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Neoplastic Lumbosacral Plexopathy Follow-up

  • Author: Rajesh R Yadav, MD; Chief Editor: Robert H Meier, III, MD  more...
 
Updated: Jul 27, 2015
 

Prognosis

See the list below:

  • Neoplastic lumbosacral plexopathy (NLP) progresses much faster than does radiation-related plexopathy, and the patient survival rate is limited. Median survival is 5.5 months from the time of diagnosis, with a range of 1-34 months. In one study, at 1-month follow-up visit, only 15-17% of patients demonstrated improvement in pain or weakness, and 28% showed improvement in CT scan findings. Over half of the patients (59%) demonstrated gradual worsening of neurologic deficits.
  • In another study, 13 patients who underwent palliative irradiation for NLP had median survival of 185 days, with a range of 47-636 days.[23]
 
Contributor Information and Disclosures
Author

Rajesh R Yadav, MD Associate Professor, Section of Physical Medicine and Rehabilitation, MD Anderson Cancer Center, University of Texas Medical School at Houston

Rajesh R Yadav, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Michael T Andary, MD, MS Professor, Residency Program Director, Department of Physical Medicine and Rehabilitation, Michigan State University College of Osteopathic Medicine

Michael T Andary, MD, MS is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, American Association of Neuromuscular and Electrodiagnostic Medicine, American Medical Association, Association of Academic Physiatrists

Disclosure: Received honoraria from Allergan for speaking and teaching.

Chief Editor

Robert H Meier, III, MD Director, Amputee Services of America; Active Medical Staff, Presbyterian/St Luke’s Hospital, Spalding Rehabilitation Hospital, Select Specialty Hospital; Consulting Staff, Kindred Hospital

Robert H Meier, III, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, Association of Academic Physiatrists

Disclosure: Nothing to disclose.

References
  1. Jang DH, Byun SH, Jeon JY, Lee SJ. The relationship between lumbosacral plexopathy and pelvic fractures. Am J Phys Med Rehabil. 2011 Sep. 90(9):707-12. [Medline].

  2. Klimek M, Kosobucki R, Luczynska E, Bieda T, Urbanski K. Radiotherapy-induced lumbosacral plexopathy in a patient with cervical cancer: a case report and literature review. Contemp Oncol (Pozn). 2012. 16(2):194-6. [Medline]. [Full Text].

  3. Jaeckle KA, Young DF, Foley KM. The natural history of lumbosacral plexopathy in cancer. Neurology. 1985. 35:8-15. [Medline].

  4. Agar M, Broadbent A, Chye R. The management of malignant psoas syndrome: case reports and literature review. J Pain Symptom Manage. 2004 Sep. 28(3):282-93. [Medline].

  5. Jaeckle KA. Neurological manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol. 2004 Dec. 24(4):385-93. [Medline].

  6. Ladha SS, Spinner RJ, Suarez GA, et al. Neoplastic lumbosacral radiculoplexopathy in prostate cancer by direct perineural spread: an unusual entity. Muscle Nerve. 2006 Nov. 34(5):659-65. [Medline].

  7. Dalmau J, Graus F, Marco M. Hot and dry foot' as initial manifestation of neoplastic lumbosacral plexopathy. Neurology. 1989 Jun. 39(6):871-2. [Medline].

  8. Dhillon SS, Sarac E. Lumbosacral plexopathy after dual kidney transplantation. Am J Kidney Dis. 2000 Nov. 36(5):1045-8. [Medline].

  9. Garcia-Manzanares MD, Forner-Cordero I, Lavara-Perona MC, et al. Bilateral lumbosacral plexopathy after mesenteric thrombosis. Spinal Cord. 1999 Jul. 37(7):522-5. [Medline].

  10. Stoeckli TC, Mackin GA, De Groote MA. Lumbosacral plexopathy in a patient with pulmonary tuberculosis. Clin Infect Dis. 2000 Jan. 30(1):226-7. [Medline].

  11. Abdelhamid MF, Sandler B, Awad RW. Ischaemic lumbosacral plexopathy following aorto-iliac bypass graft: case report and review of literature. Ann R Coll Surg Engl. 2007 Jul. 89(5):W12-3. [Medline]. [Full Text].

