Laboratory Studies
- No specific laboratory studies are necessary when a diagnosis of lumbar facet arthropathy is being considered.
Imaging Studies
- Abnormalities on plain radiographs, computed tomography (CT) scans, and magnetic resonance imaging (MRI) scans[31] are not specific for patients with back pain; degenerative changes are often found in asymptomatic persons. Although some clinicians may use plain radiography and CT scanning to investigate or even diagnose facet joint pain, no radiographic findings identify lumbar facet joints as the source of low back pain and referred lower extremity pain.[32]
- A limited number of studies have attempted to establish correlation between osteoarthritic changes and response to blocking of the joints. While some earlier studies demonstrated such a relationship, others have failed to do so. Furthermore, findings from MRI scans, CT scans, dynamic bending radiographs, and radionuclide bone scans cannot be used to reliably help predict lumbar facet joint pain.
- Schwarzer and colleagues concluded that CT scanning has no place in the diagnosis of lumbar facet joint pain.[33] They used the stringent criteria of 80% pain relief for the duration of bupivacaine anesthesia and negative relief with saline control injection. The investigators did not observe any correlation between CT-scan findings and response to diagnostic injections.
Procedures
- The use of diagnostic blocks is fundamental to a diagnosis of lumbar facet joint pain. Regardless of the symptoms, one characteristic that all patients with such pain share is the relief of pain once a local anesthetic has been injected. Fluoroscopically guided blocks of the joints constitute the only available standard to correlate with any clinical or radiographic test for facet joint pain.[34]
- Single diagnostic blocks are a poor standard. Those employed without the provision of controls led to a false-positive rate of 38% in a lumbar study[18] and a 27% false-positive rate in a cervical study, with a 32% placebo rate in still another investigation. If an investigator relied on a single, uncontrolled block, 1 of every 3 apparently positive blocks would be a false positive. A reliable diagnosis must be accompanied by observation in relation to control subjects.
- Control observation can be achieved either with saline injection around the joint while shielding the patient from view of the injections or through use of a confirmatory block. In a confirmatory block, relief achieved with the first local anesthetic is accompanied by relief provided by a second injection for a duration commensurate with the half-life of the second local anesthetic. A patient with genuine facet joint pain should experience relief with the first injection and feel no relief if injected with saline or, if injected with the confirmatory block, experience the same relief that he/she did with the first injection, but for a longer period of time.
- The use of double blocks to confirm facet pain is not without limitations. When an appropriate duration of relief with a confirmatory block was required, Lord and colleagues found in cervical studies that specificity was high (88%) but that sensitivity was low (54%) in comparison with double-blinded, randomized, placebo-controlled triple blocks.[35] When diagnostic criteria for the double blocks were expanded to include all patients with reproducible relief, regardless of duration, sensitivity increased to 100% but specificity was lowered to 65%. The authors concluded that a clinician's choice of controls depends on the implications of the results. If innocuous therapy is prescribed, relief of pain, regardless of duration, with a double block may suffice. When diagnostic certainty is critical, such as in a medicolegal context or when surgical intervention is contemplated, placebo-controlled blocks are recommended.
- The use of saline around the joint for control observation also has limitations. Of the various possible combinations of responses to 2 injections, pain relief in the same patient with local anesthetic and with saline poses a dilemma. The clinician could conclude that the patient does not have facet joint pain, having falsely responded to the local anesthetic and to the saline. However, a response to the saline injection does not necessarily negate the validity of the first injection with local anesthetic; it may instead indicate that the patient responded to a placebo. The individual may have true facet pain in addition to being a placebo responder. Because of this, some clinicians often proceed with RF neurotomy in patients who obtain 80% relief with lidocaine and with saline, depending on the clinical presentation. Studies are being conducted to report outcomes based on such an approach.
- Facet diagnostic blocks can be performed intra-articularly and at the dorsal medial branches that supply the joint. The latter site is used if the joint is not accessible or as a means of avoiding the theoretical risk of needle damage to the joint. Barnsley and Bogduk found that local anesthetic blocks of the cervical medial branches are a specific test for the diagnosis of cervical facet joint pain. In their study, local anesthetic always reached the target nerve and did not affect any other diagnostically important structures.[36] Dreyfuss and colleagues determined that, with the use of appropriate technique, lumbar medial branch blocks are target specific.[37] The use of 0.5 mL of lidocaine adequately bathed the site of the target nerve and trivialized the spread to the dorsal root or the epidural spread to other potential pain generators.
- With well-controlled studies reporting 7-14% prevalence rates for facet joint pain, clinicians must adopt stringent criteria for diagnosing facet joint pain. In this way, they can avoid unnecessarily subjecting a large portion of patients with chronic low back pain to various treatments aimed at facet joint pain.
