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Relapsing Polychondritis Differential Diagnoses

  • Author: Nicholas Compton, MD; Chief Editor: Herbert S Diamond, MD  more...
 
Updated: Jun 21, 2016
 
 

Diagnostic ConsiderationsAuricular chondritisInflammatory arthritisNasal chondritis/saddle-nose deformityOcular inflammationTracheal obstructionRespiratory tree chondritisCNS alterationsAortitis

Other conditions to consider in the differential diagnosis of polychondritis include the following:

  • Rheumatoid arthritis
  • Polyarteritis nodosa
  • Cogan syndrome
  • Infectious perichondritis
  • MAGIC syndrome (relapsing polychondritis [RP] plus Behçet disease)
  • Trauma (especially in boxers and wrestlers)
  • Congenital syphilis
  • Chronic external otitis
  • Auricular calcification (secondary to other conditions, eg, trauma, Addison disease, diabetes, hyperthyroidism)

Causes include the following:

Causes include the following:

  • Rheumatoid arthritis (adult or juvenile)
  • Reactive arthritis
  • Acute gonococcal arthropathy
  • Granulomatosis with polyangiitis (formerly known as Wegener granulomatosis)
  • Polyarteritis nodosa
  • Systemic lupus erythematosus and other collagen-vascular disorders

Causes include the following:

  • Infectious perichondritis
  • Granulomatosis with polyangiitis (formerly known as Wegener granulomatosis)
  • Congenital syphilis
  • Nasal NK/peripheral T-cell lymphoma (formerly known as angiocentric lymphoma)

Causes include the following:

  • Reactive arthritis (ie, conjunctivitis plus arthritis plus urethritis)
  • Rheumatoid arthritis, Behçet disease, enteropathic arthritis, or Still disease (ie, iritis or chorioretinitis plus arthritis)
  • Polyarteritis nodosa or granulomatosis with polyangiitis (ie, scleritis or episcleritis plus arthritis)
  • Sjögren syndrome (ie, keratoconjunctivitis sicca plus arthritis)
  • Cogan syndrome (ie, intersitial keratitis plus cochlear and vestibular damage)
  • Arteriosclerosis, syphilis, collagen vascular disease, herpes zoster, sickle cell disease, migraine, coagulation disorders (ie, ischemic optic neuropathy)

Causes include the following:

  • Trauma (eg, strangulation)
  • Prolonged intubation
  • Sarcoidosis
  • Granulomatosis with polyangiitis
  • Endoluminal malignancy
  • Tuberculosis/sarcoidosis webs

Perichondritis of the larynx resulting from any of the following:

  • Herpes
  • Syphilis
  • Erysipelas
  • Tonsillitis
  • Peritonsillar abscess
  • Tuberculosis
  • Measles
  • Diphtheria
  • Scarlet fever
  • Avitaminosis
  • Blastomycosis
  • Actinomycosis
  • Granulomatosis with polyangiitis
  • Xanthoma
  • Typhus
  • Vincent infection
  • Anthrax

Causes include the following:

  • Septic meningitis (fungal, bacterial, mycobacterial)
  • Aseptic meningitis unrelated to relapsing polychondritis, ie, viral
  • Temporal arteritis
  • Malignancy
  • Drug toxicity
  • Encephalitis or meningoencephalitis
  • Other causes of cerebral vasculitis
  • Other causes of seizure disorder
  • Leprosy

Causes include the following:

Differential Diagnoses

 
 
Contributor Information and Disclosures
Author

Nicholas Compton, MD Staff Physician, Department of Medicine, Division of Dermatology, University of Washington Medical Center

Nicholas Compton, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, Medical Dermatology Society

Disclosure: Nothing to disclose.

Coauthor(s)

Karin I Harp, MD Consulting Staff, Department of Dermatology, Everett Clinic

Karin I Harp, MD is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

Gregory J Raugi, MD, PhD Professor, Department of Internal Medicine, Division of Dermatology, University of Washington at Seattle School of Medicine; Chief, Dermatology Section, Primary and Specialty Care Service, Veterans Administration Medical Center of Seattle

Gregory J Raugi, MD, PhD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Jane H Buckner, MD Member, Director of Translation Research, Benaroya Research Institute; Clinical Associate Professor, Division of Rheumatology, University of Washington School of Medicine

Jane H Buckner, MD is a member of the following medical societies: American College of Physicians, Phi Beta Kappa, Sigma Xi, American College of Rheumatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Elliot Goldberg, MD Dean of the Western Pennsylvania Clinical Campus, Professor, Department of Medicine, Temple University School of Medicine

Elliot Goldberg, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American College of Rheumatology

Disclosure: Nothing to disclose.

