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Pancoast Tumor Imaging

  • Author: Melanie Guerrero, MD; Chief Editor: Eugene C Lin, MD  more...
 
Updated: Nov 23, 2015
 

Overview

Pancoast tumors are neoplasms of pulmonary origin located at the apical pleuropulmonary groove (superior sulcus).[1, 2] Pancoast tumors and their associated morbidities are presented in images below.

Pancoast tumor. A 53-year-old man with a 50 pack-y Pancoast tumor. A 53-year-old man with a 50 pack-year history of smoking began experiencing upper back pain for several weeks. PA chest radiograph shows asymmetry of the apices (superior sulcus). The right apex is more opaque than the left. When the image is enlarged, the partially destroyed second and third right posterior ribs near the costovertebral junction can be seen.
Pancoast tumor. Axial nonenhanced CT image of the Pancoast tumor. Axial nonenhanced CT image of the upper dorsal spine demonstrates a soft tissue mass destroying the vertebra on the right and the right posterior elements, including the pedicle and part of the posterior spinous process.
Pancoast tumor. Sagittal fast spin-echo T2-weighte Pancoast tumor. Sagittal fast spin-echo T2-weighted MRI shows collapsed vertebrae and cord compression at C7, T1, and T2 caused by a soft tissue mass.

By direct extension, Pancoast tumors typically involve the lower trunks of the brachial plexus, intercostal nerves, stellate ganglion, adjacent ribs, and vertebrae.

More than 95% of Pancoast tumors are non–small cell carcinomas, most commonly squamous cell carcinomas (52%) or adenocarcinomas and large cell carcinomas (approximately 23% for each subtype).[1] Small cell carcinomas are seen in fewer than 5% of cases.[3]

Staging of Pancoast tumor involves the tumor, node, and metastasis (TNM) classification system, in which T indicates site and size of the primary tumor, N is related to nodal involvement according to site, and M indicates the presence or absence of distant metastases. These tumors are, at a minimum, T3N0M0 (T3 for chest wall invasion, stage IIB), and they are considered T4 lesions if the brachial plexus, mediastinal structures, or vertebral bodies are involved at the time of presentation. When supraclavicular nodes are involved, they are designated as N3 nodes, although they may be the first nodal station involved. Metastatic tumor in the ipsilateral nonprimary-tumor lobe of the lung or metastases to other organ systems is considered M1.[4]

Preferred examination

Compared with other examinations, magnetic resonance imaging (MRI) is more accurate in identification of the extent of tumor involvement; it is superior to computed tomography (CT) scanning in the detection of invasion of adjacent organs (eg, vertebral bodies, brachial plexus, subclavian vessels).[5, 6, 7, 8]  Histologic diagnosis is made in 95% of the cases by means of percutaneous transthoracic needle biopsy with fluoroscopic, ultrasonographic, or CT scan localization.[9, 10]  Among other considerations, CT scanning or MRI of the brain is recommended in the initial evaluation, because distant metastases to the brain are not infrequent, and diagnosis of these is necessary for staging.[11]

Noninvasive preoperative evaluation of the mediastinum with CT or MRI is limited by substantial false-positive and false-negative results (30-40%, depending on the criteria used to define enlarged lymph nodes and the patient population). Positron emission tomography (PET) scanning and, possibly, surgical assessment of the mediastinum with lymph node sampling should be strongly considered before curative surgery is attempted.

Intervention

Preoperative radiation therapy at doses of 2000-6500 cGy, followed by surgical resection, is the most common form of treatment for Pancoast tumors. However, the advantage of preoperative radiation therapy has not been definitively demonstrated, and the dose of radiation has not been clearly established. The overall 5-year survival rate in patients treated with preoperative radiation therapy and surgery is reported to be 20-35%.[1, 12, 13]

Radiation therapy at a dose of 6000 cGy or greater has been used as a primary treatment modality for inoperable tumors, with successful palliation of pain in as many as 90% of patients. The reported 5-year survival rate is 0-29% in these patients, which is likely a result of extensive disease involvement at initial presentation.

The routine use of intraoperative and postoperative radiation therapy is not currently recommended, except in patients in whom unresectable tumors are found at the time of surgery.

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Radiography

Posteroanterior (PA) chest radiographs show unilateral apical opacity (as seen in the image below) or just asymmetry of the apices of greater than 5 mm. Local rib destruction can sometimes be observed. Lordotic chest views can be beneficial, but the findings can also be misleading.

Pancoast tumor. A 53-year-old man with a 50 pack-y Pancoast tumor. A 53-year-old man with a 50 pack-year history of smoking began experiencing upper back pain for several weeks. PA chest radiograph shows asymmetry of the apices (superior sulcus). The right apex is more opaque than the left. When the image is enlarged, the partially destroyed second and third right posterior ribs near the costovertebral junction can be seen.

