Multimedia
 | Media file 1: Lateral radiograph of the cervical spine in a 10-year-old boy. The spinous process of the C3 vertebra is expanded by a mass with ossific matrix. |
 | Media file 2: T1-weighted sagittal magnetic resonance image of the spine in a 10-year-old boy (same patient as in Images 1 and 3-5 in Multimedia). This image suggests the presence of a mass that involves the posterior elements of the C3 vertebra. |
 | Media file 3: T1-weighted gadolinium-enhanced sagittal magnetic resonance image of the spine in a 10-year-old boy (same patient as in Images 1-2 and 4-5 in Multimedia). This image reveals contrast enhancement of a mass that is occupying the posterior elements of the C3 vertebra. |
 | Media file 4: T2-weighted sagittal magnetic resonance image of the spine in a 10-year-old boy (same patient as in Images 1-3 and 5 in Multimedia). This image delineates the extent of the mass and reveals a homogeneous high signal intensity in the surrounding soft tissues, which is consistent with edema. |
 | Media file 5: Computed tomography scan of the cervical spine in a 10-year-old boy (same patient as in Images 1-4 in Multimedia). This image reveals a lytic lesion that involves the posterior elements of the C3 vertebra. Cortical expansion of the spinous process and an ossified matrix are noted; these findings are typical and classic findings in cases of osteoblastomas. |
 | Media file 6: Knee radiograph from a 16-year-old boy with lower leg pain. This image reveals a somewhat poorly defined and nonspecific lucent lesion in the proximal tibial metaphysis. |
 | Media file 7: Bone scan in a 16-year-old boy complaining of pain (same patient as in Images 6 and 8-9 in Multimedia). This image demonstrates increased radiotracer activity in the right proximal tibia that corresponds to the site of the lesion. The increased uptake in the right distal femur is likely due to tumor-associated relative hyperperfusion of the right knee. |
 | Media file 8: T1-weighted sagittal magnetic resonance image in a 16-year-old boy with lower leg pain (same patient as in Images 6-7 and 9 in Multimedia). This image demonstrates a focal lesion of low signal intensity in the right proximal tibia, with surrounding low-signal-intensity edema. |
 | Media file 9: T2-weighted coronal magnetic resonance image with fat saturation performed on the knee of a 16-year-old male (same patient as in Images 6-8 in Multimedia). This image emphasizes the presence of edema in the adjacent marrow. |
 | Media file 10: Radiograph of the left hip in a 14-year-old boy. This image demonstrates a lytic lesion in the intertrochanteric region of the left femur with a faint, diffuse, surrounding sclerosis. The long bones are the second most common location for osteoblastomas. |
 | Media file 11: Computed tomography scan of the left proximal femur in a 14-year-old boy (same patient as in Images 10 and 12-14 in Multimedia). This image reveals a cortically based nidus with surrounding thickened bone. |
 | Media file 12: T1-weighted magnetic resonance image in a 14-year-old boy (same patient as in Images 10-11 and 13-14 in Multimedia). The lesion demonstrates low signal intensity in this image. |
 | Media file 13: Gadolinium-enhanced magnetic resonance image in a 14-year-old boy (same patient as in Images 10-12 and 14). This image demonstrates enhancement in the lesion. |
 | Media file 14: Fat-suppressed T2-weighted magnetic resonance image in a 14-year-old boy (same patient as in Images 10-13). The lesion is hyperintense in this image. Note the surrounding bone marrow edema, depicted with high signal intensity. |
 | Media file 15: Radiograph of the right shoulder in a 39-year-old woman. This image reveals a large lytic lesion arising in the proximal part of the humerus. |
 | Media file 16: Bone scan in a 39-year-old woman (same patient as in Images 15 and 17-19 in Multimedia). This image demonstrates abnormal radiotracer accumulation at the anatomic site corresponding to that which is shown in the radiograph in Image 15. |