Chief Editor

Herbert S Diamond, MD Visiting Professor of Medicine, Division of Rheumatology, State University of New York Downstate Medical Center; Chairman Emeritus, Department of Internal Medicine, Western Pennsylvania Hospital

Herbert S Diamond, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American College of Rheumatology, American Medical Association, Phi Beta Kappa

Disclosure: Nothing to disclose.

Additional Contributors

Bryan L Martin, DO Associate Dean for Graduate Medical Education, Designated Institutional Official, Associate Medical Director, Director, Allergy Immunology Program, Professor of Medicine and Pediatrics, Ohio State University College of Medicine

Bryan L Martin, DO is a member of the following medical societies: American Academy of Allergy Asthma and Immunology, American College of Allergy, Asthma and Immunology, American College of Osteopathic Internists, American College of Physicians, American Medical Association, American Osteopathic Association

Disclosure: Nothing to disclose.

References
  1. Longo L, Greco A, Rea A, Lo Vasco VR, De Virgilio A, De Vincentiis M. Relapsing polychondritis: A clinical update. Autoimmun Rev. 2016 Jun. 15 (6):539-43. [Medline].

  2. Jaksch-Wartenhorst R. Polychondropathia. Wien Arch F Inn Med. 1923. 6:93-100.

  3. Pearson CM, Kline HM, Newcomer VD. Relapsing polychondritis. N Engl J Med. 1960 Jul 14. 263:51-8. [Medline].

  4. Childs LF, Rickert S, Wengerman OC, Lebovics R, Blitzer A. Laryngeal Manifestations of Relapsing Polychondritis and a Novel Treatment Option. J Voice. 2011 Nov 12. [Medline].

  5. Arnaud L, Mathian A, Haroche J, Gorochov G, Amoura Z. Pathogenesis of relapsing polychondritis: a 2013 update. Autoimmun Rev. 2014 Feb. 13(2):90-5. [Medline].

  6. Foidart JM, Abe S, Martin GR, et al. Antibodies to type II collagen in relapsing polychondritis. N Engl J Med. 1978 Nov 30. 299(22):1203-7. [Medline].

  7. Hansson AS, Heinegard D, Piette JC, Burkhardt H, Holmdahl R. The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis. Arthritis Rheum. 2001 Oct. 44(10):2402-12. [Medline].

  8. Ebringer R, Rook G, Swana GT, Bottazzo GF, Doniach D. Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rheumatic diseases. Ann Rheum Dis. 1981 Oct. 40(5):473-9. [Medline].

  9. Tanaka Y, Nakamura M, Matsui T, et al. Proteomic surveillance of autoantigens in relapsing polychondritis. Microbiol Immunol. 2006. 50(2):117-26. [Medline].

  10. Takagi D, Iwabuchi K, Iwabuchi C, Nakamaru Y, Maguchi S, Ohwatari R. Immunoregulatory defects of V alpha 24V+ beta 11+ NKT cells in development of Wegener's granulomatosis and relapsing polychondritis. Clin Exp Immunol. 2004 Jun. 136(3):591-600. [Medline].

  11. Stabler T, Piette JC, Chevalier X, Marini-Portugal A, Kraus VB. Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. Arthritis Rheum. 2004 Nov. 50(11):3663-7. [Medline].

  12. Buckner JH, Van Landeghen M, Kwok WW, Tsarknaridis L. Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis. Arthritis Rheum. 2002 Jan. 46(1):238-44. [Medline].

  13. McCune WJ, Schiller AL, Dynesius-Trentham RA, Trentham DE. Type II collagen-induced auricular chondritis. Arthritis Rheum. 1982 Mar. 25(3):266-73. [Medline].

  14. Buckner JH, Wu JJ, Reife RA, Terato K, Eyre DR. Autoreactivity against matrilin-1 in a patient with relapsing polychondritis. Arthritis Rheum. 2000 Apr. 43(4):939-43. [Medline].

