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Aneurysmal Bone Cyst Imaging

  • Author: Mahesh Kumar Neelala Anand, MBBS, DNB, FRCR; Chief Editor: Felix S Chew, MD, MBA, MEd  more...
Updated: Jun 24, 2016


An aneurysmal bone cyst is an expansile osteolytic lesion with a thin wall, containing blood-filled cystic cavities. The term aneurysmal is derived from its radiographic appearance.[1, 2]  Radiographs usually are adequate for diagnosis and for characterizing typical lesions. Cross-sectional imaging may be required when lesions are in unusual locations, such as the axial skeleton. Exclusion of fractures or complications from the lesion may sometimes be difficult.[3, 4, 5]

The solid variant is a recently identified variant of aneurysmal bone cysts. This variant has a predilection for the axial skeleton and occurs in persons aged 20 years or younger. Solid variants have a variable radiologic appearance, which ranges from that of a completely cystic aneurysmal bone cyst to a moth-eaten appearance with cortical destruction and soft-tissue extension.

See the image below of an aneurysmal bone cyst.

Aneurysmal bone cyst of the upper arm. Courtesy of Aneurysmal bone cyst of the upper arm. Courtesy of Johannes Stahl, The Virtual Radiological Case Collection.


Bush et al, in a retrospective study of 5 patients with large aneurysmal bone cysts of the axial skeleton, found that the morbidity of CT-guided intralesional injection of 32P chromic phosphate was lower than associated morbidities with surgical or other nonsurgical treatments. The authors reported that only one minor complication occurred with 32P chromic phosphate and that all lesions were seen to have ossified on follow-up CT (average follow-up, 2 y).[6]

Chowdhry et al reviewed the cases of aneurysmal bone cysts of the feet in 16 patients and found that the metatarsals were the most commonly affected site (44%). Surgical curettage of the lesions proved to be sufficient treatment in 11 of the 16 patients.[7]



The accuracy of radiography is high, especially with lesions in the appendicular skeleton. Cross-sectional imaging may be useful in defining the extent of spinal, thoracic cage, and pelvic bone involvement but may not increase the specificity to a large extent. (See the image below.)

Aneurysmal bone cyst of the upper arm. Courtesy of Aneurysmal bone cyst of the upper arm. Courtesy of Johannes Stahl, The Virtual Radiological Case Collection.

The classic description of an aneurysmal bone cyst includes an eccentric radiolucency and a purely lytic or, occasionally, trabecular process, with its epicenter in the metaphysis of an unfused long bone. The trabeculae in the cyst may create a soap-bubble appearance in the lesion.

The margins of the lesion are well defined, with a smooth inner margin and a rim of bone sclerosis. The tumor does not usually extend into the epiphyseal plate until after complete fusion, when it may occasionally do so. The expansion or ballooning of the cortex occasionally may result in the loss of the sharp definition of its margin. In this case, the finding should correctly be interpreted as an aggressive lesion rather than as solely diagnostic of malignant change. New bone may horizontally traverse the angle between the original cortex and the expanded part of the bone; this occurs because the periosteum is lifted. No periosteal reaction occurs, except when the periosteum is fractured.

Typically, the spinal lesion is osteolytic, with a predilection for the posterior elements. The lesion may involve the lamina, arches, pedicles, or spinous processes, with or without extension into the vertebral body. The lesion may extend into the adjacent vertebral body, violating the intervertebral disk and causing vertebral collapse and/or extension into the spinal canal, adjacent ribs, and paravertebral soft tissues.[1, 8, 9]

As in the innominate bones, flat bones have osteolysis with an expansile lesion. Expanded bone may displace the adjacent viscera, such as the urinary bladder, when occurring in the pelvis. Lesions in the skull have osteolysis, with expansion of both inner and outer tables with intracranial extension. Mandibular and maxillary lesions are multilocular, expansile, and osteolytic; they predominate in the region of the molar teeth.

Aneurysmal bone cysts are difficult to distinguish from malignant lesions in some locations. It may mimic a sarcoma in the ribs, scapula, or sternum, especially when associated with a large soft-tissue component.


Computed Tomography

Cross-sectional CT is the most useful imaging examination, because it can demonstrate the intraosseous and extraosseous extents of the lesion. CT can be used to determine the nature of the matrix of the tumor, especially when tumors are in complex locations, such as the facial skeleton, spine, thoracic cage, and pelvis.[10] Spinal CT can demonstrate stenosis of the spinal canal due to involvement of the posterior elements.

Fluid-fluid levels may be seen in the cysts. Fluid levels are depicted only when the patient is lying motionless for about 10 minutes and when the scans are obtained in the plane perpendicular to that of the fluid levels. Fluid-fluid levels also are seen in many other bone lesions, and this finding is not specific to aneurysmal bone cysts. These levels may be seen in malignant and benign lesions, such as giant cell tumors, and in telangiectatic osteosarcomas.

The extent of the disease can be estimated better with CT than with plain radiography. The specificity is slightly increased when fluid levels are depicted, but the fluid levels may be present in many other conditions.


