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Osteosarcoma, Variants: Multimedia

Author: Geoff Hide, MBBS, MRCP, FRCR, Consultant Musculoskeletal Radiologist, Department of Radiology, Freeman Hospital; Honorary Clinical Lecturer, Faculty of Medical Sciences, University of Newcastle upon Tyne
Contributor Information and Disclosures

Updated: May 21, 2007

Multimedia

Frontal radiograph of the distal femur in a patie...Media file 1: Frontal radiograph of the distal femur in a patient with telangiectatic osteosarcoma. The radiograph shows mixed medullary sclerosis and lucency, cortical destruction medially, aggressive periosteal changes, and a large soft-tissue mass with peripheral ossification.
Frontal radiograph of the distal femur in a patie...

Frontal radiograph of the distal femur in a patient with telangiectatic osteosarcoma. The radiograph shows mixed medullary sclerosis and lucency, cortical destruction medially, aggressive periosteal changes, and a large soft-tissue mass with peripheral ossification.

Coronal short-tau inversion recovery (STIR) magne...Media file 2: Coronal short-tau inversion recovery (STIR) magnetic resonance imaging (MRI) scan of the same patient as in Image 1. Note the abnormal signal intensity of the bone marrow in the metaphysis of the femur, the cortical destruction, and the prominent soft-tissue mass with the surrounding edema or reactive zone.
Coronal short-tau inversion recovery (STIR) magne...

Coronal short-tau inversion recovery (STIR) magnetic resonance imaging (MRI) scan of the same patient as in Image 1. Note the abnormal signal intensity of the bone marrow in the metaphysis of the femur, the cortical destruction, and the prominent soft-tissue mass with the surrounding edema or reactive zone.

Axial T2-weighted magnetic resonance imaging (MRI...Media file 3: Axial T2-weighted magnetic resonance imaging (MRI) scan of the same patient as in Images 1-2. A fluid-fluid level is present within the abnormal extraosseous tumor mass (arrow). The abnormal intramedullary tissue is less obvious in this sequence than in others.
Axial T2-weighted magnetic resonance imaging (MRI...

Axial T2-weighted magnetic resonance imaging (MRI) scan of the same patient as in Images 1-2. A fluid-fluid level is present within the abnormal extraosseous tumor mass (arrow). The abnormal intramedullary tissue is less obvious in this sequence than in others.

Lateral radiograph of the proximal tibia in a pat...Media file 4: Lateral radiograph of the proximal tibia in a patient with parosteal osteosarcoma. Note the opaque, lobulated, amorphous or cloudlike mass of abnormal, ossified tumor, which is inseparable from the posterior aspect of the tibia.
Lateral radiograph of the proximal tibia in a pat...

Lateral radiograph of the proximal tibia in a patient with parosteal osteosarcoma. Note the opaque, lobulated, amorphous or cloudlike mass of abnormal, ossified tumor, which is inseparable from the posterior aspect of the tibia.

Axial computed tomography (CT) scan of the same p...Media file 5: Axial computed tomography (CT) scan of the same patient as in Image 4. The ossified tumor mass is readily shown, and the thickened cortex is visible at the junction of tumor and normal bone (arrow). The medullary cavity of the tibia appears normal.
Axial computed tomography (CT) scan of the same p...

Axial computed tomography (CT) scan of the same patient as in Image 4. The ossified tumor mass is readily shown, and the thickened cortex is visible at the junction of tumor and normal bone (arrow). The medullary cavity of the tibia appears normal.

Axial T1-weighted magnetic resonance imaging (MRI...Media file 6: Axial T1-weighted magnetic resonance imaging (MRI) scan of the same patient as in Images 4-5. The medullary cavity of the tibia shows predominantly normal signal intensity, except posteriorly, where the slightly reduced signal intensity raises the possibility of early tumoral invasion (arrow). This area was normal on histologic examination.
Axial T1-weighted magnetic resonance imaging (MRI...

Axial T1-weighted magnetic resonance imaging (MRI) scan of the same patient as in Images 4-5. The medullary cavity of the tibia shows predominantly normal signal intensity, except posteriorly, where the slightly reduced signal intensity raises the possibility of early tumoral invasion (arrow). This area was normal on histologic examination.

Anteroposterior (AP) radiograph of the proximal t...Media file 7: Anteroposterior (AP) radiograph of the proximal tibia in a child with periosteal osteosarcoma. The metal pointer localizes the lesion for biopsy.
Anteroposterior (AP) radiograph of the proximal t...

Anteroposterior (AP) radiograph of the proximal tibia in a child with periosteal osteosarcoma. The metal pointer localizes the lesion for biopsy.

Coronal short-tau inversion recovery (STIR) magne...Media file 8: Coronal short-tau inversion recovery (STIR) magnetic resonance imaging (MRI) scan of the same patient as in Image 7. The ossified component of the tumor shows low signal intensity (white arrow), but superficially, hyperintense material (black arrow) is present. This may be chondroblastic soft-tissue extension of tumor, adjacent reactive edema, or a combination of both.
Coronal short-tau inversion recovery (STIR) magne...

