eMedicine Specialties > Pulmonology > Obstructive Airways Diseases
Chronic Obstructive Pulmonary Disease: Multimedia
Updated: Oct 26, 2009
Multimedia
![]() | Media file 2: Chronic obstructive pulmonary disease (COPD). Gross pathology of advanced emphysema. Large bullae are present on the surface of the lung. |
![]() | Media file 3: Chronic obstructive pulmonary disease (COPD). Gross pathology of a patient with emphysema showing bullae on the surface. |
![]() | Media file 4: Chronic obstructive pulmonary disease (COPD). Histopathology of chronic bronchitis showing hyperplasia of mucous glands and infiltration of the airway wall with inflammatory cells. |
![]() | Media file 6: Chronic obstructive pulmonary disease (COPD). At high magnification, in emphysema, loss of alveolar walls and dilatation of airspaces occurs. |
![]() | Media file 7: Chronic obstructive pulmonary disease (COPD). Pressure volume curve comparing lungs with emphysema lungs and restrictive lungs to normal lungs. |
![]() | Media file 11: Chronic obstructive pulmonary disease (COPD). A CT scan shows hyperlucency due to hypovascularity and bullae formation diffusely, predominantly in upper lobes. |
![]() | Media file 14: Severe bullous disease observed on CT scan in a patient with chronic obstructive pulmonary disease (COPD). |
![]() | Media file 15: Chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation. |
![]() | Media file 16: Chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation. |
![]() | Media file 17: Chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation. |
![]() | Media file 18: Chronic obstructive pulmonary disease (COPD). |
![]() | Media file 19: Chronic obstructive pulmonary disease (COPD). Bilevel positive airway pressure (BiPAP). |
More on Chronic Obstructive Pulmonary Disease |
| Overview: Chronic Obstructive Pulmonary Disease |
| Differential Diagnoses & Workup: Chronic Obstructive Pulmonary Disease |
| Treatment & Medication: Chronic Obstructive Pulmonary Disease |
| Follow-up: Chronic Obstructive Pulmonary Disease |
Multimedia: Chronic Obstructive Pulmonary Disease |
| References |
| « Previous Page |
References
GOLD - The Global Initiative for Chronic Obstructive Lung Disease. Available at www.goldcopd.com.
[Guideline] Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. National Guideline Clearinghouse. 2008;[Full Text].
Feghali-Bostwick CA, Gadgil AS, Otterbein LE, Pilewski JM, Stoner MW, Csizmadia E. Autoantibodies in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. Jan 15 2008;177(2):156-63. [Medline].
Houben JM, Mercken EM, Ketelslegers HB, et al. Telomere shortening in chronic obstructive pulmonary disease. Respir Med. Feb 2009;103(2):230-6. [Medline].
Ofir D, Laveneziana P, Webb KA, Lam YM, O'Donnell DE. Mechanisms of dyspnea during cycle exercise in symptomatic patients with GOLD stage I chronic obstructive pulmonary disease. Am J Respir Crit Care Med. Mar 15 2008;177(6):622-9. [Medline].
Belman MJ, Botnick WC, Shin JW. Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. Mar 1996;153(3):967-75. [Medline].
O'Donnell DE, Lam M, Webb KA. Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. Aug 1999;160(2):542-9. [Medline].
Marin JM, Carrizo SJ, Gascon M, Sanchez A, Gallego B, Celli BR. Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. May 2001;163(6):1395-9. [Medline].
O'Donnell DE, Fluge T, Gerken F, et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J. Jun 2004;23(6):832-40. [Medline].
Marin JM, Carrizo SJ, Gascon M, Sanchez A, Gallego B, Celli BR. Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. May 2001;163(6):1395-9. [Medline].
Martinez F, Montes de Oca M, Whyte R, et al. Lung-volume reduction surgery improves dyspnea, dynamic hyperinflation and respiratory muscle function. Am J Respir Crit Care Med. 1997;155:2018-2023.
Celli BR. Update on the management of COPD. Chest. Jun 2008;133(6):1451-62. [Medline].
Maclay JD, Rabinovich RA, MacNee W. Update in chronic obstructive pulmonary disease 2008. Am J Respir Crit Care Med. Apr 1 2009;179(7):533-41. [Medline].
