eMedicine Specialties > Radiology > Musculoskeletal

Hypertrophic Osteoarthropathy: Multimedia

Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR, LRCP, Chairman of Medical Imaging, Professor of Radiology, NGHA, King Fahad National Guard Hospital, King Abdulaziz Medical City, Riyadh, Saudi Arabia
Coauthor(s): Mohammed Jassim Al-Salman, MBBS, Consulting Radiologist, King Abdul Aziz Medical City, National Guard Hospital; Dare Mutiyu Seriki, MBBS, FRCR, MRCP, Staff Physician, Department of Radiology, Hope Hospital, UK; Ian Turnbull, MB, ChB, MD, DMRD, FRCR, Lecturer, Department of Radiology, University of Manchester; Consulting Neuroradiologist, Hope Hospital, Salford, Manchester and North Manchester General Hospital, UK; Sumaira MacDonald, MBChB, PhD, MRCP, FRCR, Lecturer, Sheffield University Medical School; Endovascular Fellow, Sheffield Vascular Institute
Contributor Information and Disclosures

Updated: Jul 23, 2008

Multimedia

Radiograph of both hands in a 42-year-old man wit...Media file 1: Radiograph of both hands in a 42-year-old man with a family history of primary hypertrophic osteoarthropathy who had coarsened facial features and thickness of the scalp. Note the soft tissue clubbing and acro-osteolysis of the terminal phalanges.
Radiograph of both hands in a 42-year-old man wit...

Radiograph of both hands in a 42-year-old man with a family history of primary hypertrophic osteoarthropathy who had coarsened facial features and thickness of the scalp. Note the soft tissue clubbing and acro-osteolysis of the terminal phalanges.

Macroradiograph of the left hand in a patient kno...Media file 2: Macroradiograph of the left hand in a patient known to have long-standing bronchiectasis shows extensive lamellar periosteal new bone formation around the shafts of the distal radius, ulna, metacarpals, and proximal phalanges.
Macroradiograph of the left hand in a patient kno...

Macroradiograph of the left hand in a patient known to have long-standing bronchiectasis shows extensive lamellar periosteal new bone formation around the shafts of the distal radius, ulna, metacarpals, and proximal phalanges.

Radiograph in a patient with long-standing bronch...Media file 3: Radiograph in a patient with long-standing bronchiectasis (same patient as in Image 2 in Multimedia) shows extensive lamellar periosteal reaction around the lower parts of the femora.
Radiograph in a patient with long-standing bronch...

Radiograph in a patient with long-standing bronchiectasis (same patient as in Image 2 in Multimedia) shows extensive lamellar periosteal reaction around the lower parts of the femora.

A 53-year-old male smoker presented with lower-li...Media file 4: A 53-year-old male smoker presented with lower-limb pain around the hips, knees, and ankles. Chest radiograph was obtained as a part of the workup and demonstrates an opacity in the left apical region (arrow) suggestive of a bronchial neoplasm. Results of percutaneous needle biopsy confirmed a squamous carcinoma (see also Images 5-6 in Multimedia).
A 53-year-old male smoker presented with lower-li...

A 53-year-old male smoker presented with lower-limb pain around the hips, knees, and ankles. Chest radiograph was obtained as a part of the workup and demonstrates an opacity in the left apical region (arrow) suggestive of a bronchial neoplasm. Results of percutaneous needle biopsy confirmed a squamous carcinoma (see also Images 5-6 in Multimedia).

Radiograph in a 53-year-old male smoker with lowe...Media file 5: Radiograph in a 53-year-old male smoker with lower-limb pain around the hips, knees, and ankles (same patient as in Images 4 and 6 in Multimedia) shows a subtle periosteal reaction around the upper parts of the femora on the medial aspects.
Radiograph in a 53-year-old male smoker with lowe...

Radiograph in a 53-year-old male smoker with lower-limb pain around the hips, knees, and ankles (same patient as in Images 4 and 6 in Multimedia) shows a subtle periosteal reaction around the upper parts of the femora on the medial aspects.

Anteroposterior radiograph of the right ankle in ...Media file 6: Anteroposterior radiograph of the right ankle in a 53-year-old male smoker with lower-limb pain around the hips, knees, and ankles (same patient as in Images 4-5 in Multimedia) shows lamellar periosteal new bone formation around the lower shafts of the tibia and fibula.
Anteroposterior radiograph of the right ankle in ...

Anteroposterior radiograph of the right ankle in a 53-year-old male smoker with lower-limb pain around the hips, knees, and ankles (same patient as in Images 4-5 in Multimedia) shows lamellar periosteal new bone formation around the lower shafts of the tibia and fibula.

Radiograph in a 32-year-old woman treated for Gra...Media file 7: Radiograph in a 32-year-old woman treated for Graves disease (thyrotoxicosis) who presented with a vague discomfort in the hands. Radiograph shows a mixture of hair-on-end and lamellar periosteal reaction around the distal shafts of the second metacarpal bones caused by thyroid acropachy.
Radiograph in a 32-year-old woman treated for Gra...

