Brown-Sequard Syndrome Medication
- Author: Carol Vandenakker-Albanese, MD; Chief Editor: Stephen Kishner, MD, MHA more...
The use of medications for Brown-Séquard syndrome is dependent on the etiology and acuity of onset. Acute treatment of traumatic SCI involves immediate dosing of methyl prednisolone. Acute immobility that is unrelated to a bleed requires anticoagulation therapy, if not contraindicated. Gastrointestinal protection is strongly recommended.
Other medications are used to manage symptoms and complications as needed, including antibiotics, antispasmodics, pain medications, and laxatives.
Multiple studies have demonstrated improved outcomes for patients with traumatic SCIs who were given high-dose steroids early in the clinical course. (Although the previously mentioned study by Pollard and Apple did not find these results in incomplete cervical SCIs. ) These drugs have anti-inflammatory properties and cause profound and varied metabolic effects. Corticosteroids modify the body's immune response to diverse stimuli.
Methylprednisolone decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing increased capillary permeability.
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