eMedicine Specialties > Radiology > Brain/Spine

Tuberculosis, CNS: Multimedia

Author: Peter D Corr, MD, MB, ChB, FRCR, Professor of Radiology, United Arab Emirates University
Contributor Information and Disclosures

Updated: Dec 30, 2008

Multimedia

Contrast-enhanced computed tomography (CT) scan i...Media file 1: Contrast-enhanced computed tomography (CT) scan in a patient with tuberculous meningitis demonstrating marked enhancement in the basal cistern and meninges, with dilatation of the ventricles.
Contrast-enhanced computed tomography (CT) scan i...

Contrast-enhanced computed tomography (CT) scan in a patient with tuberculous meningitis demonstrating marked enhancement in the basal cistern and meninges, with dilatation of the ventricles.

Petechial hemorrhages in the subcortical white ma...Media file 2: Petechial hemorrhages in the subcortical white matter of the brain as a result of tuberculous meningitisassociated vasculitis.
Petechial hemorrhages in the subcortical white ma...

Petechial hemorrhages in the subcortical white matter of the brain as a result of tuberculous meningitisassociated vasculitis.

Extensive infarcts of the right basal ganglia and...Media file 3: Extensive infarcts of the right basal ganglia and internal capsule after the appearance of vasculitis in the thalamoperforating arteries in a child treated for tuberculous meningitis.
Extensive infarcts of the right basal ganglia and...

Extensive infarcts of the right basal ganglia and internal capsule after the appearance of vasculitis in the thalamoperforating arteries in a child treated for tuberculous meningitis.

T2-weighted magnetic resonance image of a biopsy-...Media file 4: T2-weighted magnetic resonance image of a biopsy-proven, right parietal tuberculoma. Note the lowsignal-intensity rim of the lesion and the surrounding hyperintense vasogenic edema.
T2-weighted magnetic resonance image of a biopsy-...

T2-weighted magnetic resonance image of a biopsy-proven, right parietal tuberculoma. Note the lowsignal-intensity rim of the lesion and the surrounding hyperintense vasogenic edema.

T1-weighted gadolinium-enhanced magnetic resonanc...Media file 5: T1-weighted gadolinium-enhanced magnetic resonance image in a patient with multiple enhancing tuberculomas in both cerebellar hemispheres.
T1-weighted gadolinium-enhanced magnetic resonanc...

T1-weighted gadolinium-enhanced magnetic resonance image in a patient with multiple enhancing tuberculomas in both cerebellar hemispheres.

T1-weighted gadolinium-enhanced magnetic resonanc...Media file 6: T1-weighted gadolinium-enhanced magnetic resonance image in a child with a tuberculous abscess in the left parietal region. Note the enhancing thick-walled abscess.
T1-weighted gadolinium-enhanced magnetic resonanc...

T1-weighted gadolinium-enhanced magnetic resonance image in a child with a tuberculous abscess in the left parietal region. Note the enhancing thick-walled abscess.

T1-weighted gadolinium-enhanced magnetic resonanc...Media file 7: T1-weighted gadolinium-enhanced magnetic resonance image of the thoracic spinal cord in a patient with acquired immunodeficiency syndrome (AIDS) and leptomeningeal tuberculosis. Note the numerous granulomas on the dorsal surface of the cord and the dural enhancement.
T1-weighted gadolinium-enhanced magnetic resonanc...

T1-weighted gadolinium-enhanced magnetic resonance image of the thoracic spinal cord in a patient with acquired immunodeficiency syndrome (AIDS) and leptomeningeal tuberculosis. Note the numerous granulomas on the dorsal surface of the cord and the dural enhancement.

T2-weighted magnetic resonance image of the thora...Media file 8: T2-weighted magnetic resonance image of the thoracic spinal cord of a patient with 2 hyperintense intramedullary tuberculomas.
T2-weighted magnetic resonance image of the thora...

T2-weighted magnetic resonance image of the thoracic spinal cord of a patient with 2 hyperintense intramedullary tuberculomas.

Contrast-enhanced computed tomography (CT) scan o...Media file 9: Contrast-enhanced computed tomography (CT) scan of a child with tuberculous meningitis demonstrating acute hydrocephalus and meningeal enhancement.
Contrast-enhanced computed tomography (CT) scan o...

Contrast-enhanced computed tomography (CT) scan of a child with tuberculous meningitis demonstrating acute hydrocephalus and meningeal enhancement.

T2-weighted magnetic resonance image of a patient...Media file 10: T2-weighted magnetic resonance image of a patient with a tuberculoma in the right parietal lobe.
T2-weighted magnetic resonance image of a patient...

T2-weighted magnetic resonance image of a patient with a tuberculoma in the right parietal lobe.

Proton spectroscopy trace of a patient with an in...Media file 11: Proton spectroscopy trace of a patient with an intracerebral tuberculoma (same patient as in Image 10) demonstrating an elevated lactate peak (LA) with diminished N-acetyl aspartate (NAA) and choline (CH) peaks typical of an inflammatory mass in the brain.
Proton spectroscopy trace of a patient with an in...

