Updated: Jan 2, 2009
The anterior cruciate ligament (ACL) originates from the tibial plateau just medial and anterior to the tibial eminence. The ACL tracts from the tibia superiorly, laterally, and posteriorly, to its insertion on the posterior aspect of the medial wall of the lateral femoral condyle. The ACL is composed of 2 bundles, the anteromedial bundle and the posterolateral bundle. The ACL provides 85% of the total restraining force to anterior translation of the tibia. An ACL tear is a common injury that occurs in all types of sports. This injury usually occurs during a sudden cut or deceleration, as it typically is a noncontact injury. The patient states, "I planted, twisted, and then heard a pop." Before the advent of arthroscopic knee surgery in the early 1970s, ACL tear was often a career-ending injury.
Related eMedicine topics:
Anterior Cruciate Ligament Injury [Sports Medicine]
Anterior Cruciate Ligament Pathology
Knee, Anterior Cruciate Ligament Injuries (MRI)
Like all ligaments, the anterior cruciate ligament (ACL) is composed of type I collagen. The ultrastructure of a ligament is close to that of tendons, but the fibers in a ligament are more variable and have a higher elastin content. Ligaments receive their blood supply from their insertion sites. The vascularity within a ligament is uniform, and each ligament contains mechanoreceptors and free nerve endings that are hypothesized to aid in stabilizing the joint. Avulsion of ligaments generally occurs between the unmineralized and mineralized fibrocartilage layers. The more common ACL tear, however, is a midsubstance tear. This type of tear occurs primarily as the ligament is transected by the pivoting lateral femoral condyle.
Epidemiologic studies estimate that approximately 1 in 3000 individuals sustains an ACL injury each year in the United States. This figure corresponds to an overall injury rate approaching 200,000 injuries annually. This estimate is low for women, because ACL injury rates are estimated to be 2-8 times higher in women than in men participating in the same sports. The average cost for surgical repair of an ACL tear is approximately $11,500. If all ACL injuries were repaired, the associated expenditure for 100,000 procedures would eclipse $2 billion annually.
International statistics are not available.
Not a single report of mortality was found in 6 different studies examining the morbidity and mortality of anterior cruciate ligament repair. The total number of patients in these combined studies was 363. Morbidity was divided into 5 classes. The first class included patients who were symptomatic with activities of daily living (ADL). The second class included patients who were able to perform all ADL. Patients in the third class were able to perform mildly stressful sports (eg, jogging, swimming, biking, cross-country skiing). The fourth class included patients who were able to perform moderately stressful sports, including baseball, alpine skiing, racquet sports, dance, and lacrosse. The last class included patients who returned to perfect health and were capable of performing very stressful sports, such as soccer, basketball, football/rugby, volleyball, gymnastics, and hockey. Postsurgery status of patients was as follows:
No known correlation exists between race and occurrence of ACL injuries.
According to numerous studies, female athletes sustain a greater number of anterior cruciate ligament (ACL) injuries than do male athletes. These results are well supported in 2 different papers. The first paper, by Arendt and Dick, showed that female athletes sustained significantly higher incidences of ACL injuries than their male counterparts did when competing in collegiate soccer and basketball.1 The authors' data demonstrated that women have a 2.4 and a 4.1 times greater chance of incurring ACL injury when compared with males in soccer and basketball, respectively. A second paper, by Hutchinson and Ireland, reported that female athletes competing in the 1988 Olympic basketball trials sustained 81% of ACL injuries during the trials.2
Anterior cruciate ligament injuries occur most commonly in individuals aged 14-29 years. These years correspond to a high degree of athletic activity.
Obtain as much information as possible directly from the patient. The important facts can be clarified by asking questions about the following:
Up to 50% of patients with acute knee injuries who report feeling or hearing a snapping or popping sound are found to have an anterior cruciate ligament (ACL) injury. A hemarthrosis almost always is present because of the vascular supply to the ACL. When a complete ligamentous tear occurs, pain may begin immediately, followed by resolution. Immediately following injury, minimal effusion or spasm is present, so ACL injury usually can be identified easily. Several hours after injury, effusion and spasm make diagnosis of an ACL tear more difficult.
