevalence, correlates, and comorbidity. J Am Acad Child Adolesc Psychiatry. Sep 2011;50(9):870-80. [Medline]. [Full Text].
Fichter MM, Kohlboeck G, Quadflieg N, Wyschkon A, Esser G. From childhood to adult age: 18-year longitudinal results and prediction of the course of mental disorders in the community. Soc Psychiatry Psychiatr Epidemiol. Sep 2009;44(9):792-803. [Medline].
Kuusikko S, Pollock-Wurman R, Jussila K, Carter AS, Mattila ML, Ebeling H, et al. Social anxiety in high-functioning children and adolescents with Autism and Asperger syndrome. J Autism Dev Disord. Oct 2008;38(9):1697-709. [Medline].
Weinstock LS. Gender differences in the presentation and management of social anxiety disorder. J Clin Psychiatry. 1999;60 Suppl 9:9-13. [Medline].
Lau AS, Fung J, Wang SW, Kang SM. Explaining elevated social anxiety among Asian Americans: emotional attunement and a cultural double bind. Cultur Divers Ethnic Minor Psychol. Jan 2009;15(1):77-85. [Medline].
Hsu L, Alden LE. Cultural influences on willingness to seek treatment for social anxiety in Chinese- and European-heritage students. Cultur Divers Ethnic Minor Psychol. Jul 2008;14(3):215-23. [Medline].
Guntheroth W. Link among mitral valve prolapse, anxiety disorders, and inheritance. Am J Cardiol. May 1 2007;99(9):1350. [Medline].
Bögels SM, Alden L, Beidel DC, et al. Social anxiety disorder: questions and answers for the DSM-V. Depress Anxiety. Feb 2010;27(2):168-89. [Medline].
Letamendi AM, Chavira DA, Hitchcock CA, Roesch SC, Shipon-Blum E, Stein MB. Selective Mutism Questionnaire: Measurement Structure and Validity. J Am Acad Child Adolesc Psychiatry. Aug 8 2008;[Medline].
van Peer JM, Spinhoven P, van Dijk JG, Roelofs K. Cortisol-induced enhancement of emotional face processing in social phobia depends on symptom severity and motivational context. Biol Psychol. May 2009;81(2):123-30. [Medline].
Mazeh D, Bodner E, Weizman R, Delayahu Y, Cholostoy A, Martin T, et al. Co-morbid social phobia in schizophrenia. Int J Soc Psychiatry. May 2009;55(3):198-202. [Medline].
Evans KC, Wright CI, Wedig MM, Gold AL, Pollack MH, Rauch SL. A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder. Depress Anxiety. 2008;25(6):496-505. [Medline].
Stein MB, Goldin PR, Sareen J, Zorrilla LT, Brown GG. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry. Nov 2002;59(11):1027-34. [Medline].
Bögels SM, Perotti EC. Does Father Know Best? A Formal Model of the Paternal Influence on Childhood Social Anxiety. J Child Fam Stud. Apr 2011;20(2):171-181. [Medline]. [Full Text].
Maeda F, Nathan JH. Understanding taijin kyofusho through its treatment, Morita therapy. J Psychosom Res. Jun 1999;46(6):525-30. [Medline].
Blair K, Shaywitz J, Smith BW, Rhodes R, Geraci M, Jones M, et al. Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. Am J Psychiatry. Sep 2008;165(9):1193-202. [Medline].
Miller G. Society for Neuroscience meeting. Pills and games help conquer fear. Science. Nov 21 2003;302(5649):1321. [Medline].
Victor AM, Bernstein GA. Anxiety disorders and posttraumatic stress disorder update. Psychiatr Clin North Am. Mar 2009;32(1):57-69. [Medline].
Davidson JR. Pharmacotherapy of social anxiety disorder: what does the evidence tell us?. J Clin Psychiatry. 2006;67 Suppl 12:20-6. [Medline].
Katzelnick DJ, Kobak KA, Greist JH, et al. Sertraline for social phobia: a double-blind, placebo-controlled crossover study. Am J Psychiatry. Sep 1995;152(9):1368-71. [Medline].
Pande AC, Davidson JR, Jefferson JW, et al. Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol. Aug 1999;19(4):341-8. [Medline].
Guastella AJ, Richardson R, Lovibond PF, Rapee RM, Gaston JE, Mitchell P, et al. A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder. Biol Psychiatry. Mar 15 2008;63(6):544-9. [Medline].
Rapee RM, Gaston JE, Abbott MJ. Testing the efficacy of theoretically derived improvements in the treatment of social phobia. J Consult Clin Psychol. Apr 2009;77(2):317-27. [Medline].
