Acute Rheumatic Fever Follow-up

  • Author: Robert J Meador, MD; Chief Editor: Herbert S Diamond, MD   more...
 
Updated: Sep 8, 2011
 

Further Inpatient Care

  • Although inpatient care is believed to be initially mandatory in individuals with active carditis, prolonged hospitalization is usually not necessary.
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Further Outpatient Care

  • Periodic monitoring at 3- to 4-month intervals is critical to evaluate for progress with the resumption of physical activity, resolution of the constitutional symptoms, and freedom from adverse effects from medications.
  • Less frequent visits, perhaps once a year, are appropriate while following a prophylaxis regimen.
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Transfer

  • Transfer to a short-term–care facility should be arranged when patients have active life-threatening sequelae, notably carditis.
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Deterrence/Prevention

  • Patients should be educated to seek medical attention upon the first signs of pharyngitis.
  • Once the disease is established, patients should be educated regarding benefits and risks of compliance with their medical regimen, which may be protracted.
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Complications

  • Acute episodes are self-limited, with an average duration of 3 months for untreated attacks. Recurrence tends to occur within the first few years of the attack.
  • The outcome of carditis is likely to be more severe if patients have pre-existing heart disease. Carditis resolves without sequelae in 65-75% of patients.
  • Severe cardiac failure, total disability, and death may occur years after the acute attack.
  • The risk of developing a new episode is highest during the 5 years following an acute attack. This justifies prophylaxis for all patients for at least 5 years or until the patient reaches age 18 years.
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Prognosis

  • The course followed by a patient after a first attack is highly variable and unpredictable. Approximately 90% of episodes last less than 3 months. Only a minority persist longer, in the form of unremitting rheumatic carditis or prolonged chorea.
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Contributor Information and Disclosures
Author

Robert J Meador, MD  Rheumatology Fellow, Department of Rheumatology, Baylor Garland Family Practice Clinic

Robert J Meador, MD is a member of the following medical societies: Texas Medical Association

Disclosure: Nothing to disclose.

Coauthor(s)

I Jon Russell, MD, PhD, MS, FACR  Director, University Clinical Research Center, Associate Professor, Department of Internal Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio

I Jon Russell, MD, PhD, MS, FACR is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American College of Rheumatology, International Association for the Study of Pain, and International MYOPAIN Society (IMS)

Disclosure: Jazz Pharma Consulting fee Consulting; Pfizer Pharma Grant/research funds Independent contractor; Pfizer Pharma Consulting fee Speaking and teaching; Lily Pharma Grant/research funds Independent contractor; Lily Pharma Consulting fee Speaking and teaching

Specialty Editor Board

Francisco Talavera, PharmD, PhD  Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Medscape Salary Employment

Lawrence H Brent, MD  Associate Professor of Medicine, Jefferson Medical College of Thomas Jefferson University; Chair, Program Director, Department of Medicine, Division of Rheumatology, Albert Einstein Medical Center

Lawrence H Brent, MD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Immunologists, American College of Physicians, and American College of Rheumatology

Disclosure: Abbott Honoraria Speaking and teaching; Centocor Consulting fee Consulting; Genentech Grant/research funds Other; HGS/GSK Honoraria Speaking and teaching; Omnicare Consulting fee Consulting; Pfizer Honoraria Speaking and teaching; Roche Speaking and teaching; Savient Honoraria Speaking and teaching; UCB Honoraria Speaking and teaching

Alex J Mechaber, MD, FACP  Senior Associate Dean for Undergraduate Medical Education, Associate Professor of Medicine, University of Miami Miller School of Medicine

Alex J Mechaber, MD, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians-American Society of Internal Medicine, and Society of General Internal Medicine

Disclosure: Nothing to disclose.

Chief Editor

Herbert S Diamond, MD  Adjunct Professor of Medicine, Division of Rheumatology, University of Pittsburgh School of Medicine; Chairman Emeritus, Department of Internal Medicine, Western Pennsylvania Hospital

Herbert S Diamond, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American College of Rheumatology, American Medical Association, and Phi Beta Kappa

Disclosure: Merck Ownership interest Other; Smith Kline Ownership interest Other; Zimmer Ownership interest Other

References
  1. Yoshinoya S, Pope RM. Detection of immune complexes in acute rheumatic fever and their relationship to HLA-B5. J Clin Invest. Jan 1980;65(1):136-45. [Medline].

  2. Chun LT, Reddy DV, Yamamoto LG. Rheumatic fever in children and adolescents in Hawaii. Pediatrics. Apr 1987;79(4):549-52. [Medline].

  3. Jones TD. Diagnosis of rheumatic fever. JAMA. 1944;126:481-85.

  4. Digenea AS, Ayoub EM. Guidelines for the diagnosis of rheumatic fever: Jones criteria updates 1992. Circulation 87. Circulation. 1993;87:302.

  5. Barash J, Mashiach E, Navon-Elkan P, Berkun Y, Harel L, Tauber T, et al. Differentiation of post-streptococcal reactive arthritis from acute rheumatic fever. J Pediatr. Nov 2008;153(5):696-9. [Medline].

