Eosinophilia-Myalgia Syndrome Medication
- Author: Thomas A Medsger, Jr, MD; Chief Editor: Herbert S Diamond, MD more...
No standard of care exists for eosinophilia-myalgia syndrome (EMS). Because the initial outbreak was sudden and widespread, only anecdotal reports and a few retrospective studies are available to aid in treatment decisions. Furthermore, the variable presentation of the syndrome and subjective nature of the symptoms complicates interpretation of these studies.
For early manifestations of EMS, patients are treated according to their symptoms, with muscle relaxants, analgesics, diuretics, and vitamins.
In addition, prednisone is commonly prescribed because inflammation plays a role. However, in general, most authors have concluded that treatment with corticosteroids is not beneficial in reducing the severity or duration of symptoms. Long-term steroid therapy has no role.
Chronic symptoms, such as muscle pain, spasm, weakness, neuropathy, and skin thickening, are noninflammatory and are treated symptomatically. Intermittent use of muscle relaxants and analgesics may be required.
These agents have anti-inflammatory properties and cause profound and varied metabolic effects. Corticosteroids modify the body's immune response to diverse stimuli.
Results in prompt resolution of eosinophilia. Subjective improvement noted in symptoms of dyspnea, myalgia, and edema in most patients.
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