eMedicine Specialties > Radiology > Gastrointestinal

Pancreas, Mucinous Cystic Neoplasm: Multimedia

Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR, LRCP, Chairman of Medical Imaging, Professor of Radiology, NGHA, King Fahad National Guard Hospital, King Abdulaziz Medical City, Riyadh, Saudi Arabia
Coauthor(s): Aali J Sheen, MD, MBChB, FRCS, Consulting Hepatobiliary Surgeon, HepatoBiliary Unit, Manchester Royal Infirmary; Sumaira MacDonald, MBChB, PhD, MRCP, FRCR, Lecturer, Sheffield University Medical School; Endovascular Fellow, Sheffield Vascular Institute; Haren Varia, MB ChB, FRCR, Consultant, Department of Clinical Radiology, Blackpool, Fylde and Wyre NHS Trust
Contributor Information and Disclosures

Updated: Mar 12, 2009

Multimedia

Sonogram through the left hypochondrium shows a l...Media file 1: Sonogram through the left hypochondrium shows a large septate mass anterior to the kidney (K). (See Images 2-3 in Multimedia.)
Sonogram through the left hypochondrium shows a l...

Sonogram through the left hypochondrium shows a large septate mass anterior to the kidney (K). (See Images 2-3 in Multimedia.)

Nonenhanced axial CT scans in the same patient as...Media file 2: Nonenhanced axial CT scans in the same patient as in Image 1 shows a large septate mass in the left hypochondrium. Note the smooth external contour typical of a mucinous cystic neoplasm (MCN). (See Images 1 and 3 in Multimedia.)
Nonenhanced axial CT scans in the same patient as...

Nonenhanced axial CT scans in the same patient as in Image 1 shows a large septate mass in the left hypochondrium. Note the smooth external contour typical of a mucinous cystic neoplasm (MCN). (See Images 1 and 3 in Multimedia.)

Enhanced axial CT scans in the same patient as in...Media file 3: Enhanced axial CT scans in the same patient as in Image 2 shows a large septate mass in the left hypochondrium with rim enhancement and enhancement of the septa. At surgery, a mucinous adenoma was confirmed. Note the smooth external contour typical of MCN. (See Images 1-2 in Multimedia.)
Enhanced axial CT scans in the same patient as in...

Enhanced axial CT scans in the same patient as in Image 2 shows a large septate mass in the left hypochondrium with rim enhancement and enhancement of the septa. At surgery, a mucinous adenoma was confirmed. Note the smooth external contour typical of MCN. (See Images 1-2 in Multimedia.)

Contrast-enhanced axial CT scans through the tail...Media file 4: Contrast-enhanced axial CT scans through the tail of the pancreas show a large enhancing tumor occupying the left hypochondrium with both cystic and solid components. (See Image 5 in Multimedia.)
Contrast-enhanced axial CT scans through the tail...

Contrast-enhanced axial CT scans through the tail of the pancreas show a large enhancing tumor occupying the left hypochondrium with both cystic and solid components. (See Image 5 in Multimedia.)

Superior mesenteric angiograms in the same patien...Media file 5: Superior mesenteric angiograms in the same patient as in Image 4 in Multimedia show a hypervascular tumor. The tumor also derives its blood supply from the celiac axis (not shown). At surgery, a mucinous carcinoma of the pancreatic tail was confirmed.
Superior mesenteric angiograms in the same patien...

Superior mesenteric angiograms in the same patient as in Image 4 in Multimedia show a hypervascular tumor. The tumor also derives its blood supply from the celiac axis (not shown). At surgery, a mucinous carcinoma of the pancreatic tail was confirmed.

Axial and sagittal sonograms through the pancreas...Media file 6: Axial and sagittal sonograms through the pancreas show a 1.93-cm cystic mass in the head of the pancreas. (See Image 7 in Multimedia.)
Axial and sagittal sonograms through the pancreas...

Axial and sagittal sonograms through the pancreas show a 1.93-cm cystic mass in the head of the pancreas. (See Image 7 in Multimedia.)

