The brachial plexus represents a complex network of nerves formed from the ventral rami of the lower cervical nerves (C5-C8) and the greater portion of the ventral ramus of the first thoracic nerve (T1). The ventral rami or roots coalesce to form trunks, divisions, cords, and branches, which provide motor and sensory innervation to the upper limb and thorax.
Pathology of the brachial plexus is widely varied, but tends to be due to similar mechanisms based on age. In neonates, the most common pathology of to the brachial plexus is related to birth trauma. In adolescents and young adults, pathology is often due to high-speed trauma, such as motor vehicle accidents. In adults, neoplasm (intrinsic or extrinsic masses) or postradiation injury frequently is the cause. Traumatic injuries to the brachial plexus are associated with weakness and paresthesias of the upper extremity on the affected side. Thorough neurologic examination can be performed to localize the injury and to help pinpoint the location of pathology. See the image below.
Clinical evaluation of the brachial plexus can be challenging or impossible without good imaging correlation. Although the physical examination has traditionally been a mainstay in evaluating and localizing pathology involving the brachial plexus, physical examination is especially difficult in patients with scarring and fibrosis secondary to surgery or irradiation. Electrophysiologic studies can also be used to detect abnormalities in nerve conduction, but they are poor for localizing a lesion. [1, 2]
Plain radiography can depict large lesions affecting the brachial plexus or the presence of fractures in the setting of trauma. However, radiographs are far less sensitive than other studies.
Computed tomography (CT) scanning has increased sensitivity for depicting extrinsic masses that compress the nerves compared with radiographs, but CT offers poor soft tissue contrast for direct evaluation of the nerves of the brachial plexus.
Although conventional and CT myelography can be used to evaluate the nerve roots of the brachial plexus and to assess for pseudomeningocele formation, MRI has become increasingly important in the evaluation of brachial plexus pathology owing to the improved soft tissue resolution. With MRI, not only can the nerve roots of the brachial plexus be visualized, but also the trunks, divisions, and cords can be better seen and characteristics such as course, caliber, signal intensity, fascicular pattern, and size can be better evaluated. Additionally, improved soft tissue differentiation allows for improved detection of intrinsic and extrinsic pathology. MRI also has the additional benefit of multiplanar imaging. The tissue resolution of MRI is constantly improving with new pulse sequences and coil designs. [1, 3, 4, 5, 6, 7, 8, 9]
Indications for brachial plexus MRI include symptomology, pain, neural deficit, or muscular atrophy that may be due to brachial plexus pathology, postradiation treatment evaluation, or preoperative evaluation of known intrinsic or extrinsic lesions within the neck, clavicular region, or axilla.
Correlation of imaging results with electrophysiologic findings also increases overall specificity and sensitivity. [10, 11, 12, 13] According to Nardin et al in 1999, [2, 3] electromyelography (EMG) and MRI examinations are complementary. Their study demonstrated that the sensitivity of EMG and MRI were 72% and 60%, respectively. More recent large multicenter trials performed at 1.5 Tesla and 3 Tesla have demonstrated even higher sensitivity and specificity of MRI alone at 81% and 90%, respectively. 
Compared with radiography and CT scanning, with which changes in the shape or position of the brachial plexus have been used to assess pathology,  MRI can directly visualize the nerve. Sequences such as fat-saturated T2-weighted spin-echo, short-tau inversion recovery (STIR), and gadolinium-enhanced T1-weighted spin-echo sequences help in depicting subtle changes in the signal intensity of the nerves or enhancement and aid in refining the differential diagnosis. In addition, maximum-intensity projections can make localization and visualization of the pathology most understandable for referring clinicians and surgeons. [16, 17]
High-resolution 3-Tesla MR neurography and recent advances in 3-dimensional techniques also allow for improved visualization and evaluation of the brachial plexus, but may not be universally available. 
See the images below.
Technique and Imaging Parameters
The brachial plexus can be identified on MRI by first identifying the anterior scalene muscle. The brachial plexus and subclavian artery (relationship outlined above) are deep to the anterior scalene. The roots are best seen on axial images, whereas the remaining components are well seen on coronal and sagittal images.
Normal components of the brachial plexus have intermediate-to-low signal intensity on images obtained with all sequences and are surrounded by fat. Conversely, abnormal nerves may demonstrate focal or diffuse enlargement, deviation, discontinuity, elevated T2-weighted signal, and/or effacement of the perineural fat planes. Segmental or confluent postcontrast enhancement of the brachial plexus can also be visualized in the setting of infiltrative tumor or infection. [4, 19, 20, 14]
See the images below.