Casanova C, Cote C, de Torres JP, et al. Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. Mar 15 2005;171(6):591-7. [Medline].
Morissette MC, Vachon-Beaudoin G, Parent J, Chakir J, Milot J. Increased p53 level, Bax/Bcl-x(L) ratio, and TRAIL receptor expression in human emphysema. Am J Respir Crit Care Med. Aug 1 2008;178(3):240-7. [Medline].
Hodge S, Hodge G, Jersmann H, et al. Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. Jul 15 2008;178(2):139-48. [Medline].
Buist AS, McBurnie MA, Vollmer WM, et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet. Sep 1 2007;370(9589):741-50. [Medline].
Halbert RJ, Natoli JL, Gano A, Badamgarav E, Buist AS, Mannino DM. Global burden of COPD: systematic review and meta-analysis. Eur Respir J. Sep 2006;28(3):523-32. [Medline].
Casanova C, Cote C, Marin JM, et al. Distance and oxygen desaturation during the 6-min walk test as predictors of long-term mortality in patients with COPD. Chest. Oct 2008;134(4):746-52. [Medline].
[Best Evidence] Mottillo S, Filion KB, Belisle P, et al. Behavioural interventions for smoking cessation: a meta-analysis of randomized controlled trials. Eur Heart J. Mar 2009;30(6):718-30. [Medline].
[Guideline] US Preventive Services Task Force. Counseling and interventions to prevent tobacco use and tobacco-caused disease in adults and pregnant women: US Preventive Services Task Force Reaffirmation Recommendation Statement. Ann Int Med. Apr 21 2009;150(8):551-555. [Full Text].
Maclay JD, Rabinovich RA, MacNee W. Update in chronic obstructive pulmonary disease 2008. Am J Respir Crit Care Med. Apr 1 2009;179(7):533-41. [Medline].
Casaburi R, Mahler DA, Jones PW, et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J. Feb 2002;19(2):217-24. [Medline].
Donohue JF, van Noord JA, Bateman ED, et al. A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest. Jul 2002;122(1):47-55. [Medline].
Vincken W, van Noord JA, Greefhorst AP, et al. Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium. Eur Respir J. Feb 2002;19(2):209-16. [Medline].
Tashkin DP, Celli B, Senn S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. Oct 9 2008;359(15):1543-54. [Medline].
[Best Evidence] Calverley PM, Rabe KF, Goehring UM, Kristiansen S, Fabbri LM, Martinez FJ. Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet. Aug 29 2009;374(9691):685-94. [Medline].
Calverley PM, Anderson JA, Celli B, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med. Feb 22 2007;356(8):775-89. [Medline].
[Best Evidence] Sin DD, Tashkin D, Zhang X, et al. Budesonide and the risk of pneumonia: a meta-analysis of individual patient data. Lancet. Aug 29 2009;374(9691):712-9. [Medline].
Seemungal TA, Wilkinson TM, Hurst JR, Perera WR, Sapsford RJ, Wedzicha JA. Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations. Am J Respir Crit Care Med. Dec 1 2008;178(11):1139-47. [Medline].
[Best Evidence] Sasaki T, Nakayama K, Yasuda H, et al. A randomized, single-blind study of lansoprazole for the prevention of exacerbations of chronic obstructive pulmonary disease in older patients. J Am Geriatr Soc. Aug 2009;57(8):1453-7. [Medline].
Sandland CJ, Morgan MD, Singh SJ. Patterns of domestic activity and ambulatory oxygen usage in COPD. Chest. Oct 2008;134(4):753-60. [Medline].
Carrera M, Marin JM, Anton A, et al. A controlled trial of noninvasive ventilation for chronic obstructive pulmonary disease exacerbations. J Crit Care. Sep 2009;24(3):473.e7-14. [Medline].
Keenan SP, Kernerman PD, Cook DJ, Martin CM, McCormack D, Sibbald WJ. Effect of noninvasive positive pressure ventilation on mortality in patients admitted with acute respiratory failure: a meta-analysis. Crit Care Med. Oct 1997;25(10):1685-92. [Medline].