 | Media file 17: Computed tomography scan in a 39-year-old woman (same patient as in Images 15-16 and 18-19 in Multimedia). This image demonstrates faint matrix mineralization. |
 | Media file 18: T1-weighted magnetic resonance image of the shoulder in a 39-year-old woman (same patient as in Images 15-17 and 19). This image reveals a lesion of low signal intensity in the right proximal humerus. Note the extension of the predominantly metaphyseal tumor into the epiphysis. The pathologic specimen demonstrated findings that were consistent with aggressive osteoblastoma. |
 | Media file 19: T2-weighted coronal magnetic resonance image of the shoulder in a 39-year-old woman (same patient as in Images 15-18). The tumor demonstrates heterogeneous signal intensity. |
 | Media file 20: Oblique view of the ankle. This radiograph reveals a lucent lesion within the talus, an uncommon location for osteoblastomas. Although this appearance is consistent for an osteoblastoma, it is nonspecific. |
 | Media file 21: Lateral radiograph of the ankle (same patient as in Images 20 and 22-24). |
 | Media file 22: The computed tomography scan findings are nonspecific and have a benign appearance in this image (same patient as in Images 20-21 and 23-24). |
 | Media file 23: T1-weighted sagittal magnetic resonance image of the left foot (same patient as in Images 20-22 and 24). This image reveals a lesion with low signal intensity in the talus. |
 | Media file 24: T2-weighted magnetic resonance image (MRI) of the left foot (same patient as in Images 20-23). This image demonstrates high signal intensity; the characteristics of this lesion are typical of a neoplastic process, but no specific finding suggests the diagnosis of an osteoblastoma. MRI clearly delineates the extent of the disease process. |
 | Media file 25: Anteroposterior radiographic view of the pelvis in a 14-year-old girl who presented with right hip pain. This image reveals a lucent, slightly expansile lesion in the acetabulum. |
 | Media file 26: Magnified radiographic view of the pelvis in a 14-year-old girl who presented with right hip pain (same patient as in Images 25 and 27-29). This image reveals the same lucent, slightly expansile lesion in the acetabulum as in Image 25. |
 | Media file 27: Bone scan in a 14-year-old girl (same area and same patient as in Images 25-26 and 28-29 in Multimedia). This image reveals radiotracer accumulation in the patient's right hip. |
 | Media file 28: Axial computed tomography scan of the right hip in a 14-year-old girl (same patient as in Images 25-27 and 29). This image reveals small amounts of matrix mineralization and cortical expansion. |
 | Media file 29: T1-weighted coronal magnetic resonance image through the pelvis in a 14-year-old girl (same patient as in Images 25-28). In this image, the lesion is hypointense compared with the adjacent bone marrow. |
 | Media file 30: T1-weighted coronal gadolinium-enhanced magnetic resonance image. This image demonstrates a lesion that enhances slightly, as can be seen in cases with osteoblastomas. |
 | Media file 31: Axial computed tomography scan that was obtained through the tibial diaphysis. This image demonstrates how an osteoblastoma can resemble a large osteoid osteoma, with the typical radiographic features of a central nidus and surrounding reactive bone. |
More on Osteoblastoma |
| Overview: Osteoblastoma |
| Imaging: Osteoblastoma |
| Follow-up: Osteoblastoma |
 Multimedia: Osteoblastoma |
| References |
| « Previous Page |
References
Resnick D. Tumors and tumor-like lesions of bone: imaging and pathology of specific lesions. Diagnosis of Bone and Joint Disorders. 3rd ed. Philadelphia, Pa: WB Saunders Co; 1995:3647-57.
Frassica FJ, Waltrip RL, Sponseller PD, Ma LD, McCarthy EF Jr. Clinicopathologic features and treatment of osteoid osteoma and osteoblastoma in children and adolescents. Orthop Clin North Am. Jul 1996;27(3):559-74. [Medline].
de Oliveira CR, Mendonça BB, de Camargo OP, et al. Classical osteoblastoma, atypical osteoblastoma, and osteosarcoma: a comparative study based on clinical, histological, and biological parameters. Clinics. Apr 2007;62(2):167-74. [Medline]. [Full Text].
