eMedicine Specialties > Radiology > Musculoskeletal

Paget Disease: Multimedia

Author: Mitchell J Kline, MD, Consulting Staff, Department of Diagnostic Radiology, University of Louisville, Clark Memorial and Floyd Memorial Hospitals
Contributor Information and Disclosures

Updated: Dec 12, 2007

Multimedia

Photomicrograph of bone involved with late-stage ...Media file 1: Photomicrograph of bone involved with late-stage Paget disease demonstrates intersecting remodeling lines forming a mosaic pattern.
Photomicrograph of bone involved with late-stage ...

Photomicrograph of bone involved with late-stage Paget disease demonstrates intersecting remodeling lines forming a mosaic pattern.

Lateral radiograph of the tibia in a patient with...Media file 2: Lateral radiograph of the tibia in a patient with Paget sarcoma reveals a destructive bone-forming mass in the proximal tibia (osteosarcoma).
Lateral radiograph of the tibia in a patient with...

Lateral radiograph of the tibia in a patient with Paget sarcoma reveals a destructive bone-forming mass in the proximal tibia (osteosarcoma).

Anteroposterior radiograph of the hip in a patien...Media file 3: Anteroposterior radiograph of the hip in a patient with Paget disease demonstrates dense sclerosis involving the femoral head and neck (arrows). This is a high-risk area for insufficiency fracture.
Anteroposterior radiograph of the hip in a patien...

Anteroposterior radiograph of the hip in a patient with Paget disease demonstrates dense sclerosis involving the femoral head and neck (arrows). This is a high-risk area for insufficiency fracture.

Anteroposterior radiograph of the femur in a pati...Media file 4: Anteroposterior radiograph of the femur in a patient with late-stage Paget disease reveals a transverse insufficiency fracture through the proximal femoral shaft (banana fracture).
Anteroposterior radiograph of the femur in a pati...

Anteroposterior radiograph of the femur in a patient with late-stage Paget disease reveals a transverse insufficiency fracture through the proximal femoral shaft (banana fracture).

Lateral skull radiograph in a patient with Paget ...Media file 5: Lateral skull radiograph in a patient with Paget disease demonstrates a large, well-circumscribed lytic lesion (arrows) in the frontal and parietal bones (osteoporosis circumscripta).
Lateral skull radiograph in a patient with Paget ...

Lateral skull radiograph in a patient with Paget disease demonstrates a large, well-circumscribed lytic lesion (arrows) in the frontal and parietal bones (osteoporosis circumscripta).

Lateral radiograph of the calvarium in a patient ...Media file 6: Lateral radiograph of the calvarium in a patient with Paget disease reveals multiple patches of sclerotic bone in the calvarium (cotton wool appearance).
Lateral radiograph of the calvarium in a patient ...

Lateral radiograph of the calvarium in a patient with Paget disease reveals multiple patches of sclerotic bone in the calvarium (cotton wool appearance).

Lateral radiograph of the lumbar spine in a patie...Media file 7: Lateral radiograph of the lumbar spine in a patient with Paget disease demonstrates enlargement of an involved vertebral body (arrow), with sclerosis more prominent at the vertebral endplates (picture frame vertebra).
Lateral radiograph of the lumbar spine in a patie...

Lateral radiograph of the lumbar spine in a patient with Paget disease demonstrates enlargement of an involved vertebral body (arrow), with sclerosis more prominent at the vertebral endplates (picture frame vertebra).

Lateral radiograph of the upper thoracic spine re...Media file 8: Lateral radiograph of the upper thoracic spine reveals a densely sclerotic vertebral body (ivory vertebra) caused by Paget disease (arrow). The appearance mimics findings that can be observed with malignant neoplasm such as lymphoma or metastatic disease.
Lateral radiograph of the upper thoracic spine re...

Lateral radiograph of the upper thoracic spine reveals a densely sclerotic vertebral body (ivory vertebra) caused by Paget disease (arrow). The appearance mimics findings that can be observed with malignant neoplasm such as lymphoma or metastatic disease.

Anteroposterior radiograph of the pelvis demonstr...Media file 9: Anteroposterior radiograph of the pelvis demonstrates thickening of the right iliopectineal line (small arrows), as well as later-stage involvement with Paget disease, including trabecular coarsening and patchy sclerosis (large arrow).
Anteroposterior radiograph of the pelvis demonstr...

Anteroposterior radiograph of the pelvis demonstrates thickening of the right iliopectineal line (small arrows), as well as later-stage involvement with Paget disease, including trabecular coarsening and patchy sclerosis (large arrow).

Anteroposterior radiograph of the right hip, cone...Media file 10: Anteroposterior radiograph of the right hip, coned down on the obturator ring, reveals patchy sclerosis and disorganized coarsened trabecula characteristic of late-stage Paget disease. An insufficiency fracture of the ischium inferior to the acetabulum (arrows) is present.
Anteroposterior radiograph of the right hip, cone...

