eMedicine Specialties > Radiology > Musculoskeletal

Chondromyxoid Fibroma: Follow-up

Author: Gregory Scott Stacy, MD, Assistant Professor, Department of Radiology, University of Chicago Hospitals
Coauthor(s): John George, MD, Chief of Staff, Karol Marcinkowski University of Medical Sciences
Contributor Information and Disclosures

Updated: Mar 17, 2009

Intervention

Treatment in patients with CMF usually involves curettage or en bloc resection, with a preference for en bloc resection. Radiation therapy is contraindicated because of the risk of inducing malignancy. Periodic follow-up studies are indicated because of the significant recurrence rate of CMFs.

Medicolegal Pitfalls

  • Patients with CMF present with generic symptoms that are very similar to those of other benign and malignant bone tumors.
  • Imaging findings may be suggestive of CMF, but ultimately, an analysis of biopsy specimens is required for a definitive diagnosis.
  • The lesion shares some imaging features with chondrosarcoma, which is treated more aggressively.

Special Concerns

  • The recurrence of CMF after curettage has been documented in numerous patients. Most recurrent tumors are observed in patients younger than 20 years. Recurrent tumors retain the histologic and gross characteristics of the original tumor.
 


More on Chondromyxoid Fibroma

Overview: Chondromyxoid Fibroma
Imaging: Chondromyxoid Fibroma
Follow-up: Chondromyxoid Fibroma
Multimedia: Chondromyxoid Fibroma
References
Further Reading

References

  1. Jaffe HL, Lichtenstein L. Chondromyxoid fibroma of bone: A distinctive benign tumor likely to be mistaken especially for chondrosarcoma. Arch Pathol. 1948;45:541.

  2. Lersundi A, Mankin HJ, Mourikis A. Chondromyxoid fibroma: a rarely encountered and puzzling tumor. Clin Orthop Relat Res. Oct 2005;439:171-5.

  3. Budny AM, Ismail A, Osher L. Chondromyxoid fibroma. J Foot Ankle Surg. Mar-Apr 2008;47(2):153-9. [Medline].

  4. Safar A, Nelson M, Neff JR. Recurrent anomalies of 6q25 in chondromyxoid fibroma. Hum Pathol. Mar 2000;31(3):306-11.

  5. Veras EF, Santamaria IB, Luna MA. Sinonasal chondromyxoid fibroma. Ann Diagn Pathol. Feb 2009;13(1):41-6. [Medline].

  6. Desai SS, Jambhekar NA, Samanthray S. Chondromyxoid fibromas: a study of 10 cases. J Surg Oncol. Jan 1 2005;89(1):28-31.

  7. Murata H, Horie N, Matsui T, Akai T, Ueda H, Oshima Y, et al. Clinical usefulness of thallium-201 scintigraphy and magnetic resonance imaging in the diagnosis of chondromyxoid fibroma. Ann Nucl Med. Apr 2008;22(3):221-4. [Medline].

  8. Yalniz E, Alicioglu B, Yalcin O, Yilmaz B. Non specific magnetic resonance features of chondromyxoid fibroma of the iliac bone. J BUON. Jul-Sep 2007;12(3):407-9. [Medline].

  9. Hamada K, Tomita Y, Konishi E, Fujimoto T, Jin YF, Outani H, et al. FDG-PET evaluation of chondromyxoid fibroma of left ilium. Clin Nucl Med. Jan 2009;34(1):15-7. [Medline].

  10. Adams MJ, Spencer GM, Totterman S, Hicks DG. Quiz: case report 776. Chondromyxoid fibroma of femur. Skeletal Radiol. 1993;22(5):358-61. [Medline].

  11. Beggs IG, Stoker DJ. Chondromyxoid fibroma of bone. Clin Radiol. Nov 1982;33(6):671-9. [Medline].

  12. Bruder E, Zanetti M, Boos N, von Hochstetter AR. Chondromyxoid fibroma of two thoracic vertebrae. Skeletal Radiol. May 1999;28(5):286-9. [Medline].

  13. DAHLIN DC. Chondromyxoid fibroma of bone, with emphasis on its morphological relationship to benign chondroblastoma. Cancer. Jan-Feb 1956;9(1):195-203.

  14. Durr HR, Lienemann A, Nerlich A, et al. Chondromyxoid fibroma of bone. Arch Orthop Trauma Surg. 2000;120(1-2):42-7. [Medline].