Nonenhanced (left) and contrast-enhanced axial CT...Media file 7: Nonenhanced (left) and contrast-enhanced axial CT scans through the pancreas in the same patient as in Image 6 in Multimedia. These scans confirm the presence of a cystic mass in the anterior part of the head of the pancreas. The contrast-enhanced image shows a septum within the mass.
Nonenhanced (left) and contrast-enhanced axial CT...

Nonenhanced (left) and contrast-enhanced axial CT scans through the pancreas in the same patient as in Image 6 in Multimedia. These scans confirm the presence of a cystic mass in the anterior part of the head of the pancreas. The contrast-enhanced image shows a septum within the mass.

T2-weighted (top) and short-tau inversion recover...Media file 8: T2-weighted (top) and short-tau inversion recovery (STIR) (bottom) MRIs through the pancreas in the same patient as in Images 6-7 in Multimedia. MRIs show a hyperintense lesion in the head of the pancreas.
T2-weighted (top) and short-tau inversion recover...

T2-weighted (top) and short-tau inversion recovery (STIR) (bottom) MRIs through the pancreas in the same patient as in Images 6-7 in Multimedia. MRIs show a hyperintense lesion in the head of the pancreas.

Magnetic resonance cholangiopancreatogram (MRCP) ...Media file 9: Magnetic resonance cholangiopancreatogram (MRCP) in the same patient as in Images 6-8 in Multimedia shows the cystic mass in the region of the head of the pancreas. At surgery, a mucinous adenoma was confirmed.
Magnetic resonance cholangiopancreatogram (MRCP) ...

Magnetic resonance cholangiopancreatogram (MRCP) in the same patient as in Images 6-8 in Multimedia shows the cystic mass in the region of the head of the pancreas. At surgery, a mucinous adenoma was confirmed.

Pancreatic intraductal papillary mucinous tumor (...Media file 10: Pancreatic intraductal papillary mucinous tumor (IPMT). Contrast-enhanced axial CT scans through the pancreas show a 5.5-cm cystic tumor in the pancreatic head. Note the upstream, gross dilatation of the pancreatic duct. The accessory pancreatic duct is also dilated.
Pancreatic intraductal papillary mucinous tumor (...

Pancreatic intraductal papillary mucinous tumor (IPMT). Contrast-enhanced axial CT scans through the pancreas show a 5.5-cm cystic tumor in the pancreatic head. Note the upstream, gross dilatation of the pancreatic duct. The accessory pancreatic duct is also dilated.

Pancreatic intraductal papillary mucinous tumor (...Media file 11: Pancreatic intraductal papillary mucinous tumor (IPMT). (Top) Superior mesenteric angiogram in the same patient as in Image 10 shows capillary vascularity in the mass in the pancreatic head mass during the arterial phase. (Bottom) The portal venous phase image shows displacement of the portal venous branches and encasement of the junction of the superior mesenteric vein and the portal vein. M denotes the pancreatic mass.
Pancreatic intraductal papillary mucinous tumor (...

Pancreatic intraductal papillary mucinous tumor (IPMT). (Top) Superior mesenteric angiogram in the same patient as in Image 10 shows capillary vascularity in the mass in the pancreatic head mass during the arterial phase. (Bottom) The portal venous phase image shows displacement of the portal venous branches and encasement of the junction of the superior mesenteric vein and the portal vein. M denotes the pancreatic mass.

Pancreatic intraductal papillary mucinous tumor (...Media file 12: Pancreatic intraductal papillary mucinous tumor (IPMT). Contrast-enhanced axial CT scans through the pancreas show a multiseptate tumor in the head of the pancreas.
Pancreatic intraductal papillary mucinous tumor (...

Pancreatic intraductal papillary mucinous tumor (IPMT). Contrast-enhanced axial CT scans through the pancreas show a multiseptate tumor in the head of the pancreas.

