eMedicine Specialties > Radiology > Genitourinary

Adrenal Adenoma: Multimedia

Author: Perry J Horwich, MD, Staff Physician, Instructor of Radiology, Department of Radiology, Beth Israel - Deaconess Medical Center
Coauthor(s): Stephen A Okon, MD, Consulting Staff, Assistant Professor of Radiology, Department of Radiology, Beth Israel Medical Center
Contributor Information and Disclosures

Updated: May 4, 2009

Multimedia

Homogeneous, well-defined, 7-HU ovoid mass is see...Media file 1: Homogeneous, well-defined, 7-HU ovoid mass is seen in the right adrenal gland; this finding is diagnostic of a benign adrenal adenoma. (Image was obtained in the same patient as in Image 2 in Multimedia.)
Homogeneous, well-defined, 7-HU ovoid mass is see...

Homogeneous, well-defined, 7-HU ovoid mass is seen in the right adrenal gland; this finding is diagnostic of a benign adrenal adenoma. (Image was obtained in the same patient as in Image 2 in Multimedia.)

Homogeneous, well-defined, 7-HU, ovoid mass is se...Media file 2: Homogeneous, well-defined, 7-HU, ovoid mass is seen in the right adrenal gland; this finding is diagnostic of a benign adrenal adenoma. (CT scan obtained in the same patient as in Image 1 in Multimedia.)
Homogeneous, well-defined, 7-HU, ovoid mass is se...

Homogeneous, well-defined, 7-HU, ovoid mass is seen in the right adrenal gland; this finding is diagnostic of a benign adrenal adenoma. (CT scan obtained in the same patient as in Image 1 in Multimedia.)

Contrast-enhanced CT scan demonstrates a homogene...Media file 3: Contrast-enhanced CT scan demonstrates a homogeneously enhancing ovoid mass in the left adrenal gland. As in this case, attenuation measurements of adrenal masses on contrast-enhanced CT scans are frequently nondiagnostic. (Image was obtained in the same patient as in Images 4 and 5 in Multimedia.)
Contrast-enhanced CT scan demonstrates a homogene...

Contrast-enhanced CT scan demonstrates a homogeneously enhancing ovoid mass in the left adrenal gland. As in this case, attenuation measurements of adrenal masses on contrast-enhanced CT scans are frequently nondiagnostic. (Image was obtained in the same patient as in Images 4 and 5 in Multimedia.)

Contrast-enhanced CT scan demonstrates a homogene...Media file 4: Contrast-enhanced CT scan demonstrates a homogeneously enhancing ovoid mass in the left adrenal gland. As in this case, attenuation measurements of adrenal masses on contrast-enhanced CT scans are frequently nondiagnostic. (Image was obtained in the same patient as in Images 3 and 5 in Multimedia.)
Contrast-enhanced CT scan demonstrates a homogene...

Contrast-enhanced CT scan demonstrates a homogeneously enhancing ovoid mass in the left adrenal gland. As in this case, attenuation measurements of adrenal masses on contrast-enhanced CT scans are frequently nondiagnostic. (Image was obtained in the same patient as in Images 3 and 5 in Multimedia.)

MRIs obtained with in-phase (left) and out-of-pha...Media file 5: MRIs obtained with in-phase (left) and out-of-phase (right) imaging after CT imaging. Note how the signal intensity in the left adrenal mass (white arrow) decreases (ie, the mass is darker) relative to that of the spleen on the out-of-phase images. As in this case, a signal intensity decrease of 20% or greater is diagnostic of a benign adrenal adenoma. (Image was obtained in the same patient as in Images 3 and 4 in Multimedia.)
MRIs obtained with in-phase (left) and out-of-pha...

MRIs obtained with in-phase (left) and out-of-phase (right) imaging after CT imaging. Note how the signal intensity in the left adrenal mass (white arrow) decreases (ie, the mass is darker) relative to that of the spleen on the out-of-phase images. As in this case, a signal intensity decrease of 20% or greater is diagnostic of a benign adrenal adenoma. (Image was obtained in the same patient as in Images 3 and 4 in Multimedia.)

