The need for renal transplantation has grown as the number of patients with diabetes has increased in the American population. The obesity epidemic in the United States and in many other developed regions represents and expanding threat of chronic kidney disease (CKD)
Strategies to delay or prevent progression of diabetic nephropathy have decreased the rate of persons with diabetes who develop end-stage renal disease (ESRD); however, for those with ESRD attributed to diabetes, kidney transplantation affords better survival and rehabilitation than either hemodialysis or peritoneal dialysis. [1, 2]
In the author's experience, the most common imaging procedure in the renal transplant recipient is ultrasonography.  Immediate complications related to surgery can be demonstrated. US enables suitable localization prior to biopsy in most patients. Duplex US also provides important information concerning the vascular status of the graft in cases of acute rejection. Delayed complications related to the renal transplant, such as lymphocele, may occur.
Ultrasound is the most frequent imaging method used in the postoperative period and for long-term follow-up. Ultrasound is widely available. The relatively low cost and high degree of safety of ultrasound allow for serial examinations, which may be necessary during the postoperative period. 
Concurrent with sonographic studies, radionuclide studies are frequently performed. The nuclear studies provide valuable information concerning functional status during the immediate postoperative period and during episodes of rejection. Correlation between renal sonographic and nuclear medicine findings helps to differentiate between purely functional disease, such as acute tubular necrosis or rejection, and abnormal fluid collections, such as hematomas, abscesses, and lymphoceles.
Ploussard et al studied the use of systematic aortofemoral color Doppler ultrasound (DUS) in recipients of a first renal transplantation and found that of 84 patients presenting with a normal preoperative physical arterial examination, 12 (14.3%) had an abnormal DUS, revealing atherosclerosis but not stenosis. Of the 16 patients who had had an abnormal examination, 10 (62.5%) also had abnormal findings on DUS, including 4 cases of iliac stenosis, 3 of whom required surgical procedure modification because of right iliac artery stenosis. 
CT and MRI studies of the abdomen and pelvis offer similar information. [6, 7] In most cases, CT is preferred because CT-guided aspiration and drainage procedures may obviate surgical interventions. Angiographic study of the transplant may involve CT angiography, MR angiography, or intra-arterial catheter angiography if therapeutic procedures are to be performed. In general, the examination with the least risk should be selected for the diagnostic survey of the renal transplant.
The assessment of potential complications may require the application of a variety of imaging techniques. Multislice CT offers a relatively fast examination with high resolution; however, some applications require the use of IV contrast, which may be contraindicated in some renal transplants that are in rejection or have decreased renal function.
MRI is offers high resolution with excellent tissue differentiation but is expensive for routine use and is motion sensitive. The use of contrast agents based upon gadolinium is contraindicated in cases of renal transplant failure. Recent advances in time-of-flight imaging have allowed satisfactory imaging of renal vessels without the use of IV contrast agents. 
The donor evaluation is most likely done with MRI(A) (magnetic resonance angiography) and CT(A) (computed tomographic angiography).
See the images below displaying complications associated with kidney transplantation.
Perioperative complications occur in 15-20% of renal transplants. Most initial complications can be corrected if detected promptly. The radiologist should help to select the most effective imaging methods for evaluating the many problems encountered in renal transplantation. In the author's experience, ultrasonography (US) is a safe, rapid, and portable means to first detect most surgical emergencies. [8, 9, 10, 11]
Although a full discussion of the potential infections in renal transplant patients is beyond the scope of this discussion, a careful review of chest radiographs, abdominal and pelvic sonograms, and CT scans must include a consideration of unusual fungal, protozoan, and bacterial infections. 
After the first few hours, a clinical milestone is the production of urine by the renal transplant. Poor function of the renal transplant may be the result of acute tubular necrosis (ATN). ATN is related to "warm" renal ischemia. Both the severity and duration of ATN is worse in cadaveric transplants. Because of the sensitivity of the injured renal transplant, nuclear medicine examinations are most commonly used to study ATN and to differentiate other causes of poor renal function in the immediate posttransplantation period.
Nuclear medicine scanning and flow studies remain the primary means for evaluating vascular supply to the transplant after surgery. The main advantage of nuclear medicine scans is that they demonstrate the pathophysiology involved. Developments in Doppler US and MRI show promise in improving the quality of renal vascular imaging without the use of potentially nephrotoxic intravenous (IV) contrast materials.