Pancreatic intraductal papillary mucinous tumor (...Media file 13: Pancreatic intraductal papillary mucinous tumor (IPMT). Contrast-enhanced CT scans through the pancreas show gross dilatation of the pancreatic duct. At surgery, IPMT was confirmed.
Pancreatic intraductal papillary mucinous tumor (...

Pancreatic intraductal papillary mucinous tumor (IPMT). Contrast-enhanced CT scans through the pancreas show gross dilatation of the pancreatic duct. At surgery, IPMT was confirmed.

Pancreatic microcystic adenoma. Plain radiograph ...Media file 14: Pancreatic microcystic adenoma. Plain radiograph shows tumor calcification in a microcystic adenoma (left upper quadrant). Calcification in the microcystic adenoma presents as a central cluster arranged in a sunburst or stellate arrangement. Central calcification is better evaluated with CT than with radiography. (See Image 16 in Multimedia.)
Pancreatic microcystic adenoma. Plain radiograph ...

Pancreatic microcystic adenoma. Plain radiograph shows tumor calcification in a microcystic adenoma (left upper quadrant). Calcification in the microcystic adenoma presents as a central cluster arranged in a sunburst or stellate arrangement. Central calcification is better evaluated with CT than with radiography. (See Image 16 in Multimedia.)

Pancreatic microcystic adenoma. Sonogram in the s...Media file 15: Pancreatic microcystic adenoma. Sonogram in the same patient as in Image 14 in Multimedia shows a cystic mass in the region of the tail of the pancreas.
Pancreatic microcystic adenoma. Sonogram in the s...

Pancreatic microcystic adenoma. Sonogram in the same patient as in Image 14 in Multimedia shows a cystic mass in the region of the tail of the pancreas.

Pancreatic microcystic adenoma. Contrast-enhanced...Media file 16: Pancreatic microcystic adenoma. Contrast-enhanced axial CT scans in the same patient as in Images 14-15 shows a hypervascular tumor in the pancreatic tail with sunburst calcification. Note the Swiss-cheese enhancement.
Pancreatic microcystic adenoma. Contrast-enhanced...

Pancreatic microcystic adenoma. Contrast-enhanced axial CT scans in the same patient as in Images 14-15 shows a hypervascular tumor in the pancreatic tail with sunburst calcification. Note the Swiss-cheese enhancement.

ERCP typically shows a patulous ampulla of Vater ...Media file 17: ERCP typically shows a patulous ampulla of Vater with discharging mucus, which is often diagnostic for IPMT.
ERCP typically shows a patulous ampulla of Vater ...

ERCP typically shows a patulous ampulla of Vater with discharging mucus, which is often diagnostic for IPMT.

More on Pancreas, Mucinous Cystic Neoplasm

Overview: Pancreas, Mucinous Cystic Neoplasm
Imaging: Pancreas, Mucinous Cystic Neoplasm
Follow-up: Pancreas, Mucinous Cystic Neoplasm
Multimedia: Pancreas, Mucinous Cystic Neoplasm
References
Further Reading

References

  1. Jorba R, Fabregat J, Borobia FG, Busquets J, Ramos E, Torras J, et al. [Cystic neoplasms of the pancreas. Diagnostic and therapeutic management.]. Cir Esp. Dec 2008;84(6):296-306. [Medline].

  2. Tibayan F, Vierra M, Mindelzun B. Clinical presentation of mucin-secreting tumors of the pancreas. Am J Surg. May 2000;179(5):349-51. [Medline].

  3. Hong HS, Kim MJ. [Diagnosis of pancreatic intraductal papillary mucinous neoplasm]. Korean J Gastroenterol. Oct 2008;52(4):207-13. [Medline].

  4. Michael H, Gress F. Diagnosis of cystic neoplasms with endoscopic ultrasound. Gastrointest Endosc Clin N Am. Oct 2002;12(4):719-33. [Medline].

  5. Telford JJ, Carr-Locke DL. The role of ERCP and pancreatoscopy in cystic and intraductal tumors. Gastrointest Endosc Clin N Am. Oct 2002;12(4):747-57. [Medline].