Magnetic Resonance Imaging

T1-weighted images show predominantly low to intermediate signal intensity with or without fluid levels. Acute hemorrhage into the cyst may have high signal intensity. T2-weighted images show areas of low to intermediate signal intensity or some areas of heterogeneous high signal intensity, depending on the contents of the cyst. A rim of low signal intensity with internal septa may produce a multicystic appearance.[11]

MRI images of aggressive lesions show tumor enhancement with gadolinium enhancement, especially when they are associated with other tumors.[12, 13] Spinal cord compression and signal-intensity alteration in the cord can be evaluated when neurologic symptoms are present.

Gadolinium-based contrast agents have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD). For more information, see the eMedicine topic Nephrogenic Fibrosing Dermopathy. The disease has occurred in patients with moderate to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or MRA scans.

NSF/NFD is a debilitating and sometimes fatal disease. Characteristics include red or dark patches on the skin; burning, itching, swelling, hardening, and tightening of the skin; yellow spots on the whites of the eyes; joint stiffness with trouble moving or straightening the arms, hands, legs, or feet; pain deep in the hip bones or ribs; and muscle weakness. For more information, see FDA Information on Gadolinium-Based Contrast Agents.

Degree of confidence

A recent study reviewing the value of fine-needle aspiration cytology of bone lesions containing fluid-fluid levels suggested that the vast majority of lesions with fluid-fluid levels on MRI were benign unless the clinical and radiological features were not atypical.[14] Of 53 patients with fluid-fluid levels seen in bone lesions, 78% were aneurysmal bone cysts, 14% were simple bone cysts, and 8% were lesions with aneurysmal change. Fourteen patients underwent fine-needle aspiration cytology, of which 9 (64%) were nondiagnostic. The remaining patients underwent primary curettage and grafting and diagnosis confirmed all lesions as benign. Therefore, it is believed that it is unlikely that fine-needle aspiration cytology adds value in lesions containing fluid-fluid levels and primary bone grafting may be safe.


Nuclear Imaging

Demonstration of a solitary lesion on bone scintigraphy helps distinguish an aneurysmal bone cyst from a brown tumor, a hemophilic pseudotumor, etc.[15] Radioisotope uptake is increased. The common pattern is the accumulation of the tracer in the periphery of the lesion, with little intensity in the center; this finding is present in about 65% of cases. The appearance of the lesion is nonspecific, with no correlation of isotopic activity to lesional size, shape, contents, osteoblastic activity, or identifiable histologic abnormality.



On angiograms, aneurysmal bone cysts are hypovascular lesions with a hypervascular localized region. This feature is contrary to that of other malignant lesions, such as osteosarcoma and chondrosarcoma, which have gross hypervascularity. Hypervascular regions in aneurysmal bone cysts may affect the prognosis, because the number and size of the lesions are positively correlated with the likelihood of lesional recurrence after treatment.

Contributor Information and Disclosures

Mahesh Kumar Neelala Anand, MBBS, DNB, FRCR Consultant Interventional Radiologist, Department of Radiology, Matrix Medical Imaging Limited, UK; Consultant Interventional Radiologist, Mediclinic Hospitals, UAE

Mahesh Kumar Neelala Anand, MBBS, DNB, FRCR is a member of the following medical societies: Cardiovascular and Interventional Radiological Society of Europe, European Society of Gastrointestinal and Abdominal Radiology, British Society of Interventional Radiology, Indian Radiological and Imaging Association, British Society of Gastroenterology, Radiological Society of North America, Royal College of Radiologists

Disclosure: Nothing to disclose.

Specialty Editor Board

Bernard D Coombs, MB, ChB, PhD Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand

Disclosure: Nothing to disclose.

Murali Sundaram, MBBS FRCR, FACR, Professor of Radiology and Consulting Staff, Cleveland Clinic Lerner College of Medicine of CWRU

Murali Sundaram, MBBS is a member of the following medical societies: American College of Radiology, American Medical Association, American Roentgen Ray Society, Association of University Radiologists, International Skeletal Society, Radiological Society of North America, Society of Skeletal Radiology

Disclosure: Nothing to disclose.

Chief Editor

Felix S Chew, MD, MBA, MEd Professor, Department of Radiology, Vice Chairman for Academic Innovation, Section Head of Musculoskeletal Radiology, University of Washington School of Medicine

Felix S Chew, MD, MBA, MEd is a member of the following medical societies: American Roentgen Ray Society, Association of University Radiologists, Radiological Society of North America

Disclosure: Nothing to disclose.

Additional Contributors

Michael A Bruno, MD, MS, FACR Professor of Radiology and Medicine, Pennsylvania State University College of Medicine; Director, Radiology Quality Management Services, The Penn State Milton S Hershey Medical Center

Michael A Bruno, MD, MS, FACR is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, Association of University Radiologists, Radiological Society of North America, Society of Nuclear Medicine and Molecular Imaging, Society of Skeletal Radiology

Disclosure: Received royalty from Oxford Press for book author/editor & reviewer; Received royalty from Elsevier Press for book author / editor.


Eric A Wang, MD Consulting Staff, Department of Radiology, Carolinas Medical Center

Eric A Wang, MD is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, and Radiological Society of North America

Disclosure: Nothing to disclose.

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Aneurysmal bone cyst of the upper arm. Courtesy of Johannes Stahl, The Virtual Radiological Case Collection.
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