eMedicine Specialties > Pulmonology > Sleep-Related Disorders
Obstructive Sleep Apnea: Follow-up
Updated: Jul 30, 2009
Follow-up
Further Outpatient Care
Nasal CPAP therapyMany obstructive sleep apnea (OSA) patients note an immediate improvement in alertness, concentration, and memory, but achieving maximum improvement in neurocognitive symptoms may take as long as 2 months. Adequate adherence is defined as routine use of CPAP for more than 4.5 hours per night. Follow-up visits should be scheduled at least once after CPAP treatment is first started and at least yearly thereafter. Follow-up evaluation is required to ensure symptomatic improvement, CPAP compliance, and equipment maintenance.
CPAP therapy - Compliance issues
Nasal congestion can be treated with antihistamines and/or topical corticosteroids. Nasal dryness can be treated with topical saline sprays or humidification. If the air generated by the unit is too cold, the patient should use a heated humidifier.
If excessive air leaks through the mouth, patients should use a chin strap to keep their mouths closed or they should try an oronasal mask. Consider consultation with an otolaryngologist to rule out sinus dysfunction. If a poorly fitting mask causes skin breakdown and/or air leaks, patients should try mask of different sizes and/or models; a variety of interfaces are now available.
Patients with claustrophobia may try using nasal pillows or behavioral management. If patients feel a sensation of increased resistance to expiration, use of a CPAP unit with a ramp feature is indicated. This unit permits the patient to fall asleep with little or no pressure applied, and the pressure gradually increases to the set optimal level over a predetermined interval (usually 15-30 min). BiPAP may be used as an alternative.
OA therapy
Regular follow-up with a dental professional allows for adjustment of the dental appliance. The first adjustment is based on symptoms. Follow-up also helps ensure compliance with therapy and helps identify adverse effects or complications, device deterioration, or maladjustment.
Follow-up PSG after the final adjustment of the OA ensures that OSA is adequately treated. However, PSG should be deferred until an adequate symptomatic response and patient comfort are achieved with adjustments to the appliance.
Follow-up with a sleep disorders specialist ensures that OSA is adequately treated. Regular follow-up is required until patient's symptoms resolve and until PSG shows no evidence of clinically significant SDB. Follow-up also helps in determining if another treatment modality is required because of treatment failure or intolerance.
Close collaboration is required between the sleep disorders specialist and dental professional. Pay attention to compliance, comfort, dental complications, and evidence of recurrent OSA.
Surgery
Follow-up with a sleep disorders specialist ensures that OSA resolves. Follow-up PSG is essential to determine if OSA has been treated adequately. It should be performed after the surgical site has adequately healed. The most effective timing appears to be 4-6 months after surgery to ensure steady body weight, completion of healing, and stabilization of sleep architecture.
Patient Education
A physician, trained technician, or nurse should train patients receiving CPAP for at least the first month of therapy. This training promotes long-term adherence with treatment. For excellent patient education resources, visit eMedicine's Ear, Nose, and Throat Center and Sleep Disorders Center. In addition, see eMedicine's patient education articles Snoring, Sleep Disorders and Aging, and Insomnia.
Miscellaneous
Medicolegal Pitfalls
The following measures should be undertaken in patients with OSA:
- Assess the patient's risk for motor vehicle accidents. The patients at highest risk should immediately be warned of the potential risk of driving until effective therapy is started.
- Warn any patient with OSA of the potential dangers of driving while sleepy. Inform the patient of the potential personal and social risk.
- Provide additional counseling depending on other risk factors (eg, occupation).
- Advise patients to not drive until their OSA is treated adequately.
- Provide additional counseling to family members as appropriate, and help patients explore alternatives to driving if they are unaware of their sleepiness or if they are unwilling to acknowledge their increased risk.
- Diagnose and treat OSA expeditiously.
- Document in writing any warnings, concerns, and/or recommendations given to the patient. This documentation reinforces the importance of the message to the patient and helps reduce the risk of legal liability for medical personnel.
- Routinely plan follow-up to determine the effectiveness of therapy and compliance with therapy. Ascertain whether daytime sleepiness is substantially reduced or eliminated. Continue evaluations at regular intervals until therapy controls the patients' condition.
Assess the risk of driving in any patient with OSA. Criteria that increase this risk are as follows:
- The patient has had previous motor vehicle accidents.
- The patient has had near-miss incidents while driving.
- The patient has evidence of severe daytime sleepiness or impaired driving performance.
Laws regarding impaired drivers, including those with OSA, vary from state to state. In some states, the clinician is obligated to report patients under specific conditions (ie, mandatory reporting statute), whereas other states permit reporting but do not require it (ie, permissive reporting statute). Mandatory statutes take 1 of the 2 following approaches:
- With the categorical approach, the clinician is obligated to report patients who have specified medical conditions, such as epilepsy. In these states, the reporting obligation is based on diagnosis alone.
