Acute Pulmonary Embolism (Helical CT) 

Pulmonary embolism (PE) was clinically described in the early 1800s, and von Virchow first described the connection between venous thrombosis and PE.^{[1, 2]} In 1922, Wharton and Pierson reported the first radiographic description of PE.^[3] Images depicting clots in the pulmonary arterial system are provided below.

Imaging has played an important role in the diagnosis of PE. For many years, ventilation-perfusion (V/Q) scintigraphy has been the main imaging modality for the evaluation of patients with suspected PE. However, with the advent of and the widespread availability of faster computed tomography (CT) scanners, CT scanning has emerged as another important diagnostic test for the evaluation of not only PE, but also of deep venous thrombosis (DVT) in select patients.

Three primary influences predispose a patient to thrombus formation; these form the so-called Virchow triad: (1) endothelial injury, (2) stasis or turbulence of blood flow, and (3) blood hypercoagulability.^{[1, 2, 4]}

More than 90% of all PEs arise from thrombi within the large deep veins of the legs, typically the popliteal vein and the larger veins above it.^{[1, 2, 4]} The pathophysiologic consequences of thromboembolism in the lung largely depend on the cardiopulmonary status of the patient and on the size of the embolus, which, in turn, dictates the size of the occluded pulmonary artery.

Preferred examination

In patients with possible PE, chest radiographic findings may indicate if lung scanning (V/Q) or helical CT scanning should be the next method of evaluation. If the chest radiograph is normal, V/Q findings may be diagnostic; if the chest radiograph is abnormal, helical CT should be performed.^{[4, 5, 6]}

A quantitative D-dimer assay is reported to have high negative predictive value and may be effective for excluding the need for pulmonary CT angiography (CTA) in selected cases.^[7] Another study shows that using a clinical decision rule with D-dimer level improved pulmonary CTA and better identified positives for pulmonary embolisms.^[8]

Conventional pulmonary angiography is invasive, time consuming, and more expensive than other tests. The role of conventional angiography is limited to patients in whom other results are nondiagnostic or the clinical suspicion is high.^{[9, 10, 11]} In patients with suspected DVT, the workup should start with leg ultrasonography.

Limitations of techniques

V/Q findings may be nondiagnostic.

Iodinated contrast agents are needed for helical CT pulmonary angiography, and their use may not be possible in patients with impaired renal function or a severe allergy to the contrast material.

Small (subsegmental) emboli may be missed with CT angiography. Compared with CT scanning, conventional pulmonary angiography requires more expertise and support staff. Conventional angiography is also invasive, time consuming, more expensive, and less available. In addition, a chronic central mural thrombus that is easily seen with CT scanning may be missed at pulmonary angiography.^[12]

Chest radiographs are abnormal in most cases of PE, but the findings are nonspecific. Common radiographic abnormalities include atelectasis, pleural effusion, parenchymal opacities, and elevation of a hemidiaphragm. The classic radiographic findings of pulmonary infarction include a wedge-shaped, pleura-based, triangular opacity with an apex pointing toward the hilus (Hampton hump) or decreased vascularity (Westermark sign). These findings are suggestive of PE but are infrequently observed.

A prominent central pulmonary artery (knuckle sign), cardiomegaly (especially on the right side of the heart), and pulmonary edema are other findings. In the appropriate clinical setting, these findings could be consistent with acute cor pulmonale. A normal-appearing chest radiograph in a patient with severe dyspnea and hypoxemia but without evidence of bronchospasm or a cardiac shunt is strongly suggestive of PE. Generally, chest radiographs cannot be used to conclusively prove or exclude PE; however, radiography and electrocardiography may be useful for establishing alternative diagnoses.

Technical advances in CT scanning, including the development of multidetector-array scanners, have led to the emergence of CT scanning as an important diagnostic technique in suspected PE.^{[13, 14]} Contrast-enhanced CT scanning is increasingly used as the initial radiologic study in the diagnosis of PE, especially in patients with abnormal chest radiographs in whom scintigraphic results are more likely to be nondiagnostic. (See the image below.)^{[4, 5, 6]}

CT scanning shows emboli directly, as does pulmonary angiography, and it is also noninvasive, cheaper, and widely available. CT scanning is the only test that can provide significant additional information related to alternate diagnoses; this is a clear advantage of CT scanning compared with either pulmonary angiography or scintigraphy.^[15] A CT image depicting an acute pulmonary embolism is provided below.

Because DVT and PE are part of the same disease process, CT venography can easily be performed after CT pulmonary angiography, without the administration of additional contrast material.^{[11, 16, 17]} This study requires only a few extra minutes and allows "one-stop imaging" for PE and DVT.

The technique for CT pulmonary angiography with single-section helical CT involves the following parameters: 3-mm collimation, 2-mm reconstruction interval, pitch of 2, and an average acquisition time of 24 seconds. Iodinated contrast medium is administered as a bolus with an automated injector. Generally, a large volume (100-150 mL) of contrast material is administered at a high flow rate (4 mL/s) for good-quality diagnostic opacification of vessels.^[18]

CT venograms can be acquired 3-4 minutes after the start of the administration of contrast material. The new multidetector-row CT (MDCT) scanners are considerably faster, allowing the performance of thin-section (1.25-mm) helical CT pulmonary angiography during a shorter breath hold (15-17 seconds). With introduction of dual-source CT technology, ECG-gated CTA of the chest may become practical and help provide clinicians with cardiac functional information.

Efforts should be made to minimize the radiation dose by using all available equipment-specific dose reduction techniques.

