eMedicine Specialties > Radiology > Gastrointestinal

Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma: Follow-up

Author: Vu H Nguyen, MD, Staff Physician, Department of Radiology, University of Wisconsin Hospitals and Clinics
Coauthor(s): Andrew Taylor, MD, Professor, Department of Radiology, University of Wisconsin Hospitals and Clinics
Contributor Information and Disclosures

Updated: Aug 5, 2008

Intervention

Previously, the only proven treatment for gastrointestinal stromal tumors (GISTs) was surgical resection.5,6 Radiation therapy and chemotherapy have been ineffective.

Imatinib mesylate (Gleevec; Novartis) initially helps control disease in 80% or more of patients. Imatinib mesylate is an inhibitor of tyrosine kinases, including the KIT receptor and the PDGRF receptors and their oncogenic activated forms.12 Imatinib mesylate has proved to be effective in early- and late-stage disease. Posttreatment, liver lesions become better defined and cystlike (see Image 4). In one study, an objective response was observed in 50-60% of cases; in 10-15% of cases, the disease progressed despite therapy.25 In other patients, resistance developed following initial responses. Factors thought to be involved include gene amplification and the presence of additional mutations, which may lend GIST tumors an inherent resistance.26,27,28,29,30

 


More on Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma

Overview: Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma
Imaging: Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma
Follow-up: Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma
Multimedia: Gastrointestinal Stromal Tumors - Leiomyoma/Leiomyosarcoma
References
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References

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Further Reading

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Keywords

gastrointestinal stromal tumors, gastrointestinal neoplasms, GIST, GI stromal tumors, GI tumors, gastrointestinal tumors, leiomyoma, leiomyosarcoma, gastrointestinal sarcoma, gastrointestinal mesenchymal tumor, GISTs, leiomyoblastoma, schwannoma, CD34, CD117, c-kit, benign tumors, stomach cancer

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Contributor Information and Disclosures

Author

Vu H Nguyen, MD, Staff Physician, Department of Radiology, University of Wisconsin Hospitals and Clinics
Vu H Nguyen, MD is a member of the following medical societies: American College of Radiology and Radiological Society of North America
Disclosure: Nothing to disclose.

Coauthor(s)

Andrew Taylor, MD, Professor, Department of Radiology, University of Wisconsin Hospitals and Clinics
Andrew Taylor, MD is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Udo P Schmiedl, MD, PhD, Clinical Professor, Department of Radiology, University of Washington; Consulting Staff, Swedish Medical Center, University of Washington Medical Center, Seattle Radiologists
Udo P Schmiedl, MD, PhD is a member of the following medical societies: American College of Radiology and Radiological Society of North America
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Eugene C Lin, MD, Clinical Assistant Professor of Radiology, University of Washington Medical School
Eugene C Lin, MD is a member of the following medical societies: American College of Nuclear Medicine, American College of Radiology, Radiological Society of North America, and Society of Nuclear Medicine
Disclosure: Nothing to disclose.

 
 
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