- With the functional approach, the clinician is required to report patients with certain medical conditions only if the clinician believes that a condition impairs the patient's driving ability.
American Thoracic Society guidelines on reporting of patients to the appropriate state authorities are as follows36 :
- In states with permissive reporting mechanisms, the clinician should at a minimum notify the state's department of motor vehicles when a highest-risk patient (ie, a patient with OSA with severe daytime sleepiness and a previous motor vehicle accident or near-miss incident) (1) is unwilling to restrict driving until effective treatment is started, (2) is noncompliant or unwilling to accept treatment, or (3) has an untreatable condition or one that is not amenable to expeditious treatment ( £ 2 mo of diagnosis).
- Increased occupational exposure to driving or increased occupational risk for an accident of substantial importance to the public may be other indications for reporting. Examples of patients in this situation are truck drivers who are transporting hazardous waste and school bus drivers.
- A diagnosis of OSA without additional risk factors for impaired driving should not be the basis for reporting a patient unless required by state law.
The US Department of Transportation convened a group of respiratory experts at its Conference on Pulmonary/Respiratory Disorders in Commercial Drivers in September 1990. The group recommends that operators with suspected sleep apnea should not be medically qualified for commercial vehicle operation "until the diagnosis has been eliminated or accurately treated."
A US Federal Aviation Administration specification letter entitled "Sleep Apnea Evaluation Specifications" states that the complications of OSA present a risk to flying safety and recommends an initial workup, acceptable treatments, and follow-up for pilots being evaluated for OSA.
More on Obstructive Sleep Apnea |
| Overview: Obstructive Sleep Apnea |
| Differential Diagnoses & Workup: Obstructive Sleep Apnea |
| Treatment & Medication: Obstructive Sleep Apnea |
Follow-up: Obstructive Sleep Apnea |
| Multimedia: Obstructive Sleep Apnea |
| References |
| Further Reading |
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References
Guilleminault C, Tilkian A, Dement WC. The sleep apnea syndromes. Annu Rev Med. 1976;27:465-84. [Medline].
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. Apr 1993;328(17):1230-5. [Medline].
Johnson EO, Roth T. An epidemiologic study of sleep-disordered breathing symptoms among adolescents. Sleep. Sep 1 2006;29(9):1135-42. [Medline].
Downey R 3rd, Perkin RM, MacQuarrie J. Upper airway resistance syndrome: sick, symptomatic but underrecognized. Sleep. Oct 1993;16(7):620-3. [Medline].
Hoffstein V. Snoring. Chest. Jan 1996;109(1):201-22. [Medline].
Bonnet MH. Effect of sleep disruption on sleep, performance, and mood. Sleep. 1985;8(1):11-9. [Medline].
Lavie P. Who was the first to use the term Pickwickian in connection with sleepy patients? History of sleep apnoea syndrome. Sleep Med Rev. Feb 2008;12(1):5-17. [Medline].
Bickelmann AG, Burwell CS, Robin ED, Whaley RD. Extreme obesity associated with alveolar hypoventilation; a Pickwickian syndrome. Am J Med. Nov 1956;21(5):811-8. [Medline].
Gastaut H, Tassinari CA, Duron B. [Polygraphic study of diurnal and nocturnal (hypnic and respiratory) episodal manifestations of Pickwick syndrome]. Rev Neurol (Paris). Jun 1965;112(6):568-79. [Medline].
Jung R, Kuhlo W. Neurophysiological studies of abnormal night sleep and the pickwickian syndrome. Prog Brain Res. 1965;18:140-59. [Medline].
Sullivan CE, Issa FG, Berthon-Jones M, Eves L. Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet. Apr 18 1981;1(8225):862-5. [Medline].
Fujita S, Conway W, Zorick F, Roth T. Surgical correction of anatomic azbnormalities in obstructive sleep apnea syndrome: uvulopalatopharyngoplasty. Otolaryngol Head Neck Surg. Nov-Dec 1981;89(6):923-34. [Medline].
Dement WC. Kryger MH, Roth T, Dement WC, eds. Principles and Practice of Sleep Medicine. 4th ed. Philadelphia, Pa: Elsevier; 2005:1-12.
American Academy of Sleep Medicine. International Classification of Sleep Disorders: Diagnostic and Coding Manual, Second Edition. Westchester, Ill: American Academy of Sleep Medicine; 2005.
Schwab RJ, Pasirstein M, Pierson R, Mackley A, Hachadoorian R, Arens R, et al. Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am J Respir Crit Care Med. Sep 2003;168(5):522-30. [Medline].
