eMedicine Specialties > Physical Medicine and Rehabilitation > Plexopathy
Neoplastic Lumbosacral Plexopathy: Follow-up
Updated: Dec 4, 2008
Follow-up
Prognosis
- Neoplastic lumbosacral plexopathy (NLP) progresses much faster than does radiation-related plexopathy, and the patient survival rate is limited. Median survival is 5.5 months from the time of diagnosis, with a range of 1-34 months. In one study, at 1-month follow-up visit, only 15-17% of patients demonstrated improvement in pain or weakness, and 28% showed improvement in CT scan findings. Over half of the patients (59%) demonstrated gradual worsening of neurologic deficits.
- In another study, 13 patients who underwent palliative irradiation for NLP had median survival of 185 days, with a range of 47-636 days.19
Miscellaneous
Medicolegal Pitfalls
- If the diagnosis of neoplastic lumbosacral plexopathy is not established in a timely manner and proper treatment pursued, the physician is at risk for medicolegal consequences.
More on Neoplastic Lumbosacral Plexopathy |
| Overview: Neoplastic Lumbosacral Plexopathy |
| Differential Diagnoses & Workup: Neoplastic Lumbosacral Plexopathy |
| Treatment & Medication: Neoplastic Lumbosacral Plexopathy |
Follow-up: Neoplastic Lumbosacral Plexopathy |
| References |
| « Previous Page |
References
Jaeckle KA, Young DF, Foley KM. The natural history of lumbosacral plexopathy in cancer. Neurology. 1985;35:8-15. [Medline].
Agar M, Broadbent A, Chye R. The management of malignant psoas syndrome: case reports and literature review. J Pain Symptom Manage. Sep 2004;28(3):282-93. [Medline].
Jaeckle KA. Neurological manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol. Dec 2004;24(4):385-93. [Medline].
Ladha SS, Spinner RJ, Suarez GA, et al. Neoplastic lumbosacral radiculoplexopathy in prostate cancer by direct perineural spread: an unusual entity. Muscle Nerve. Nov 2006;34(5):659-65. [Medline].
Dalmau J, Graus F, Marco M. 'Hot and dry foot' as initial manifestation of neoplastic lumbosacral plexopathy. Neurology. Jun 1989;39(6):871-2. [Medline].
Dhillon SS, Sarac E. Lumbosacral plexopathy after dual kidney transplantation. Am J Kidney Dis. Nov 2000;36(5):1045-8. [Medline].
Garcia-Manzanares MD, Forner-Cordero I, Lavara-Perona MC, et al. Bilateral lumbosacral plexopathy after mesenteric thrombosis. Spinal Cord. Jul 1999;37(7):522-5. [Medline].
Stoeckli TC, Mackin GA, De Groote MA. Lumbosacral plexopathy in a patient with pulmonary tuberculosis. Clin Infect Dis. Jan 2000;30(1):226-7. [Medline].
Abdelhamid MF, Sandler B, Awad RW. Ischaemic lumbosacral plexopathy following aorto-iliac bypass graft: case report and review of literature. Ann R Coll Surg Engl. Jul 2007;89(5):W12-3. [Medline]. [Full Text].
Abdellaoui A, West NJ, Tomlinson MA, et al. Lower limb paralysis from ischaemic neuropathy of the lumbosacral plexus following aorto-iliac procedures. Interact Cardiovasc Thorac Surg. Aug 2007;6(4):501-2. [Medline]. [Full Text].
Melikoglu MA, Kocabas H, Sezer I, et al. Internal iliac artery pseudoaneurysm: an unusual cause of sciatica and lumbosacral plexopathy. Am J Phys Med Rehabil. Aug 2008;87(8):681-3. [Medline].
You JS, Park YS, Park S, et al. Lumbosacral plexopathy due to common iliac artery aneurysm misdiagnosed as intervertebral disc herniation. J Emerg Med. Jul 8 2008;[Medline].
Taylor BV, Kimmel DW, Krecke KN, et al. Magnetic resonance imaging in cancer-related lumbosacral plexopathy. Mayo Clin Proc. Sep 1997;72(9):823-9. [Medline].
Wouter van Es H, Engelen AM, Witkamp TD, et al. Radiation-induced brachial plexopathy: MR imaging. Skeletal Radiol. May 1997;26(5):284-8. [Medline].
Ahmad A, Barrington S, Maisey M, et al. Use of positron emission tomography in evaluation of brachial plexopathy in breast cancer patients. Br J Cancer. Feb 1999;79(3-4):478-82. [Medline].
Wilbourn AJ. Electrodiagnosis of plexopathies. Neurol Clin. 1985;3:511-29. [Medline].
Sloan P, Basta M, Storey P, et al. Mexiletine as an adjuvant analgesic for the management of neuropathic cancer pain. Anesth Analg. Sep 1999;89(3):760-1. [Medline]. [Full Text].
Crosby V, Wilcock A, Corcoran R. The safety and efficacy of a single dose (500 mg or 1 g) of intravenous magnesium sulfate in neuropathic pain poorly responsive to strong opioid analgesics in patients with cancer. J Pain Symptom Manage. Jan 2000;19(1):35-9. [Medline].
Russi EG, Pergolizzi S, Gaeta M, et al. Palliative-radiotherapy in lumbosacral carcinomatous neuropathy. Radiother Oncol. Feb 1993;26(2):172-3. [Medline].
Dahele M, Davey P, Reingold S, et al. Radiation-induced lumbo-sacral plexopathy (RILSP): an important enigma. Clin Oncol (R Coll Radiol). Jun 2006;18(5):427-8. [Medline].
Ebner I, Anderl H, Mikuz G, et al. [Plexus neuropathy: tumor infiltration or radiation damage]. Rofo. Jun 1990;152(6):662-6. [Medline].
Inoue C, Hayashi A, Yoshizawa T, et al. [Effect of intravenous immunoglobulin therapy in a case of idiopathic recurrent brachial and lumbosacral plexopathy]. Rinsho Shinkeigaku. Jun 1999;39(6):661-4. [Medline].
Pettigrew LC, Glass JP, Maor M, et al. Diagnosis and treatment of lumbosacral plexopathies in patients with cancer. J Arch Neurol. 1984;41:1282-5. [Medline].
Planner AC, Donaghy M, Moore NR. Causes of lumbosacral plexopathy. Clin Radiol. Dec 2006;61(12):987-95. [Medline].
Stubgen JP. Neuromuscular disorders in systemic malignancy and its treatment. Muscle Nerve. Jun 1995;18(6):636-48. [Medline].
Thomas JE, Cascino TL, Earle JD. Differential diagnosis between radiation and tumor plexopathy of the pelvis. Neurology. Jan 1985;35(1):1-7. [Medline].
Further Reading
Keywords
neoplastic lumbosacral plexopathy, plexus, lumbosacral, breast cancer, sciatic nerve, colorectal cancer, psoas, neoplastic, psoas muscle, femoral nerve, iliopsoas, iliopsoas muscle, ilioinguinal nerve, obturator nerve, abdominal cancer, cervical cancer, pelvic tumor, retroperitoneal tumor, NLP, lumbosacral plexus, lumbosacral plexopathy, proximal lumbosacral plexopathy, malignant psoas syndrome, MPS, malignant lumbosacral plexopathy, lumbosacral carcinomatous, neuropathy tumor-induced lumbosacral plexopathy, tumor, lumbar plexus, sacral plexus
Follow-up: Neoplastic Lumbosacral Plexopathy