eMedicine Specialties > Radiology > Musculoskeletal

Bone Infarct: Multimedia

Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR, Consultant Radiologist, North Manchester General Hospital, The Pennine Acute NHS Trust, Manchester UK
Coauthor(s): Mohammed Jassim Al-Salman, MBBS, Consulting Radiologist, King Abdul Aziz Medical City, National Guard Hospital; Muthusamy Chandramohan, MBBS, DMRD, FRCR, Consultant Radiologist, Bradford Teaching Hospitals, UK; Ian Turnbull, MB, ChB, MD, DMRD, FRCR, Lecturer, Department of Radiology, University of Manchester; Consulting Neuroradiologist, Hope Hospital, Salford, Manchester and North Manchester General Hospital, UK; Sumaira MacDonald, MBChB, PhD, MRCP, FRCR, Lecturer, Sheffield University Medical School; Endovascular Fellow, Sheffield Vascular Institute; Charles Edward Hutchinson, MD, FRCR, Senior Lecturer, Department of Diagnostic Radiology, University of Manchester
Contributor Information and Disclosures

Updated: May 7, 2008

Multimedia

Diagram shows how the vascular supply to the femo...Media file 1: Diagram shows how the vascular supply to the femoral head is maintained by the retinacular blood vessels in the pertrochanteric fracture of the femur.
Diagram shows how the vascular supply to the femo...

Diagram shows how the vascular supply to the femoral head is maintained by the retinacular blood vessels in the pertrochanteric fracture of the femur.

Diagram shows how a subcapital fracture of the fe...Media file 2: Diagram shows how a subcapital fracture of the femoral neck cuts off of the blood supply to the femoral head, resulting in osteonecrosis.
Diagram shows how a subcapital fracture of the fe...

Diagram shows how a subcapital fracture of the femoral neck cuts off of the blood supply to the femoral head, resulting in osteonecrosis.

Diagram shows the blood supply to the humeral hea...Media file 3: Diagram shows the blood supply to the humeral head.
Diagram shows the blood supply to the humeral hea...

Diagram shows the blood supply to the humeral head.

Diagram shows the blood supply to the talus via t...Media file 4: Diagram shows the blood supply to the talus via the artery of the tarsal canal.
Diagram shows the blood supply to the talus via t...

Diagram shows the blood supply to the talus via the artery of the tarsal canal.

Diagram shows the blood supply to the scaphoid bo...Media file 5: Diagram shows the blood supply to the scaphoid bone.
Diagram shows the blood supply to the scaphoid bo...

Diagram shows the blood supply to the scaphoid bone.

Plain radiograph in a middle-aged man with should...Media file 6: Plain radiograph in a middle-aged man with shoulder discomfort demonstrates an irregularly calcified bone infarct in the diametaphysis of the right humerus.
Plain radiograph in a middle-aged man with should...

Plain radiograph in a middle-aged man with shoulder discomfort demonstrates an irregularly calcified bone infarct in the diametaphysis of the right humerus.

Coronal T1-weighted MRI in a 12-year-old boy with...Media file 7: Coronal T1-weighted MRI in a 12-year-old boy with early Legg-Calvé-Perthes disease demonstrates slight irregularity of the right femoral capital epiphysis with abnormal signal intensity. The left hip appears normal.
Coronal T1-weighted MRI in a 12-year-old boy with...

Coronal T1-weighted MRI in a 12-year-old boy with early Legg-Calvé-Perthes disease demonstrates slight irregularity of the right femoral capital epiphysis with abnormal signal intensity. The left hip appears normal.

Coronal T1 weighted MR image of a 20-year-old wom...Media file 8: Coronal T1 weighted MR image of a 20-year-old woman with bilateral late-stage Legg-Calvé-Perthes disease demonstrates flattening of the right femoral head and acetabulum.
Coronal T1 weighted MR image of a 20-year-old wom...

Coronal T1 weighted MR image of a 20-year-old woman with bilateral late-stage Legg-Calvé-Perthes disease demonstrates flattening of the right femoral head and acetabulum.

Coronal T1-weighted MRI of the left hip in the pa...Media file 9: Coronal T1-weighted MRI of the left hip in the patient in Image 8, shows a short, broad femoral neck. This bone remodeling is associated with Legg-Calvé-Perthes disease (same patient as in Image 8 in Multimedia).
Coronal T1-weighted MRI of the left hip in the pa...