Badgley CE. The articular facet in relation to low back pain and sciatic radiation. J Bone Joint Surg. 1941;23:481.
Ghormley RK. Low-back pain with special reference to the articular facets, with presentation of an operative procedure. JAMA. 1933;101:1773-7.
Rees WS. Multiple bilateral subcutaneous rhizolysis of segmental nerves in the treatment of intervertebral disc syndrome. Ann Gen Prac. 1972;26:126.
Shealy CN. Facets in back and sciatic pain. A new approach to a major pain syndrome. Minn Med. Mar 1974;57(3):199-203. [Medline].
Hirsch C, Ingelmark BE, Miller M. The anatomical basis for low back pain. Studies on the presence of sensory nerve endings in ligamentous, capsular and intervertebral disc structures in the human lumbar spine. Acta Orthop Scand. 1963;33:1-17. [Medline].
Mooney V, Robertson J. The facet syndrome. Clin Orthop Relat Res. Mar-Apr 1976;(115):149-56. [Medline].
McCall IW, Park WM, O'Brien JP. Induced pain referral from posterior lumbar elements in normal subjects. Spine. Sep-Oct 1979;4(5):441-6. [Medline].
Marks R. Distribution of pain provoked from lumbar facet joints and related structures during diagnostic spinal infiltration. Pain. Oct 1989;39(1):37-40. [Medline].
Kuslich SD, Ulstrom CL, Michael CJ. The tissue origin of low back pain and sciatica: a report of pain response to tissue stimulation during operations on the lumbar spine using local anesthesia. Orthop Clin North Am. Apr 1991;22(2):181-7. [Medline].
Bokov A, Isrelov A, Skorodumov A, Aleynik A, Simonov A, Mlyavykh S. An analysis of reasons for failed back surgery syndrome and partial results after different types of surgical lumbar nerve root decompression. Pain Physician. Nov-Dec 2011;14(6):545-57. [Medline].
Ashton IK, Ashton BA, Gibson SJ, et al. Morphological basis for back pain: the demonstration of nerve fibers and neuropeptides in the lumbar facet joint capsule but not in ligamentum flavum. J Orthop Res. Jan 1992;10(1):72-8. [Medline].
Giles LG, Harvey AR. Immunohistochemical demonstration of nociceptors in the capsule and synovial folds of human zygapophyseal joints. Br J Rheumatol. Oct 1987;26(5):362-4. [Medline].
Grönblad M, Korkala O, Konttinen YT, et al. Silver impregnation and immunohistochemical study of nerves in lumbar facet joint plical tissue. Spine. Jan 1991;16(1):34-8. [Medline].
Adams MA, Hutton WC. The effect of posture on the role of the apophysial joints in resisting intervertebral compressive forces. J Bone Joint Surg Br. Aug 1980;62(3):358-62. [Medline]. [Full Text].
Schmidt H, Heuer F, Wilke HJ. Interaction between finite helical axes and facet joint forces under combined loading. Spine. Dec 1 2008;33(25):2741-8. [Medline].
Jackson RP, Jacobs RR, Montesano PX. 1988 Volvo award in clinical sciences. Facet joint injection in low-back pain. A prospective statistical study. Spine. Sep 1988;13(9):966-71. [Medline].
Carette S, Marcoux S, Truchon R, et al. A controlled trial of corticosteroid injections into facet joints for chronic low back pain. N Engl J Med. Oct 3 1991;325(14):1002-7. [Medline].
Schwarzer AC, Aprill CN, Derby R, et al. The false-positive rate of uncontrolled diagnostic blocks of the lumbar zygapophysial joints. Pain. Aug 1994;58(2):195-200. [Medline].
Schwarzer AC, Aprill CN, Derby R, et al. Clinical features of patients with pain stemming from the lumbar zygapophysial joints. Is the lumbar facet syndrome a clinical entity?. Spine. May 15 1994;19(10):1132-7. [Medline].
Moran R, O'Connell D, Walsh MG. The diagnostic value of facet joint injections. Spine. Dec 1988;13(12):1407-10. [Medline].
Schwarzer AC, Wang S, Laurent R, et al. The role of the zygapophysial joint in chronic low back pain [abstract]. Aust NZ J Med. 1992;22:185.
Schwarzer AC, Wang SC, Bogduk N, et al. Prevalence and clinical features of lumbar zygapophysial joint pain: a study in an Australian population with chronic low back pain. Ann Rheum Dis. Feb 1995;54(2):100-6. [Medline]. [Full Text].
Manchikanti L, Boswell MV, Singh V, et al. Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions. BMC Musculoskelet Disord. May 28 2004;5:15. [Medline]. [Full Text].
Raymond J, Dumas JM. Intraarticular facet block: diagnostic test or therapeutic procedure?. Radiology. May 1984;151(2):333-6. [Medline]. [Full Text].