Confalonieri M, Garuti G, Cattaruzza MS, et al. A chart of failure risk for noninvasive ventilation in patients with COPD exacerbation. Eur Respir J. Feb 2005;25(2):348-55. [Medline].
Duiverman ML, Wempe JB, Bladder G, et al. Nocturnal non-invasive ventilation in addition to rehabilitation in hypercapnic patients with COPD. Thorax. Dec 2008;63(12):1052-7. [Medline].
Fishman A, Martinez F, Naunheim K, et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med. May 22 2003;348(21):2059-73. [Medline].
Titman A, Rogers CA, Bonser RS, Banner NR, Sharples LD. Disease-specific survival benefit of lung transplantation in adults: a national cohort study. Am J Transplant. Jul 2009;9(7):1640-9. [Medline].
Burton CM, Milman N, Carlsen J, et al. The Copenhagen National Lung Transplant Group: survival after single lung, double lung, and heart-lung transplantation. J Heart Lung Transplant. Nov 2005;24(11):1834-43. [Medline].
Cote CG, Celli BR. Pulmonary rehabilitation and the BODE index in COPD. Eur Respir J. Oct 2005;26(4):630-6. [Medline].
Alsaeedi A, Sin DD, McAlister FA. The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials. Am J Med. Jul 2002;113(1):59-65. [Medline].
Anthonisen NR. Prognosis in chronic obstructive pulmonary disease: results from multicenter clinical trials. Am Rev Respir Dis. Sep 1989;140(3 Pt 2):S95-9. [Medline].
Anthonisen NR, Connett JE, Kiley JP, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA. Nov 16 1994;272(19):1497-505. [Medline].
Belman MJ, Botnick WC, Shin JW. Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. Mar 1996;153(3):967-75. [Medline].
Brenes GA. Anxiety and chronic obstructive pulmonary disease: prevalence, impact, and treatment. Psychosom Med. Nov-Dec 2003;65(6):963-70. [Medline].
Burrows B, Bloom JW, Traver GA, Cline MG. The course and prognosis of different forms of chronic airways obstruction in a sample from the general population. N Engl J Med. Nov 19 1987;317(21):1309-14. [Medline].
Chapman KR. Therapeutic algorithm for chronic obstructive pulmonary disease. Am J Med. Oct 21 1991;91(4A):17S-23S. [Medline].
Davis RM, Novotny TE. The epidemiology of cigarette smoking and its impact on chronic obstructive pulmonary disease. Am Rev Respir Dis. Sep 1989;140(3 Pt 2):S82-4. [Medline].
Dunn WF, Nelson SB, Hubmayr RD. Oxygen-induced hypercarbia in obstructive pulmonary disease. Am Rev Respir Dis. Sep 1991;144(3 Pt 1):526-30. [Medline].
Fabbri LM, Luppi F, Beghé B, Rabe KF. Update in chronic obstructive pulmonary disease 2005. Am J Respir Crit Care Med. May 15 2006;173(10):1056-65. [Medline].
Ferguson GT, Cherniack RM. Management of chronic obstructive pulmonary disease. N Engl J Med. Apr 8 1993;328(14):1017-22. [Medline].
Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J. Jun 25 1977;1(6077):1645-8. [Medline].
Karpel JP, Kotch A, Zinny M, Pesin J, Alleyne W. A comparison of inhaled ipratropium, oral theophylline plus inhaled beta-agonist, and the combination of all three in patients with COPD. Chest. Apr 1994;105(4):1089-94. [Medline].
Lopez-Majano V, Dutton RE. Regulation of respiration during oxygen breathing in chronic obstructive lung disease. Am Rev Respir Dis. Aug 1973;108(2):232-40. [Medline].
Mannino DM, Watt G, Hole D, Gillis C, Hart C, McConnachie A. The natural history of chronic obstructive pulmonary disease. Eur Respir J. Mar 2006;27(3):627-43. [Medline].
McKay SE, Howie CA, Thomson AH, Whiting B, Addis GJ. Value of theophylline treatment in patients handicapped by chronic obstructive lung disease. Thorax. Mar 1993;48(3):227-32. [Medline].