  6. Bryant PA, Robins-Browne R, Carapetis JR, Curtis N. Some of the people, some of the time: susceptibility to acute rheumatic fever. Circulation. Feb 10 2009;119(5):742-53. [Medline].

  7. Carapetis JR, Brown A, Wilson NJ, Edwards KN, Rheumatic Fever Guidelines Writing Group. An Australian guideline for rheumatic fever and rheumatic heart disease: an abridged outline. Med J Aust. Jun 4 2007;186(11):581-6. [Medline].

  8. Erdem G, Mizumoto C, Esaki D, Reddy V, Kurahara D, Yamaga K. Group A streptococcal isolates temporally associated with acute rheumatic fever in Hawaii: differences from the continental United States. Clin Infect Dis. Aug 1 2007;45(3):e20-4. [Medline].

  9. Gerber MA, Baltimore RS, Eaton CB, Gewitz M, Rowley AH, Shulman ST, et al. Prevention of rheumatic fever and diagnosis and treatment of acute Streptococcal pharyngitis: a scientific statement from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young, the Interdisciplinary Council on Functional Genomics and Translational Biology, and the Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics. Circulation. Mar 24 2009;119(11):1541-51. [Medline].

  10. Gibofsky A, Kerwar S, Zabriskie JB. Rheumatic fever. The relationships between host, microbe, and genetics. Rheum Dis Clin North Am. May 1998;24(2):237-59. [Medline].

  11. Guzman, L. Rheumatic Fever. In: Klippel J, ed. Primer on the Rheumatic Diseases. 11th ed. Atlanta, Ga: Arthritis Foundation; 1997:168-71.

  12. Gündogdu F, Islamoglu Y, Pirim I, Gurlertop Y, Dogan H, Arslan S. Human leukocyte antigen (HLA) class I and II alleles in Turkish patients with rheumatic heart disease. J Heart Valve Dis. May 2007;16(3):293-9. [Medline].

  13. Kaplan EL. Pathogenesis of acute rheumatic fever and rheumatic heart disease: evasive after half a century of clinical, epidemiological, and laboratory investigation. Heart. Jan 2005;91(1):3-4. [Medline].

  14. McLean A, Waters M, Spencer E, Hadfield C. Experience with cardiac valve operations in Cape York Peninsula and the Torres Strait Islands, Australia. Med J Aust. Jun 4 2007;186(11):560-3. [Medline].

  15. Minola E, Arosio M, Rizzo G, et al. Clinical and laboratory features of acute rheumatic fever: a 18-year experience. Infez Med. 2005;13(1):28-32. [Medline].

  16. Parrillo S, Parrillo CV. Rheumatic Fever. eMedicine Journal [serial online]. 2001;Available at: http://emedicine.medscape.com/article/808945-overview. [Full Text].

  17. Rubio C. Acute Rheumatic Fever. In: West SR, ed. Rheumatology Secrets. Vol 1. Philadelphia, Pa: Hanley & Belfus; 1997:260-4.

  18. Soudarssanane MB, Karthigeyan M, Mahalakshmy T, Sahai A, Srinivasan S, Subba Rao KS. Rheumatic fever and rheumatic heart disease: primary prevention is the cost effective option. Indian J Pediatr. Jun 2007;74(6):567-70. [Medline].

  19. Stanevicha V, Eglite J, Zavadska D, Sochnevs A, Shantere R, Gardovska D. HLA Class II DR and DQ genotypes and haplotypes associated with rheumatic fever among clinically homogenous patients in children in Latvia. Arthritis Res Ther. Jun 10 2007;9(3):R58. [Medline].

  20. Steinhoff MC, Abd el Khalek MK, Khallaf N, et al. Effectiveness of clinical guidelines for the presumptive treatment of streptococcal pharyngitis in Egyptian children. Lancet. Sep 27 1997;350(9082):918-21. [Medline].

  21. Stollerman GH. The nature of rheumatogenic streptococci. Mt Sinai J Med. May-Sep 1996;63(3-4):144-58. [Medline].

  22. [Guideline] Thatai D, Turi ZG. Current guidelines for the treatment of patients with rheumatic fever. Drugs. Apr 1999;57(4):545-55. [Medline].

  23. Tibazarwa KB, Volmink JA, Mayosi BM. Incidence of acute rheumatic fever in the world: a systematic review of population-based studies. Heart. Dec 2008;94(12):1534-40. [Medline].

  24. Weidebach W, Goldberg AC, Chiarella JM, et al. HLA class II antigens in rheumatic fever. Analysis of the DR locus by restriction fragment-length polymorphism and oligotyping. Hum Immunol. Aug 1994;40(4):253-8. [Medline].

  25. Zakkar M, Amirak E, Chan KM, Punjabi PP. Rheumatic mitral valve disease: current surgical status. Prog Cardiovasc Dis. May-Jun 2009;51(6):478-81. [Medline].

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Clinical manifestations and time course of acute rheumatic fever.
Chest radiograph showing cardiomegaly due to carditis of acute rheumatic fever.
Erythema marginatum, the characteristic rash of acute rheumatic fever.
 
 
 
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