Jambhekar NA, Desai S, Khapake D. Osteoblastoma: a study of 12 cases. Indian J Pathol Microbiol. Oct 2006;49(4):487-90. [Medline].
Kyriakos M, El-Khoury GY, McDonald DJ, et al. Osteoblastomatosis of bone. A benign, multifocal osteoblastic lesion, distinct from osteoid osteoma and osteoblastoma, radiologically simulating a vascular tumor. Skeletal Radiol. Mar 2007;36(3):237-47. [Medline].
Berry M, Mankin H, Gebhardt M, Rosenberg A, Hornicek F. Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. Sep 1 2008;98(3):179-83. [Medline].
Akbarnia BA, Rooholamini SA. Scoliosis caused by benign osteoblastoma of the thoracic or lumbar spine. J Bone Joint Surg Am. Sep 1981;63(7):1146-55. [Medline]. [Full Text].
Griffin JB. Benign osteoblastoma of the thoracic spine. Case report with fifteen-year follow-up. J Bone Joint Surg Am. Sep 1978;60(6):833-5. [Medline]. [Full Text].
Kroon HM, Schurmans J. Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology. Jun 1990;175(3):783-90. [Medline]. [Full Text].
Saifuddin A, White J, Sherazi Z, et al. Osteoid osteoma and osteoblastoma of the spine. Factors associated with the presence of scoliosis. Spine. Jan 1 1998;23(1):47-53. [Medline].
Bertoni F, Unni KK, McLeod RA, Dahlin DC. Osteosarcoma resembling osteoblastoma. Cancer. Jan 15 1985;55(2):416-26. [Medline].
Dorfman HD, Weiss SW. Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcoma. Semin Diagn Pathol. Aug 1984;1(3):215-34. [Medline].
Mitchell ML, Ackerman LV. Metastatic and pseudomalignant osteoblastoma: a report of two unusual cases. Skeletal Radiol. 1986;15(3):213-8. [Medline].
Tonai M, Campbell CJ, Ahn GH, Schiller AL, Mankin HJ. Osteoblastoma: classification and report of 16 patients. Clin Orthop Relat Res. Jul 1982;167:222-35. [Medline].
Marsh BW, Bonfiglio M, Brady LP, Enneking WF. Benign osteoblastoma: range of manifestations. J Bone Joint Surg Am. Jan 1975;57(1):1-9. [Medline]. [Full Text].
Khermosh O, Schujman E. Benign osteoblastoma of the calcaneous. Clin Orthop Relat Res. 1977;127:197-9. [Medline].
Jones AC, Prihoda TJ, Kacher JE, Odingo NA, Freedman PD. Osteoblastoma of the maxilla and mandible: a report of 24 cases, review of the literature, and discussion of its relationship to osteoid osteoma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Nov 2006;102(5):639-50. [Medline].
Rawal YB, Angiero F, Allen CM, et al. Gnathic osteoblastoma: clinicopathologic review of seven cases with long-term follow-up. Oral Oncol. Feb 2006;42(2):123-30. [Medline].
Kent JN, Castro HF, Girotti WR. Benign osteoblastoma of the maxilla. Case report and review of the literature. Oral Surg Oral Med Oral Pathol. Feb 1969;27(2):209-19. [Medline].
Potter C, Conner GH, Sharkey FE. Benign osteoblastoma of the temporal bone. Am J Otol. Apr 1983;4(4):318-22. [Medline].
Williams RN, Boop WC Jr. Benign osteoblastoma of the skull. Case report. J Neurosurg. Dec 1974;41(6):769-72. [Medline].
Tulloh HP, Harry D. Osteoblastoma in a rib in childhood. Clin Radiol. Jul 1969;20(3):337-8. [Medline].
Papagelopoulos PJ, Galanis EC, Sim FH, Unni KK. Osteoblastoma of the acetabulum. Orthopedics. Mar 1998;21(3):355-8. [Medline].