Black JE, Hirshkowitz M. Modafinil for treatment of residual excessive sleepiness in nasal continuous positive airway pressure-treated obstructive sleep apnea/hypopnea syndrome. Sleep. Apr 2005;28(4):464-71. [Medline].
Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, et al. Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation. Sep 2 2008;118(10):1080-111. [Medline].
Becker HF, Jerrentrup A, Ploch T, Grote L, Penzel T, Sullivan CE, et al. Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation. Jan 2003;107(1):68-73. [Medline].
Wang H, Parker JD, Newton GE, Floras JS, Mak S, Chiu KL, et al. Influence of obstructive sleep apnea on mortality in patients with heart failure. J Am Coll Cardiol. Apr 17 2007;49(15):1625-31. [Medline].
Kaneko Y, Floras JS, Usui K, Plante J, Tkacova R, Kubo T, et al. Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med. Mar 2003;348(13):1233-41. [Medline].
[Best Evidence] Mehra R, Stone KL, Varosy PD, et al. Nocturnal Arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: outcomes of sleep disorders in older men (MrOS sleep) study. Arch Intern Med. Jun 22 2009;169(12):1147-55. [Medline].
Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Javier Nieto F, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. Jan 2001;163(1):19-25. [Medline].
Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA. Apr 28 2004;291(16):2013-6. [Medline].
Freedman DS, Khan LK, Serdula MK, Galuska DA, Dietz WH. Trends and correlates of class 3 obesity in the United States from 1990 through 2000. JAMA. Oct 2002;288(14):1758-61. [Medline].
[Best Evidence] Tonelli de Oliveira AC, Martinez D, Vasconcelos LF, et al. Diagnosis of obstructive sleep apnea syndrome and its outcomes with home portable monitoring. Chest. Feb 2009;135(2):330-6. [Medline].
American Sleep Disorders Association. Practice parameters for the treatment of snoring and obstructive sleep apnea with oral appliances. Sleep. Jul 1995;18(6):511-3. [Medline].
Tsai WH, Vazquez JC, Oshima T, Dort L, Roycroft B, Lowe AA, et al. Remotely controlled mandibular positioner predicts efficacy of oral appliances in sleep apnea. Am J Respir Crit Care Med. Aug 15 2004;170(4):366-70. [Medline].
Raphaelson MA, Alpher EJ, Bakker KW, Perlstrom JR. Oral appliance therapy for obstructive sleep apnea syndrome: progressive mandibular advancement during polysomnography. Cranio. Jan 1998;16(1):44-50. [Medline].
Petelle B, Vincent G, Gagnadoux F, Rakotonanahary D, Meyer B, Fleury B. One-night mandibular advancement titration for obstructive sleep apnea syndrome: a pilot study. Am J Respir Crit Care Med. Apr 2002;165(8):1150-3. [Medline].
Li KK, Powell NB, Riley RW. Overview of phase I surgery for obstructive sleep apnea syndrome. Ear Nose Throat J. Nov 1999;78(11):836-7, 841-5. [Medline].
Li KK, Riley RW, Powell NB, Troell R, Guilleminault C. Overview of phase II surgery for obstructive sleep apnea syndrome. Ear Nose Throat J. Nov 1999;78(11):851, 854-7. [Medline].
Powell NB, Riley RW, Troell RJ, Li K, Blumen MB, Guilleminault C. Radiofrequency volumetric tissue reduction of the palate in subjects with sleep-disordered breathing. Chest. May 1998;113(5):1163-74. [Medline].
Li KK, Powell NB, Riley RW, Troell RJ, Guilleminault C. Radiofrequency volumetric reduction of the palate: An extended follow- up study. Otolaryngol Head Neck Surg. Mar 2000;122(3):410-4. [Medline].
Coleman SC, Smith TL. Midline radiofrequency tissue reduction of the palate for bothersome snoring and sleep-disordered breathing: A clinical trial. Otolaryngol Head Neck Surg. Mar 2000;122(3):387-94. [Medline].
[Best Evidence] Antic NA, Buchan C, Esterman A, et al. A randomized controlled trial of nurse-led care for symptomatic moderate-severe obstructive sleep apnea. Am J Respir Crit Care Med. Mar 15 2009;179(6):501-8. [Medline].
American Thoracic Society. Sleep apnea, sleepiness, and driving risk. Am J Respir Crit Care Med. Nov 1994;150(5 Pt 1):1463-73. [Medline].
Badr MS. Pathophysiology of upper airway obstruction during sleep. Clin Chest Med. Mar 1998;19(1):21-32. [Medline].