Coronal T1-weighted MRI of the left hip in the patient in Image 8, shows a short, broad femoral neck. This bone remodeling is associated with Legg-Calvé-Perthes disease (same patient as in Image 8 in Multimedia).

Plain radiograph in a 68-year-old man with hip pa...Media file 10: Plain radiograph in a 68-year-old man with hip pain demonstrates patchy sclerosis of both femoral heads that is consistent with avascular necrosis.
Plain radiograph in a 68-year-old man with hip pa...

Plain radiograph in a 68-year-old man with hip pain demonstrates patchy sclerosis of both femoral heads that is consistent with avascular necrosis.

Radionuclide bone scan of the pelvis in a 68-year...Media file 11: Radionuclide bone scan of the pelvis in a 68-year-old man with hip pain demonstrates a bilateral central area of diminished uptake surrounded by a zone of increased uptake in the femoral head consistent with avascular necrosis (same patient as in Image 10 in Multimedia).
Radionuclide bone scan of the pelvis in a 68-year...

Radionuclide bone scan of the pelvis in a 68-year-old man with hip pain demonstrates a bilateral central area of diminished uptake surrounded by a zone of increased uptake in the femoral head consistent with avascular necrosis (same patient as in Image 10 in Multimedia).

Plain radiograph of the pelvis in a man demonstra...Media file 12: Plain radiograph of the pelvis in a man demonstrates collapse of the left femoral head due to osteonecrosis.
Plain radiograph of the pelvis in a man demonstra...

Plain radiograph of the pelvis in a man demonstrates collapse of the left femoral head due to osteonecrosis.

Coronal T2-weighted MRI in a 35-year-old man with...Media file 13: Coronal T2-weighted MRI in a 35-year-old man with bilateral avascular necrosis of the hip demonstrates a central region of increased signal intensity and a peripheral region of decreased signal intensity. The double-line sign is characteristic of osteonecrosis.
Coronal T2-weighted MRI in a 35-year-old man with...

Coronal T2-weighted MRI in a 35-year-old man with bilateral avascular necrosis of the hip demonstrates a central region of increased signal intensity and a peripheral region of decreased signal intensity. The double-line sign is characteristic of osteonecrosis.

Coronal T1-weighted MRI in a 42-year-old man with...Media file 14: Coronal T1-weighted MRI in a 42-year-old man with bilateral avascular necrosis shows an area of osteonecrosis in both femoral heads in which a serpentine area of low signal intensity surrounds a central area of intermediate signal intensity similar to that of fat.
Coronal T1-weighted MRI in a 42-year-old man with...

Coronal T1-weighted MRI in a 42-year-old man with bilateral avascular necrosis shows an area of osteonecrosis in both femoral heads in which a serpentine area of low signal intensity surrounds a central area of intermediate signal intensity similar to that of fat.

Coronal T2-weighted MRI of the patient seen in Im...Media file 15: Coronal T2-weighted MRI of the patient seen in Image 14.
Coronal T2-weighted MRI of the patient seen in Im...

Coronal T2-weighted MRI of the patient seen in Image 14.

Plain radiograph of the right knee joint in a 52-...Media file 16: Plain radiograph of the right knee joint in a 52-year-old woman with abrupt onset of right knee pain demonstrates subtle loss of bone density in the proximal aspect of the tibia (arrow).
Plain radiograph of the right knee joint in a 52-...

Plain radiograph of the right knee joint in a 52-year-old woman with abrupt onset of right knee pain demonstrates subtle loss of bone density in the proximal aspect of the tibia (arrow).

Radionuclide bone scan of the right knee joint in...Media file 17: Radionuclide bone scan of the right knee joint in a 52-year-old woman with abrupt onset of right knee pain shows increased accumulation of the isotope in the medial aspect of the tibia plateau consistent with spontaneous osteonecrosis (same patient as in Image 16 in Multimedia).
Radionuclide bone scan of the right knee joint in...

Radionuclide bone scan of the right knee joint in a 52-year-old woman with abrupt onset of right knee pain shows increased accumulation of the isotope in the medial aspect of the tibia plateau consistent with spontaneous osteonecrosis (same patient as in Image 16 in Multimedia).

Posttraumatic osteonecrosis of the right femoral ...Media file 18: Posttraumatic osteonecrosis of the right femoral head in a woman. Note the arclike subchondral radiolucency secondary to subchondral fracture and collapse.
Posttraumatic osteonecrosis of the right femoral ...