CT scanning and CT-guided interventions remain an important means for examining the preoperative renal donor candidate and for evaluating the complications that develop in patients who undergo renal transplants. The complementary nature of nuclear medicine studies and US in the imaging evaluation of hydronephrosis, renal artery stenosis, flank pain, renal masses, pyelonephritis, and kidney transplant was confirmed in the author's test group.
MRI of the abdomen has evolved into an excellent alternative means for the diagnosis of most renal transplantation complications and for the examination of the living related donor. The contrast agents used for MRI are nontoxic to the transplanted kidney, and MRI often can be used to assess renal function, vascular supply, and postoperative complications. However, MRI remains expensive and may be contraindicated in certain patients. Whenever 2 or more diagnostic techniques are used in the diagnosis of renal transplantation, comparison between the techniques is often very useful. Comparison of recent, current studies with remote, prior examinations is critical. New fluid collections are of greater significance than are slowly resolving fluid collections.
Limitations of techniques
Conventional radiographs provide a limited amount of useful information about the complex clinical presentations of renal transplantation. Often, chest radiographic findings are nonspecific because chronic interstitial pulmonary disease is difficult to differentiate, whereas abdominal radiographs may fail to illustrate fluid collections.
Ultrasound is safe, portable when necessary, and free from radiation. Generally, it should be the first cross-sectional examination in renal transplantation; however, sonograms may fail to differentiate gas from calcifications, and bowel gas may obscure important findings.
CT is not limited by bowel gas; however, the use of IV iodinated contrast material must be limited in many cases.
Radionuclide studies offer important functional information, but the findings are often nonspecific, and the images have relatively poor spatial resolution.
Abdominal and pelvic MRI is valuable. Some patients object to the MRI experience, and others have direct contraindications, such as cardiac pacemakers or cerebral aneurysm clips.
Although Doppler ultrasound and scintigraphy with captopril, when the patient is hypertensive, are helpful, both tests have limitations.
Interventional radiology plays an important role in the care and treatment of renal transplant recipients. Historically, catheter angiography has been performed to evaluate the anatomy of the renal arterial and venous systems of potential renal donors. To lower costs and reduce risk, CTA or MRA has largely replaced conventional DSA in the preoperative phase of renal transplantation. However, image-guided interventional techniques play a vital role in the relief of mechanical urinary obstruction, drainage of abscess and cystic fluid collections, and aspiration biopsy of neoplastic and infectious processes.
Traditionally, the potential donor was examined with intravenous urography (IVU) and angiography. That no longer occurs. Although a number of pretransplantation urologic evaluations have been recommended in the literature, no one specific universally accepted protocol exists. The expense and potential risk of using IV contrast material should limit duplication of tests. In general, CT of the abdomen and kidneys can be performed at the time of the evaluation of the renal vasculature. If magnetic resonance angiography (MRA) is selected for the renal vascular evaluation, an IVU (as an MR Urogram) can follow with sufficient spatial resolution to obviate the need for a radiopaque injection to perform a standard IVU.
Radiographic images pertaining to kidney transplantation are provided below.
Degree of confidence
Donor anomalies related to the upper collecting system and duplicated ureters may make the kidney from a living related donor unacceptable. This is readily illustrated on CT and MRI examinations, replacing IVU. To confirm 2 kidneys with no gross abnormality, US can be used as a screening study. Conventional angiography was long considered the criterion standard for the evaluation of the renal arteries and veins of the living related donor candidate. Today, as noted before, CTA (with spiral multidetector and multiplanar reconstruction) and MRA have become the imaging techniques of choice.
Prior to transplantation, if there is the question of recipient kidney size or gross abnormality, US can be performed. If vascular status, severe arteriosclerosis, or venous abnormalities of the pelvic arteries is suspected that might complicate the creation of the renal artery anastomosis, MRA or CTA can be performed. Angioplasty or stent placement may be required with a subsequent interventional procedure.
As with all imaging techniques, anomalies and misleading images can imitate pathologic situations. The radiologist must be aware of absent or duplicated vessels, benign masses (cortical invagination), and physiologic phenomenon (diuresis) that can simulate hydronephrosis.
An increased interest in CT imaging has paralleled the improvement in the image quality and speed of the CT examination. With the introduction of spiral CT imaging, both the resolution and speed of the available examinations have improved. [13, 14] Concurrent with improved imaging, the expanded role of interventional radiologic procedures has created an important role for CT imaging in transplant recipients.
CT scans associated with kidney transplantation are provided below.
CT of the renal donor may reveal small renal cell cancers, cysts,  upper collecting system duplications, and partial renal collecting system obstructions. Particularly important, the CT examination should be performed prior to the IV administration of contrast agent to look for renal stones, as well as immediately after administration of the bolus.