To determine the patient's normal amount of laxity, examine the uninjured knee first.
Anterior cruciate ligament (ACL) injuries haveno single cause. ACL injuries can be related to extrinsic factors and intrinsic factors. Numerous studies document the fact that poor levels of conditioning correlate directly with increased levels of injury. Research also has demonstrated that improved conditioning results in reduced numbers of injuries.
Knee Dislocations
Meniscal Injury
Patellar dislocation/fracture
Femoral, tibial, or fibular fracture
The postoperative rehabilitation program begins as soon as the patient awakens from anesthesia, especially because patients are discharged earlier now than they were in previous years. Quadriceps co-contractions make up the first exercise that patients should be taught for the maintenance of terminal extension.
Passive motion is emphasized with active flexion and assisted extension in the sitting or prone position to ensure good leg control (ie, ability to flex the hip and lift the leg against gravity without assistance.) A continuous passive motion machine (CPM) can be used to establish 0-30° of motion immediately postoperatively and to progress to 60° of knee flexion by the morning following the operation. The patient then begins gait training with crutches (weight bearing as tolerated), with the knee in an immobilizer. The patient usually can be discharged on the first postoperative day and should be encouraged to avoid crowds, keep the leg elevated when not ambulating, use the crutches at all times for protection, and continue frequent icing.
A number of different programs are used by different physical therapists. The therapy program chosen depends on the activity level of the patient and the type of surgery performed, coexistent injuries (meniscal or other ligamentous injury), the surgeon, the insurance policy, and time constraints.
Goal-oriented rehabilitation for patellar tendon grafts
The following rehabilitation program is an accelerated program for patellar tendon grafts. Note that the other grafts rehabilitate slightly differently. This rehabilitation program is classified as a goal-oriented approach. The dates listed are not meant to be followed strictly and can be varied by a day or 2, depending on the physician or the patient's schedule.
On day 3 following surgery, have the patient return to the surgeon for evaluation. Begin therapy on an outpatient basis, concentrating on gait training and other ambulation-oriented activities. The goal is to maintain terminal knee extension and progression toward 90° of flexion. The therapist emphasizes a normal heel-to-toe gait pattern, and the patient may weight bear as tolerated on the involved leg. Continue passive flexion ROM exercises. Have the patient increase quadriceps activity, introducing the partial squat with progression from bilateral to unilateral, placing increased body weight on the extremity involved at no more than 45° of flexion. Continue these exercises for 1 week. Continue the knee immobilizer when ambulating and continue regular icing of the knee.
On day 10 following surgery, have the patient return to the surgeon for evaluation. Advance therapy to include wall slide-squats and a stationary bike as tolerated. Place emphasis on terminal extension, progressive flexion, and full weight-bearing ambulation with normal heel-to-toe mechanics. In a controlled environment (no pets, children, or distractions), have the patient begin practicing crutch ambulation while out of the knee immobilizer. The patient should achieve full terminal knee extension and approximately 90-100° of knee flexion.
Three to 4 weeks after the surgery, the aggressive patient is ambulating with normal gait mechanics. At this point, the knee immobilizer can be removed. Advance the patient's activity to include loaded squats, swimming, eccentric quadriceps strengthening, bridging with a physioball, and a stair stepper. During this time, if the therapist is not observant, the patient can develop tendonitis of the quadriceps tendon or other repetitive use injuries of the lower extremity. Application of ice after each therapy session is very important.
Six weeks after surgery, release the patient to light jogging or bicycling. If the patient is older and has concomitant degenerative joint disease, encourage bicycling. The graft is still very weak at this stage, so advise the patient that it is important not to fall. The patient should jog only on a track or other flat protected surface. At this point, active ROM should be approaching 0-125° with minimal or no joint effusion. Work on balance and proprioception with activity drills.
