Mononeuritis Multiplex Differential Diagnoses
- Author: Divakara Kedlaya, MBBS; Chief Editor: Robert H Meier III, MD more...
Diagnostic Considerations
Conditions to consider in the differential diagnosis of mononeuritis multiplex include the following:
- Ischemic monomelic neuropathy
- Meralgia paresthetica
- Neoplastic brachial plexopathy
- Neoplastic lumbosacral plexopathy
- Piriformis syndrome
- Post ̶ head injury autonomic complications
- Postpolio syndrome
- Posttraumatic syringomyelia
- Radiation-induced brachial plexopathy
- Radiation-induced lumbosacral plexopathy
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Thoracic outlet syndrome
- Traumatic brachial plexopathy
- Lyme disease
- Sjögren syndrome
- Cryoglobulinemia
- Temporal arteritis
- Scleroderma
- Sarcoidosis
- Leprosy (Hansen disease)
- Acute viral hepatitis A
- AIDS
- Hypereosinophilia
- Cryoglobulinemia
- Paraneoplastic peripheral neuropathy
Differential Diagnoses
- Acute Poliomyelitis
- Alcoholic Neuropathy
- Brachial Neuritis
- Charcot-Marie-Tooth Disease
- Chronic Pain Syndrome
- Compartment Syndrome
- Complex Regional Pain Syndromes
- Diabetic Lumbosacral Plexopathy
- Diabetic Neuropathy
- Guillain-Barre Syndrome
Vial C, Bouhour F. [Vasculitis multiple mononeuropathies]. Rev Prat. Nov 15 2008;58(17):1896-9. [Medline].
Magy L. [What is a peripheral neuropathy?]. Rev Prat. Nov 15 2008;58(17):1873-7, 1880-1. [Medline].
Bennett DL, Groves M, Blake J, et al. The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5 year retrospective study. J Neurol Neurosurg Psychiatry. Dec 2008;79(12):1376-81. [Medline]. [Full Text].
Pagnoux C. Churg-Strauss syndrome: evolving concepts. Discov Med. Mar 2010;9(46):243-52. [Medline].
Garzoni L, Vanoni F, Rizzi M, et al. Nervous system dysfunction in Henoch-Schonlein syndrome: systematic review of the literature. Rheumatology (Oxford). Dec 2009;48(12):1524-9. [Medline].
Makol A, Grover M. Adalimumab induced mononeuritis multiplex in a patient with refractory rheumatoid arthritis: a case report. Cases J. Oct 30 2008;1(1):287. [Medline]. [Full Text].
Greenberg MK, Sonoda T. Mononeuropathy multiplex complicating idiopathic thrombocytopenic purpura. Neurology. Sep 1991;41(9):1517-8. [Medline].
Kumar S. Painful mononeuritis multiplex in idiopathic thrombocytopenic purpura. Indian Pediatr. Jun 2005;42(6):621-2. [Medline].
Khadilkar SV, Benny R, Kasegaonkar PS. Proprioceptive loss in leprous neuropathy: a study of 19 patients. Neurol India. Oct-Dec 2008;56(4):450-5. [Medline]. [Full Text].
Lenglet T, Haroche J, Schnuriger A, et al. Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome. J Neurol. Jul 2011;258(7):1321-6. [Medline].
Modi M, Vats AK, Prabhakar S, Singla V, Mishra S. Acro-osteolysis and mononeuritis multiplex as a presenting symptom of systemic angiitis of Wegener's type. Indian J Med Sci. Apr 2007;61(4):212-5. [Medline].
Peshin R, O'Gradaigh D. Mononeuritis multiplex as a presenting feature of Wegener granulomatosis: a case report. Clin Rheumatol. Aug 2007;26(8):1389-90. [Medline].
Mauermann ML, Ryan ML, Moon JS, et al. Case of mononeuritis multiplex onset with rituximab therapy for Waldenstrom's macroglobulinemia. J Neurol Sci. Sep 15 2007;260(1-2):240-3. [Medline].
Isobe N, Kira J, Kawamura N, et al. Neural damage associated with atopic diathesis: a nationwide survey in Japan. Neurology. Sep 8 2009;73(10):790-7. [Medline].
Said G, Lacroix-Ciaudo C, Fujimura H, et al. The peripheral neuropathy of necrotizing arteritis: a clinicopathological study. Ann Neurol. May 1988;23(5):461-5. [Medline].
O'Connor AB, Dworkin RH. Treatment of neuropathic pain: an overview of recent guidelines. Am J Med. Oct 2009;122(10 Suppl):S22-32. [Medline].
Finnerup NB, Sindrup SH, Jensen TS. The evidence for pharmacological treatment of neuropathic pain. Pain. Sep 2010;150(3):573-81. [Medline].