Anteroposterior radiograph of the right hip, coned down on the obturator ring, reveals patchy sclerosis and disorganized coarsened trabecula characteristic of late-stage Paget disease. An insufficiency fracture of the ischium inferior to the acetabulum (arrows) is present.

Coned down anteroposterior radiograph of the knee...Media file 11: Coned down anteroposterior radiograph of the knee demonstrates an abnormal lucency in the distal femur with a flame-shaped or "blade of grass"-shaped proximal margin caused by the advancing lytic phase of Paget disease (black arrows). Courtesy of Lee F. Rogers.
Coned down anteroposterior radiograph of the knee...

Coned down anteroposterior radiograph of the knee demonstrates an abnormal lucency in the distal femur with a flame-shaped or "blade of grass"-shaped proximal margin caused by the advancing lytic phase of Paget disease (black arrows). Courtesy of Lee F. Rogers.

Lateral coned down radiograph of the tibia reveal...Media file 12: Lateral coned down radiograph of the tibia reveals replacement of the tibial tubercle with pagetic bone that has mixed osteolysis and sclerosis (arrows).
Lateral coned down radiograph of the tibia reveal...

Lateral coned down radiograph of the tibia reveals replacement of the tibial tubercle with pagetic bone that has mixed osteolysis and sclerosis (arrows).

Anteroposterior radiograph of the distal forearm ...Media file 13: Anteroposterior radiograph of the distal forearm demonstrates mixed-phase Paget disease in the distal radius with lytic disease proximally (white arrows) and coarsened trabeculae more distally (black arrow).
Anteroposterior radiograph of the distal forearm ...

Anteroposterior radiograph of the distal forearm demonstrates mixed-phase Paget disease in the distal radius with lytic disease proximally (white arrows) and coarsened trabeculae more distally (black arrow).

Anteroposterior radiograph of the proximal femur ...Media file 14: Anteroposterior radiograph of the proximal femur involved with intermediate (mixed phase) Paget disease reveals characteristic insufficiency fractures on the convex surface of the bone (arrow).
Anteroposterior radiograph of the proximal femur ...

Anteroposterior radiograph of the proximal femur involved with intermediate (mixed phase) Paget disease reveals characteristic insufficiency fractures on the convex surface of the bone (arrow).

CT image of the first sacral vertebra demonstrate...Media file 15: CT image of the first sacral vertebra demonstrates marked cortical thickening (arrows) and trabecular coarsening. Courtesy of Lee F. Rogers.
CT image of the first sacral vertebra demonstrate...

CT image of the first sacral vertebra demonstrates marked cortical thickening (arrows) and trabecular coarsening. Courtesy of Lee F. Rogers.

Axial T1-weighted MRI of the knee in a patient wi...Media file 16: Axial T1-weighted MRI of the knee in a patient with Paget disease reveals prominent dark lines in the medullary bone, indicating trabecular coarsening (arrows). Courtesy of Lee F. Rogers.
Axial T1-weighted MRI of the knee in a patient wi...

Axial T1-weighted MRI of the knee in a patient with Paget disease reveals prominent dark lines in the medullary bone, indicating trabecular coarsening (arrows). Courtesy of Lee F. Rogers.

Sagittal T1-weighted MRI of the lumbar spine demo...Media file 17: Sagittal T1-weighted MRI of the lumbar spine demonstrates enlargement of the fourth lumbar vertebral body with no central canal encroachment (arrows). Courtesy of Lee F. Rogers.
Sagittal T1-weighted MRI of the lumbar spine demo...

Sagittal T1-weighted MRI of the lumbar spine demonstrates enlargement of the fourth lumbar vertebral body with no central canal encroachment (arrows). Courtesy of Lee F. Rogers.

Whole-body bone scan in a patient with polyostoti...Media file 18: Whole-body bone scan in a patient with polyostotic Paget disease reveals intense uptake of radiopharmaceutical in the femur, pelvis, spine, and proximal right humerus. The cortical discontinuity of the proximal right humerus represents an insufficiency fracture (arrow). Courtesy of Lee F. Rogers.
Whole-body bone scan in a patient with polyostoti...

Whole-body bone scan in a patient with polyostotic Paget disease reveals intense uptake of radiopharmaceutical in the femur, pelvis, spine, and proximal right humerus. The cortical discontinuity of the proximal right humerus represents an insufficiency fracture (arrow). Courtesy of Lee F. Rogers.

Anterior image of the thoracic and lumbar spine i...Media file 19: Anterior image of the thoracic and lumbar spine in a 75-year-old man demonstrates intense radiopharmaceutical uptake in the third lumbar vertebra, which is involved with Paget disease (arrows). Courtesy of Lee F. Rogers.
Anterior image of the thoracic and lumbar spine i...