  15. Lamoureux JL, Buckner JH, David CS, Bradley DS. Mice expressing HLA-DQ6alpha8beta transgenes develop polychondritis spontaneously. Arthritis Res Ther. 2006. 8(4):R134. [Medline].

  16. McAdam LP, O'Hanlan MA, Bluestone R, Pearson CM. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore). 1976 May. 55(3):193-215. [Medline].

  17. Zeuner M, Straub RH, Rauh G, Albert ED, Scholmerich J, Lang B. Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. J Rheumatol. 1997 Jan. 24(1):96-101. [Medline].

  18. Michet CJ Jr, McKenna CH, Luthra HS, O'Fallon WM. Relapsing polychondritis. Survival and predictive role of early disease manifestations. Ann Intern Med. 1986 Jan. 104(1):74-8. [Medline].

  19. Trentham DE, Le CH. Relapsing polychondritis. Ann Intern Med. 1998 Jul 15. 129(2):114-22. [Medline].

  20. Priori R, Conti F, Pittoni V, Valesini G. Relapsing polychondritis: a syndrome rather than a distinct clinical entity?. Clin Exp Rheumatol. 1997 May-Jun. 15(3):334-5. [Medline].

  21. Piette JC, El-Rassi R, Amoura Z. Antinuclear antibodies in relapsing polychondritis. Ann Rheum Dis. 1999 Oct. 58(10):656-7. [Medline].

  22. Haigh R, Scott-Coombes D, Seckl JR. Acute mastitis; a novel presentation of relapsing polychondritis. Postgrad Med J. 1987 Nov. 63(745):983-4. [Medline].

  23. Cohen PR. Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy-associated mucocutaneous paraneoplastic syndromes. Int J Dermatol. 2006 Jan. 45(1):70-80. [Medline].

  24. Kent PD, Michet CJ Jr, Luthra HS. Relapsing polychondritis. Curr Opin Rheumatol. 2004 Jan. 16(1):56-61. [Medline].

  25. Letko E, Zafirakis P, Baltatzis S, Voudouri A, Livir-Rallatos C, Foster CS. Relapsing polychondritis: a clinical review. Semin Arthritis Rheum. 2002 Jun. 31(6):384-95. [Medline].

  26. Hager MH, Moore ME. Relapsing polychondritis syndrome associated with pustular psoriasis, spondylitis and arthritis mutilans. J Rheumatol. 1987 Feb. 14(1):162-4. [Medline].

  27. Cipriano PR, Alonso DR, Baltaxe HA, Gay WA Jr, Smith JP. Multiple aortic aneurysms in relapsing polychondritis. Am J Cardiol. 1976 Jun. 37(7):1097-102. [Medline].

  28. Bernard P, Bedane C, Delrous JL, Catanzano G, Bonnetblanc JM. Erythema elevatum diutinum in a patient with relapsing polychondritis. J Am Acad Dermatol. 1992 Feb. 26(2 Pt 2):312-5. [Medline].

  29. Weinberger A, Myers AR. Relapsing polychondritis associated with cutaneous vasculitis. Arch Dermatol. 1979 Aug. 115(8):980-1. [Medline].

  30. Astudillo L, Launay F, Lamant L, Sailler L, Bazex J, Couret B. Sweet's syndrome revealing relapsing polychondritis. Int J Dermatol. 2004 Oct. 43(10):720-2. [Medline].

  31. Cohen PR. Sweet's syndrome and relapsing polychondritis: is their appearance in the same patient a coincidental occurrence or a bona fide association of these conditions?. Int J Dermatol. 2004 Oct. 43(10):772-7. [Medline].

  32. Disdier P, Andrac L, Swiader L, et al. Cutaneous panniculitis and relapsing polychondritis: two cases. Dermatology. 1996. 193(3):266-8. [Medline].

  33. Firestein GS, Gruber HE, Weisman MH, Zvaifler NJ, Barber J, O'Duffy JD. Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome. Five patients with features of relapsing polychondritis and Behçet's disease. Am J Med. 1985 Jul. 79(1):65-72. [Medline].

