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Nonoperative Treatment of Osteoporotic Compression Fractures Overview of Osteoporotic Compression Fractures

  • Author: Grant Cooper, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
 
Updated: Apr 01, 2015
 

Overview of Osteoporotic Compression Fractures

Osteoporosis and osteoporotic vertebral compression fractures are commonly encountered clinical problems. The definition of osteoporosis is diminished bone density measuring 2.5 standard deviations below the average bone density of healthy, 25-year-old, same-sex members of the population. In the United States, approximately 35% of women older than 65 years have osteoporosis.

Vertebral compression fracture (seen in the image below) is the most common complication of osteoporosis. More than 700,000 new vertebral compression fractures occur every year in the United States alone, accounting for more than 100,000 hospital admissions and resulting in close to $1.5 billion in annual costs.

Go to Osteoporosis and Pediatric Osteoporosis for more complete information on this topic.

Anteroposterior and lateral radiographs of an L1 o Anteroposterior and lateral radiographs of an L1 osteoporotic wedge compression fracture.

Most of patients experiencing an osteoporotic vertebral compression fracture remain asymptomatic or minimally symptomatic; however, a large number of these patients do experience significant pain, resulting in decreased quality of life and disability. Conventional medical treatment for these patients includes pain medication, activity limitation, physical therapy, and (possibly) bracing.[1, 2]

Patients with osteoporotic vertebral compression fractures are usually treated nonoperatively.

Types of vertebral compression fractures

Vertebral compression fractures characteristically demonstrate a wedge-shaped pattern (seen in the images below) with gross collapse of the anterior portion of the vertebral body and relative preservation of the posterior body height.

Anterior wedge compression fracture with an intact Anterior wedge compression fracture with an intact posterior vertebral cortex.
Osteoporotic spine. Note the considerable reductio Osteoporotic spine. Note the considerable reduction in overall bone density and the lateral wedge fracture of L2.

A second common form of fracture is a central crush fracture, which frequently occurs in the lower lumbar spine. Increased interpedicular space, involvement of the posterior cortex, or laminar fracture suggest a burst fracture (seen in the image below), which may be unstable.

A vertebral burst fracture. A vertebral burst fracture.

Etiology of osteoporotic compression fractures

Cortical and trabecular bone loss, as well as disruption of the microarchitecture of bone, are all typical of osteoporosis. Spinal flexion and axial compression have been shown to place maximal stress on the superior endplate of the vertebral body. The asymmetry of the vertebral body produces maximal stress at the anterior aspect of the cortical shell.

A combination of these factors, that is, decreased, asymmetrical, and irregular bone density, is a hallmark of osteoporotic bone loss. Coupled with even minimal flexion and/or axial loading, these factors predispose the osteoporotic vertebrae to wedge-shaped compression fractures, acquired kyphosis, and general height loss.

Once 1 vertebral compression fracture has occurred, a biomechanical environment is created that favors additional fractures. This occurs as a result of the vertebral compression fracture causing an additional kyphosis, shifting the patient's center of gravity anteriorly and producing a longer moment arm. This longer moment arm increases kyphotic angulation and places additional stress on the vertebrae, particularly the vertebrae adjacent to the primary fracture.

Progressive kyphosis, additional fractures, and neurologic changes are potential complications of osteoporotic compression fractures. These complications can be minimized with appropriate, expeditious care.

All vertebral compression fractures require a systematic examination to rule out an underlying systemic illness, such as malignancy, infection, or renal or liver disease.

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Treatment Assessment

The critical element in deciding a treatment regimen is pain and percentage of vertebral collapse. If a patient rates his/her pain as being greater than 4 out of 10 (if 10 equals the worst pain imaginable and 0 equals no pain) or the vertebral bodies are collapsed more than 40%, then kyphoplasty or vertebroplasty is indicated as an initial intervention. Other patients may initially attempt more conservative care.

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Nonoperative Therapies

According to American College of Radiology (ACR) Appropriateness Criteria for the management of vertebral compression fractures, updated in 2013, conservative management is the traditional first-line therapy for painful vertebral compression fractures. In most patients, according to the ACR, pain from these fractures resolves spontaneously, even without medication use.[3]

Physical therapy

Heat, massage, analgesic medications, and bed rest may provide symptomatic relief. (However, bed rest and immobilization can cause disuse, osteopenia, and an increased risk of a thromboembolic event.)