Posttraumatic osteonecrosis of the right femoral head in a woman. Note the arclike subchondral radiolucency secondary to subchondral fracture and collapse.

Plain radiograph of the left wrist in a man with ...Media file 19: Plain radiograph of the left wrist in a man with posttraumatic osteonecrosis of the scaphoid bone shows sclerosis of the proximal portion of the scaphoid bone.
Plain radiograph of the left wrist in a man with ...

Plain radiograph of the left wrist in a man with posttraumatic osteonecrosis of the scaphoid bone shows sclerosis of the proximal portion of the scaphoid bone.

Plain radiograph of the right wrist of a man dem...Media file 20: Plain radiograph of the right wrist of a man demonstrates sclerosis, irregularity, and collapse of the lunate bone consistent with osteonecrosis Kienböck disease.
Plain radiograph of the right wrist of a man dem...

Plain radiograph of the right wrist of a man demonstrates sclerosis, irregularity, and collapse of the lunate bone consistent with osteonecrosis Kienböck disease.

Osteonecrosis of the third metatarsal head (ie, F...Media file 21: Osteonecrosis of the third metatarsal head (ie, Freiberg disease) in a 60-year-old woman is shown as flattening of the third metatarsal head, widening of the third metatarsal, and expansion of the corresponding proximal phalangeal base.
Osteonecrosis of the third metatarsal head (ie, F...

Osteonecrosis of the third metatarsal head (ie, Freiberg disease) in a 60-year-old woman is shown as flattening of the third metatarsal head, widening of the third metatarsal, and expansion of the corresponding proximal phalangeal base.

Plain radiograph of the left ankle in a patient w...Media file 22: Plain radiograph of the left ankle in a patient with ankle injury demonstrates subchondral radiolucent band (arrow) in proximal talus, the Hawkins impingement sign, which represents bone resorption and an intact blood supply.
Plain radiograph of the left ankle in a patient w...

Plain radiograph of the left ankle in a patient with ankle injury demonstrates subchondral radiolucent band (arrow) in proximal talus, the Hawkins impingement sign, which represents bone resorption and an intact blood supply.

Plain radiograph of the left ankle in an adult pa...Media file 23: Plain radiograph of the left ankle in an adult patient with osteonecrosis of the talus. Note the increased radiopacity of the body of the talus.
Plain radiograph of the left ankle in an adult pa...

Plain radiograph of the left ankle in an adult patient with osteonecrosis of the talus. Note the increased radiopacity of the body of the talus.

Patchy irregular sclerotic lesion characteristic ...Media file 24: Patchy irregular sclerotic lesion characteristic of bone infarct is seen in the proximal metadiaphysis of right humerus in a patient with pancreatitis.
Patchy irregular sclerotic lesion characteristic ...

Patchy irregular sclerotic lesion characteristic of bone infarct is seen in the proximal metadiaphysis of right humerus in a patient with pancreatitis.

Radioisotopic bone scan of the right humerus in a...Media file 25: Radioisotopic bone scan of the right humerus in a patient with pancreatitis shows a hot lesion, the result of revascularization, which is a part of the reparative process.
Radioisotopic bone scan of the right humerus in a...

Radioisotopic bone scan of the right humerus in a patient with pancreatitis shows a hot lesion, the result of revascularization, which is a part of the reparative process.

Plain abdominal radiograph in a patient with sick...Media file 26: Plain abdominal radiograph in a patient with sickle cell disease shows generalized coarsening of the bone trabeculae with characteristic H-shaped vertebrae due to a growth disturbance. Note the calcified and contracted spleen (same patient as in Image 25 in Multimedia).
Plain abdominal radiograph in a patient with sick...

Plain abdominal radiograph in a patient with sickle cell disease shows generalized coarsening of the bone trabeculae with characteristic H-shaped vertebrae due to a growth disturbance. Note the calcified and contracted spleen (same patient as in Image 25 in Multimedia).

Lateral view of the knee in a deep-sea diver show...Media file 27: Lateral view of the knee in a deep-sea diver shows dysbaric osteonecrosis in the diaphysis of the femur and tibia. Note the irregular calcific deposits with a shell-like pattern, which is typical of a bone infarct.
Lateral view of the knee in a deep-sea diver show...

