eMedicine Specialties > Radiology > Pediatrics

Neuroblastoma: Follow-up

Author: Steven F West, DO, Consulting Staff, Department of Radiology, Brookhaven Memorial Hospital Medical Center
Coauthor(s): Jennith D Correa, DO, Staff Physician, Department of Emergency Medicine, Mount Sinai Medical Center; Michelle Germaine, DO, Staff Physician, Department of Obstetrics and Gynecology, St Vincent Catholic Medical Center; Dvorah Balsam, MD, Chief, Division of Pediatric Radiology, Nassau University Medical Center; Professor, Department of Clinical Radiology, State University of New York at Stony Brook; Joel Rosen, MD, Chief, Department of Nuclear Medicine, Nassau University Medical Center
Contributor Information and Disclosures

Updated: Aug 4, 2008

Intervention

The role for interventional radiology is controversial. Percutaneous biopsy can offer diagnostic and prognostic factors that are necessary to assign the patient to a low, intermediate, or high-risk treatment protocol, such as DNA index, N-MYC status, and favorable or unfavorable histology. Dr Shimada, who defined the current histologic system, currently does not recognize the role of percutaneous needle biopsy for diagnosis.16  

Radiofrequency ablation potentially can treat limited hepatic or bone metastases. However, hepatic metastases often regress with age or treatment, and bone metastases can respond to chemotherapy or radiotherapy.

 


More on Neuroblastoma

Overview: Neuroblastoma
Imaging: Neuroblastoma
Follow-up: Neuroblastoma
Multimedia: Neuroblastoma
References
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References

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  2. De Bernardi B, Gambini C, Haupt R, Granata C, Rizzo A, Conte M, et al. Retrospective study of childhood ganglioneuroma. J Clin Oncol. Apr 1 2008;26(10):1710-6. [Medline].

  3. Strenger V, Kerbl R, Dornbusch HJ, Ladenstein R, Ambros PF, Ambros IM, et al. Diagnostic and prognostic impact of urinary catecholamines in neuroblastoma patients. Pediatr Blood Cancer. May 2007;48(5):504-9. [Medline].

  4. Hossain MS, Ozaki T, Wang H, Nakagawa A, Takenobu H, Ohira M, et al. N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma. Oncogene. Jun 30 2008;[Medline].

  5. Hero B, Simon T, Spitz R, Ernestus K, Gnekow AK, Scheel-Walter HG, et al. Localized infant neuroblastomas often show spontaneous regression: results of the prospective trials NB95-S and NB97. J Clin Oncol. Mar 20 2008;26(9):1504-10. [Medline].

  6. Woods WG, Gao RN, Shuster JJ. Screening of infants and mortality due to neuroblastoma. N Engl J Med. Apr 4 2002;346(14):1041-6. [Medline].

  7. Schilling FH, Spix C, Berthold F. Neuroblastoma screening at one year of age. N Engl J Med. Apr 4 2002;346(14):1047-53. [Medline].

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  9. Currarino G. The Genitourinary Tract. In: Silverman FN, Kuhn JP, eds. Essentials of Caffey's Pediatric X-Ray Diagnosis. 1990: 724-9.

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  11. Rozovsky K, Koplewitz BZ, Krausz Y, Revel-Vilk S, Weintraub M, Chisin R, et al. Added value of SPECT/CT for correlation of MIBG scintigraphy and diagnostic CT in neuroblastoma and pheochromocytoma. AJR Am J Roentgenol. Apr 2008;190(4):1085-90. [Medline].

  12. Sofka CM, Semelka RC, Kelekis NL, et al. Magnetic resonance imaging of neuroblastoma using current techniques. Magn Reson Imaging. Feb 1999;17(2):193-8. [Medline].

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  14. Schmidt M, Simon T, Hero B, Schicha H, Berthold F. The prognostic impact of functional imaging with (123)I-mIBG in patients with stage 4 neuroblastoma >1 year of age on a high-risk treatment protocol: Results of the German Neuroblastoma Trial NB97. Eur J Cancer. Jul 2008;44(11):1552-8. [Medline].

  15. Lonergan GJ, Schwab CM, Suarez ES. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. Jul-Aug 2002;22(4):911-34. [Medline].

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  19. Donnelly LF. Fundamentals of Pediatric Radiology. 2001: 163-5.

  20. Hoffer FA, Chung T, Diller L. Percutaneous biopsy for prognostic testing of neuroblastoma. Radiology. 1996;200:213-6.

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Further Reading

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Keywords

neuroblastoma, esthesioneuroblastoma, ganglioneuroblastoma, ganglioneuroma, neuroectodermal tumor, neuroblasts, Homer-Wright rosettes, pediatric neoplasm, pediatric malignancy, Hirschsprung disease, fetal alcohol syndrome, Digeorge syndrome

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Contributor Information and Disclosures

Author

Steven F West, DO, Consulting Staff, Department of Radiology, Brookhaven Memorial Hospital Medical Center
Steven F West, DO is a member of the following medical societies: American College of Radiology, American Medical Association, American Roentgen Ray Society, American Society of Neuroradiology, and Radiological Society of North America
Disclosure: Nothing to disclose.

Coauthor(s)

Jennith D Correa, DO, Staff Physician, Department of Emergency Medicine, Mount Sinai Medical Center
Jennith D Correa, DO is a member of the following medical societies: American Osteopathic Association
Disclosure: Nothing to disclose.

Michelle Germaine, DO, Staff Physician, Department of Obstetrics and Gynecology, St Vincent Catholic Medical Center
Disclosure: Nothing to disclose.

Dvorah Balsam, MD, Chief, Division of Pediatric Radiology, Nassau University Medical Center; Professor, Department of Clinical Radiology, State University of New York at Stony Brook
Disclosure: Nothing to disclose.

Joel Rosen, MD, Chief, Department of Nuclear Medicine, Nassau University Medical Center
Disclosure: Nothing to disclose.

Medical Editor

Fredric A Hoffer, MD, FAAP, FSIR, Professor of Radiology, University of Washington; Section Chief of Interventional Radiology, Department of Radiology, Seattle Children's Hospital and Regional Medical Center
Fredric A Hoffer, MD, FAAP, FSIR is a member of the following medical societies: American Academy of Pediatrics, Children's Oncology Group, Radiological Society of North America, Society for Pediatric Radiology, and Society of Interventional Radiology
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Kieran McHugh, MBBCh, Honorary Lecturer, The Institute of Child Health; Consultant Pediatric Radiologist, Department of Radiology, Great Ormond Street Hospital for Children, London, UK
Kieran McHugh, MBBCh is a member of the following medical societies: American Roentgen Ray Society and Royal College of Radiologists
Disclosure: Nothing to disclose.

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, The Angeles Clinic and Research Institute
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Eugene C Lin, MD, Clinical Assistant Professor of Radiology, University of Washington Medical School
Eugene C Lin, MD is a member of the following medical societies: American College of Nuclear Medicine, American College of Radiology, Radiological Society of North America, and Society of Nuclear Medicine
Disclosure: Nothing to disclose.

 
 
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