In the early stages, Pancoast tumors are difficult to detect on PA chest radiographs because of the difficulty in interpreting overlying shadows at the apices.

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Computed Tomography

CT scanning is best in demonstrating bony destruction. MRI appears to be superior in demonstrating chest wall invasion. Also, the anatomy above the lung apex is better demonstrated on multiplanar MRI, because the nerves of the brachial plexus and blood vessels follow a horizontal and parallel course, meeting above the apex of the lung.

Pancoast tumor. Axial nonenhanced CT image of the Pancoast tumor. Axial nonenhanced CT image of the upper dorsal spine demonstrates a soft tissue mass destroying the vertebra on the right and the right posterior elements, including the pedicle and part of the posterior spinous process.

In an older study of 31 patients with superior pulmonary sulcus tumors,[5] CT scanning had a sensitivity of 60% and a specificity of 65%, with an overall accuracy of 63% in the evaluation of the extent of disease.

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Magnetic Resonance Imaging

MRI provides superior delineation of the normal anatomy of the brachial plexus because of its multiplanar capabilities. The absence of streak artifact from bone and accurate identification of vessels are some of the advantages of MRI. It also has superior soft-tissue contrast, and it is more accurate than other methods in documenting or excluding brachial plexus involvement by the tumor. (See the images below.)[14]

Pancoast tumor. Sagittal fast spin-echo T2-weighte Pancoast tumor. Sagittal fast spin-echo T2-weighted MRI shows collapsed vertebrae and cord compression at C7, T1, and T2 caused by a soft tissue mass.
Pancoast tumor. Sagittal gradient-echo T2-weighted Pancoast tumor. Sagittal gradient-echo T2-weighted MRI demonstrates a soft tissue mass involving C7, T1, and T2, with collapse of the vertebrae and moderate cord compression.
Pancoast tumor. Axial T1-weighted image shows cord Pancoast tumor. Axial T1-weighted image shows cord compression caused by a large, enhancing mass. The right subclavian artery is not involved.

Compared with other techniques, MRI is more accurate in the evaluation of extension to the vertebral body, spinal canal, brachial plexus, and subclavian artery. This advantage is important, because vertebral body, spinal canal, and upper brachial plexus invasion are contraindications to surgical resection.

In an older study of 31 patients with Pancoast tumors, MRI had a sensitivity of 88%, a specificity of 100%, and an overall accuracy of 94%.[5]

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Ultrasonography

Some have suggested that all patients with Pancoast tumors should undergo ultrasonographic examination of the ipsilateral scalene area and that percutaneous biopsy should be performed on nodes with a transverse diameter of greater than 1 cm. The purpose of these studies is to assist in staging of the disease. The use of a sector ultrasonographic unit with a supraclavicular approach has been useful in guiding needle aspirations, with a yield for pathologic diagnosis in 91% of cases.

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Nuclear Imaging

PET scanning is a promising modality for the detection of distant metastases and mediastinal involvement.[11]

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Angiography

On occasion, subclavian artery angiography may be indicated to rule out local invasion of these vessels by the tumor.

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Contributor Information and Disclosures
Author

Melanie Guerrero, MD Consulting Staff, Department of Pulmonary and Critical Care Medicine, Walter Reed Army Medical Center

Melanie Guerrero, MD is a member of the following medical societies: American College of Chest Physicians, American College of Physicians-American Society of Internal Medicine

Disclosure: Nothing to disclose.

Coauthor(s)

Scott C Williams, MD Section Chief, Nuclear Medicine Associate Attending Radiologist, Advanced Radiology Consultants, Bridgeport Hospital

Scott C Williams, MD is a member of the following medical societies: American College of Radiology, American Medical Association, American Roentgen Ray Society, Radiological Society of North America

Disclosure: Nothing to disclose.

Specialty Editor Board

Bernard D Coombs, MB, ChB, PhD Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand

Disclosure: Nothing to disclose.

Chief Editor

Eugene C Lin, MD Attending Radiologist, Teaching Coordinator for Cardiac Imaging, Radiology Residency Program, Virginia Mason Medical Center; Clinical Assistant Professor of Radiology, University of Washington School of Medicine

Eugene C Lin, MD is a member of the following medical societies: American College of Nuclear Medicine, American College of Radiology, Radiological Society of North America, Society of Nuclear Medicine and Molecular Imaging

Disclosure: Nothing to disclose.