  12. Abdellaoui A, West NJ, Tomlinson MA, et al. Lower limb paralysis from ischaemic neuropathy of the lumbosacral plexus following aorto-iliac procedures. Interact Cardiovasc Thorac Surg. 2007 Aug. 6(4):501-2. [Medline]. [Full Text].

  13. Melikoglu MA, Kocabas H, Sezer I, et al. Internal iliac artery pseudoaneurysm: an unusual cause of sciatica and lumbosacral plexopathy. Am J Phys Med Rehabil. 2008 Aug. 87(8):681-3. [Medline].

  14. You JS, Park YS, Park S, et al. Lumbosacral plexopathy due to common iliac artery aneurysm misdiagnosed as intervertebral disc herniation. J Emerg Med. 2008 Jul 8. [Medline].

  15. Taylor BV, Kimmel DW, Krecke KN, et al. Magnetic resonance imaging in cancer-related lumbosacral plexopathy. Mayo Clin Proc. 1997 Sep. 72(9):823-9. [Medline].

  16. Wouter van Es H, Engelen AM, Witkamp TD, et al. Radiation-induced brachial plexopathy: MR imaging. Skeletal Radiol. 1997 May. 26(5):284-8. [Medline].

  17. Soldatos T, Andreisek G, Thawait GK, Guggenberger R, Williams EH, Carrino JA, et al. High-resolution 3-T MR neurography of the lumbosacral plexus. Radiographics. 2013 Jul-Aug. 33(4):967-87. [Medline].

  18. Ahmad A, Barrington S, Maisey M, et al. Use of positron emission tomography in evaluation of brachial plexopathy in breast cancer patients. Br J Cancer. 1999 Feb. 79(3-4):478-82. [Medline].

  19. Wilbourn AJ. Electrodiagnosis of plexopathies. Neurol Clin. 1985. 3:511-29. [Medline].

  20. Son BC, Yoon JH, Kim DR, Lee SW. Dorsal rhizotomy for pain from neoplastic lumbosacral plexopathy in advanced pelvic cancer. Stereotact Funct Neurosurg. 2014. 92 (2):109-16. [Medline].

  21. Sloan P, Basta M, Storey P, et al. Mexiletine as an adjuvant analgesic for the management of neuropathic cancer pain. Anesth Analg. 1999 Sep. 89(3):760-1. [Medline]. [Full Text].

  22. Crosby V, Wilcock A, Corcoran R. The safety and efficacy of a single dose (500 mg or 1 g) of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancer. J Pain Symptom Manage. 2000 Jan. 19(1):35-9. [Medline].

  23. Russi EG, Pergolizzi S, Gaeta M, et al. Palliative-radiotherapy in lumbosacral carcinomatous neuropathy. Radiother Oncol. 1993 Feb. 26(2):172-3. [Medline].

  24. Dahele M, Davey P, Reingold S, et al. Radiation-induced lumbo-sacral plexopathy (RILSP): an important enigma. Clin Oncol (R Coll Radiol). 2006 Jun. 18(5):427-8. [Medline].

  25. Ebner I, Anderl H, Mikuz G, et al. [Plexus neuropathy: tumor infiltration or radiation damage]. Rofo. 1990 Jun. 152(6):662-6. [Medline].

  26. Inoue C, Hayashi A, Yoshizawa T, et al. [Effect of intravenous immunoglobulin therapy in a case of idiopathic recurrent brachial and lumbosacral plexopathy]. Rinsho Shinkeigaku. 1999 Jun. 39(6):661-4. [Medline].

  27. Pettigrew LC, Glass JP, Maor M, et al. Diagnosis and treatment of lumbosacral plexopathies in patients with cancer. J Arch Neurol. 1984. 41:1282-5. [Medline].

  28. Planner AC, Donaghy M, Moore NR. Causes of lumbosacral plexopathy. Clin Radiol. 2006 Dec. 61(12):987-95. [Medline].

  29. Stubgen JP. Neuromuscular disorders in systemic malignancy and its treatment. Muscle Nerve. 1995 Jun. 18(6):636-48. [Medline].

  30. Thomas JE, Cascino TL, Earle JD. Differential diagnosis between radiation and tumor plexopathy of the pelvis. Neurology. 1985 Jan. 35(1):1-7. [Medline].

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