  6. Grenacher L, Klauß M. [Computed tomography of pancreatic tumors.]. Radiologe. Feb 2009;49(2):107-123. [Medline].

  7. Fisher WE, Hodges SE, Yagnik V, Morón FE, Wu MF, Hilsenbeck SG, et al. Accuracy of CT in predicting malignant potential of cystic pancreatic neoplasms. HPB (Oxford). 2008;10(6):483-90. [Medline].

  8. Hong TM, Lee RC, Chiang JH. Intraductal papillary mucinous tumor of the pancreas: computerized tomography and magnetic resonance imaging features. Kaohsiung J Med Sci. Feb 2003;19(2):55-61. [Medline].

  9. Sahani D, Prasad S, Saini S. Cystic pancreatic neoplasms evaluation by CT and magnetic resonance cholangiopancreatography. Gastrointest Endosc Clin N Am. Oct 2002;12(4):657-72. [Medline].

  10. Rickes S, Unkrodt K, Neye H. Differentiation of pancreatic tumours by conventional ultrasound, unenhanced and echo-enhanced power Doppler sonography. Scand J Gastroenterol. Nov 2002;37(11):1313-20. [Medline].

  11. Schachter PP, Shimonov M, Czerniak A. The role of laparoscopy and laparoscopic ultrasound in the diagnosis of cystic lesions of the pancreas. Gastrointest Endosc Clin N Am. Oct 2002;12(4):759-67, vii-viii. [Medline].

  12. Bounds BC. Diagnosis and fine needle aspiration of intraductal papillary mucinous tumor by endoscopic ultrasound. Gastrointest Endosc Clin N Am. Oct 2002;12(4):735-45, vii. [Medline].

  13. Sperti C, Pasquali C, Chierichetti F. Value of 18-fluorodeoxyglucose positron emission tomography in the management of patients with cystic tumors of the pancreas. Ann Surg. Nov 2001;234(5):675-80. [Medline].

  14. Sendler A, Avril N, Roder JD. [Can the extent of pancreatic tumors be evaluated reliably enough by positron emission tomography (PET)]. Langenbecks Arch Chir Suppl Kongressbd. 1998;115:1485-7. [Medline].

  15. Sparchez Z. Ultrasound-guided percutaneous pancreatic biopsy. Indications, performance and complications. Rom J Gastroenterol. Dec 2002;11(4):335-41. [Medline].

  16. Schwartz DA, Wiersema MJ. Endoscopic ultrasound techniques for pancreatic cystic neoplasms. Gastrointest Endosc Clin N Am. Oct 2002;12(4):709-18. [Medline].

  17. Anderson MA, Scheiman JM. Nonmucinous cystic pancreatic neoplasms. Gastrointest Endosc Clin N Am. Oct 2002;12(4):769-79, viii. [Medline].

  18. Hines OJ, Reber HA. Pancreatic surgery. Curr Opin Gastroenterol. Sep 2008;24(5):603-11. [Medline].

  19. Kitagawa Y, Unger TA, Taylor S. Mucus is a predictor of better prognosis and survival in patients with intraductal papillary mucinous tumor of the pancreas. J Gastrointest Surg. Jan 2003;7(1):12-8; discussion 18-9. [Medline].

  20. Maire F, Hammel P, Terris B. Prognosis of malignant intraductal papillary mucinous tumours of the pancreas after surgical resection. Comparison with pancreatic ductal adenocarcinoma. Gut. Nov 2002;51(5):717-22. [Medline].

  21. Nakagohri T, Asano T, Kenmochi T. Long-term surgical outcome of noninvasive and minimally invasive intraductal papillary mucinous adenocarcinoma of the pancreas. World J Surg. Sep 2002;26(9):1166-9. [Medline].

  22. Katoh H, Rossi RL, Braasch JW. Cystadenoma and cystadenocarcinoma of the pancreas. Hepatogastroenterology. Dec 1989;36(6):424-30. [Medline].