At 3 months, recommend that the patient begin a gradual return to normal activities. At this point, most people do not require bracing, but occasionally, some athletes request a brace to increase their own comfort level when competing.
Open kinetic chain (OKC) and closed kinetic chain (CKC) exercises
Significant discussion surrounds the difference between OKC and CKC exercises during ACL rehabilitation. The difference concerns the assumption that CKC exercises are safer than OKC exercises because they place less strain on the ACL graft, producing less patellofemoral pain. The second assumption is that CKC exercises are more functional and are equally effective in improving quadriceps muscle force production.
A study by Beynnon and colleagues showed no difference in ACL strain characteristics between OKC and CKC exercises.12,13 A report by Fleming and coauthors argues that, with improved anatomical placement of the ACL graft, the graft may respond more like the intact ACL during OKC and CKC exercises. Therefore, these 2 articles argue that both types of exercise can be performed safely.
With regard to safety, OKC and CKC exercises can be applied in a manner that minimizes the risk of excessive graft strain and patellofemoral compression. Using different knee joint motion excursions for each type of exercise is the key to risk reduction. When OKC knee extensions are performed, limit knee joint motion to more flexed positions. During CKC lower extremity exercises, limit knee joint motions to more extended positions.
Nonoperative treatment
Patients may for a variety of reasons— if, for example, they are not highly active or athletic or are minimally symptomatic —opt for nonoperative treatment. In these cases, after initial control of pain and effusion, start hamstring and quadriceps activation/disinhibition and protected weight bearing in a hinged brace. As swelling and pain slowly resolve, ROM should return to normal, or nearly normal, parameters. Start exercises that take place in an anterior/posterior plane (eg, stationary cycling). Exercises need to be nonballistic.
Several options exist for the patient who elects to have surgery. For complete rupture, no local healing response is detectable at the injury site, and a graft must be used to replace the ACL.15 Today, 4 options are used. The first 3 types are autografts using the central one third of the patellar ligament (considered a bone-ligament-bone graft), the quadruple semitendinosus/gracilis tendon, or the quadriceps tendon.16,17 The fourth type of graft is a cadaveric allograft.
Ultimately, the decision as to which graft is best is still a matter of contention. The agreement is that the patellar and hamstring grafts are superior to the quadriceps graft and the allograft; however, the decision as to which is the better of the patellar and hamstring grafts depends on which surgeon is operating.
With regard to osteoarthritis, the type of graft does not appear to influence the development of osteoarthritis. In spite of the type of graft, a certain percentage of patients develop osteoarthritis in the reconstructed knee, especially patients with concomitant or subsequent meniscectomy.
In anterior cruciate ligament injury cases, presurgical consultations with other services generally are needed only in connection with surgical clearance. After surgery, it is important to consult with a specialist in physical medicine and rehabilitation (PMR) for initiation of a program to facilitate the patient's rehabilitation.
Some patients, especially those who are minimally involved in sports, elect not to have surgery and instead choose bracing. Several custom and off-the-shelf, anterior cruciate ligament–specific braces are available. For patients who are involved in vigorous sports, the use of braces without surgical stabilization is not recommended.
The goal of pharmacotherapy is to reduce morbidity.
These agents have analgesic, anti-inflammatory, and antipyretic activities. Their mechanism of action is not known, but they may inhibit cyclooxygenase activity and prostaglandin synthesis. Other mechanisms may exist as well, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell-membrane functions.
DOC for patients with mild to moderate pain. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.
600-800 mg PO tid
Not established
Coadministration with aspirin increases risk of inducing serious NSAID-related side effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effect of hydralazine, captopril, and beta blockers; may decrease diuretic effects of furosemide and thiazides; monitor PT closely (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrently
Documented hypersensitivity; peptic ulcer disease, recent GI bleeding or perforation, renal insufficiency, or high risk of bleeding
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
Caution in congestive heart failure, hypertension, and decreased renal and hepatic function; caution in anticoagulation abnormalities or during anticoagulant therapy
Pain control is essential to quality patient care. If nonsteroidal anti-inflammatory drugs (NSAIDs) are not sufficient, then narcotics may be given. Analgesics ensure patient comfort, promote pulmonary toilet, and have sedating properties, which are beneficial to patients who have sustained trauma or injuries.