  15. Hau MA, Fox EJ, Rosenberg AE, Mankin HJ. Chondromyxoid fibroma of the metacarpal. Skeletal Radiol. Dec 2001;30(12):719-21. [Medline].

  16. Kreicbergs A, Lonnquist PA, Willems J. Chondromyxoid fibroma. A review of the literature and a report on our own experience. Acta Pathol Microbiol Immunol Scand [A]. Jul 1985;93(4):189-97. [Medline].

  17. Lopez-Ben R, Siegal GP, Hadley MN. Chondromyxoid fibroma of the cervical spine: case report. Neurosurgery. Feb 2002;50(2):409-11. [Medline].

  18. Macdonald D, Fornasier V, Holtby R. Chondromyxoid fibroma of the acromium with soft tissue extension. Skeletal Radiol. Mar 2000;29(3):168-70. [Medline].

  19. Marin C, Gallego C, Manjon P, Martinez-Tello FJ. Juxtacortical chondromyxoid fibroma: imaging findings in three cases and a review of the literature. Skeletal Radiol. Nov 1997;26(11):642-9. [Medline].

  20. Mitchell M, Sartoris DJ, Resnick D. Case report 713. Chondromyxoid fibroma of the third metatarsal. Skeletal Radiol. 1992;21(4):252-5. [Medline].

  21. Moser RP, Kransdorf MJ, Gilkey FW. Chondromyxoid fibroma. In: Davidson AJ, ed. Cartilaginous Tumors of the Skeleton: Afip Atlas of Radiologic-Pathologic Correlation. Hanley & Belfus;1990:114-54.

  22. Murphy NB, Price CH. The radiological aspects of chondromyxoid fibroma of bone. Clin Radiol. Apr 1971;22(2):261-9. [Medline].

  23. Park JM, Woo YK, Kang MI, et al. Oncogenic osteomalacia associated with soft tissue chondromyxoid fibroma. Eur J Radiol. Aug 2001;39(2):69-72. [Medline].

  24. Park SH, Kong KY, Chung HW, et al. Juxtacortical chondromyxoid fibroma arising in an apophysis. Skeletal Radiol. Aug 2000;29(8):466-9. [Medline].

  25. Rahimi A, Beabout JW, Ivins JC, Dahlin DC. Chondromyxoid fibroma: a clinicopathologic study of 76 cases. Cancer. Sep 1972;30(3):726-36. [Medline].

  26. RCNA. Chondromyxoid fibroma. Radiol Clin North Am. 1993;31:251-3.

  27. Tarhan NC, Yologlu Z, Tutar NU, et al. Chondromyxoid fibroma of the temporal bone: CT and MRI findings. Eur Radiol. 2000;10(10):1678-80. [Medline].

  28. Yamaguchi T, Dorfman HD. Radiographic and histologic patterns of calcification in chondromyxoid fibroma. Skeletal Radiol. Oct 1998;27(10):559-64. [Medline].

Keywords

chondromyxoid fibroma, CMF, fibromyxoid chondroma, myxofibrous chondroma, primary osseous neoplasm, benign bone tumor, osseous tumor, lower extremity tumor

Contributor Information and Disclosures

Author

Gregory Scott Stacy, MD, Assistant Professor, Department of Radiology, University of Chicago Hospitals
Gregory Scott Stacy, MD is a member of the following medical societies: American College of Radiology, American Medical Association, American Roentgen Ray Society, Radiological Society of North America, and Society of Skeletal Radiology
Disclosure: Nothing to disclose.

Coauthor(s)

John George, MD, Chief of Staff, Karol Marcinkowski University of Medical Sciences
Disclosure: Nothing to disclose.

Medical Editor

Michael A Bruno, MD, Associate Professor, Departments of Radiology and Medicine, Pennsylvania State University College of Medicine; Director, Radiology Quality Management Services, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine
Michael A Bruno, MD is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, Association of University Radiologists, Radiological Society of North America, Society of Nuclear Medicine, and Society of Skeletal Radiology
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Murali Sundaram, MBBS, FRCR, FACR, Consulting Staff, Department of Diagnostic Radiology, The Cleveland Clinic Foundation
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Felix S Chew, MD, MBA, EdM, Professor, Department of Radiology, Vice Chairman for Radiology Informatics, Section Head of Musculoskeletal Radiology, University of Washington
Felix S Chew, MD, MBA, EdM is a member of the following medical societies: American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

RELATED MEDSCAPE ARTICLES
Articles
 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.