Homogeneously enhancing ovoid mass is seen in the...Media file 6: Homogeneously enhancing ovoid mass is seen in the left adrenal gland. (Image was obtained in the same patient as in Images 7 and 8 in Multimedia.)
Homogeneously enhancing ovoid mass is seen in the...

Homogeneously enhancing ovoid mass is seen in the left adrenal gland. (Image was obtained in the same patient as in Images 7 and 8 in Multimedia.)

Homogeneously enhancing ovoid mass is seen in the...Media file 7: Homogeneously enhancing ovoid mass is seen in the left adrenal gland. (Image was obtained in the same patient as in Images 6 and 8 in Multimedia.)
Homogeneously enhancing ovoid mass is seen in the...

Homogeneously enhancing ovoid mass is seen in the left adrenal gland. (Image was obtained in the same patient as in Images 6 and 8 in Multimedia.)

An adrenal adenoma (arrows) is diagnosed with fol...Media file 8: An adrenal adenoma (arrows) is diagnosed with follow-up MRI when decreased signal intensity is seen on the out-of-phase image. (Image was obtained in the same patient as in Images 6 and 7 in Multimedia.)
An adrenal adenoma (arrows) is diagnosed with fol...

An adrenal adenoma (arrows) is diagnosed with follow-up MRI when decreased signal intensity is seen on the out-of-phase image. (Image was obtained in the same patient as in Images 6 and 7 in Multimedia.)

MRI images demonstrate a homogeneous ovoid mass i...Media file 9: MRI images demonstrate a homogeneous ovoid mass in the right adrenal gland (arrows). A concomitant loss of signal intensity, relative to that of the spleen, with out-of-phase imaging is diagnostic of benign adrenal adenoma.
MRI images demonstrate a homogeneous ovoid mass i...

MRI images demonstrate a homogeneous ovoid mass in the right adrenal gland (arrows). A concomitant loss of signal intensity, relative to that of the spleen, with out-of-phase imaging is diagnostic of benign adrenal adenoma.

Dynamic and delayed contrast-enhanced CT scans de...Media file 10: Dynamic and delayed contrast-enhanced CT scans demonstrate a homogeneously enhancing mass in the right adrenal gland. The degree to which enhancement diminishes over time is referred to as washout, which can be calculated by using the following formula: [1 - (attenuation at 10 minutes/attenuation at 80 seconds)] X 100, where the attenuations are in Hounsfield units. In this case, the washout equals [1 – (36/99)] X 100, or 64%. Findings from a recent publication in a major journal suggests that any washout greater than 50% is diagnostic of a benign adrenal adenoma. Further studies are needed to confirm these promising results.
Dynamic and delayed contrast-enhanced CT scans de...

Dynamic and delayed contrast-enhanced CT scans demonstrate a homogeneously enhancing mass in the right adrenal gland. The degree to which enhancement diminishes over time is referred to as washout, which can be calculated by using the following formula: [1 - (attenuation at 10 minutes/attenuation at 80 seconds)] X 100, where the attenuations are in Hounsfield units. In this case, the washout equals [1 – (36/99)] X 100, or 64%. Findings from a recent publication in a major journal suggests that any washout greater than 50% is diagnostic of a benign adrenal adenoma. Further studies are needed to confirm these promising results.

More on Adrenal Adenoma

Overview: Adrenal Adenoma
Imaging: Adrenal Adenoma
Follow-up: Adrenal Adenoma
Multimedia: Adrenal Adenoma
References
Further Reading

References

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  2. Boland GW, Lee MJ, Gazelle GS, Halpern EF, McNicholas MM, Mueller PR. Characterization of adrenal masses using unenhanced CT: an analysis of the CT literature. AJR Am J Roentgenol. Jul 1998;171(1):201-4. [Medline].