  23. Horvath KD, Chabot JA. An aggressive resectional approach to cystic neoplasms of the pancreas. Am J Surg. Oct 1999;178(4):269-74. [Medline].

  24. Das A, Wells CD, Nguyen CC. Incidental Cystic Neoplasms of Pancreas: What Is the Optimal Interval of Imaging Surveillance?. Am J Gastroenterol. Jun 16 2008;[Medline].

  25. Abe H, Kubota K, Mori M. Serous cystadenoma of the pancreas with invasive growth: benign or malignant?. Am J Gastroenterol. Oct 1998;93(10):1963-6.

  26. Alles AJ, Warshaw AL, Southern JF. Expression of CA 72-4 (TAG-72) in the fluid contents of pancreatic cysts. A new marker to distinguish malignant pancreatic cystic tumors from benign neoplasms and pseudocysts. Ann Surg. Feb 1994;219(2):131-4.

  27. Azar C, Van de Stadt J, Rickaert F. Intraductal papillary mucinous tumours of the pancreas. Clinical and therapeutic issues in 32 patients. Gut. Sep 1996;39(3):457-64.

  28. Buetow PC, Rao P, Thompson LD. From the Archives of the AFIP. Mucinous cystic neoplasms of the pancreas: radiologic-pathologic correlation. Radiographics. Mar-Apr 1998;18(2):433-49.

  29. de Lima JE, Javitt MC, Mathur SC. Mucinous cystic neoplasm of the pancreas. Radiographics. May-Jun 1999;19(3):807-11.

  30. Fernandez-del Castillo C, Warshaw AL. Cystic tumors of the pancreas. Surg Clin North Am. Oct 1995;75(5):1001-16.

  31. Fernandez-del Castillo C, Warshaw AL. Cystic tumors of the pancreas. Surg Clin North Am. Oct 1995;75(5):1001-16.

  32. Fukushima N, Mukai K, Kanai Y. Intraductal papillary tumors and mucinous cystic tumors of the pancreas: clinicopathologic study of 38 cases. Hum Pathol. Sep 1997;28(9):1010-7.

  33. Hammel P, Levy P, Voitot H. Preoperative cyst fluid analysis is useful for the differential diagnosis of cystic lesions of the pancreas. Gastroenterology. Apr 1995;108(4):1230-5.

  34. Johnson CD, Stephens DH, Charboneau JW. Cystic pancreatic tumors: CT and sonographic assessment. AJR Am J Roentgenol. Dec 1988;151(6):1133-8.

  35. Kato T, Fukatsu H, Ito K. Fluorodeoxyglucose positron emission tomography in pancreatic cancer: an unsolved problem. Eur J Nucl Med. Jan 1995;22(1):32-9. [Medline].

  36. Kloppel G, Solcia E, Longnecker DS, et al. Histologic Typing of Tumours of the Exocrine Pancreas. 2nd ed. New York, NY: Springer-Verlag; 1996.

  37. Liu Q, He Z, Bie P. Solitary pancreatic tuberculous abscess mimicking prancreatic cystadenocarcinoma: a case report. BMC Gastroenterol. Jan 10 2003;3(1):1. [Medline].

  38. Martin I, Hammond P, Scott J. Cystic tumours of the pancreas. Br J Surg. Nov 1998;85(11):1484-6.

  39. Mathieu D, Guigui B, Valette PJ. Pancreatic cystic neoplasms. Radiol Clin North Am. Jan 1989;27(1):163-76.

  40. Nakamura A, Horinouchi M, Goto M. New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. J Pathol. Jun 2002;197(2):201-10. [Medline].

  41. Pyke CM, van Heerden JA, Colby TV. The spectrum of serous cystadenoma of the pancreas. Clinical, pathologic, and surgical aspects. Ann Surg. Feb 1992;215(2):132-9.

  42. Raimondo M, Tachibana I, Urrutia R. Invasive cancer and survival of intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol. Oct 2002;97(10):2553-8. [Medline].