Early postinjection-phase images best demonstrate the renal cortex, while images obtained approximately 40 seconds after injection of the contrast agent bolus best show the combined enhancement within the renal medullary space and the renal pyramids. Nephrogram-phase images have been shown to be most sensitive in the overall detection of renal masses. By reexamining the kidneys, ureters, and bladder after a 2-3-minute delay, accurate evaluation of the renal collecting system, ureters, and urinary bladder is possible.
By carefully reviewing the axial CT images obtained during the first 20-30 seconds after the IV bolus, most renal artery duplications and many renal vein anomalies can be detected. Image collimation of 2-3 mm with an image index of 1-2 mm is necessary to separate small vessels, which are closely positioned. The patient must hold his or her breath during the arterial phase of CT scanning. Special imaging reformatting and reconstruction methods improve the general diagnostic accuracy of renal CT angiography and, in selected cases, the demonstration of small accessory arteries and venous anomalies that otherwise might not be detected. Such 3-dimensional (3D) imaging also provides the surgical team with an excellent overall review of the surgical anatomy.
CT scanning is useful in the evaluation of both immediate and delayed complications of renal transplantation. Multidetector CT urography has been shown superior to conventional IVP in the detection of urinary leaks and ureteral obstructions. In the immediate posttransplantation period, perigraft hemorrhage and urinary leaks can be detected with CT. In most cases, either US or functional nuclear medicine imaging should be performed first. CT scanning is the best means for surveying the most common intermediate and delayed surgical complications. CT findings are related to density differences between areas of hemorrhage, lymphoceles, and abscesses. [15, 16]
Degree of confidence
Regarding the donor, after a careful review of the axial CT images with a cine technique on a workstation or picture archiving and communication system (PACS), the evaluation of maximum intensity projection images in multiple projections and variable slab thicknesses is useful. Coronal, curved, multiplanar, reformatted images best outline the full length of each renal artery.
Measurements of the renal arteries are obtained; these include the diameter of the renal artery origins and distance of each renal artery to a major branching point. The presence of fibromuscular hyperplasia or renal artery stenosis due to ASVD is assessed. Volume image sets displayed using 3D image rendering is useful in complex cases and in explaining surgical options to the renal transplantation team.
Immediate complications related to recipient renal transplantation is best evaluated with combined or independent renal US, functional renal nuclear medicine study, CT, and occasionally MRI. Acute perirenal collections with a high CT attenuation of 28 Hounsfield units (HU) or greater is most likely perinephric hemorrhage. Perirenal or pararenal fluid collections of 18-24 HU are most likely lymphoceles. Complex fluid collections anywhere in the abdomen or pelvis of more than 28 HU on a delayed basis may be abscess cavities or chronic (liquefying) hematoma. In general, the findings of perirenal transplant complications have a pattern similar to that of diseases of the abdomen in other immunocompromised patients. Multidetector CT urography is more complete and precise compared to more conventional diagnostic techniques. The overall diagnostic accuracy of CT urography has been reported to be 90%.
The process of organ transplantation begins with the evaluation of patients with end-stage kidney disease, which may require CT and/or MRI imaging depending on the clinical presentation. Chronic renal failure makes the potential transplant recipient more susceptible to a wide range of neoplasms, including carcinoma of the kidney. The significance of an atypical cyst or a small renal deformity is much greater in the face of chronic renal insufficiency. In a patient with a polycystic kidney, bleeding into a cyst may mimic a small cystic renal cell carcinoma. The bleeding associated with polycystic renal disease is not necessarily related to renal cell carcinoma.
A detailed surgical history is useful in the evaluation of the transplanted kidney. In cases in which native vessels are thrombosed, unusual alternate venous outflow patterns may result. In cases of IVC thrombosis, the transplanted kidney renal vein may drain into the mesenteric veins. This should not be mistaken for a pathological AVF or other primary venous anomaly.
Surgical complications after pancreas transplantation include difficulties in the management of organ rejection, as well as the potential for pancreatitis with or without ischemic necrosis.
Magnetic Resonance Imaging
Gadolinium-enhanced MRA is rapidly becoming the technique of choice for imaging the renal arteries (see the images below). MRA has several advantages compared with conventional digital subtraction angiography (DSA). MRI and MRA are noninvasive and use no ionizing radiation. Gadolinium-based contrast media are safe to use in patients with renal insufficiency because the agents have minimal nephrotoxic effects. MRA provides true anatomic images and permits multiplanar reformatting. High-performance MR gradient systems allow the acquisition of 3D volumes in a single breath hold of shorter than 30 seconds. Imaging of the renal arteries is important in the examination of potential renal donors and of transplant patients with suspected renal artery stenosis.