Revel ME, Listrat VM, Chevalier XJ, et al. Facet joint block for low back pain: identifying predictors of a good response. Arch Phys Med Rehabil. Sep 1992;73(9):824-8. [Medline].
Manchikanti L, Manchikanti KN, Cash KA, et al. Age-related prevalence of facet-joint involvement in chronic neck and low back pain. Pain Physician. Jan 2008;11(1):67-75. [Medline]. [Full Text].
Varlotta GP, Lefkowitz TR, Schweitzer M, Errico TJ, Spivak J, Bendo JA, et al. The lumbar facet joint: a review of current knowledge: Part II: diagnosis and management. Skeletal Radiol. Feb 2011;40(2):149-57. [Medline].
Kalichman L, Li L, Kim DH, et al. Facet joint osteoarthritis and low back pain in the community-based population. Spine. Nov 1 2008;33(23):2560-5. [Medline].
Dory MA. Arthrography of the lumbar facet joints. Radiology. Jul 1981;140(1):23-7. [Medline]. [Full Text].
Lippitt AB. The facet joint and its role in spine pain. Management with facet joint injections. Spine. Oct 1984;9(7):746-50. [Medline].
Carrino JA, Lurie JD, Tosteson AN, et al. Lumbar spine: reliability of MR imaging findings. Radiology. Jan 2009;250(1):161-70. [Medline].
Maus T. Imaging the back pain patient. Phys Med Rehabil Clin N Am. Nov 2010;21(4):725-66. [Medline].
Schwarzer AC, Wang SC, O'Driscoll D, et al. The ability of computed tomography to identify a painful zygapophysial joint in patients with chronic low back pain. Spine. Apr 15 1995;20(8):907-12. [Medline].
Cohen SP, Hurley RW. The ability of diagnostic spinal injections to predict surgical outcomes. Anesth Analg. Dec 2007;105(6):1756-75, table of contents. [Medline].
Lord SM, Barnsley L, Wallis BJ, et al. Chronic cervical zygapophysial joint pain after whiplash. A placebo-controlled prevalence study. Spine. Aug 1 1996;21(15):1737-44; discussion 1744-5. [Medline].
Barnsley L, Bogduk N. Medial branch blocks are specific for the diagnosis of cervical zygapophyseal joint pain. Reg Anesth. Nov-Dec 1993;18(6):343-50. [Medline].
Dreyfuss P, Schwarzer AC, Lau P, et al. Specificity of lumbar medial branch and L5 dorsal ramus blocks. A computed tomography study. Spine. Apr 15 1997;22(8):895-902. [Medline].
Kroll HR, Kim D, Danic MJ, et al. A randomized, double-blind, prospective study comparing the efficacy of continuous versus pulsed radiofrequency in the treatment of lumbar facet syndrome. J Clin Anesth. Nov 2008;20(7):534-7. [Medline].
Lynch MC, Taylor JF. Facet joint injection for low back pain. A clinical study. J Bone Joint Surg Br. Jan 1986;68(1):138-41. [Medline]. [Full Text].
Gallagher J, Petriccioone di Vadi PL, Wedley JR. Radiofrequency facet joint denervation in the treatment of low back pain: a prospective controlled double-blind study to assess its efficacy. Pain Clin. 1994;7(3):193-8.
van Kleef M, Barendse GA, Kessels A, et al. Randomized trial of radiofrequency lumbar facet denervation for chronic low back pain. Spine. Sep 15 1999;24(18):1937-42. [Medline].
Dreyfuss P, Halbrook B, Pauza K, et al. Efficacy and validity of radiofrequency neurotomy for chronic lumbar zygapophysial joint pain. Spine. May 15 2000;25(10):1270-7. [Medline].
Leclaire R, Fortin L, Lambert R, et al. Radiofrequency facet joint denervation in the treatment of low back pain: a placebo-controlled clinical trial to assess efficacy. Spine. Jul 1 2001;26(13):1411-6; discussion 1417. [Medline].
van Wijk RM, Geurts JW, Wynne HJ, et al. Radiofrequency denervation of lumbar facet joints in the treatment of chronic low back pain: a randomized, double-blind, sham lesion-controlled trial. Clin J Pain. Jul-Aug 2005;21(4):335-44. [Medline].
Schofferman J, Kine G. Effectiveness of repeated radiofrequency neurotomy for lumbar facet pain. Spine. Nov 1 2004;29(21):2471-3. [Medline].
Kornick C, Kramarich SS, Lamer TJ, et al. Complications of lumbar facet radiofrequency denervation. Spine. Jun 15 2004;29(12):1352-4. [Medline].
Barnsley L, Lord S, Bogduk N. Comparative local anaesthetic blocks in the diagnosis of cervical zygapophysial joint pain. Pain. Oct 1993;55(1):99-106. [Medline].