Bracing used to be common. However, the use of extension bracing has become controversial because of concerns regarding the placement of increased stress on the posterior elements of the spine.

Patients should be treated for their osteoporosis with anti-osteoporotic medications, including second-generation bisphosphonates, as well as with (daily) 1500 mg of elemental calcium and 400 IU of vitamin D.

A structured exercise program is essential and should be tailored to enhance axial muscle strength. Early mobilization should be employed to prevent secondary complications of immobility. Back strengthening exercises may improve kyphotic deformity.[4] Back extension exercises should be used preferentially over abdominal flexion exercises.[5, 6]

Weight-bearing exercises are considered the mainstay of therapy to prevent extension of osteoporosis. Crunches and sit-ups should be excluded. Many consider Pilates to be an excellent physical exercise regimen. If balance is impaired, Tai Chi Chuan is recommended as a means of helping the patient to prevent falls.

Occupational therapy

This is primarily used in an inpatient setting.

Recreational therapy

This is primarily used in an inpatient setting. Along with occupational therapy, recreational therapy is an important component of a patient's transition from an inpatient setting to an outpatient setting.

Pharmacologic therapy

Oral medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and narcotics,[3] have many roles in the treatment of patients with osteoporotic vertebral compression fractures.

Pain relief is of paramount concern. Pain medications may be used for a short period, typically 1-2 months. However, if pain requiring medication persists for longer than 1 month, vertebroplasty or kyphoplasty should be strongly considered. If pain medications do not provide adequate pain relief during the first month, these procedures should be considered sooner.

Anti-osteoporotic medications are essential. Miacalcin may be taken intranasally and has been purported to reduce the pain from compression fractures.

As always, the benefits of the medications need to be weighed against the adverse effects. Anti-inflammatory medications may produce adverse gastrointestinal effects.

Analgesic medications are often poorly tolerated, especially in elderly patients. Strong analgesic drugs may cause confusion, disorientation, increased risk of falling, constipation, and respiratory depression.

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Indications for and Pitfalls of Surgical Intervention

The 2 main minimally invasive surgical procedures for osteoporotic compression fractures are kyphoplasty and vertebroplasty. (Kyphoplasty is seen in the first 2 images below; vertebroplasty is seen in the third image).[7, 8, 9, 10, 11, 12, 13, 14, 15, 16]

Patients with compression fractures that do not co Patients with compression fractures that do not compromise the spinal canal can be treated by means of a kyphoplasty. The use of a percutaneous balloon allows for expansion of the fractured vertebrae. The void created by the balloon is then filled with bone cement.
Fluoroscopic view of a kyphoplasty procedure. Fluoroscopic view of a kyphoplasty procedure.
Vertebroplasty. Anterior wedge compression fractur Vertebroplasty. Anterior wedge compression fracture after fusion of the fracture fragments with polymethylmethacrylate.

More aggressive surgical intervention in an osteoporotic spine is fraught with difficulties. Advanced patient age, the presence of comorbid diseases, and difficulty in securing fixation to weakened osteoporotic bone make surgical intervention an absolute last resort.

However, surgical intervention may be required in patients with neurologic impairment, such as paresis, paralysis, saddle anesthesia, or bowel or bladder changes. Surgical intervention may also be required in a patient who is clinically unimproved despite adequate conservative care.[7, 8, 9]

Surgery may be indicated in a patient with radiographic evidence of instability. This is exhibited by ligamentous disruption with potential pending canal compromise or when movement is exhibited on dynamic or motion radiographic examination.[17]

The advancement of kyphosis despite adequate conservative care may also be an indication for surgery.

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Patient Consultations

In patients with an underlying systemic disease, appropriate medical consultations are required.

Consulting a physiatrist is appropriate, and consultation can help to assess functional limitations.

A rheumatologist is an appropriate consultation for osteoporosis management.

Consulting an orthopedic surgeon or a neurosurgeon is appropriate if surgery is being considered.[18]

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Indications for Inpatient Care

Inpatient care is not generally required for patients with osteoporotic vertebral compression fractures. However, if neurologic injury has occurred and/or another underlying systemic disease has been detected, inpatient care may be appropriate.

Transfer to an inpatient facility is also indicated for patients who are unable to care for themselves at home.