A variety of MRI protocols and techniques have been described in the evaluation of the brachial plexus. Described are the general protocols used at the authors’ institution to best satisfy the needs of patients and clinicians; these protocols are tailored as needed.
A surface coil provides resolution higher than that of a body coil, but it increases artifact due to respiratory motion. A combination of each may be used in sequences for the brachial plexus. As such, the surface coil is used for the spinal cord and exiting spinal nerve roots, whereas the body coil is used to image the plexus lateral to the interscalene triangle.
Field of view
Examination of the brachial plexus begins with the roots and trucks in the proximal aspects within the supraclavicular region and continues to the origin of the terminal branches at the lateral margin of the pectoralis minor muscle in the infraclavicular region.
The field of view (FOV) is 17-22 cm for the direct coronal orientation and 14-17 cm for sagittal or oblique sagittal orientations.
A matrix of 512 X 256 or 512 X 512 is used.
The recommended section thickness is 3-4 mm, with an intersection gap of 0-0.5 mm for direct coronal imaging and 4-5 mm with an intersection gap of 1-2 mm for sagittal or oblique sagittal imaging. If axial images are obtained, 4-mm thickness with a 1- to 1.5-mm intersection gap may be performed.
Images should be obtained in at least 2 planes. Direct coronal plane imaging is preferred over oblique coronal imaging because the brachial plexus has a shallow obliquity relative to the true coronal plane and because it can be imaged on 1 or 2 coronal sections.
Cross-sectional imaging of the nerve components of the plexus may be performed by using either the true sagittal or the oblique sagittal plane on the side of interest. True sagittal imaging allows for comparison with the standard cross-sectional anatomy, which some find helpful in the recognition of appropriate anatomic landmarks. However, oblique sagittal imaging more accurately represents the true cross-section of the brachial plexus than true sagittal imaging and thus allows for increased sensitivity to pathology, including changes in caliber, alteration in signal intensity, or presence of a fascicular pattern to the nerve components.
Thin-section axial, coronal, and sagittal contrast-enhanced T1-weighted sequences with or without fat suppression can be helpful in the evaluation of tumor, infection, or stretch injury. Some institutions include a contrast-enhanced T1-weighted axial sequence as part of their routine evaluation of the brachial plexus.
Gadolinium-based contrast agents (gadopentetate dimeglumine [Magnevist], gadobenate dimeglumine [MultiHance], gadodiamide [Omniscan], gadoversetamide [OptiMARK], gadoteridol [ProHance]) have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD). For more information, see Nephrogenic Systemic Fibrosis. The disease has occurred in patients with moderate– to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or MR angiography scans.
NSF/NFD is a debilitating and sometimes fatal disease. Characteristics include red or dark patches on the skin; burning, itching, swelling, hardening, and tightening of the skin; yellow spots on the whites of the eyes; joint stiffness with trouble moving or straightening the arms, hands, legs, or feet; pain deep in the hip bones or ribs; and muscle weakness.
T1- and T2-weighted images are obtained with identical parameters in terms of FOV, matrix, section thickness, and imaging plane.
STIR or frequency-selective fat-saturation methods may be used for T2-weighted MRI to increase the conspicuity of abnormal signal intensity from the signal intensity of adjacent fat. Each has its advantages and disadvantages. STIR has been described as being more reliable than the other method because of its uniform and consistent fat suppression and excellent T2-like contrast when long repetition times are used.
The STIR method has several disadvantages. For example, it has a relatively low signal-to-noise ratio, it offers relatively low tissue contrast, and it is more susceptible to flow artifacts than other methods.
In contrast, frequency-selective fat-saturation methods have the advantage of an improved signal-to-noise ratio, T1-weighted imaging, and reduced flow-related artifacts. The major disadvantage of this type of fat suppression is the nonuniformity of fat suppression with the FOV primarily from inhomogeneity of B0. This variability in fat suppression is exacerbated by the nonuniformity in B1.
When radiation injury, neoplasm, stretch injury, infection, or inflammatory etiologies are present or suspected, contrast-enhanced fat-suppressed T1-weighted MRI should be performed. The suggested protocol is summarized in the images below.