eMedicine Specialties > Radiology > Musculoskeletal

Osteosarcoma, Variants: Follow-up

Author: Geoff Hide, MBBS, MRCP, FRCR, Consultant Musculoskeletal Radiologist, Department of Radiology, Freeman Hospital; Honorary Clinical Lecturer, Faculty of Medical Sciences, University of Newcastle upon Tyne
Contributor Information and Disclosures

Updated: May 21, 2007

Intervention

Histologic confirmation of the nature of the tumor is initially required; the analysis should be performed after MRI and in consultation with the tumor surgeon. Biopsy must be performed after the MRI study because hemorrhage occurring at the time of biopsy alters the signal intensity characteristics of the tumor at subsequent MRI examinations. The site of the biopsy track must be planned to prevent contaminating the muscle compartments that the surgeon would not otherwise excise. The biopsy track is removed during surgery, and consideration should be given to marking the track with suture material or dye if there will be a delay between biopsy and formal excision.

Tumors are often densely sclerotic and difficult to examine with percutaneous biopsy, but the associated soft-tissue component is often amenable to sonography-guided biopsy.

Treatment is geared around surgery, with limb salvage when possible. Presurgical chemotherapy is used. The response to chemotherapy is assessed in the resected specimen or by means of pre-resection biopsy. The response is considered good when tumor necrosis is greater than 90%. This necrosis is a predictor of a successful outcome.

 


More on Osteosarcoma, Variants

Overview: Osteosarcoma, Variants
Imaging: Osteosarcoma, Variants
Follow-up: Osteosarcoma, Variants
Multimedia: Osteosarcoma, Variants
References
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References

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Further Reading

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Keywords

primary malignant tumor of bone, bone tumor, bone malignancy

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Contributor Information and Disclosures

Author

Geoff Hide, MBBS, MRCP, FRCR, Consultant Musculoskeletal Radiologist, Department of Radiology, Freeman Hospital; Honorary Clinical Lecturer, Faculty of Medical Sciences, University of Newcastle upon Tyne
Geoff Hide, MBBS, MRCP, FRCR is a member of the following medical societies: British Medical Association, Royal College of Physicians, and Royal College of Radiologists
Disclosure: Nothing to disclose.

Medical Editor

Amilcare Gentili, MD, Clinical Professor of Radiology, University of California at San Diego; Consulting Staff, Department of Radiology, Thornton Hospital
Amilcare Gentili, MD is a member of the following medical societies: American Roentgen Ray Society, Radiological Society of North America, and Society of Skeletal Radiology
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Murali Sundaram, MBBS, FRCR, FACR, Consulting Staff, Department of Diagnostic Radiology, The Cleveland Clinic Foundation
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Felix S Chew, MD, MBA, EdM, Professor, Department of Radiology, Vice Chairman for Radiology Informatics, Section Head of Musculoskeletal Radiology, University of Washington
Felix S Chew, MD, MBA, EdM is a member of the following medical societies: American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

 
 
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