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Patient Follow-up

Serial radiographs should be obtained for 1 year following injury to be sure no kyphotic progression has occurred.

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Fracture Prevention

In addition to taking anti-osteoporotic medications, as well as (daily) 1500 mg of elemental calcium and 400 IU of vitamin D, patients should be taught to modify their activities by employing fall-prevention strategies. (Fifty percent of patients with painful vertebral fractures give a history of a recent fall.)

The results of a study by Bischoff-Ferrari et al indicated that vitamin D offers dose-dependent protection against fractures, with doses of more than 400 IU per day reducing fractures by at least 20% in individuals aged 65 years or older. Calcium supplementation was reported not to have affected the results.[19]

A patient with a painful vertebral compression fracture typically describes an abrupt onset of pain during an atraumatic, low-exertion activity, such as coughing or sneezing. Therefore, patients should be given the pneumococcal vaccine and undergo yearly influenza vaccinations to reduce their risk of severe coughing (which can result in a vertebral compression fracture).

Patients should be instructed in proper weight-bearing exercises and extension exercises.

For patient education information, see eMedicineHealth's Osteoporosis Center, as well as Osteoporosis, Osteoporosis Medications, and Vertebral Compression Fracture.

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Contributor Information and Disclosures
Author

Grant Cooper, MD Co-Founder, Co-Director, Princeton Spine and Joint Center

Grant Cooper, MD is a member of the following medical societies: Sigma Xi

Disclosure: Nothing to disclose.

Coauthor(s)

Julie Lin, MD Assistant Professor, Department of Rehabilitation Medicine, Weill Medical College of Cornell University; Assistant Attending Physiatrist, Physiatry Department, Hospital for Special Surgery

Julie Lin, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, Physiatric Association of Spine, Sports and Occupational Rehabilitation, American Association of Neuromuscular and Electrodiagnostic Medicine, American Medical Association, North American Spine Society

Disclosure: Nothing to disclose.

Joseph M Lane, MD Professor of Orthopedic Surgery, Weill Medical College of Cornell University; Chief, Metabolic Bone Disease Service, Hospital for Special Surgery

Joseph M Lane, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Association of University Professors, American Orthopaedic Association, American Society for Bone and Mineral Research, Medical Society of the State of New York, National Osteoporosis Foundation, North American Spine Society, Orthopaedic Research Society, American Federation for Aging Research, Musculoskeletal Tumor Society, Association of Bone and Joint Surgeons

Disclosure: Received consulting fee from Bone Therapeutics,BiologicsMD, for consulting; Received consulting fee from Graftys; Harvest, ISTO, Royal Pain MD for consulting; Received consulting fee from Agnovos, Inc. Kuros, Inc. for consulting.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Patrick M Foye, MD Director of Coccyx Pain Center, Professor and Interim Chair of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School; Co-Director of Musculoskeletal Fellowship, Co-Director of Back Pain Clinic, University Hospital

Patrick M Foye, MD is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, International Spine Intervention Society, American Association of Neuromuscular and Electrodiagnostic Medicine, Association of Academic Physiatrists

Disclosure: Nothing to disclose.

Chief Editor

Stephen Kishner, MD, MHA Professor of Clinical Medicine, Physical Medicine and Rehabilitation Residency Program Director, Louisiana State University School of Medicine in New Orleans

Stephen Kishner, MD, MHA is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation, American Association of Neuromuscular and Electrodiagnostic Medicine

Disclosure: Nothing to disclose.

Additional Contributors

Everett C Hills, MD, MS Assistant Professor of Physical Medicine and Rehabilitation, Assistant Professor of Orthopaedics and Rehabilitation, Penn State Milton S Hershey Medical Center and Pennsylvania State University College of Medicine

Everett C Hills, MD, MS is a member of the following medical societies: American Academy of Disability Evaluating Physicians, Association of Academic Physiatrists, American Academy of Physical Medicine and Rehabilitation, American Association for Physician Leadership, American Congress of Rehabilitation Medicine, American Medical Association, American Society of Neurorehabilitation, Pennsylvania Medical Society

Disclosure: Nothing to disclose.

References
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  2. Prather H, Watson JO, Gilula LA. Nonoperative management of osteoporotic vertebral compression fractures. Injury. 2007 Sep. 38 Suppl 3:S40-8. [Medline].