Indicated for the treatment of mild to moderate pain.
1-2 tab PO q4-6h prn
Not established
Toxicity increases with CNS depressants or tricyclic antidepressants
Documented hypersensitivity
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Caution in patients dependent on opiates, since this substitution may result in acute opiate-withdrawal symptoms; caution in severe renal or hepatic dysfunction
These drugs can be used as an alternative if the patient has GI upset or a history of GI bleeding with NSAID use. Because of the cost, these medications are not always a first-line choice.
Inhibits primarily COX-2. COX-2 is considered an inducible isoenzyme, being induced during pain and inflammatory stimuli. Inhibition of COX-1 may contribute to NSAID GI toxicity. At therapeutic concentrations, COX-1 isoenzyme is not inhibited; thus, GI toxicity may be decreased. Seek the lowest dose of celecoxib for each patient.
200 mg/d PO qd; alternatively, 100 mg PO bid
Not established
Coadministration with fluconazole may cause increase in plasma concentrations because of inhibition of celecoxib metabolism; coadministration of celecoxib with rifampin may decrease celecoxib plasma concentrations
Documented hypersensitivity
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
May cause fluid retention and peripheral edema; caution in compromised cardiac function, hypertension, and conditions predisposing to fluid retention; severe heart failure and hyponatremia because may deteriorate circulatory hemodynamics; NSAIDs may mask usual signs of infection; caution in the presence of existing controlled infections; evaluate symptoms and signs suggesting liver dysfunction or in abnormal liver lab results
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anterior cruciate ligament injury, ligament, knee surgery, ligaments, knee injury, knee injuries, torn ACL, ACL injury, ACL reconstruction, torn ligament, knee ligaments, anterior cruciate ligament, anterior cruciate, ligament tear, ACL tear, anteromedial bundle, posterolateral bundle, hemarthrosis, Segond fracture
Tarek Souryal, MD, Head Team Physician, Dallas Mavericks; Former Chief, Department of Surgery, Division of Orthopedic Surgery, Las Colinas Medical Center; Clinical Professor, Departments of Orthopedic Surgery and Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center
Tarek Souryal, MD is a member of the following medical societies: American Orthopaedic Society for Sports Medicine
Disclosure: Nothing to disclose.
Kenneth Adams, MD, Assistant Professor, Department of Physical Medicine and Rehabilitation, University of Texas Southwestern
Kenneth Adams, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, American Medical Association, and Texas Medical Association
Disclosure: Nothing to disclose.
Robert E Windsor, MD, FAAPMR, FAAEM, FAAPM, President and Director, Georgia Pain Physicians, PC; Clinical Associate Professor, Department of Physical Medicine and Rehabilitation, Emory University School of Medicine
Robert E Windsor, MD, FAAPMR, FAAEM, FAAPM is a member of the following medical societies: American Academy of Pain Medicine, American Academy of Physical Medicine and Rehabilitation, American College of Sports Medicine, American Medical Association, International Association for the Study of Pain, Physiatric Association of Spine, Sports and Occupational Rehabilitation, and Texas Medical Association
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.
Michael T Andary, MD, MS, Residency Program Director, Professor, Department of Physical Medicine and Rehabilitation, Michigan State University College of Osteopathic Medicine
Michael T Andary, MD, MS is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, American Association of Neuromuscular and Electrodiagnostic Medicine, American Medical Association, and Association of Academic Physiatrists
Disclosure: allergan Honoraria Speaking and teaching
Kelly L Allen, MD, Regional Medical Director, IMX-Medical Management Services
Disclosure: Nothing to disclose.
Consuelo T Lorenzo, MD, Consulting Staff, Department of Physical Medicine and Rehabilitation, Alegent Health Care, Immanuel Rehabilitation Center
Consuelo T Lorenzo, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation
Disclosure: Nothing to disclose.
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