Radiograph in a 32-year-old woman treated for Graves disease (thyrotoxicosis) who presented with a vague discomfort in the hands. Radiograph shows a mixture of hair-on-end and lamellar periosteal reaction around the distal shafts of the second metacarpal bones caused by thyroid acropachy.

Differential diagnosis. Radiograph of the lower l...Media file 8: Differential diagnosis. Radiograph of the lower legs in a patient presenting with infected ulceration of the right lower leg caused by venous insufficiency. Note the extensive lamellar periosteal new bone around the shafts of the tibia and fibula.
Differential diagnosis. Radiograph of the lower l...

Differential diagnosis. Radiograph of the lower legs in a patient presenting with infected ulceration of the right lower leg caused by venous insufficiency. Note the extensive lamellar periosteal new bone around the shafts of the tibia and fibula.

Differential diagnosis. Lateral radiograph of the...Media file 9: Differential diagnosis. Lateral radiograph of the tibia and fibula in a patient with chronic venous insufficiency shows periosteal new bone formation around the tibia and fibula. Note the arterial and venous calcifications.
Differential diagnosis. Lateral radiograph of the...

Differential diagnosis. Lateral radiograph of the tibia and fibula in a patient with chronic venous insufficiency shows periosteal new bone formation around the tibia and fibula. Note the arterial and venous calcifications.

Differential diagnosis. Anteroposterior radiograp...Media file 10: Differential diagnosis. Anteroposterior radiograph of the femur in an athlete with a previous history of trauma to the thigh shows a traumatic periostitis of the mid femur. Note the calcific myositis.
Differential diagnosis. Anteroposterior radiograp...

Differential diagnosis. Anteroposterior radiograph of the femur in an athlete with a previous history of trauma to the thigh shows a traumatic periostitis of the mid femur. Note the calcific myositis.

Differential diagnosis. Radiograph of the arm in ...Media file 11: Differential diagnosis. Radiograph of the arm in a 3-month-old male infant presenting with fever and irritability shows massive periosteal new bone formation around the humerus, radius, and ulna associated with infantile cortical hyperostosis (Caffey disease). Note the sparing of the proximal phalanges.
Differential diagnosis. Radiograph of the arm in ...

Differential diagnosis. Radiograph of the arm in a 3-month-old male infant presenting with fever and irritability shows massive periosteal new bone formation around the humerus, radius, and ulna associated with infantile cortical hyperostosis (Caffey disease). Note the sparing of the proximal phalanges.

Differential diagnosis. Radionuclide scans show t...Media file 12: Differential diagnosis. Radionuclide scans show the typical appearance of secondary hypertrophic osteoarthropathy caused by a bronchogenic carcinoma.
Differential diagnosis. Radionuclide scans show t...

Differential diagnosis. Radionuclide scans show the typical appearance of secondary hypertrophic osteoarthropathy caused by a bronchogenic carcinoma.

More on Hypertrophic Osteoarthropathy

Overview: Hypertrophic Osteoarthropathy
Imaging: Hypertrophic Osteoarthropathy
Follow-up: Hypertrophic Osteoarthropathy
Multimedia: Hypertrophic Osteoarthropathy
References
Further Reading

References

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  2. Larkin JG. Miscellaneous neurologic, cardiac, pulmonary, and metabolic disorders with rheumatic manifestations. Curr Opin Rheumatol. Feb 1992;4(1):106-12. [Medline].

  3. Martinez-Lavin M, Vargas A, Rivera-Viñas M. Hypertrophic osteoarthropathy: a palindrome with a pathogenic connotation. Curr Opin Rheumatol. Jan 2008;20(1):88-91. [Medline].

  4. Harifi G, Younsi R, Ouilki I, Belkhou A, El Hassani S. [Primary hypertrophic osteoarthropathy in an adolescent]. Rev Med Interne. Apr 2008;29(4):335-6. [Medline].

  5. Spicknall KE, Zirwas MJ, English JC 3rd. Clubbing: an update on diagnosis, differential diagnosis, pathophysiology, and clinical relevance. J Am Acad Dermatol. Jun 2005;52(6):1020-8. [Medline].

  6. Doyle L. Pathogenesis of secondary hypertrophic osteoarthropathy: a hypothesis. Eur Respir J. Feb 1989;2(2):105-6. [Medline].

  7. Stevens M, Helms C, El-Khoury G, Chow S. Unilateral hypertrophic osteoarthropathy associated with aortobifemoral graft infection. AJR Am J Roentgenol. Jun 1998;170(6):1584-6. [Medline].

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  9. Moreira AL, Porto NS, Moreira JS, Ulbrich-Kulczynski JM, Irion KL. Clubbed fingers: radiological evaluation of the nail bed thickness. Clin Anat. May 2008;21(4):314-8. [Medline].

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  12. Sainani NI, Lawande MA, Parikh VP, Pungavkar SA, Patkar DP, Sase KS. MRI diagnosis of hypertrophic osteoarthropathy from a remote childhood malignancy. Skeletal Radiol. Jun 2007;36 Suppl 1:S63-6. [Medline].