Additional Contributors

Judith K Amorosa, MD, FACR Clinical Professor of Radiology and Vice Chair for Faculty Development and Medical Education, Rutgers Robert Wood Johnson Medical School

Judith K Amorosa, MD, FACR is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, Association of University Radiologists, Radiological Society of North America, Society of Thoracic Radiology

Disclosure: Nothing to disclose.

References
  1. Davis GA, Knight SR. Pancoast tumors. Neurosurg Clin N Am. 2008 Oct. 19(4):545-57, v-vi. [Medline].

  2. Foroulis CN, Zarogoulidis P, Darwiche K, Katsikogiannis N, Machairiotis N, Karapantzos I, et al. Superior sulcus (Pancoast) tumors: current evidence on diagnosis and radical treatment. J Thorac Dis. 2013 Sep. 5 Suppl 4:S342-58. [Medline].

  3. Fontinele e Silva J, Barbosa Mde P, Viegas CL. Small cell carcinoma in Pancoast syndrome. J Bras Pneumol. 2009 Feb. 35(2):190-3. [Medline].

  4. Deslauriers J, Gregoire J. Clinical and surgical staging of non-small cell lung cancer. Chest. 2000 Apr. 117(4 Suppl 1):96S-103S. [Medline].

  5. Heelan RT, Demas BE, Caravelli JF, et al. Superior sulcus tumors: CT and MR imaging. Radiology. 1989 Mar. 170(3 Pt 1):637-41. [Medline].

  6. Webb WR, Gatsonis C, Zerhouni EA, et al. CT and MR imaging in staging non-small cell bronchogenic carcinoma: report of the Radiologic Diagnostic Oncology Group. Radiology. 1991 Mar. 178(3):705-13. [Medline].

  7. Manenti G, Raguso M, D'Onofrio S, Altobelli S, Scarano AL, Vasili E, et al. Pancoast tumor: the role of magnetic resonance imaging. Case Rep Radiol. 2013. 2013:479120. [Medline]. [Full Text].

  8. Gu R, Kang MY, Gao ZL, Zhao JW, Wang JC. Differential diagnosis of cervical radiculopathy and superior pulmonary sulcus tumor. Chin Med J (Engl). 2012 Aug. 125(15):2755-7. [Medline].

  9. Gofeld M, Bhatia A. Alleviation of Pancoast's tumor pain by ultrasound-guided percutaneous ablation of cervical nerve roots. Pain Pract. 2008 Jul-Aug. 8(4):314-9. [Medline].

  10. Yang PC, Lee LN, Luh KT, et al. Ultrasonography of Pancoast tumor. Chest. 1988 Jul. 94(1):124-8. [Medline].

  11. Ozmen O, Yilmaz U, Dadali Y, Tatci E, Gokcek A, Aydin E, et al. Use of FDG PET/CT in Patients with Pancoast Tumors: Does It Add Any Contribution to Patient Management?. Cancer Biother Radiopharm. 2015 Oct. 30 (8):359-67. [Medline].

  12. Kuraishi H, Yamashita J, Tsuchiya Y, Kokubu F, Takizawa K. [A case of lung adenocarcinoma of pancoast type successfully treated with concurrent chemoradiotherapy]. Gan To Kagaku Ryoho. 2009 Feb. 36(2):291-3. [Medline].

  13. Detterbeck FC. Changes in the treatment of Pancoast tumors. Ann Thorac Surg. 2003 Jun. 75(6):1990-7. [Medline].

  14. Manenti G, Raguso M, D'Onofrio S, Altobelli S, Scarano AL, Vasili E, et al. Pancoast tumor: the role of magnetic resonance imaging. Case Rep Radiol. 2013. 2013:479120. [Medline].

 
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Pancoast tumor. A 53-year-old man with a 50 pack-year history of smoking began experiencing upper back pain for several weeks. PA chest radiograph shows asymmetry of the apices (superior sulcus). The right apex is more opaque than the left. When the image is enlarged, the partially destroyed second and third right posterior ribs near the costovertebral junction can be seen.
Pancoast tumor. Axial nonenhanced CT image of the upper dorsal spine demonstrates a soft tissue mass destroying the vertebra on the right and the right posterior elements, including the pedicle and part of the posterior spinous process.
Pancoast tumor. Sagittal fast spin-echo T2-weighted MRI shows collapsed vertebrae and cord compression at C7, T1, and T2 caused by a soft tissue mass.
Pancoast tumor. Sagittal gradient-echo T2-weighted MRI demonstrates a soft tissue mass involving C7, T1, and T2, with collapse of the vertebrae and moderate cord compression.
Pancoast tumor. Axial T1-weighted image shows cord compression caused by a large, enhancing mass. The right subclavian artery is not involved.
 
 
 
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