  3. Ho LM, Paulson EK, Brady MJ, Wong TZ, Schindera ST. Lipid-poor adenomas on unenhanced CT: does histogram analysis increase sensitivity compared with a mean attenuation threshold?. AJR Am J Roentgenol. Jul 2008;191(1):234-8. [Medline].

  4. Halefoglu AM, Bas N, Yasar A, Basak M. Differentiation of adrenal adenomas from nonadenomas using CT histogram analysis method: A prospective study. Eur J Radiol. Jan 21 2009;[Medline].

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  7. Yoh T, Hosono M, Komeya Y, Im SW, Ashikaga R, Shimono T, et al. Quantitative evaluation of norcholesterol scintigraphy, CT attenuation value, and chemical-shift MR imaging for characterizing adrenal adenomas. Ann Nucl Med. Jul 2008;22(6):513-9. [Medline].

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  12. Boland GW, Blake MA, Hahn PF, Mayo-Smith WW. Incidental adrenal lesions: principles, techniques, and algorithms for imaging characterization. Radiology. Dec 2008;249(3):756-75. [Medline].

  13. Pena CS, Boland GW, Hahn PF, et al. Characterization of indeterminate (lipid-poor) adrenal masses: use of washout characteristics at contrast-enhanced CT. Radiology. Dec 2000;217(3):798-802. [Medline].

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  15. Clinical Trials (PDQ®). Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59). National Cancer Institute. Available at http://www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=585137&version=HealthProfessional&protocolsearchid=5407345#ContactInfo_CDR0000585137. Accessed November 10, 2008.

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Further Reading

Related eMedicine topics

Adrenal Adenoma (Endocrinology)

Adrenal Carcinoma

Adrenal Metastases

Adrenal Surgery

Clinical guidelines

ACR Appropriateness Criteria® incidentally discovered adrenal mass. American College of Radiology - Medical Specialty Society.  2000 (revised 2007).  8 pages.  NGC:005995

Stereotactic radiosurgery for patients with pituitary adenomas. IRSA - Professional Association.  2004 Apr.  12 pages.  NGC:003598

Clinical trials

Study of Adrenal Gland Tumors

Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59)

Adrenal Tumors - Pathogenesis and Therapy

Keywords

adrenal adenoma, adrenal cortical nodular hyperplasia, adrenal tumor, adrenal gland tumor, benign adrenal tumor, adrenal cortical adenoma

Contributor Information and Disclosures

Author

Perry J Horwich, MD, Staff Physician, Instructor of Radiology, Department of Radiology, Beth Israel - Deaconess Medical Center
Perry J Horwich, MD is a member of the following medical societies: American College of Radiology, International Society for Magnetic Resonance in Medicine, and Radiological Society of North America
Disclosure: Nothing to disclose.

Coauthor(s)

Stephen A Okon, MD, Consulting Staff, Assistant Professor of Radiology, Department of Radiology, Beth Israel Medical Center
Stephen A Okon, MD is a member of the following medical societies: American Medical Association and American Roentgen Ray Society
Disclosure: Nothing to disclose.

Medical Editor

Glenn Krinsky, MD, Chief of Abdominal Imaging Section, Associate Professor, Department of Radiology, New York University School of Medicine
Glenn Krinsky, MD is a member of the following medical societies: Alpha Omega Alpha and Radiological Society of North America
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Arnold C Friedman, MD, FACR, Associate Chairman, Department of Radiology, University of Florida Health Science Center; Chief, Department of Radiology, Shands-Jacksonville Hospital
Arnold C Friedman, MD, FACR is a member of the following medical societies: American College of Radiology, American Institute of Ultrasound in Medicine, American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, Resolution Imaging Medical Corporation
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Eugene C Lin, MD, Consulting Radiologist, Virginia Mason Medical Center; Clinical Assistant Professor of Radiology, University of Washington School of Medicine
Eugene C Lin, MD is a member of the following medical societies: American College of Nuclear Medicine, American College of Radiology, Radiological Society of North America, and Society of Nuclear Medicine
Disclosure: Nothing to disclose.

 
 
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