Lateral view of the knee in a deep-sea diver shows dysbaric osteonecrosis in the diaphysis of the femur and tibia. Note the irregular calcific deposits with a shell-like pattern, which is typical of a bone infarct.

Plain abdominal radiograph in a 19-year-old man w...Media file 28: Plain abdominal radiograph in a 19-year-old man with hemophilia. Osteonecrosis of the right humeral head is associated with calcified hematoma in the left groin.
Plain abdominal radiograph in a 19-year-old man w...

Plain abdominal radiograph in a 19-year-old man with hemophilia. Osteonecrosis of the right humeral head is associated with calcified hematoma in the left groin.

Sagittal T1-weighted MRI of the cervical spine in...Media file 29: Sagittal T1-weighted MRI of the cervical spine in a 37-year-old woman who underwent radiation therapy for a slow-growing cystic glioma of the cervical cord. The fatty marrow change in vertebral bodies C4 through T1 is a result of radiation-induced ischemia. Note the posterior vertebral scalloping of the C7 and T1 due to long-standing spinal cord expansion caused by the tumor.
Sagittal T1-weighted MRI of the cervical spine in...

Sagittal T1-weighted MRI of the cervical spine in a 37-year-old woman who underwent radiation therapy for a slow-growing cystic glioma of the cervical cord. The fatty marrow change in vertebral bodies C4 through T1 is a result of radiation-induced ischemia. Note the posterior vertebral scalloping of the C7 and T1 due to long-standing spinal cord expansion caused by the tumor.

More on Bone Infarct

Overview: Bone Infarct
Imaging: Bone Infarct
Follow-up: Bone Infarct
Multimedia: Bone Infarct
References

References

  1. Hara H, Akisue T, Fujimoto T, Kishimoto K, Imabori M, Kishimoto S, et al. Magnetic resonance imaging of medullary bone infarction in the early stage. Clin Imaging. Mar-Apr 2008;32(2):147-51. [Medline].

  2. Alli NA, Wainwright RD, Mackinnon D, Poyiadjis S, Naidu G. Skull bone infarctive crisis and deep vein thrombosis in homozygous sickle cell disease- case report and review of the literature. Hematology. Apr 2007;12(2):169-74. [Medline].

  3. Alpaslan AM, Aksoy MC, Yazici M. Interruption of the blood supply of femoral head: an experimental study on the pathogenesis of Legg-Calve-Perthes Disease. Arch Orthop Trauma Surg. Aug 2007;127(6):485-91. [Medline].

  4. Wong AL, Sakamoto KM, Johnson EE. Differentiating osteomyelitis from bone infarction in sickle cell disease. Pediatr Emerg Care. Feb 2001;17(1):60-3; quiz 64. [Medline].

  5. Rifai A, Nyman R. Scintigraphy and ultrasonography in differentiating osteomyelitis from bone infarction in sickle cell disease. Acta Radiol. Jan 1997;38(1):139-43. [Medline].

  6. Martino AM, Winfield JA. Salmonella osteomyelitis with epidural abscess. A case report with review of osteomyelitis in children with sickle cell anemia. Pediatr Neurosurg. 1990-91;16(6):321-5. [Medline].

  7. Podlesh SW, Boyden DK. Diagnosis of acute bone/bone marrow infarction of the mandible in sickle hemoglobinopathy. Report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. May 1996;81(5):547-9. [Medline].

  8. Resar LM, Oliva MM, Casella JF. Skull infarction and epidural hematomas in a patient with sickle cell anemia. J Pediatr Hematol Oncol. Nov 1996;18(4):413-5. [Medline].

  9. Madani G, Papadopoulou AM, Holloway B, Robins A, Davis J, Murray D. The radiological manifestations of sickle cell disease. Clin Radiol. Jun 2007;62(6):528-38. [Medline].

  10. Jain R, Sawhney S, Rizvi SG. Acute bone crises in sickle cell disease: the T1 fat-saturated sequence in differentiation of acute bone infarcts from acute osteomyelitis. Clin Radiol. Jan 2008;63(1):59-70. [Medline].

  11. Gould CF, Ly JQ, Lattin GE Jr, Beall DP, Sutcliffe JB 3rd. Bone tumor mimics: avoiding misdiagnosis. Curr Probl Diagn Radiol. May-Jun 2007;36(3):124-41. [Medline].