Anterior image of the thoracic and lumbar spine in a 75-year-old man demonstrates intense radiopharmaceutical uptake in the third lumbar vertebra, which is involved with Paget disease (arrows). Courtesy of Lee F. Rogers.

More on Paget Disease

Overview: Paget Disease
Imaging: Paget Disease
Follow-up: Paget Disease
Multimedia: Paget Disease
References

References

  1. Paget J. On a form of chronic inflammation of bones (osteitis deformans). Med Chir Tr. 1877;60:37.

  2. Singer FR. Update on the viral etiology of Paget''s disease of bone. J Bone Miner Res. Oct 1999;14 Suppl 2:29-33. [Medline].

  3. Barker DJ. The epidemiology of Paget''s disease of bone. Br Med Bull. Oct 1984;40(4):396-400. [Medline].

  4. Siris ES, Ottman R, Flaster E. Familial aggregation of Paget''s disease of bone. J Bone Miner Res. May 1991;6(5):495-500. [Medline].

  5. Layfield R. The molecular pathogenesis of Paget disease of bone. Expert Rev Mol Med. 2007;9(27):1-13. [Medline].

  6. Guyer PB, Chamberlain AT. Paget''s disease of bone in two American cities. Br Med J. Apr 5 1980;280(6219):985. [Medline].

  7. Barker DJ, Clough PW, Guyer PB. Paget''s disease of bone in 14 British towns. Br Med J. May 7 1977;1(6070):1181-3. [Medline].

  8. Schmorl G. Ueber Ostitis deformans Paget. Virchows Arch. 1932;283:694-751.

  9. Rojas-Villarraga A, Patarroyo PA, Contreras AS, Restrepo JF, Iglesias-Gamarra A. Paget disease of bone in Colombia and Latin America. J Clin Rheumatol. Apr 2006;12(2):57-60. [Medline].

  10. Harrington KD. Surgical management of neoplastic complications of Paget''s disease. J Bone Miner Res. Oct 1999;14 Suppl 2:45-8. [Medline].

  11. Smith J, Botet JF, Yeh SD. Bone sarcomas in Paget disease: a study of 85 patients. Radiology. Sep 1984;152(3):583-90. [Medline].

  12. Deyrup AT, Montag AG, Inwards CY, Xu Z, Swee RG, Krishnan Unni K. Sarcomas arising in Paget disease of bone: a clinicopathologic analysis of 70 cases. Arch Pathol Lab Med. Jun 2007;131(6):942-6. [Medline].

  13. , Sharma H, Mehdi SA, MacDuff E, Reece AT, Jane MJ. Paget sarcoma of the spine: Scottish Bone Tumor Registry experience. Spine. May 20 2006;31(12):1344-50. [Medline].

  14. Hamdy RC. Paget's Disease of the Bone: Assessment and Management. Westport, CT:. Greenwood Publishing Group;1981.

  15. Gebhart M, Vandeweyer E, Nemec E. Paget''s disease of bone complicated by giant cell tumor. Clin Orthop. Jul 1998;(352):187-93. [Medline].

  16. Altman RD, Collins B. Musculoskeletal manifestations of Paget''s disease of bone. Arthritis Rheum. Oct 1980;23(10):1121-7. [Medline].

  17. Tiegs RD. Paget''s disease of bone: indications for treatment and goals of therapy. Clin Ther. Nov-Dec 1997;19(6):1309-29; discussion 1523-4. [Medline].

Further Reading

Keywords

osteitis deformans, Paget's disease

Contributor Information and Disclosures

Author

Mitchell J Kline, MD, Consulting Staff, Department of Diagnostic Radiology, University of Louisville, Clark Memorial and Floyd Memorial Hospitals
Mitchell J Kline, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Radiology, American Roentgen Ray Society, Radiological Society of North America, and Society of Skeletal Radiology
Disclosure: Nothing to disclose.

Medical Editor

Leon Lenchik, MD, Director, Densitometry Minifellowship, Assistant Professor, Department of Radiology, Wake Forest University Medical Center
Leon Lenchik, MD is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, and Radiological Society of North America
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Wilfred CG Peh, MD, MBBS, FRCP(Glasg), FRCP(Edin), FRCR, MHSM, Clinical Professor, Faculty of Medicine, National University of Singapore; Senior Consultant Radiologist, Programme Office, Singapore Health Services
Wilfred CG Peh, MD, MBBS, FRCP(Glasg), FRCP(Edin), FRCR, MHSM is a member of the following medical societies: American Roentgen Ray Society, British Institute of Radiology, International Skeletal Society, Radiological Society of North America, Royal College of Physicians, and Royal College of Radiologists
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Felix S Chew, MD, MBA, EdM, Professor, Department of Radiology, Vice Chairman for Radiology Informatics, Section Head of Musculoskeletal Radiology, University of Washington
Felix S Chew, MD, MBA, EdM is a member of the following medical societies: American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.