When a PE is identified, it is characterized as acute or chronic. An embolus is acute if it is situated centrally within the vascular lumen or if it occludes a vessel (vessel cutoff sign; see the image below). Acute PE commonly causes distention of the involved vessel.

An embolus is chronic if (1) it is eccentric and contiguous with the vessel wall (see the image below), (2) it reduces the arterial diameter by more than 50%, (3) evidence of recanalization within the thrombus is present, and (4) an arterial web is present.

A PE is further characterized as central or peripheral, depending on the location or the arterial branch involved. Central vascular zones include the following:

main pulmonary artery

• The left and right main pulmonary arteries
• The anterior trunk
• The right and left interlobar arteries
• The left upper lobe trunk
• The right middle lobe artery
• The right and left lower lobe arteries

Peripheral vascular zones include the following:

• The segmental and subsegmental arteries of the right upper lobe
• The right middle lobe
• The right lower lobe
• The left upper lobe
• The lingula
• The left lower lobe

There is ongoing research in the field of postprocessing of CT scan data for acute PE, one dealing with the detection of perfusion defects as an adjunct to transverse CT scans for detection of small peripheral PE and another focusing on the automatic computer-aided detection of endoluminal clots.

Degree of confidence

In most cases, when spiral CT scan findings are positive for PE, the emboli are multiple, with intraluminal filling defects observed in the larger central arteries and in the segmental and subsegmental vessels.^[19] An apparent filling defect in a single segmental or (especially) subsegmental vessel can be challenging. One should consider all the pitfalls, especially those related to volume-averaging artifacts before diagnosing an isolated subsegmental embolus. The emboli are often bilateral and more common in the arteries to the lower lobes.

The sensitivity of spiral CT scanning in the evaluation of central PE is as high as 100%. However, it is reportedly variable and lower (see the table below). Also, the reported incidence of isolated subsegmental PEs varies from 5% in the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) study to 36% in another study.^[6] Moreover, the true significance of small emboli has not been proven conclusively. Small thromboemboli may have clinical significance in patients with limited cardiopulmonary reserve.

Pulmonary angiography demonstrates subsegmental vessels in more detail than does CT scanning, although the superimposition of the small vessels remains a limiting factor. As a result, the interobserver agreement rate for isolated subsegmental PE is only 45%.^[20]

Investigators have reported uneventful clinical outcomes in patients (with a negative predictive value of 99%) in whom CT scans were interpreted as negative for PE and who were not treated with anticoagulation or catheter-directed pharmacologic thrombolysis. The outcome was similar to those of patients with clinically suspected PE but without emboli on pulmonary arteriograms. This finding indicates that, although some small emboli may be missed at helical CT scanning, the subsequent morbidity rate with PE does not appear to be high.

The new MDCT scanners are considerably faster, allowing the performance of thin-section (1.25-mm) helical CT pulmonary angiography during a shorter breath hold (15-17 seconds). The segmental and subsegmental vessels are better demonstrated, findings are easier to interpret, and interobserver agreement is improved with this technique.

Although MDCT increases diagnostic capabilities, however, the large amount of data (a thin-section 16-detector row CT pulmonary angiography results in 500-600 axial slices) generated puts a substantial strain on any image analysis and archiving system. Development of dedicated algorithms for computer-aided detection and greater use of maximum intensity projection reconstruction techniques may be helpful in the future for identification of pulmonary emboli in large-volume MDCT data sets.

Table. Accuracy of helical CT* pulmonary angiography (Open Table in a new window)

The pitfalls of CT scanning, especially those related to volume averaging of perivascular tissue, branching points, and nonvertical vessels, can be limited by using a trackball on a workstation and by knowing the vascular anatomy. The lymphatic and connective tissue, more commonly adjacent to central vessels, are located between the artery and the bronchus. (See the image below.)

Flow-related and motion artifacts can result in pseudofilling defects and should be kept in mind when the quality of study is evaluated and when the image is interpreted. Flow-related pseudofilling defects can also result in false-positive findings on the CT venogram.

Overall, findings in 2-4% of CT pulmonary angiographic examinations are nondiagnostic because of severe motion artifacts (severe dyspnea) or poor venous access.^[26] In 8-10% of examinations, the scans are suboptimal in quality; these allow for confident evaluation of only the central pulmonary arteries. In addition to CT pulmonary angiograms, CT venograms obtained may be useful in patients with a nondiagnostic angiogram, particularly if it is positive for DVT. (See the image below.)

Few investigators have reported the feasibility of magnetic resonance imaging (MRI) in the evaluation of PE. However, the role of MRI is mostly limited to the evaluation of patients who have impaired renal function or other contraindications for the use of iodinated contrast material.^{[27, 28]} Newer blood-pool contrast agents and respiratory navigators may enhance the role of MRI in the diagnosis of PE.

The 1990 PIOPED trial was a multi-institutional study of V/Q scanning and pulmonary angiography.^[29] The investigators revealed that a V/Q scan with normal findings virtually excludes PE and that a scan with high-probability findings is virtually diagnostic for the disease. However, the diagnosis was established or excluded in only 174 (24.4%) of 713 patients—that is, those with scans showing clear and concordant clinical and lung findings. Most patients, including those with underlying cardiopulmonary disease, had indeterminate or nondiagnostic V/Q findings and required additional imaging. Therefore, in patients with abnormal chest radiographs, the use of helical CT scanning rather than scintigraphy as the primary screening test is reasonable.

A second group of PIOPED investigators (PIOPED II) formulated recommendations based on their own studies as well as others.^[6] The authors included information regarding clinical probability assessment scoring indexes as well as empirical assessment, flowcharts, and various patient scenarios (eg, patients with impaired renal function, pregnant patients, etc).