  12. Steinberg ME, Steinberg DR. Classification systems for osteonecrosis: an overview. Orthop Clin North Am. Jul 2004;35(3):273-83, vii-viii. [Medline].

  13. Farahati J, Trenn G, John-Mikolajewski V, et al. Use of various diagnostic methods in a patient with Gaucher disease type I. Clin Nucl Med. Aug 1996;21(8):619-25. [Medline].

  14. Ahn BC, Lee J, Suh KJ, et al. Intramedullary fat necrosis of multiple bones associated with pancreatitis. J Nucl Med. Aug 1998;39(8):1401-4. [Medline].

  15. Abdelwahab IF, Klein MJ, Hermann G, Springfield D. Angiosarcomas associated with bone infarcts. Skeletal Radiol. Oct 1998;27(10):546-51. [Medline].

  16. Hara H, Akisue T, Fujimoto T, Kishimoto K, Imabori M, Kishimoto S, et al. Magnetic resonance imaging of medullary bone infarction in the early stage. Clin Imaging. Mar-Apr 2008;32(2):147-51. [Medline].

  17. Eisenberg B, Coates GG, Holder LR. Technetium-99m MDP bone scan and MRI correlation in the detection of occult bone infarction. Clin Nucl Med. Dec 1994;19(12):1104-5. [Medline].

Further Reading

Keywords

osteonecrosis, aseptic necrosis, avascular necrosis, ischemic necrosis, metaphyseal lesion, diaphyseal lesions, bone blood supply, ischemic bone death, bone necrosis, bone death, bone infarction, idiopathic osteonecrosis, secondary osteonecrosis, Legg-Calvé-Perthes disease, slipped femoral capital epiphysis, bone infarction, spontaneous bone infarct, AVN, traumatic osteonecrosis, Gaucher disease, hemophilia, Caisson disease, dysbaric osteonecrosis, pancreatitis, systemic lupus erythematosus, radiation-induced osteonecrosis

Contributor Information and Disclosures

Author

Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR, Consultant Radiologist, North Manchester General Hospital, The Pennine Acute NHS Trust, Manchester UK
Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR is a member of the following medical societies: American Institute of Ultrasound in Medicine, Royal College of Physicians, Royal College of Physicians and Surgeons of the United States, Royal College of Radiologists, and Royal College of Surgeons of England
Disclosure: Nothing to disclose.

Coauthor(s)

Mohammed Jassim Al-Salman, MBBS, Consulting Radiologist, King Abdul Aziz Medical City, National Guard Hospital
Disclosure: Nothing to disclose.

Muthusamy Chandramohan, MBBS, DMRD, FRCR, Consultant Radiologist, Bradford Teaching Hospitals, UK
Disclosure: Nothing to disclose.

Ian Turnbull, MB, ChB, MD, DMRD, FRCR, Lecturer, Department of Radiology, University of Manchester; Consulting Neuroradiologist, Hope Hospital, Salford, Manchester and North Manchester General Hospital, UK
Disclosure: Nothing to disclose.

Sumaira MacDonald, MBChB, PhD, MRCP, FRCR, Lecturer, Sheffield University Medical School; Endovascular Fellow, Sheffield Vascular Institute
Sumaira MacDonald, MBChB, PhD, MRCP, FRCR is a member of the following medical societies: British Medical Association, Royal College of Physicians, and Royal College of Radiologists
Disclosure: Nothing to disclose.

Charles Edward Hutchinson, MD, FRCR, Senior Lecturer, Department of Diagnostic Radiology, University of Manchester
Charles Edward Hutchinson, MD, FRCR is a member of the following medical societies: British Institute of Radiology
Disclosure: Nothing to disclose.

Medical Editor

Michael A Bruno, MD, Associate Professor, Departments of Radiology and Medicine, Pennsylvania State University College of Medicine; Director, Radiology Quality Management Services, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine
Michael A Bruno, MD is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, Association of University Radiologists, Radiological Society of North America, Society of Nuclear Medicine, and Society of Skeletal Radiology
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Javier Beltran, MD, Chair, Department of Radiology, Maimonides Medical Center
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, Resolution Imaging Medical Corporation
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Felix S Chew, MD, MBA, EdM, Professor, Department of Radiology, Vice Chairman for Radiology Informatics, Section Head of Musculoskeletal Radiology, University of Washington
Felix S Chew, MD, MBA, EdM is a member of the following medical societies: American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

 
 
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