eMedicine Specialties > Radiology > Gastrointestinal

Hepatocellular Carcinoma, Fibrolamellar: Multimedia

Author: W Ross Stevens, MD, Clinical Professor, Department of Radiology, Southern Illinois University School of Medicine; Head, Radiology Residency Director, Division of Gastrointestinal Radiology, St John's Hospital
Contributor Information and Disclosures

Updated: Aug 22, 2007

Multimedia

Contrast-enhanced computed tomography (CT) scan o...Media file 1: Contrast-enhanced computed tomography (CT) scan of fibrolamellar carcinoma demonstrates a large, heterogeneously enhancing mass in the right lobe of the liver, with a hypoattenuating central scar and punctate, central calcification.
Contrast-enhanced computed tomography (CT) scan o...

Contrast-enhanced computed tomography (CT) scan of fibrolamellar carcinoma demonstrates a large, heterogeneously enhancing mass in the right lobe of the liver, with a hypoattenuating central scar and punctate, central calcification.

Photograph of a resected gross pathologic specime...Media file 2: Photograph of a resected gross pathologic specimen of fibrolamellar carcinoma shows a lobulated, tan-colored mass with a stellate, central scar (same patient as in Image 1).
Photograph of a resected gross pathologic specime...

Photograph of a resected gross pathologic specimen of fibrolamellar carcinoma shows a lobulated, tan-colored mass with a stellate, central scar (same patient as in Image 1).

Computed tomography (CT) scan in a patient with f...Media file 3: Computed tomography (CT) scan in a patient with fibrolamellar carcinoma shows metastatic lymphadenopathy in the porta hepatisgastrohepatic region.
Computed tomography (CT) scan in a patient with f...

Computed tomography (CT) scan in a patient with fibrolamellar carcinoma shows metastatic lymphadenopathy in the porta hepatisgastrohepatic region.

T1-weighted magnetic resonance image of the liver...Media file 4: T1-weighted magnetic resonance image of the liver in a patient with fibrolamellar carcinoma shows a lobulated and well-defined mass with a relatively homogeneous, hypointense appearance.
T1-weighted magnetic resonance image of the liver...

T1-weighted magnetic resonance image of the liver in a patient with fibrolamellar carcinoma shows a lobulated and well-defined mass with a relatively homogeneous, hypointense appearance.

T2-weighted magnetic resonance image (same patien...Media file 5: T2-weighted magnetic resonance image (same patient as in Image 4) shows a fibrolamellar carcinoma with increased signal intensity relative to that of the surrounding liver.
T2-weighted magnetic resonance image (same patien...

T2-weighted magnetic resonance image (same patient as in Image 4) shows a fibrolamellar carcinoma with increased signal intensity relative to that of the surrounding liver.

Ultrasonogram shows a heterogeneous echotexture m...Media file 6: Ultrasonogram shows a heterogeneous echotexture mass in the liver that corresponds to a fibrolamellar carcinoma.
Ultrasonogram shows a heterogeneous echotexture m...

Ultrasonogram shows a heterogeneous echotexture mass in the liver that corresponds to a fibrolamellar carcinoma.

Digital subtraction arteriogram (obtained by inje...Media file 7: Digital subtraction arteriogram (obtained by injection of the celiac axis) demonstrates fibrolamellar carcinoma; the carcinoma appears as an area of hypervascularity and tumor blush in the inferior aspect of the liver.
Digital subtraction arteriogram (obtained by inje...

Digital subtraction arteriogram (obtained by injection of the celiac axis) demonstrates fibrolamellar carcinoma; the carcinoma appears as an area of hypervascularity and tumor blush in the inferior aspect of the liver.

More on Hepatocellular Carcinoma, Fibrolamellar

Overview: Hepatocellular Carcinoma, Fibrolamellar
Imaging: Hepatocellular Carcinoma, Fibrolamellar
Follow-up: Hepatocellular Carcinoma, Fibrolamellar
Multimedia: Hepatocellular Carcinoma, Fibrolamellar
References

References

  1. Titelbaum DS, Burke DR, Meranze SG, et al. Fibrolamellar hepatocellular carcinoma: pitfalls in nonoperative diagnosis. Radiology. Apr 1988;167(1):25-30. [Medline][Full Text].

  2. Broders AC. The grading of carcinoma. Minn Med. 1925;8:726-30.

  3. McLarney JK, Rucker PT, Bender GN, et al. Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics. Mar-Apr 1999;19(2):453-71. [Medline][Full Text].

  4. Bedi DG, Kumar R, Morettin LB, et al. Fibrolamellar carcinoma of the liver: CT, ultrasound and angiography. Case report. Eur J Radiol. May 1988;8(2):109-12. [Medline].

  5. Berman MM, Libbey NP, Foster JH. Hepatocellular carcinoma. Polygonal cell type with fibrous stroma--an atypical variant with a favorable prognosis. Cancer. Sep 15 1980;46(6):1448-55. [Medline].

  6. Brandt DJ, Johnson CD, Stephens DH, et al. Imaging of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol. Aug 1988;151(2):295-9. [Medline].

  7. Craig JR, Peters RL, Edmondson HA, et al. Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer. Jul 15 1980;46(2):372-9. [Medline].

  8. Farhi DC, Shikes RH, Murari PJ, et al. Hepatocellular carcinoma in young people. Cancer. Oct 15 1983;52(8):1516-25. [Medline].