  34. Imai H, Motegi M, Mizuki N, et al. Mouth and genital ulcers with inflamed cartilage (MAGIC syndrome): a case report and literature review. Am J Med Sci. 1997 Nov. 314(5):330-2. [Medline].

  35. Stewart SS, Ashizawa T, Dudley AW Jr, Goldberg JW, Lidsky MD. Cerebral vasculitis in relapsing polychondritis. Neurology. 1988 Jan. 38(1):150-2. [Medline].

  36. Fujiki F, Tsuboi Y, Hashimoto K, Nakajima M, Yamada T. Non-herpetic limbic encephalitis associated with relapsing polychondritis. J Neurol Neurosurg Psychiatry. 2004 Nov. 75(11):1646-7. [Medline].

  37. Ohta Y, Nagano I, Niiya D, Fujioka H, Kishimoto T, Shoji M. Nonparaneoplastic limbic encephalitis with relapsing polychondritis. J Neurol Sci. 2004 May 15. 220(1-2):85-8. [Medline].

  38. Berg AM, Kasznica J, Hopkins P, Simms RW. Relapsing polychondritis and aseptic meningitis. J Rheumatol. 1996 Mar. 23(3):567-9. [Medline].

  39. Chang-Miller A, Okamura M, Torres VE, et al. Renal involvement in relapsing polychondritis. Medicine (Baltimore). 1987 May. 66(3):202-17. [Medline].

  40. Terao C, Yoshifuji H, Yamano Y, Kojima H, Yurugi K, Miura Y, et al. Genotyping of relapsing polychondritis identified novel susceptibility HLA alleles and distinct genetic characteristics from other rheumatic diseases. Rheumatology (Oxford). 2016 May 30. [Medline].

  41. Labarthe MP, Bayle-Lebey P, Bazex J. Cutaneous manifestations of relapsing polychondritis in a patient receiving goserelin for carcinoma of the prostate. Dermatology. 1997. 195(4):391-4. [Medline].

  42. Lee KS, Ernst A, Trentham DE, Lunn W, Feller-Kopman DJ, Boiselle PM. Relapsing polychondritis: prevalence of expiratory CT airway abnormalities. Radiology. 2006 Aug. 240(2):565-73. [Medline].

  43. Yamashita H, Takahashi H, Kubota K, Ueda Y, Ozaki T, Yorifuji H, et al. Utility of fluorodeoxyglucose positron emission tomography/computed tomography for early diagnosis and evaluation of disease activity of relapsing polychondritis: a case series and literature review. Rheumatology (Oxford). 2014 Aug. 53(8):1482-90. [Medline].

  44. Carter JD. Treatment of relapsing polychondritis with a TNF antagonist. J Rheumatol. 2005 Jul. 32(7):1413. [Medline].

  45. Ratzinger G, Kuen-Spiegl M, Sepp N. Successful treatment of recalcitrant relapsing polychondritis with monoclonal antibodies. J Eur Acad Dermatol Venereol. 2009 Apr. 23(4):474-5. [Medline].

  46. Richez C, Dumoulin C, Coutouly X, Schaeverbeke T. Successful treatment of relapsing polychondritis with infliximab. Clin Exp Rheumatol. 2004 Sep-Oct. 22(5):629-31. [Medline].

  47. Seymour MW, Home DM, Williams RO, Allard SA. Prolonged response to anti-tumour necrosis factor treatment with adalimumab (Humira) in relapsing polychondritis complicated by aortitis. Rheumatology (Oxford). 2007 Nov. 46(11):1738-9. [Medline].

  48. Wendling D, Govindaraju S, Prati C, Toussirot E, Bertolini E. Efficacy of anakinra in a patient with refractory relapsing polychondritis. Joint Bone Spine. 2008 Oct. 75(5):622-4. [Medline].

  49. Vounotrypidis P, Sakellariou GT, Zisopoulos D, Berberidis C. Refractory relapsing polychondritis: rapid and sustained response in the treatment with an IL-1 receptor antagonist (anakinra). Rheumatology (Oxford). 2006 Apr. 45(4):491-2. [Medline].

  50. Handler RP. Leflunomide for relapsing polychondritis: successful longterm treatment. J Rheumatol. 2006 Sep. 33(9):1916; author reply 1916-7. [Medline].

