Approach Considerations
No specific laboratory abnormalities are associated with osteoarthritis, although researchers have investigated the use of monoclonal antibodies, synovial fluid markers, and urinary pyridinium cross-links (ie, breakdown products of cartilage) as osteoarthritic indicators.[39]
levels of acute-phase reactants are within the reference range in patients with osteoarthritis.The erythrocyte sedimentation rate is not usually elevated, although it may be slightly so in cases of erosive inflammatory arthritis. Synovial fluid analysis usually indicates a WBC count below 2000/µL, with a mononuclear predominance.
Imaging in Osteoarthritis
Radiography is the imaging method of choice in the diagnosis of osteoarthritis because it is more cost-effective than other modalities and because radiographs can be obtained more readily and quickly.[40, 41] Osteoarthritis is typically diagnosed on the basis of clinical and radiographic evidence.[12, 42, 40, 43, 44]
One important characteristic of primary osteoarthritis is that different abnormalities are found in the pressure (ie, highly stressed) and nonpressure areas of the affected joint. In the pressure areas of the joint, radiographs can depict joint-space loss, as well as subchondral bony sclerosis and cyst formation (see the image below).
This radiograph demonstrates osteoarthritis of the right hip, including the finding of sclerosis at the superior aspect of the acetabulum. Frequently, osteoarthritis at the hip is a bilateral finding, but it may occur unilaterally in an individual who has a previous history of hip trauma that was confined to that one side. MRI can depict many of the same characteristics of osteoarthritis as those depicted on radiographs, including joint narrowing, subchondral osseous changes, and osteophytes. Unlike radiography, however, MRI can depict articular cartilage directly.\ CT scanning is rarely used in the diagnosis of primary osteoarthritis, although it may be used in the diagnosis of malalignment of the patellofemoral joint or of the foot and ankle joints.
Currently, ultrasonography has no role in the clinical evaluation of osteoarthritis, although it is being investigated as a tool for monitoring cartilage degeneration. In joints affected with osteoarthritis, increased uptake of bone-seeking radiopharmaceuticals may be seen before any radiographic abnormalities are apparent. Angiography is not routinely used for the diagnosis of osteoarthritis.
For more information, see Imaging in Osteoarthritis.
Bone Scanning
Bone scans may be helpful in the early diagnosis of osteoarthritis of the hand.[45] Bone scans can also help differentiate joint pain due to osteoarthritis from pain associated with other disease processes. For example, bone scans in osteoarthritis typically yield a symmetrically patterned, very mild increased uptake. In contrast, bone scans are often negative in the early stages of multiple myeloma, a cause of bone pain in older adults that can be confused with osteoarthritis. Bone scans also can help to differentiate osteoarthritis from osteomyelitis and bone metastases.
Arthrocentesis
Arthrocentesis of the affected joint can help to exclude inflammatory arthritis, infection, and/or crystal arthropathy. Perform diagnostic joint aspiration for synovial fluid analysis to help rule out conditions other than osteoarthritis. The presence of noninflammatory joint fluid helps to distinguish osteoarthritis from other causes of joint pain. Other findings that aid in the differentiation of osteoarthritis from other conditions are negative Gram stains and cultures, as well as the absence of crystals when fluid is viewed under a polarized microscope.
For more information, see Arthrocentesis, Shoulder.
Histologic Findings
Histologically, the earliest changes in osteoarthritis occur in the cartilage. Proteoglycan staining is diminished, and eventually, irregularity of the articular surface with clefts and erosions occurs. Cartilage biopsy is generally not performed in the diagnosis of osteoarthritis.
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