  3. [Guideline] McConnell CT Jr, Wippold FJ 2nd, Ray CE Jr, et al. ACR appropriateness criteria management of vertebral compression fractures. J Am Coll Radiol. 2014 Aug. 11(8):757-63. [Medline]. [Full Text].

  4. Sinaki M, Itoi E, Wahner HW, et al. Stronger back muscles reduce the incidence of vertebral fractures: a prospective 10 year follow-up of postmenopausal women. Bone. 2002 Jun. 30(6):836-41. [Medline].

  5. Sinaki M, Mikkelsen BA. Postmenopausal spinal osteoporosis: flexion versus extension exercises. Arch Phys Med Rehabil. 1984 Oct. 65(10):593-6. [Medline].

  6. Huntoon EA, Schmidt CK, Sinaki M. Significantly fewer refractures after vertebroplasty in patients who engage in back-extensor-strengthening exercises. Mayo Clin Proc. 2008 Jan. 83(1):54-7. [Medline]. [Full Text].

  7. Chiras J, Depriester C, Weill A, et al. [Percutaneous vertebral surgery. Technics and indications]. J Neuroradiol. 1997 Jun. 24(1):45-59. [Medline]. [Full Text].

  8. Karlsson MK, Hasserius R, Gerdhem P, et al. Vertebroplasty and kyphoplasty: new treatment strategies for fractures in the osteoporotic spine. Acta Orthop. 2005 Oct. 76(5):620-7. [Medline]. [Full Text].

  9. Phillips FM. Minimally invasive treatments of osteoporotic vertebral compression fractures. Spine. 2003 Aug 1. 28(15):S45-53. [Medline].

  10. Tanigawa N, Komemushi A, Kariya S, et al. Relationship between cement distribution pattern and new compression fracture after percutaneous vertebroplasty. AJR Am J Roentgenol. 2007 Dec. 189(6):W348-52. [Medline]. [Full Text].

  11. He SC, Teng GJ, Deng G, et al. Repeat vertebroplasty for unrelieved pain at previously treated vertebral levels with osteoporotic vertebral compression fractures. Spine. 2008 Mar 15. 33(6):640-7. [Medline].

  12. McDonald RJ, Trout AT, Gray LA, et al. Vertebroplasty in multiple myeloma: outcomes in a large patient series. AJNR Am J Neuroradiol. 2008 Jan 17. [Medline]. [Full Text].

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  15. Hsieh JY, Wu CD, Wang TM, Chen HY, Farn CJ, Chen PQ. Reduction of the domino effect in osteoporotic vertebral compression fractures through short-segment fixation with intravertebral expandable pillars compared to percutaneous kyphoplasty: a case control study. BMC Musculoskelet Disord. 2013 Mar 2. 14:75. [Medline]. [Full Text].

  16. Werner CM, Osterhoff G, Schlickeiser J, Jenni R, Wanner GA, Ossendorf C, et al. Vertebral body stenting versus kyphoplasty for the treatment of osteoporotic vertebral compression fractures: a randomized trial. J Bone Joint Surg Am. 2013 Apr 3. 95(7):577-84. [Medline].

  17. Ee GW, Lei J, Guo CM, Yeo W, Tan SB, Tow PB, et al. Comparison of Clinical Outcomes and Radiographic Measurements in Four Different Treatment Modalities for Osteoporotic Compression Fractures: Retrospective Analysis. J Spinal Disord Tech. 2013 Apr 3. [Medline].

  18. Skedros JG, Holyoak JD, Pitts TC. Knowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fracture. J Bone Joint Surg Am. 2006 Jan. 88(1):18-24. [Medline].

  19. Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med. 2009 Mar 23. 169(6):551-61. [Medline].

 
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Anteroposterior and lateral radiographs of an L1 osteoporotic wedge compression fracture.
Patients with compression fractures that do not compromise the spinal canal can be treated by means of a kyphoplasty. The use of a percutaneous balloon allows for expansion of the fractured vertebrae. The void created by the balloon is then filled with bone cement.
Anterior wedge compression fracture with an intact posterior vertebral cortex.
Osteoporotic spine. Note the considerable reduction in overall bone density and the lateral wedge fracture of L2.
A vertebral burst fracture.
Vertebroplasty. Anterior wedge compression fracture after fusion of the fracture fragments with polymethylmethacrylate.
Fluoroscopic view of a kyphoplasty procedure.
 
 
 
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