Coronal short-tau inversion recovery (STIR) magnetic resonance imaging (MRI) scan of the same patient as in Image 7. The ossified component of the tumor shows low signal intensity (white arrow), but superficially, hyperintense material (black arrow) is present. This may be chondroblastic soft-tissue extension of tumor, adjacent reactive edema, or a combination of both.

Frontal radiograph of the mandible in an adult wi...Media file 9: Frontal radiograph of the mandible in an adult with gnathic osteosarcoma. The radiograph shows a large, expansile lesion in the right ramus (arrow), with a mixed lytic and sclerotic appearance.
Frontal radiograph of the mandible in an adult wi...

Frontal radiograph of the mandible in an adult with gnathic osteosarcoma. The radiograph shows a large, expansile lesion in the right ramus (arrow), with a mixed lytic and sclerotic appearance.

Axial computed tomography (CT) scan obtained with...Media file 10: Axial computed tomography (CT) scan obtained with bone window settings, in the same patient as in Image 9. Osseous expansion and the mixed lytic and sclerotic process are again appreciated. A large soft-tissue component (arrow) also is now visible.
Axial computed tomography (CT) scan obtained with...

Axial computed tomography (CT) scan obtained with bone window settings, in the same patient as in Image 9. Osseous expansion and the mixed lytic and sclerotic process are again appreciated. A large soft-tissue component (arrow) also is now visible.

Axial computed tomography (CT) scan obtained with...Media file 11: Axial computed tomography (CT) scan obtained with soft-tissue window settings, in the same patient as in Images 9-10. Extension of ossified matrix into the soft-tissue component of the tumor is shown (arrow).
Axial computed tomography (CT) scan obtained with...

Axial computed tomography (CT) scan obtained with soft-tissue window settings, in the same patient as in Images 9-10. Extension of ossified matrix into the soft-tissue component of the tumor is shown (arrow).

Anteroposterior (AP) radiograph of the proximal f...Media file 12: Anteroposterior (AP) radiograph of the proximal femur in a patient with Paget disease demonstrates the typical features of cortical thickening, osseous expansion, and trabecular coarsening. In addition, irregular bone lucency and cortical destruction are shown in the medial aspect of the shaft; this is consistent with secondary sarcoma formation.
Anteroposterior (AP) radiograph of the proximal f...

Anteroposterior (AP) radiograph of the proximal femur in a patient with Paget disease demonstrates the typical features of cortical thickening, osseous expansion, and trabecular coarsening. In addition, irregular bone lucency and cortical destruction are shown in the medial aspect of the shaft; this is consistent with secondary sarcoma formation.

Localized isotopic bone scan in the same patient ...Media file 13: Localized isotopic bone scan in the same patient as in Image 12 shows a large area of reduced uptake in the medial side of the proximal femoral shaft at the site of the secondary sarcoma (arrow).
Localized isotopic bone scan in the same patient ...

Localized isotopic bone scan in the same patient as in Image 12 shows a large area of reduced uptake in the medial side of the proximal femoral shaft at the site of the secondary sarcoma (arrow).

Coronal T1-weighted magnetic resonance imaging (M...Media file 14: Coronal T1-weighted magnetic resonance imaging (MRI) scan of the same patient as in Images 12-13. The tumor is shown in the proximal shaft of the right femur (white arrow), with cortical destruction and a large soft-tissue component (black arrow).
Coronal T1-weighted magnetic resonance imaging (M...

Coronal T1-weighted magnetic resonance imaging (MRI) scan of the same patient as in Images 12-13. The tumor is shown in the proximal shaft of the right femur (white arrow), with cortical destruction and a large soft-tissue component (black arrow).

More on Osteosarcoma, Variants

Overview: Osteosarcoma, Variants
Imaging: Osteosarcoma, Variants
Follow-up: Osteosarcoma, Variants
Multimedia: Osteosarcoma, Variants
References

References

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Further Reading

Keywords

primary malignant tumor of bone, bone tumor, bone malignancy

Contributor Information and Disclosures

Author

Geoff Hide, MBBS, MRCP, FRCR, Consultant Musculoskeletal Radiologist, Department of Radiology, Freeman Hospital; Honorary Clinical Lecturer, Faculty of Medical Sciences, University of Newcastle upon Tyne
Geoff Hide, MBBS, MRCP, FRCR is a member of the following medical societies: British Medical Association, Royal College of Physicians, and Royal College of Radiologists
Disclosure: Nothing to disclose.

Medical Editor

Amilcare Gentili, MD, Clinical Professor of Radiology, University of California at San Diego; Consulting Staff, Department of Radiology, Thornton Hospital
Amilcare Gentili, MD is a member of the following medical societies: American Roentgen Ray Society, Radiological Society of North America, and Society of Skeletal Radiology
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Murali Sundaram, MBBS, FRCR, FACR, Consulting Staff, Department of Diagnostic Radiology, The Cleveland Clinic Foundation
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Felix S Chew, MD, MBA, EdM, Professor, Department of Radiology, Vice Chairman for Radiology Informatics, Section Head of Musculoskeletal Radiology, University of Washington
Felix S Chew, MD, MBA, EdM is a member of the following medical societies: American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

 
 
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