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Pneumonia, Atypical Bacterial: Follow-up
Updated: Mar 7, 2008
Intervention
Legionella pneumonia
Delay in the treatment of Legionella pneumonia is associated with a significantly increased mortality rate.
The newer macrolides, especially azithromycin, have superior in vitro activity, with more intracellular and lung tissue penetration than erythromycin. Quinolones have even greater in vitro activity and better intracellular penetration than the macrolides.
In severely ill patients, rifampin may be used in combination with the macrolides or quinolones.
The duration of therapy is 10-14 days, with a 21-day regimen for immunosuppressed patients or those with extensive disease, as shown on chest radiographs. Chest radiographic findings may continue to deteriorate despite clinical improvement.
Mycoplasma pneumonia
In most cases, recommended treatment for Mycoplasma pneumonia includes tetracycline or a macrolide. Fluoroquinolones also may be used. Two to three weeks of therapy is generally recommended to lessen the risk of relapse.
Chlamydia pneumonia
Chlamydia pneumonia may be treated with doxycycline, a macrolide, or a fluoroquinolone. The preferred diagnostic result is a 4-fold increase in titers from the acute stage to convalescence, with supporting evidence from PCR or culture tests. Therefore, most laboratories cannot confirm the diagnosis in a timely fashion; the treatment of this pneumonia should be empirical.
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References
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Further Reading
Keywords
walking pneumonia, atypical pneumonia, Legionella pneumonia, Chlamydia pneumonia, Mycoplasma pneumonia, Mycobacterium tuberculosis, community-acquired pneumonia, CAP, Legionnaires disease, Legionnaire's disease, Legionnaires' disease, Legionella pneumophila, Legionella micdadei, Mycoplasma hominis, Ureaplasma urealyticum, Chlamydia psittaci, Chlamydia trachomatis, Chlamydia pneumoniae, TWAR agent
Follow-up: Pneumonia, Atypical Bacterial