MRI offers several advantages in the pretransplantation donor and recipient evaluation. MRI offers good spatial resolution with excellent tissue differentiation. No adverse effects related to radiation are known, and the gadolinium-based IV contrast agents can be safely used in patients with renal insufficiency. MRA with gadolinium enhancement has been improved by the development of fast 3D gradient-echo sequences. The T1 shortening effect of the IV injection of paramagnetic contrast material significantly improves vessel imaging by eliminating signal loss from saturation effects, minimizing dependence of the inflow phenomenon, and possibly decreasing intravoxel dephasing effects.
MRA demonstrates accessory renal arteries using gadolinium agents with the same degree of accuracy as CTA. MRA has been successfully applied to the diagnosis of most of the complications related to acute renal transplant vascular thrombosis. Gadopentetate dimeglumine (DTPA), when administered as an IV bolus during MRA, provides qualitative functional information concerning the renal transplant. It demonstrates the morphology in a manner similar to CT and is generally superior to diagnostic US.
Gadolinium-based contrast agents have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD). The disease has occurred in patients with moderate to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or MRA scans. NSF/NFD is a debilitating and sometimes fatal disease. Characteristics include red or dark patches on the skin; burning, itching, swelling, hardening, and tightening of the skin; yellow spots on the whites of the eyes; joint stiffness with trouble moving or straightening the arms, hands, legs, or feet; pain deep in the hip bones or ribs; and muscle weakness.
Degree of confidence
MRI has several limitations that should be considered in the choice of MRI, CT, US, or radionuclide-based imaging. The spatial resolution of MRI is generally less than that of CT, while the functional information available is generally qualitative compared with the quantitative data provided by nuclear renal scans. Patients with pacemakers, cochlear implants, most intracranial aneurysm clips, or severe claustrophobia cannot be safely examined using MRI. The use of conscious sedation in mildly claustrophobic patients and young children can be considered in MRI, but this adds to the cost.
The layering of excreted gadolinium into the urinary bladder and ureters generates artifacts that are less easily managed at MRI than at CT. During MRI, changing the patient's position requires additional time in the scanner. In comparison, prone or decubitus positioning at CT allows the mixing of contrast layers, which enables a more complete evaluation of the urinary bladder, including the anterior bladder surfaces. In general, CT of the kidneys and urinary bladder is better in the detection of renal stones and of renal, ureter, and bladder anomalies. CT with CTA generally costs less than MRI. In most applications, MRI is reserved for examination of the transplant recipient, whereas CT and CTA are used in the potential donors.
False-positive MRI findings in the transplanted kidney and/or pancreas are commonly related to movement or susceptibility artifacts. Breathing or vascular pulsatile movement may cause a misregistration of the walls of a cyst; this may be mistaken for enhancement related to renal cell carcinoma in the wall of a cyst. Benign fat-containing tissue near the surface of a transplanted kidney or pancreas may have a suspicious appearance if movement occurs during the examination. MRI is insensitive to calcified renal stones or calcifications in the walls of cysts.
False-negative MRI results related to venous anomalies and the detection of incomplete venous thrombosis is more common in MRA than in CTA.
Diagnostic ultrasonography, including duplex vascular study, is the most commonly performed examination for routine follow-up after renal transplantation (see the images below). [17, 18, 19] Typical renal transplant sonograms demonstrate the following: arcuate arteries, echo-poor medullary pyramids, hyperechoic renal sinus, absence of hydronephrosis, stable renal volume (formula: 0.5 x length x transverse x anteroposterior dimensions), normal position of renal transplant anterior to the external iliac vessels, and otherwise normal echogenicity in the parenchyma, collecting system, and surrounding tissues.
The measurement of the vascular resistive index (RI) is a part of the evaluation. The RI measures resistance to arterial flow within the renal vascular bed. RI is calculated from the peak diastolic arterial waveform. The normal RI is less than 0.7-0.8. An RI of greater than 0.9 indicates transplant dysfunction but not the cause. In some instances, a nonfunctioning renal allograft can have "normal" RI and pulsatility index (PI). 