  13. Vande Streek P, Carretta RF, Weiland FL, Shelton DK. Upper extremity radionuclide bone imaging: the wrist and hand. Semin Nucl Med. Jan 1998;28(1):14-24. [Medline].

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  15. Boas SR, Charron M, Ledesma-Medina J, et al. Hypertrophic osteoarthropathy in a child with follicular bronchiolitis. Clin Nucl Med. Jan 1995;20(1):49-51. [Medline].

  16. Herneth AM, Breitenseher MJ, Funovics M, et al. Quiz case 12. Marie-Bamberger syndrome (MBS) (hypertrophic osteoarthropathy (HOA) secondary to ulcerative colitis (UC). Eur J Radiol. Nov 1999;32(2):124-8. [Medline].

  17. Matucci-Cerinic M, Lotti T, Calvieri S. The spectrum of dermatological symptoms of pachydermoperiostosis (primary hypertrophic osteoarthropathy): a genetic, cytogenetic and ultrastructural study. Clin Exp Rheumatol. May-Jun 1992;10 Suppl 7:45-8. [Medline].

  18. Rahbar M, Sharma OP. Hypertrophic osteoarthropathy in sarcoidosis. Sarcoidosis. Sep 1990;7(2):125-7. [Medline].

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  20. Silveri F, De Angelis R, Argentati F, et al. Hypertrophic osteoarthropathy: endothelium and platelet function. Clin Rheumatol. Sep 1996;15(5):435-9. [Medline].

  21. Uppal S, Diggle CP, Carr IM, Fishwick CW, Ahmed M, Ibrahim GH, et al. Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. Nat Genet. Jun 2008;40(6):789-93. [Medline].

  22. Varan A, Kutluk T, Demirkazik FB, et al. Hypertrophic osteoarthropathy in a child with nasopharyngeal carcinoma. Pediatr Radiol. Aug 2000;30(8):570-2. [Medline].

Further Reading

Related eMedicine topics

Hypertrophic Osteoarthropathy

Pachydermoperiostosis

Keywords

hypertrophic osteoarthropathy, primary hypertrophic osteoarthropathy, hypertrophic pulmonary osteoarthropathy, pachydermoperiostosis, secondary hypertrophic osteoarthropathy, HOA, HPOA, primary HOA, secondary HOA, idiopathic hypertrophic osteoarthropathy, generalized hyperostosis with pachydermia, idiopathic familial generalized osteophytosis, Touraine-Solente-Gole syndrome,   periostitis, periosteal response, pachydermia, cutis vertices gyrata

Contributor Information and Disclosures

Author

Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR, LRCP, Chairman of Medical Imaging, Professor of Radiology, NGHA, King Fahad National Guard Hospital, King Abdulaziz Medical City, Riyadh, Saudi Arabia
Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR, LRCP is a member of the following medical societies: American Institute of Ultrasound in Medicine, Radiological Society of North America, Royal College of Physicians, Royal College of Physicians and Surgeons of the United States, Royal College of Radiologists, and Royal College of Surgeons of England
Disclosure: Nothing to disclose.

Coauthor(s)

Mohammed Jassim Al-Salman, MBBS, Consulting Radiologist, King Abdul Aziz Medical City, National Guard Hospital
Disclosure: Nothing to disclose.

Dare Mutiyu Seriki, MBBS, FRCR, MRCP, Staff Physician, Department of Radiology, Hope Hospital, UK
Disclosure: Nothing to disclose.

Ian Turnbull, MB, ChB, MD, DMRD, FRCR, Lecturer, Department of Radiology, University of Manchester; Consulting Neuroradiologist, Hope Hospital, Salford, Manchester and North Manchester General Hospital, UK
Disclosure: Nothing to disclose.

Sumaira MacDonald, MBChB, PhD, MRCP, FRCR, Lecturer, Sheffield University Medical School; Endovascular Fellow, Sheffield Vascular Institute
Sumaira MacDonald, MBChB, PhD, MRCP, FRCR is a member of the following medical societies: British Medical Association, Royal College of Physicians, and Royal College of Radiologists
Disclosure: Nothing to disclose.

Medical Editor

Giuseppe Guglielmi, MD, Associate Professor of Radiology, Department of Radiology, Scientific Institute Hospital
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Wilfred CG Peh, MD, MBBS, FRCP(Glasg), FRCP(Edin), FRCR, Clinical Professor, Faculty of Medicine, National University of Singapore; Senior Consultant Radiologist, Alexandra Hospital, Singapore
Wilfred CG Peh, MD, MBBS, FRCP(Glasg), FRCP(Edin), FRCR is a member of the following medical societies: American Roentgen Ray Society, British Institute of Radiology, International Skeletal Society, Radiological Society of North America, Royal College of Physicians, and Royal College of Radiologists
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Felix S Chew, MD, MBA, EdM, Professor, Department of Radiology, Vice Chairman for Radiology Informatics, Section Head of Musculoskeletal Radiology, University of Washington
Felix S Chew, MD, MBA, EdM is a member of the following medical societies: American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

 
 
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