  51. Kemta Lekpa F, Kraus VB, Chevalier X. Biologics in Relapsing Polychondritis: A Literature Review. Semin Arthritis Rheum. 2011 Nov 7. [Medline].

  52. Liu L, Liu S, Guan W, Zhang L. Efficacy of tocilizumab for psychiatric symptoms associated with relapsing polychondritis: the first case report and review of the literature. Rheumatol Int. 2016 Jun 3. 19 (6):46-50. [Medline].

  53. Wierzbicka M, Tokarski M, Puszczewicz M, Szyfter W. The efficacy of submucosal corticosteroid injection and dilatation in subglottic stenosis of different aetiology. J Laryngol Otol. 2016 Apr 27. 1-6. [Medline].

  54. Bermas BL, Hill JA. Effects of immunosuppressive drugs during pregnancy. Arthritis Rheum. 1995 Dec. 38(12):1722-32. [Medline].

  55. Papo T, Wechsler B, Bletry O, Piette AM, Godeau P, Piette JC. Pregnancy in relapsing polychondritis: twenty-five pregnancies in eleven patients. Arthritis Rheum. 1997 Jul. 40(7):1245-9. [Medline].

  56. Anderson NG, Garcia-Valenzuela E, Martin DF. Hypopyon uveitis and relapsing polychondritis: a report of 2 patients and review of autoimmune hypopyon uveitis. Ophthalmology. 2004 Jun. 111(6):1251-4. [Medline].

  57. Cazabon S, Over K, Butcher J. The successful use of infliximab in resistant relapsing polychondritis and associated scleritis. Eye. 2005 Feb. 19(2):222-4. [Medline].

  58. Cohen PR. Paraneoplastic relapsing polychondritis. Arch Dermatol. 2007 Jul. 143(7):949-50. [Medline].

  59. Dolev JC, Maurer TA, Reddy SG, Ramirez LE, Berger T. Relapsing polychondritis in HIV-infected patients: a report of two cases. J Am Acad Dermatol. 2004 Dec. 51(6):1023-5. [Medline].

  60. Hansson AS, Johannesson M, Svensson L, Nandakumar KS, Heinegard D, Holmdahl R. Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease. Am J Pathol. 2004 Mar. 164(3):959-66. [Medline].

  61. Herrera I, Concha R, Molina EG, Schiff ER, Altman RD. Relapsing polychondritis, chronic hepatitis C virus infection, and mixed cryoglobulemia. Semin Arthritis Rheum. 2004 Jun. 33(6):388-403. [Medline].

  62. Manghani MK, Andrews J, Higgens CS. Kaposi's sarcoma in a patient with severe relapsing polychondritis. Rheumatol Int. 2004 Sep. 24(5):309-11. [Medline].

  63. Marie I, Martinaud O, Omnient Y, Mihout B, Levesque H. Facial diplegia revealing relapsing polychondritis. Rheumatology (Oxford). 2005 Jun. 44(6):827-8. [Medline].

  64. Peebo BB, Peebo M, Frennesson C. Relapsing polychondritis: a rare disease with varying symptoms. Acta Ophthalmol Scand. 2004 Aug. 82(4):472-5. [Medline].

  65. Rozin AP, Gez E, Bergman R. Recurrent auricular chondritis and cartilage repair. Ann Rheum Dis. 2005 May. 64(5):783-4. [Medline].

  66. Segel MJ, Godfrey S, Berkman N. Relapsing polychondritis: reversible airway obstruction is not always asthma. Mayo Clin Proc. 2004 Mar. 79(3):407-9.

  67. Serratrice J, de Roux-Serratrice C, Ene N, et al. Urticarial vasculitis revealing relapsing polychondritis. Eur J Intern Med. 2005 Jun. 16(3):207-208.

  68. Sharma A, Bambery P, Wanchu A, et al. Relapsing polychondritis in North India: a report of 10 patients. Scand J Rheumatol. 2007 Nov-Dec. 36(6):462-5. [Medline].