  9. Farhi DC, Shikes RH, Silverberg SG. Ultrastructure of fibrolamellar oncocytic hepatoma. Cancer. Aug 15 1982;50(4):702-9. [Medline].

  10. Francis IR, Agha FP, Thompson NW, et al. Fibrolamellar hepatocarcinoma: clinical, radiologic, and pathologic features. Gastrointest Radiol. 1986;11(1):67-72. [Medline].

  11. Friedman AC, Lichtenstein JE, Goodman Z, et al. Fibrolamellar hepatocellular carcinoma. Radiology. Dec 1985;157(3):583-7. [Medline][Full Text].

  12. Ichikawa T, Federle MP, Grazioli L, et al. Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology. Nov 1999;213(2):352-61. [Medline][Full Text].

  13. Ichikawa T, Federle MP, Grazioli L, et al. Fibrolamellar hepatocellular carcinoma: pre- and posttherapy evaluation with CT and MR imaging. Radiology. Oct 2000;217(1):145-51. [Medline][Full Text].

  14. Joishy SK, Balasegaram M. Hepatic resection for malignant tumors of the liver: essentials for a unified surgical approach. Am J Surg. Mar 1980;139(3):360-9. [Medline].

  15. Lack EE, Neave C, Vawter GF. Hepatocellular carcinoma. Review of 32 cases in childhood and adolescence. Cancer. Oct 15 1983;52(8):1510-5. [Medline].

  16. Moreno-Luna LE, Arrieta O, García-Leiva J, et al. Clinical and pathologic factors associated with survival in young adult patients with fibrolamellar hepatocarcinoma. BMC Cancer. 2005;5:142. [Medline][Full Text].

  17. Mukai JK, Stack CM, Turner DA, et al. Imaging of surgically relevant hepatic vascular and segmental anatomy. Part 2. Extent and resectability of hepatic neoplasms. AJR Am J Roentgenol. Aug 1987;149(2):293-7. [Medline].

  18. Nagorney DM, Adson MA, Weiland LH, et al. Fibrolamellar hepatoma. Am J Surg. Jan 1985;149(1):113-9. [Medline].

  19. Soreide O, Czerniak A, Bradpiece H, et al. Characteristics of fibrolamellar hepatocellular carcinoma. A study of nine cases and a review of the literature. Am J Surg. Apr 1986;151(4):518-23. [Medline].

  20. Soyer P, Roche A, Levesque M, et al. CT of fibrolamellar hepatocellular carcinoma. J Comput Assist Tomogr. Jul-Aug 1991;15(4):533-8. [Medline].

  21. Stevens WR, Johnson CD, Stephens DH, et al. Fibrolamellar hepatocellular carcinoma: stage at presentation and results of aggressive surgical management. AJR Am J Roentgenol. May 1995;164(5):1153-8. [Medline].

  22. Stipa F, Yoon SS, Liau KH, et al. Outcome of patients with fibrolamellar hepatocellular carcinoma. Cancer. Mar 15 2006;106(6):1331-8. [Medline].

  23. Vecchio FM. Fibrolamellar carcinoma of the liver: a distinct entity within the hepatocellular tumors. A review. Appl Pathol. 1988;6(2):139-48. [Medline].

  24. Wetzel WJ, Costin JL, Petrino RL. Fibrolamellar carcinoma: distinctive clinical and morphologic variant of hepatoma. South Med J. Jun 1983;76(6):796-8. [Medline].

  25. Wong LK, Link DP, Frey CF, et al. Fibrolamellar hepatocarcinoma: radiology, management, and pathology. AJR Am J Roentgenol. Jul 1982;139(1):172-5. [Medline].

  26. Wood WJ, Rawlings M, Evans H, et al. Hepatocellular carcinoma: importance of histologic classification as a prognostic factor. Am J Surg. May 1988;155(5):663-6. [Medline].

Further Reading

Keywords

HCC, fibrolamellar carcinoma, fibrolamellar hepatoma, oncocytic hepatocellular carcinoma

Contributor Information and Disclosures

Author

W Ross Stevens, MD, Clinical Professor, Department of Radiology, Southern Illinois University School of Medicine; Head, Radiology Residency Director, Division of Gastrointestinal Radiology, St John's Hospital
W Ross Stevens, MD is a member of the following medical societies: American College of Radiology, American Medical Association, American Roentgen Ray Society, Illinois State Medical Society, and Radiological Society of North America
Disclosure: Nothing to disclose.

Medical Editor

John L Haddad, MD, Clinical Associate Professor, Department of Radiology, Weill Medical College of Cornell University; Director of Body MRI, Department of Radiology, Methodist Hospital in Houston
John L Haddad, MD is a member of the following medical societies: American College of Radiology, American Medical Association, and Radiological Society of North America
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Udo P Schmiedl, MD, PhD, Clinical Professor, Department of Radiology, University of Washington; Consulting Staff, Swedish Medical Center, University of Washington Medical Center, Seattle Radiologists
Udo P Schmiedl, MD, PhD is a member of the following medical societies: American College of Radiology and Radiological Society of North America
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

John Karani, MBBS, FRCR, Consulting Staff, Department of Radiology, King's College Hospital, London
Disclosure: Nothing to disclose.

 
 
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