Proton spectroscopy trace of a patient with an intracerebral tuberculoma (same patient as in Image 10) demonstrating an elevated lactate peak (LA) with diminished N-acetyl aspartate (NAA) and choline (CH) peaks typical of an inflammatory mass in the brain.

More on Tuberculosis, CNS

Overview: Tuberculosis, CNS
Imaging: Tuberculosis, CNS
Follow-up: Tuberculosis, CNS
Multimedia: Tuberculosis, CNS
References
Further Reading

References

  1. Friedman LN, Williams MT, Singh TP, Frieden TR. Tuberculosis, AIDS, and death among substance abusers on welfare in New York City. N Engl J Med. Mar 28 1996;334(13):828-33. [Medline].

  2. Corbett EL, Watt CJ, Walker N, et al. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med. May 12 2003;163(9):1009-21. [Medline].

  3. World Health Organization. Global Tuberculosis Control: Surveillance, Planning, Financing. Geneva: WHO Press; 2007. [Full Text].

  4. Rock RB, Olin M, Baker CA, Molitor TW, Peterson PK. Central nervous system tuberculosis: pathogenesis and clinical aspects. Clin Microbiol Rev. Apr 2008;21(2):243-61, table of contents. [Medline].

  5. Rafi W, Venkataswamy MM, Ravi V, et al. Rapid diagnosis of tuberculous meningitis: a comparative evaluation of in-house PCR assays involving three mycobacterial DNA sequences, IS6110, MPB-64 and 65 kDa antigen. J Neurol Sci. Jan 31 2007;252(2):163-8. [Medline].

  6. Srikanth SG, Taly AB, Nagarajan K, et al. Clinicoradiological features of tuberculous meningitis in patients over 50 years of age. J Neurol Neurosurg Psychiatry. May 2007;78(5):536-8. [Medline].

  7. Smith AB, Smirniotopoulos JG, Rushing EJ. From the archives of the AFIP: central nervous system infections associated with human immunodeficiency virus infection: radiologic-pathologic correlation. Radiographics. Nov-Dec 2008;28(7):2033-58. [Medline].

  8. Semlali S, El Kharras A, Mahi M, Hsaini Y, Benameur M, Aziz N, et al. [Imaging features of CNS tuberculosis]. J Radiol. Feb 2008;89(2):209-20. [Medline].

  9. Janse van Rensburg P, Andronikou S, van Toorn R, Pienaar M. Magnetic resonance imaging of miliary tuberculosis of the central nervous system in children with tuberculous meningitis. Pediatr Radiol. Dec 2008;38(12):1306-13. [Medline].

  10. Appenzeller S, Faria AV, Zanardi VA, Fernandes SR, Costallat LT, Cendes F. Vascular involvement of the central nervous system and systemic diseases: etiologies and MRI findings. Rheumatol Int. Oct 2008;28(12):1229-37. [Medline].

  11. Garg RK. Tuberculosis of the central nervous system. Postgrad Med J. Mar 1999;75(881):133-40. [Medline].

  12. Osborn AG. Diagnostic Neuroradiology. St Louis, Mo: Mosby; 1994.

  13. Shah GV. Central nervous system tuberculosis: imaging manifestations. Neuroimaging Clin N Am. May 2000;10(2):355-74. [Medline].

  14. Zimmerman RA, Gibby WA, Carmody RF, eds. Neuroimaging: Clinical and Physical Principles. New York, NY: Springer-Verlag; 1999.

Keywords

tuberculosis of the central nervous system, TB, Mycobacterium tuberculosis, cerebral tuberculosis, cerebral granulomas, tuberculomas, tuberculous granulomas, tuberculous abscesses, granulomatous meningitis, granulomatous infection, tuberculous meningitis, TBM

Contributor Information and Disclosures

Author

Peter D Corr, MD, MB, ChB, FRCR, Professor of Radiology, United Arab Emirates University
Peter D Corr, MD, MB, ChB, FRCR is a member of the following medical societies: American Roentgen Ray Society, International Skeletal Society, International Society for Magnetic Resonance in Medicine, Radiological Society of North America, Royal College of Radiologists, Royal College of Surgeons of Edinburgh, and South African Medical Association
Disclosure: Nothing to disclose.

Medical Editor

Pamela W Schaefer, MD, Assistant Professor of Radiology, Harvard Medical School; Associate Director of Neuroradiology, Clinical Director of Magnetic Resonance Imaging, Department of Radiology, Massachusetts General Hospital
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

C Douglas Phillips, MD, Professor, Departments of Radiology, Neurosurgery, and Otolaryngology, University of Virginia Health Sciences Center
C Douglas Phillips, MD is a member of the following medical societies: American College of Radiology, American Medical Association, American Society of Head and Neck Radiology, American Society of Neuroradiology, Association of University Radiologists, and Radiological Society of North America
Disclosure: Amirsys Royalty Consulting

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

James G Smirniotopoulos, MD, Professor of Radiology, Neurology, and Biomedical Informatics, Chairman, Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences
James G Smirniotopoulos, MD is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, American Society of Head and Neck Radiology, American Society of Neuroradiology, American Society of Pediatric Neuroradiology, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

 
 
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