  43. Rivera JA, Fernández-del Castillo C, Pins M. Pancreatic mucinous ductal ectasia and intraductal papillary neoplasms. A single malignant clinicopathologic entity. Ann Surg. Jun 1997;225(6):637-44; discussion 644-6.

  44. Sho M, Nakajima Y, Kanehiro H. Pattern of recurrence after resection for intraductal papillary mucinous tumors of the pancreas. World J Surg. Aug 1998;22(8):874-8. [Medline].

  45. Talamini MA, Moesinger R, Yeo CJ. Cystadenomas of the pancreas: is enucleation an adequate operation?. Ann Surg. Jun 1998;227(6):896-903.

  46. Terris B, Dubois S, Buisine MP. Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions. J Pathol. Aug 2002;197(5):632-7. [Medline].

  47. Thompson LD, Becker RC, Przygodzki RM. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas: a clinicopathologic study of 130 cases. Am J Surg Pathol. Jan 1999;23(1):1-16.

  48. Walsh RM, Henderson JM, Vogt DP. Prospective preoperative determination of mucinous pancreatic cystic neoplasms. Surgery. Oct 2002;132(4):628-33; discussion 633-4.

Keywords

mucinous cystic neoplasm of pancreas, MCN, macrocystic cystadenoma, cystadenocarcinoma, mucinous duct ectasia, mucinous ductal ectasia, papillary adenocarcinoma, ductectatic tumor, intraductal mucin-secreting neoplasm, mucinous villous adenomatosis, intraductal mucin-producing tumor, intraductal cystadenoma, pancreatic duct villous adenoma, intraductal papillary neoplasms, intraductal papillary mucinous tumor, IPMT, MUC1, MUC2

Contributor Information and Disclosures

Author

Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR, LRCP, Chairman of Medical Imaging, Professor of Radiology, NGHA, King Fahad National Guard Hospital, King Abdulaziz Medical City, Riyadh, Saudi Arabia
Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR, LRCP is a member of the following medical societies: American Institute of Ultrasound in Medicine, Royal College of Physicians, Royal College of Physicians and Surgeons of the United States, Royal College of Radiologists, and Royal College of Surgeons of England
Disclosure: Nothing to disclose.

Coauthor(s)

Aali J Sheen, MD, MBChB, FRCS, Consulting Hepatobiliary Surgeon, HepatoBiliary Unit, Manchester Royal Infirmary
Aali J Sheen, MD, MBChB, FRCS is a member of the following medical societies: British Medical Association, International Hepato-Pancreato-Biliary Association, and Royal College of Surgeons of England
Disclosure: Nothing to disclose.

Sumaira MacDonald, MBChB, PhD, MRCP, FRCR, Lecturer, Sheffield University Medical School; Endovascular Fellow, Sheffield Vascular Institute
Sumaira MacDonald, MBChB, PhD, MRCP, FRCR is a member of the following medical societies: British Medical Association, Royal College of Physicians, and Royal College of Radiologists
Disclosure: Nothing to disclose.

Haren Varia, MB ChB, FRCR, Consultant, Department of Clinical Radiology, Blackpool, Fylde and Wyre NHS Trust
Disclosure: Nothing to disclose.

Medical Editor

Zahir Amin, MD, MBBS, MRCP, FRCR, Consulting Staff, Department of Imaging, University College Hospital, UK
Zahir Amin, MD, MBBS, MRCP, FRCR is a member of the following medical societies: British Institute of Radiology, British Medical Association, and Royal College of Radiologists
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Arnold C Friedman, MD, FACR, Associate Chairman, Department of Radiology, University of Florida Health Science Center; Chief, Department of Radiology, Shands-Jacksonville Hospital
Arnold C Friedman, MD, FACR is a member of the following medical societies: American College of Radiology, American Institute of Ultrasound in Medicine, American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

John Karani, MBBS, FRCR, Consulting Staff, Department of Radiology, King's College Hospital, London
Disclosure: Nothing to disclose.

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.