Stangier U, Schramm E, Heidenreich T, Berger M, Clark DM. Cognitive Therapy vs Interpersonal Psychotherapy in Social Anxiety Disorder: A Randomized Controlled Trial. Arch Gen Psychiatry. Jul 2011;68(7):692-700. [Medline].
Maric M, Heyne DA, de Heus P, van Widenfelt BM, Westenberg PM. The Role of Cognition in School Refusal: An Investigation of Automatic Thoughts and Cognitive Errors. Behav Cogn Psychother. Jun 29 2011;1-15. [Medline].
Heyne D, Sauter FM, Van Widenfelt BM, Vermeiren R, Westenberg PM. School refusal and anxiety in adolescence: Non-randomized trial of a developmentally sensitive cognitive behavioral therapy. J Anxiety Disord. Apr 28 2011;[Medline].
Knijnik DZ, Salum GA Jr, Blanco C, Moraes C, Hauck S, Mombach CK, et al. Defense style changes with the addition of psychodynamic group therapy to clonazepam in social anxiety disorder. J Nerv Ment Dis. Jul 2009;197(7):547-51. [Medline].
Midgley N. Re-reading "Little Hans": Freud's case study and the question of competing paradigms in psychoanalysis. J Am Psychoanal Assoc. Spring 2006;54(2):537-59. [Medline].
Walter D, Hautmann C, Rizk S, et al. Short term effects of inpatient cognitive behavioral treatment of adolescents with anxious-depressed school absenteeism: an observational study. Eur Child Adolesc Psychiatry. Nov 2010;19(11):835-44. [Medline].
Altamura AC, Pioli R, Vitto M, Mannu P. Venlafaxine in social phobia: a study in selective serotonin reuptake inhibitor non-responders. Int Clin Psychopharmacol. Jul 1999;14(4):239-45. [Medline].
Bailey JE, Papadopoulos A, Lingford-Hughes A, Nutt DJ. D-Cycloserine and performance under different states of anxiety in healthy volunteers. Psychopharmacology (Berl). Sep 2007;193(4):579-85. [Medline].
Connor KM, Davidson JR, Potts NL, et al. Discontinuation of clonazepam in the treatment of social phobia. J Clin Psychopharmacol. Oct 1998;18(5):373-8. [Medline].
Hofmann SG, Pollack MH, Otto MW. Augmentation treatment of psychotherapy for anxiety disorders with D-cycloserine. CNS Drug Rev. Fall-Winter 2006;12(3-4):208-17. [Medline].
Nutt DJ, Bell CJ, Malizia AL. Brain mechanisms of social anxiety disorder. J Clin Psychiatry. 1998;59 Suppl 17:4-11. [Medline].
Schmidt NB, Richey JA, Buckner JD, Timpano KR. Attention training for generalized social anxiety disorder. J Abnorm Psychol. Feb 2009;118(1):5-14. [Medline].
Stallard P, Simpson N, Anderson S, Goddard M. The FRIENDS emotional health prevention programme: 12 month follow-up of a universal UK school based trial. Eur Child Adolesc Psychiatry. Aug 2008;17(5):283-9. [Medline].
Stein DJ, Westenberg HG, Yang H, et al. Fluvoxamine CR in the long-term treatment of social anxiety disorder: the 12- to 24-week extension phase of a multicentre, randomized, placebo-controlled trial. Int J Neuropsychopharmacol. Dec 2003;6(4):317-23. [Medline].
Stein MB, Chavira DA. Subtypes of social phobia and comorbidity with depression and other anxiety disorders. J Affect Disord. Sep 1998;50 Suppl 1:S11-6. [Medline].
Stein MB, Liebowitz MR, Lydiard RB, et al. Paroxetine treatment of generalized social phobia (social anxiety disorder): a randomized controlled trial. JAMA. Aug 26 1998;280(8):708-13. [Medline].
Velosa JF, Riddle MA. Pharmacologic treatment of anxiety disorders in children and adolescents. Child Adolesc Psychiatr Clin N Am. Jan 2000;9(1):119-33. [Medline].
Weeks JW, Heimberg RG, Fresco DM, Hart TA, Turk CL, Schneier FR, et al. Empirical validation and psychometric evaluation of the Brief Fear of Negative Evaluation Scale in patients with social anxiety disorder. Psychol Assess. Jun 2005;17(2):179-90. [Medline].
Westenberg HG. The nature of social anxiety disorder. J Clin Psychiatry. 1998;59 Suppl 17:20-6. [Medline].
White M, Dorman SM. Receiving social support online: implications for health education. Health Educ Res. Dec 2001;16(6):693-707. [Medline].
Zaider TI, Heimberg RG. Non-pharmacologic treatments for social anxiety disorder. Acta Psychiatr Scand Suppl. 2003;72-84. [Medline].