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Auricular edema and erythema sparing the lobule. Courtesy of Gregory J. Raugi, MD, PhD.
Severe auricular edema and inflammation. Courtesy of the University of Washington, Division of Dermatology.
Forward listing ear. Courtesy of the University of Washington, Division of Dermatology.
Floppy ear. Courtesy of the University of Washington, Division of Dermatology.
Bilateral inflammation and structural collapse of the auricles in a patient found to have aortic dissection. Courtesy of the University of Washington, Division of Dermatology.
Same patient as in Image 5 after 4-6 weeks of steroid treatment. Note resolution of auricular inflammation with nodularity and forward listing of the ears. Courtesy of the University of Washington, Division of Dermatology.
Close-up view of same patient as in Image 6. Forward flopping of ear with nodularity after steroid treatment. Courtesy of the University of Washington, Division of Dermatology.
Unilateral episcleritis. Courtesy of Gregory J. Raugi, MD, PhD.
Saddle-nose deformity. Courtesy of the University of Washington, Division of Dermatology.
Tracheal stenosis on chest x-ray film. Courtesy of Julie E. Takasugi, MD.
Table. Autoimmune Conditions Reported in Patients With Relapsing Polychondritis
DiseasePatients With Condition/Total PatientsReferences
Systemic vasculitis3 (5%) of 62Zeuner et al[17]
11 (10%) of 112Michet et al[18]
8 (12%) of 66Trentham and Le[19]
28 (18%) of 159McAdam et al[16]
50 (13%) of 399Total
Cutaneous leukocytoclastic vasculitis2 (33%) of 6Priori et al[20]
6 (5%) of 112Michet et al[18]
8 (7%) of 118Total
Thyroid disease8 (5%) of 159McAdam et al[16]
10 (15%) of 66Trentham and Le[19]
2 (33%) of 6Priori et al[20]
4 (4%) of 112Michet et al[18]
2 (3%) of 62Zeuner et al[17]
26 (6%) of 405Total
Rheumatoid arthritis*8 (5%) of 159McAdam et al[16]
3 (2%) of 180Piette et al[21]
8 (7%) of 112Michet et al[18]
7 (11%) of 62Zeuner et al[17]
26 (5%) of 513Total
Systemic lupus erythematosus†2 (1%) of 159McAdam et al[16]
9 (5%) of 180Piette et al[21]
1 (17%) of 6Priori et al[20]
6 (5%) of 112Michet et al[18]
3 (5%) of 62Zeuner et al[17]
21 (4%) of 519Total
Sjögren syndrome (possible)5 (3%) of 159McAdam et al[16]
5 (5%) of 111Piette et al[21]
10 (4%) of 270Total
Ulcerative colitis3 (2%) of 159McAdam et al[16]
2 (3%) of 62Zeuner et al[17]
5 (2%) of 221Total
Crohn disease2 (1%) of 180Piette et al[21]
1 (2%) 62Zeuner et al[17]
1 (100%) of 1Haigh et al[22]
4 (2%) of 243Total
Mixed connective-tissue disease5 (3%) of 180Piette et al[21]
2 (2%) of 112Michet et al[18]
7 (2%) of 292Total
Takayasu arteritis3 (2%) of 180Piette et al[21]
Mesenteric panniculitis3 (2%) of 180Piette et al[21]
Spondyloarthropathy2 (1%) of 180Piette et al[21]
3 (3%) of 112Michet et al[18]
2 (3%) of 62Zeuner et al[17]
7 (2%) of 354Total
Diabetes mellitus1 (2%) of 62Zeuner et al[17]
3 (2%) of 159McAdam et al[16]
4 (2%) of 221Total
Reactive arthritis/psoriatic arthritis2 (1%) of 159McAdam et al[16]
1 (< 1%) of 112Michet et al[18]
3 (1%) of 271Total
Systemic sclerosis2 (1%) of 159McAdam et al[16]
Raynaud syndrome2 (1%) of 159McAdam et al[16]
Glomerulonephritis2 (1%) of 159McAdam et al[16]
Dysgammaglobulinemia2 (1%)of 159McAdam et al[16]
Pernicious anemia1 (1%) of 159McAdam et al[16]
Behçet disease*1 (< 1%) of 112Michet et al[18]
Psoriasis2 (1%) of 180Piette et al[21]
Lichen planus2 (1%) of 180Piette et al[21]
Primary biliary cirrhosis1 (< 1%) of 112Michet et al[18]
*Individual patients may carry more than one autoimmune diagnosis.



†Reported as 13 (20%) of 66 prevalence by Trentham and Le without division by disease



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