Peritransplant fluid collections
Sonographic evaluation of renal transplant complications is often successful because many of the potential peritransplant complications are associated with fluid collections. The superficial nature of a typical renal transplant allows good resolution with relatively few reverberation echoes. During the immediate postoperative transplant period, most fluid collections in and around the bed of the transplant are hematomas or urinomas. A hyperacute hematoma often presents as a hypoechoic fluid-filled mass near the surgical site. Hematomas may be stable in size but can enlarge rapidly. The enlarging hematoma may compress the kidney, resulting in a reduction of urine output. Later, a hematoma becomes complex with both hypoechoic and echoic areas.
A second possible cause for fluid around the transplant during the first 24 hours following transplantation is a urinoma. A urinoma results from a leak between the renal transplant ureter and the recipient's bladder. Such a leak may be the result of surgical failure or from necrosis of the distal portion of the transplant ureter. A urinoma enlarges more slowly and remains hypoechoic. If the urinoma becomes infected the quality of the fluid may become more complex as an abscess forms. After several weeks, a spontaneous hematoma or a urinoma becomes less likely.
A lymphocele may form anywhere in the general area of the renal transplant. While lymphoceles are more likely to occur soon after the transplant, they may develop long after the skin wound has healed. An uncomplicated lymphocele is hypoechoic and remains hypoechoic unless it becomes infected. While lymphoceles are slow to develop, a lymphocele can create significant pressure resulting in urinary or venous obstruction.
An abscess may develop at any time during the life history of a renal transplant recipient. Abscesses may be around the kidney, within the transplant, or in the abdominal cavity remote from the transplant. Most abscesses have complex sonographic qualities. An abscess can be diagnosed best by comparing the sonographic texture of a fluid collection to the white blood cell count and the patient's fever curve. In cases in which an abscess is considered likely, sonographically guided aspiration is recommended. Diagnostic ultrasound may both initially diagnose the fluid mass as well as guide the surgical or radiologically based drainage. If percutaneous drainage results in a recurrence of a lymphocele, laparoscopic drainage is indicated.
Acute kidney transplant rejection
Sonographic findings include globular enlargement of the kidney, swelling and hypoechogenicity of the medullary pyramids, an indistinct cortical-medullary junction, and hypoechoic foci in the renal cortex.  Among the early findings of acute renal transplant rejection is renal enlargement. The length of a renal transplant should not increase from the stabilized posttransplantation measurements.
Although acute transplant rejection must be considered in all cases of declining renal function after initially successful renal transplantation, other acute events may occur in the immediate postoperative period or later clinical follow-up. Perinephric hematoma and acute hydronephrosis are among the complications than can result in the acute loss of kidney function.
Perinephric hematoma appears as a peripheral, mixed, hypoechoic rim or ring surrounding the kidney. The bleeding may proceed away from the kidney. The extent of the bleeding may be difficult to evaluate at US because of overlying bowel gas. Acute or chronic hydronephrosis has a presentation that is generally similar to hydronephrosis in a native kidney. The central collecting system may be dilated and filled with hypoechoic fluid (urine), and a variable degree of dilatation is generally preset in the renal collecting system. Several diseases may affect the transplanted kidney simultaneously. Mild tissue rejection may cause transplant edema, and a mechanical obstruction may cause hydronephrosis.
Comparison with prior sonographic studies and communication between the radiologist and other members of the transplantation team are critical. Correlation with findings from functional examinations, including nuclear medicine study and dynamic MRA, should be performed whenever US cannot confirm the cause of the decreased renal function. Changes in native kidneys of renal transplant patients should include a survey to detect masses. Cysts frequently develop in the kidneys of patients with ESRD. New patterns of internal echoes or rapid enlargement should be noted. Correlation with CT, MRI, or aspiration biopsy results may be necessary to exclude carcinoma or other pathology. 
Degree of confidence
If prior US results are compared and correlated with the clinical findings and if appropriate renal transplantation team members are consulted, US evaluation of renal transplants is highly accurate and clinically useful. The physical limitations of diagnostic US apply in transplantation as well.
Fluid within the peritoneal space is not a specific finding. Hypoechoic abdominal fluid may remain after peritoneal dialysis. Urine, bowel content, sepsis, and hemorrhage may have variable sonographic appearances. Recent collections should be aspirated for diagnosis by US guidance. Large fluid collections may be drained for symptomatic relief.
False-positive US results may occur if a full understanding of the surgical history of the patient is not available. In double (pediatric) renal transplantation, one of the kidneys may be much smaller than the other. The smaller kidney may be mistaken for a mass. Patients may undergo more than one renal transplant. The contralateral, or prior, transplant is generally smaller and can be mistaken for a mass.