Roy HK, Khandekar JD. Biomarkers for the early detection of cancer: an inflammatory concept. Arch Intern Med. Sep 24 2007;167(17):1822-4. [Medline].
Arkader A, Dormans JP. Osteoblastoma in the skeletally immature. J Pediatr Orthop. Jul-Aug 2008;28(5):555-60. [Medline].
Trübenbach J, Nägele T, Bauer T, Ernemann U. Preoperative embolization of cervical spine osteoblastomas: report of three cases. AJNR Am J Neuroradiol. Oct 2006;27(9):1910-2. [Medline]. [Full Text].
Samdani A, Torre-Healy A, Chou D, Cahill AM, Storm PB. Treatment of osteoblastoma at C7: a multidisciplinary approach. A case report and review of the literature. Eur Spine J. Oct 7 2008;[Medline].
Puri A, Agarwal MG, Shah M, Srinivas CH, Shukla PJ, Shrikhande SV, et al. Decision making in primary sacral tumors. Spine J. Dec 5 2008;[Medline].
Shaikh MI, Saifuddin A, Pringle J, Natali C, Sherazi Z. Spinal osteoblastoma: CT and MR imaging with pathological correlation. Skeletal Radiol. Jan 1999;28(1):33-40. [Medline].
Lefton DR, Torrisi JM, Haller JO. Vertebral osteoid osteoma masquerading as a malignant bone or soft-tissue tumor on MRI. Pediatr Radiol. Jan 2001;31(2):72-5. [Medline].
Van Dyck P, Vanhoenacker FM, Vogel J, et al. Prevalence, extension and characteristics of fluid-fluid levels in bone and soft tissue tumors. Eur Radiol. Dec 2006;16(12):2644-51. [Medline].
González-Sistal A, Baltasar Sánchez A. A complementary method for the detection of osteoblastic metastases on digitized radiographs. J Digit Imaging. Sep 2006;19(3):270-5. [Medline].
Chakrapani SD, Grim K, Kaimaktchiev V, Anderson JC. Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine. Dec 1 2008;33(25):E968-70. [Medline].
Biagini R, Orsini U, Demitri S, et al. Osteoid osteoma and osteoblastoma of the sacrum. Orthopedics. Nov 2001;24(11):1061-4. [Medline].
Chew FS, Pena CS, Keel SB. Cervical spine osteoblastoma. AJR Am J Roentgenol. Nov 1998;171(5):1244. [Medline]. [Full Text].
Crim JR, Mirra JM, Eckardt JJ, Seeger LL. Widespread inflammatory response to osteoblastoma: the flare phenomenon. Radiology. Dec 1990;177(3):835-6. [Medline]. [Full Text].
Murphey MD, Andrews CL, Flemming DJ, et al. From the archives of the AFIP. Primary tumors of the spine: radiologic pathologic correlation. Radiographics. Sep 1996;16(5):1131-58. [Medline]. [Full Text].
Papagelopoulos PJ, Galanis EC, Sim FH, Unni KK. Clinicopathologic features, diagnosis, and treatment of osteoblastoma. Orthopedics. Feb 1999;22(2):244-7; quiz 248-9. [Medline].
Ramirez JA, Sandoz JC, Kaakaji Y, Nietzschman HR. Case 3: Aggressive osteoblastoma. AJR Am J Roentgenol. Sep 1998;171(3):863, 867-8. [Medline].
Ruggieri P, McLeod RA, Unni KK, Sim FH. Osteoblastoma. Orthopedics. Jul 1996;19(7):621-4. [Medline].
Sherazi Z, Saifuddin A, Shaikh MI, Natali C, Pringle JA. Unusual imaging findings in association with spinal osteoblastoma. Clin Radiol. Sep 1996;51(9):644-8. [Medline].
Further Reading
Keywords
osteoblastoma, giant osteoid osteoma, bone neoplasm, osteoid osteoma, bone tumor, primary bone tumor, benign bone tumor, benign lesion of the bone, scoliosis, matrix mineralization