Bahammam A, Kryger M. Decision making in obstructive sleep-disordered breathing. Putting it all together. Clin Chest Med. Mar 1998;19(1):87-97. [Medline].
Kramer NR, Bonitati AE, Millman RP. Enuresis and obstructive sleep apnea in adults. Chest. Aug 1998;114(2):634-7. [Medline].
Loube DI, Gay PC, Strohl KP, Pack AI, White DP, Collop NA. Indications for positive airway pressure treatment of adult obstructive sleep apnea patients: a consensus statement. Chest. Mar 1999;115(3):863-6. [Medline].
Millman RP, Rosenberg CL, Kramer NR. Oral appliances in the treatment of snoring and sleep apnea. Clin Chest Med. Mar 1998;19(1):69-75. [Medline].
Pancer J, Al-Faifi S, Al-Faifi M, Hoffstein V. Evaluation of variable mandibular advancement appliance for treatment of snoring and sleep apnea [see comments]. Chest. Dec 1999;116(6):1511-8. [Medline].
Powell NB, Riley RW, Robinson A. Surgical management of obstructive sleep apnea syndrome. Clin Chest Med. Mar 1998;19(1):77-86. [Medline].
Redline S, Strohl KP. Recognition and consequences of obstructive sleep apnea hypopnea syndrome. Clin Chest Med. Mar 1998;19(1):1-19. [Medline].
Riley RW, Powell NB, Guilleminault C. Obstructive sleep apnea syndrome: a review of 306 consecutively treated surgical patients. Otolaryngol Head Neck Surg. Feb 1993;108(2):117-25. [Medline].
Schmidt-Nowara W, Lowe A, Wiegand L, Cartwright R, Perez-Guerra F, Menn S. Oral appliances for the treatment of snoring and obstructive sleep apnea: a review. Sleep. Jul 1995;18(6):501-10. [Medline].
Schwab RJ. Upper airway imaging. Clin Chest Med. Mar 1998;19(1):33-54. [Medline].
Schwab RJ, Goldberg AN, Pack AI. Sleep apnea syndromes. In: Fishman AP, ed. Fishman's Pulmonary Diseases and Disorders. Vol 2. 3rd ed. New York, NY: McGraw-Hill; 1999:1617-37.
Strollo PJ Jr, Sanders MH, Atwood CW. Positive pressure therapy. Clin Chest Med. Mar 1998;19(1):55-68. [Medline].
Thorpy MJ, chair. Diagnostic Classification Steering Committee. Obstructive Sleep Apnea Syndrome. In: International Classification of Sleep Disorders: Diagnostic and Coding Manual, Second Edition. Rochester, Minn: American Sleep Disorders Association; 1990:52-8.
Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. Nov 2005;353(19):2034-41. [Medline].
Further Reading
Available clinical treatment guidelines include the following:
- Practice parameters for the treatment of snoring and obstructive sleep apnea with oral appliances: an update for 2005
- Practice guidelines for the perioperative management of patients with obstructive sleep apnea: a report by the American Society of Anesthesiologists Task Force on Perioperative Management of Patients with Obstructive Sleep Apnea.
- Practice parameters for the medical therapy of obstructive sleep apnea
- Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007
- Practice parameters for the indications for polysomnography and related procedures: an update for 2005
Available clinical trials include the following:
- Minimally Invasive Tongue Suture For Obstructive Sleep Apnea
- Cardiovascular Phenotype Study in Patients With Obstructive Sleep Apnea Syndrome
- Coblation-Tonsillotomy vs Electrocautery-Tonsillectomy for the Treatment of Obstructive Sleep Apnea (OSA) in Children
- Sexual Dysfunction And Hypotestosteronemia In Patients With Obstructive Sleep Apnea Syndrome And Its Effects With CPAP Therapy
- Effects of Continuous Positive Airway Pressure (CPAP) in Patients With Resistant Hypertension and Obstructive Sleep Apnea (OSA)
Keywords
obstructive sleep apnea, OSA, sleep apnea, apnea, sleep disorder, snoring, sleep-related disorder, sleep disordered breathing, SDB, central apnea, obstructive apnea, mixed apnea, hypopnea, upper airway resistance syndrome, UARS, nasal continuous positive airway pressure, nasal CPAP, CPAP, apnea index, AI respiratory disturbance index, RDI, apnea-hypopnea index, AH, PSG, polysomnography, pickwickian syndrome, excessive daytime sleepiness, EDS, uvulopalatopharyngoplasty, UPPP, respiratory event–related arousal, RERA, oral appliance, OA, bilevel positive airway pressure, BiPAP, sleep-related breathing disorder, SRBD
Follow-up: Obstructive Sleep Apnea