[Guideline] O'Donnell DE, Hernandez P, Aaron S, et al. Canadian Thoracic Society COPD Guidelines: summary of highlights for family doctors. Can Respir J. May-Jun 2003;10(4):183-5. [Medline].
O'Donnell DE, Parker CM. COPD exacerbations . 3: Pathophysiology. Thorax. Apr 2006;61(4):354-61. [Medline].
O'Donnell DE, Sanii R, Anthonisen NR, Younes M. Effect of dynamic airway compression on breathing pattern and respiratory sensation in severe chronic obstructive pulmonary disease. Am Rev Respir Dis. Apr 1987;135(4):912-8. [Medline].
O'Donnell R, Breen D, Wilson S, Djukanovic R. Inflammatory cells in the airways in COPD. Thorax. May 2006;61(5):448-54. [Medline].
Papi A, Luppi F, Franco F, Fabbri LM. Pathophysiology of exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc. May 2006;3(3):245-51. [Medline].
Pauwels R. Global initiative for chronic obstructive lung diseases (GOLD): time to act. Eur Respir J. Dec 2001;18(6):901-2. [Medline].
Peto R, Speizer FE, Cochrane AL, et al. The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Results from 20 years of prospective observation. Am Rev Respir Dis. Sep 1983;128(3):491-500. [Medline].
Petty TL, Finigan MM. Clinical evaluation of prolonged ambulatory oxygen therapy in chronic airway obstruction. Am J Med. Aug 1968;45(2):242-52. [Medline].
Postma DS, Sluiter HJ. Prognosis of chronic obstructive pulmonary disease: the Dutch experience. Am Rev Respir Dis. Sep 1989;140(3 Pt 2):S100-5. [Medline].
Prigmore S. End-of-life decisions and respiratory disease. Nurs Times. Feb 14-20 2006;102(7):56, 59, 61. [Medline].
Ram FS, Rodriguez-Roisin R, Granados-Navarrete A. Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2006;CD004403.
Rutten FH, Cramer MJ, Lammers JW, Grobbee DE, Hoes AW. Heart failure and chronic obstructive pulmonary disease: An ignored combination?. Eur J Heart Fail. Nov 2006;8(7):706-11. [Medline].
Sanders C. The radiographic diagnosis of emphysema. Radiol Clin North Am. Sep 1991;29(5):1019-30. [Medline].
Schachter EN. Cilomilast. Drugs Today (Barc). Apr 2006;42(4):237-47. [Medline].
Sutherland ER, Martin RJ. Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. J Allergy Clin Immunol. Nov 2003;112(5):819-27; quiz 828. [Medline].
Thurlbeck WM. Overview of the pathology of pulmonary emphysema in the human. Clin Chest Med. Sep 1983;DA - 19840127(3):337-50. [Medline].
Thurlbeck WM. Pathophysiology of chronic obstructive pulmonary disease. Clin Chest Med. Sep 1990;11(3):389-403. [Medline].
Tsoumakidou M, Siafakas NM. Novel insights into the aetiology and pathophysiology of increased airway inflammation during COPD exacerbations. Respir Res. May 22 2006;7:80. [Medline].
Ulrik CS. Efficacy of inhaled salmeterol in the management of smokers with chronic obstructive pulmonary disease: a single centre randomised, double blind, placebo controlled, crossover study. Thorax. Jul 1995;50(7):750-4. [Medline].
Vestbo J. Clinical assessment, staging, and epidemiology of chronic obstructive pulmonary disease exacerbations. Proc Am Thorac Soc. May 2006;3(3):252-6. [Medline].
Weitzenblum E, Sautegeau A, Ehrhart M, Mammosser M, Pelletier A. Long-term oxygen therapy can reverse the progression of pulmonary hypertension in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. Apr 1985;131(4):493-8. [Medline].
Further Reading
Keywords
chronic obstructive pulmonary disease, COPD, chronic bronchitis, emphysema, chronic obstructive airway disease, COAD, airflow obstruction, centriacinar emphysema, panacinar emphysema, distal acinar emphysema, paraseptal emphysema






































Multimedia: Chronic Obstructive Pulmonary Disease