Beaman DN, Graziano GP, Glover RA, et al. Substance P innervation of lumbar spine facet joints. Spine. Jun 15 1993;18(8):1044-9. [Medline].
Blanchard J, Ramamurthy S, Walsh N, et al. Intravenous regional sympatholysis: a double-blind comparison of guanethidine, reserpine, and normal saline. J Pain Symptom Manage. Dec 1990;5(6):357-61. [Medline].
Boden SD, Davis DO, Dina TS, et al. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am. Mar 1990;72(3):403-8. [Medline].
Bogduk N, Schwarzer A. Facet joint pain. Aust Fam Physician. May 1995;24(5):924. [Medline].
Borenstein D. Does osteoarthritis of the lumbar spine cause chronic low back pain?. Curr Pain Headache Rep. Dec 2004;8(6):512-7. [Medline].
Carrera GF, Williams AL. Current concepts in evaluation of the lumbar facet joints. Crit Rev Diagn Imaging. 1984;21(2):85-104. [Medline].
Dolan AL, Ryan PJ, Arden NK, et al. The value of SPECT scans in identifying back pain likely to benefit from facet joint injection. Br J Rheumatol. Dec 1996;35(12):1269-73. [Medline]. [Full Text].
Dreyfuss PH, Dreyer SJ, Herring SA. Lumbar zygapophysial (facet) joint injections. Spine. Sep 15 1995;20(18):2040-7. [Medline].
Dunlop RB, Adams MA, Hutton WC. Disc space narrowing and the lumbar facet joints. J Bone Joint Surg Br. Nov 1984;66(5):706-10. [Medline]. [Full Text].
Eubanks JD, Lee MJ, Cassinelli E, et al. Prevalence of lumbar facet arthrosis and its relationship to age, sex, and race: an anatomic study of cadaveric specimens. Spine. Sep 1 2007;32(19):2058-62. [Medline].
Fairbank JC, Park WM, McCall IW, et al. Apophyseal injection of local anesthetic as a diagnostic aid in primary low-back pain syndromes. Spine. Nov-Dec 1981;6(6):598-605. [Medline].
Frost FA, Jessen B, Siggaard-Andersen J. A control, double-blind comparison of mepivacaine injection versus saline injection for myofascial pain. Lancet. Mar 8 1980;1(8167):499-500. [Medline].
Helbig T, Lee CK. The lumbar facet syndrome. Spine. Jan 1988;13(1):61-4. [Medline].
Lawrence JS, Bremner JM, Bier F. Osteo-arthrosis. Prevalence in the population and relationship between symptoms and x-ray changes. Ann Rheum Dis. Jan 1966;25(1):1-24. [Medline].
Lewinnek GE, Warfield CA. Facet joint degeneration as a cause of low back pain. Clin Orthop Relat Res. Dec 1986;(213):216-22. [Medline].
Lilius G, Laasonen EM, Myllynen P, et al. Lumbar facet joint syndrome. A randomised clinical trial. J Bone Joint Surg Br. Aug 1989;71(4):681-4. [Medline].
Magora A. Relation between the low back pain syndrome and x-ray findings. Scand J Rehabil Med. 1976;8:115-25.
Murtagh FR. Computed tomography and fluoroscopy guided anesthesia and steroid injection in facet syndrome. Spine. Jun 1988;13(6):686-9. [Medline].
Panjabi MM, Goel VK, Takata K. Physiologic strains in the lumbar spinal ligaments. An in vitro biomechanical study 1981 Volvo Award in Biomechanics. Spine. May-Jun 1982;7(3):192-203. [Medline].
Raymond J, Dumas JM, Lisbona R. Nuclear imaging as a screening test for patients referred for intraarticular facet block. J Can Assoc Radiol. Sep 1984;35(3):291-2. [Medline].
Weishaupt D, Zanetti M, Hodler J, et al. MR imaging of the lumbar spine: prevalence of intervertebral disk extrusion and sequestration, nerve root compression, end plate abnormalities, and osteoarthritis of the facet joints in asymptomatic volunteers. Radiology. Dec 1998;209(3):661-6. [Medline]. [Full Text].
Wiesel SW, Tsourmas N, Feffer HL, et al. A study of computer-assisted tomography. I. The incidence of positive CAT scans in an asymptomatic group of patients. Spine. Sep 1984;9(6):549-51. [Medline].
Wilde VE, Ford JJ, McMeeken JM. Indicators of lumbar zygapophyseal joint pain: survey of an expert panel with the Delphi technique. Phys Ther. Oct 2007;87(10):1348-61. [Medline].
Willburger RE, Wittenberg RH. Prostaglandin release from lumbar disc and facet joint tissue. Spine. Sep 15 1994;19(18):2068-70. [Medline].

