Medscape is available in 5 Language Editions – Choose your Edition here.


Radiation-Induced Lumbosacral Plexopathy Follow-up

  • Author: Rajesh R Yadav, MD; Chief Editor: Robert H Meier, III, MD  more...
Updated: Aug 02, 2015

Further Outpatient Care

See the list below:

  • After radiation-induced lumbosacral plexopathy has been diagnosed, follow up with patients on functional issues. Address issues of pain in a timely fashion.

Further Inpatient Care

See the list below:

  • Inpatient care for radiation-induced lumbosacral plexopathy is not required.


See the list below:

  • Radiation-induced lumbosacral plexopathy may result in pain and decreased functional status.


See the list below:

  • Gradual, rather than stepwise, progression of radiation-induced lumbosacral plexopathy is the rule. Eventually, patients may have significant or severe disability. Spontaneous recovery is less common.[18]

Patient Education

See the list below:

  • Educate patients about the effects of radiation and the reason for altered function, pain, and sensory deficits.
Contributor Information and Disclosures

Rajesh R Yadav, MD Associate Professor, Section of Physical Medicine and Rehabilitation, MD Anderson Cancer Center, University of Texas Medical School at Houston

Rajesh R Yadav, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Michael T Andary, MD, MS Professor, Residency Program Director, Department of Physical Medicine and Rehabilitation, Michigan State University College of Osteopathic Medicine

Michael T Andary, MD, MS is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, American Association of Neuromuscular and Electrodiagnostic Medicine, American Medical Association, Association of Academic Physiatrists

Disclosure: Received honoraria from Allergan for speaking and teaching.

Chief Editor

Robert H Meier, III, MD Director, Amputee Services of America; Active Medical Staff, Presbyterian/St Luke’s Hospital, Spalding Rehabilitation Hospital, Select Specialty Hospital; Consulting Staff, Kindred Hospital

Robert H Meier, III, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, Association of Academic Physiatrists

Disclosure: Nothing to disclose.

  1. Pettigrew LC, Glass JP, Maor M, et al. Diagnosis and treatment of lumbosacral plexopathies in patients with cancer. Arch Neurol. 1984 Dec. 41(12):1282-5. [Medline].

  2. Klimek M, Kosobucki R, Luczynska E, Bieda T, Urbanski K. Radiotherapy-induced lumbosacral plexopathy in a patient with cervical cancer: a case report and literature review. Contemp Oncol (Pozn). 2012. 16(2):194-6. [Medline]. [Full Text].

  3. Yi SK, Mak W, Yang CC, Liu T, Cui J, Chen AM, et al. Development of a standardized method for contouring the lumbosacral plexus: a preliminary dosimetric analysis of this organ at risk among 15 patients treated with intensity-modulated radiotherapy for lower gastrointestinal cancers and the incidence of radiation-induced lumbosacral plexopathy. Int J Radiat Oncol Biol Phys. 2012 Oct 1. 84(2):376-82. [Medline].

  4. Ashenhurst EM, Quartey GR, Starreveld A. Lumbo-sacral radiculopathy induced by radiation. Can J Neurol Sci. 1977 Nov. 4(4):259-63. [Medline].

  5. Jaeckle KA, Young DF, Foley KM. The natural history of lumbosacral plexopathy in cancer. Neurology. 1985 Jan. 35(1):8-15. [Medline].

  6. Abu-Rustum NR, Rajbhandari D, Glusman S, et al. Acute lower extremity paralysis following radiation therapy for cervical cancer. Gynecol Oncol. 1999 Oct. 75(1):152-4. [Medline].

  7. Iglicki F, Coffin B, Ille O, et al. Fecal incontinence after pelvic radiotherapy: evidences for a lumbosacral plexopathy. Report of a case. Dis Colon Rectum. 1996 Apr. 39(4):465-7. [Medline].

  8. Jaeckle KA. Neurological manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol. 2004 Dec. 24(4):385-93. [Medline].

  9. Jaeckle KA. Neurologic manifestations of neoplastic and radiation-induced plexopathies. Semin Neurol. 2010 Jul. 30(3):254-62. [Medline].

  10. Ozkavukcu E, Cayli E, Yagci C, et al. Ruptured iliac aneurysm presenting as lumbosacral plexopathy. Diagn Interv Radiol. 2008 Mar. 14(1):26-8. [Medline]. [Full Text].

  11. Abdellaoui A, West NJ, Tomlinson MA, et al. Lower limb paralysis from ischaemic neuropathy of the lumbosacral plexus following aorto-iliac procedures. Interact Cardiovasc Thorac Surg. 2007 Aug. 6(4):501-2. [Medline]. [Full Text].

  12. Moskovic E, Curtis S, A'Hern RP, et al. The role of diagnostic CT scanning of the brachial plexus and axilla in the follow-up of patients with breast cancer. Clin Oncol (R Coll Radiol). 1992 Mar. 4(2):74-7. [Medline].

  13. Taylor BV, Kimmel DW, Krecke KN. Magnetic resonance imaging in cancer-related lumbosacral plexopathy. Mayo Clin Proc. 1997 Sep. 72(9):823-9. [Medline].

  14. Wilbourn AJ. Electrodiagnosis of plexopathies. Neurol Clin. 1985 Aug. 3(3):511-29. [Medline].

  15. Masakado Y, Kawakami M, Suzuki K, et al. Clinical neurophysiology in the diagnosis of peroneal nerve palsy. Keio J Med. 2008 Jun. 57(2):84-9. [Medline].

  16. Pritchard J, Anand P, Broome J, et al. Double-blind randomized phase II study of hyperbaric oxygen in patients with radiation-induced brachial plexopathy. Radiother Oncol. 2001 Mar. 58(3):279-86. [Medline].

  17. Tunio M, Al Asiri M, Bayoumi Y, et al. Lumbosacral plexus delineation, dose distribution, and its correlation with radiation-induced lumbosacral plexopathy in cervical cancer patients. Onco Targets Ther. 2015. 8:21-7. [Medline].

  18. Enevoldson TP, Scadding JW, Rustin GJ, et al. Spontaneous resolution of a postirradiation lumbosacral plexopathy. Neurology. 1992 Nov. 42(11):2224-5. [Medline].

  19. Bradley WG, Fewings JD, Cumming WJ, et al. Delayed myeloradiculopathy produced by spinal X-irradiation in the rat. J Neurol Sci. 1977 Jan-Feb. 31(1):63-82. [Medline].

  20. Cavanagh JB. Prior x-irradiation and the cellular response to nerve crush: duration of effect. Exp Neurol. 1968 Oct. 22(2):253-8. [Medline].

  21. Dahele M, Davey P, Reingold S, et al. Radiation-induced lumbo-sacral plexopathy (RILSP): an important enigma. Clin Oncol (R Coll Radiol). 2006 Jun. 18(5):427-8. [Medline].

  22. Glantz MJ, Burger PC, Friedman AH. Treatment of radiation-induced nervous system injury with heparin and warfarin. Neurology. 1994 Nov. 44(11):2020-7. [Medline].

  23. Stryker JA, Sommerville K, Perez R, et al. Sacral plexus injury after radiotherapy for carcinoma of cervix. Cancer. 1990 Oct 1. 66(7):1488-92. [Medline].

  24. Stubgen JP. Neuromuscular disorders in systemic malignancy and its treatment. Muscle Nerve. 1995 Jun. 18(6):636-48. [Medline].

  25. Thomas JE, Cascino TL, Earle JD. Differential diagnosis between radiation and tumor plexopathy of the pelvis. Neurology. 1985 Jan. 35(1):1-7. [Medline].

All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.