Other false-positive results relate to the interpretation of duplex findings of renal artery stenosis and elevated RI. Tortuous renal arteries may suggest renal artery stenosis in the absence of hemodynamically significant narrowing. Increases in the RI should be interpreted carefully. Variations in the location of the sampled arterial signal may suggest elevation of the RI. Whenever possible, examinations should be performed in a standard way using a departmental protocol.
False-negative US results are related to the limitations of the technique. Gas within the vascular or ductal systems may be interpreted as calcifications. Aneurysms and venous varices may be mistaken for lymphoceles unless duplex signals are routinely assessed. The degree of hydronephrosis may be underestimated in a patient with acute transplant rejection. Comparison with prior findings and correlation with the results of other examinations help to prevent most false-negative errors.
Nuclear medicine studies have a role in all stages of postrenal transplantation evaluation. Immediately after surgery, nuclear medicine studies can be used to evaluate diminished renal function. The most immediate cause of renal transplant failure may be renal artery occlusion.
During the period immediately after the bolus IV injection of the technetium-99m mercaptotriglycylglycine (MAG3) agent, both images and activity counts are collected from the area of the abdominal aorta and the renal transplant site. Visualization of the renal artery and the renal transplant should occur within 20-30 seconds, with no significant difference between the time of aortic and renal visualization (see the images below).
The causes of diminished renal function include ATN, rejection, and drug nephrotoxicity. ATN is the most common cause of delayed graft function. ATN is associated with prolonged ischemia and reperfusion injury. ATN occurs after placement of most cadaveric grafts. Recovery is usually spontaneous within 2 weeks. ATN is less common in patients whose transplants are from living related donors.
Functional activity of the renal transplant is assessed using activity curves obtained from the renal transplant, aorta, and background. Orthoiodohippurate-131 and technetium-99m MAG3 studies demonstrate a delayed transit with a delayed time to maximum activity and a high ratio of findings at 20 minutes versus those at 3 minutes. Mechanical leaks from the renal pelvis, ureter, or urinary bladder can be detected as extrarenal nuclide collections.
Degree of confidence
Although complete thrombosis and renal graft infarction are easily determined with nuclide studies, moderately severe transplant renal artery stenosis may not have a clear pattern on a renal scan. In dual (pediatric) renal transplants, the delay in the visualization of one of the kidneys may indicate partial thrombosis or stenosis of the arterial supply to that kidney. However, in most cases, only a single renal transplant is present, and comparing its activity with that of the other kidney is not possible. The degree of renal dysfunction must be compared with the known surgical history and the current laboratory value.
Renal scans and renograms of transplanted kidneys are subject to artifacts similar to those of other nuclear medicine tests of the abdomen and pelvis. The presence of barium used for other imaging tests may cause artifacts on frontal views.
Conventional angiography has been replaced by CTA or MRA in many diagnostic applications both in the pretransplantation and posttransplantation periods. Cost, potential morbidity, and possible nephrotoxic effects of iodinated contrast must be considered. In most cases, digital subtraction angiography (DSA) provides the most fully diagnostic evaluation of the renal artery, the recipient's vascular status, and the patency of the renal veins.
In select cases, renal transplant angiography may be preferred to CTA or MRA. In all cases requiring vascular intervention, DSA angiography immediately precedes the interventional procedure. The potential diagnoses best made with angiography include renal artery stenosis, renal vein thrombosis, aneurysms, and arteriovenous fistula. Except for a pelvic location, the diagnosis of renal transplant circulation disease is similar to the diagnosis of renal artery disease in the native kidney.
Degree of confidence
Direct visualization of the lumen of a blood vessel is considered the most accurate means to determine the presence of arterial stenosis, venous thrombosis, and arteriovenous malformation (AVM) or arteriovenous fistula (AVF). Because angiography is generally performed just before therapy, other testing typically is not performed to confirm a catheter-proven lesion. Vascular flow gradients can be assessed at the time of the procedure to confirm a hemodynamically important lesion prior to treatment and to confirm the absence of a gradient after angioplasty with or without stent placement.
False-positive findings related to renal artery or iliac artery stenosis involve an overestimation of the degree of stenosis. Measurements made from 2 or more projections help to reduce errors. Direct gradient determination remains an important procedure.
Both false-positive and false-negative results can occur as a result of movement (breathing) during the angiography. DSA is particularly sensitive to misregistration artifacts. Barium in the GI tract from other tests must be avoided.