Hepatic Chemoembolization Imaging

Updated: Aug 23, 2016
  • Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: Kyung J Cho, MD, FACR, FSIR  more...
  • Print
Overview

Overview

Hepatocellular carcinoma (HCC) is the most common primary liver tumor worldwide, and its incidence is rising. Most HCCs are associated with cirrhosis. The risk of developing HCC appears to be related to the degree of activity of cirrhosis. The risk is high in patients with macronodular cirrhosis secondary to hemochromatosis and lower in those with alcoholic micronodular cirrhosis. Surgery offers the best prospect of cure, but the resectability of HCC is low. Key predictors of tumor response after chemoembolization on unresectable HCC include the tumor's size, vascularity, and number, as well as portal vein invasion. Factors associated with poor prognosis for overall patient survival include Child-Pugh class B or C, tumor size ≥4 cm, 5 or more tumors, portal vein invasion, and an alpha fetoprotein (AFP) level >83 ng/mL. [1]  Conventional and drug-eluting bead chemoembolization have been found to have a limited impact on liver function, and tumor response is not dependent on type of embolization used. [2, 3, 4]

Diagnostic imaging depicts not only the primary hepatic disease but also ascites, lymph node metastases, and thrombosis of portal or hepatic veins. Confirming portal vein patency is important because portal vein thrombosis is a relative contraindication to chemoembolization. [5, 6] If portal flow via collateral vessels remains hepatopetal, embolization may be better tolerated. Imaging also plays an important role in evaluating the effectiveness of interventional therapy.

Peptide-receptor radionuclide therapy (PRRT) is a relatively new treatment reserved for treatment of unresectable or metastatic gastroenteropancreatic neuroendocrine tumors (GEP NETs). Campana et al conducted a study to determine the time to progression of patients treated with PRRT and to identify the prognostic factors related to treatment response. The study concluded that low tumor burden and a low proliferation index represent independent prognostic factors for long progression-free survival, while previous transcatheter arterial chemoembolization (TACE) techniques represent independent prognostic factors for early tumor progression and shorter progression-free survival. The data derived from the study suggest that TACE techniques to reduce the hepatic tumor burden should be avoided. [7]

Liu et al retrospectively studied 246 consecutive patients with primary Budd-Chiari syndrome (BCS) with the view to analyze the imaging features of BCS associated HCC and the results of angioplasty/stenting of hepatic veins/inferior vena cava and TACE. The study concluded that BCS patients with inferior vena cava block and stricture of hepatic venous outflow tract seem to be associated with HCC. A single, large, irregular nodule with a peripheral location appears to be HCC. [8]

Bile duct strictures are a known complication of TACE. Anastomosis between A1 or A4 and other branches has been shown to be frequently associated with bile duct strictures 2-8 months after TACE of the bile duct branch. [9]

A review by Rempp and associates suggested that radiofrequency ablation should be used in patients with early-stage HCC with up to 3 lesions with a tumor diameter of ≤3 cm and for patients with nonresectable liver metastasis. [10]

An axial computed tomography (CT) scan of an HCC is seen below.

Contrast-enhanced axial CT scan through the liver Contrast-enhanced axial CT scan through the liver in the portal venous phase in an 88-year-old woman who presented with right upper quadrant discomfort. Scan shows a 13-cm mass occupying the right lobe of the liver; it displaces the portal vein medially. Results of laparoscopic biopsy confirmed the mass to be a well-differentiated hepatocellular carcinoma in a noncirrhotic liver.

Preferred examination

The imaging strategy in HCC depends on the clinical question to be answered and the treatment options available. Angiography is an essential part of the workup performed prior to embolization or chemoembolization, although most centers proceed to the embolization procedure if no contraindications are present. In patients with a known primary malignancy, such as colorectal cancer or islet cell tumors, an initial investigation includes an ultrasonographic examination followed by spiral or multisection, 3-phase, contrast-enhanced CT scanning. Contrast-enhanced sonography is useful in determining the differences between the grades of HCCs. Using auto-tracking contrast quantification software, the time to peak, contrast-enhanced time, and wash-out time were longer for well-differentiated hepatocellular lesions and the enhancement slope and clearance slope were lower than that of moderately to poorly differentiated carcinomas. [11, 12, 13, 14]

Magnetic resonance imaging (MRI) and radionuclide scanning are useful in confirming the diagnosis, particularly the diagnosis of benign lesions, such as hemangiomas and focal nodular hyperplasia. These lesions are increasingly encountered in the setting of malignant disease. The multiplanar capability of MRI is particularly helpful in determining the exact anatomic location of the lesions. In the setting of HCC, a protocol similar to that used for liver metastasis is performed.

Next:

CT SCAN

Postprocedural imaging

Follow-up CT scans are obtained approximately 10-14 days after chemoembolization. An early scan may be acquired if complications, such as nontarget embolization, are suspected. Because the chemotherapeutic agent is mixed with lipiodol, CT scans of a tumor reveal dense opacification associated with necrosis (see the image below).  Along with nontarget embolization, CT scans also demonstrate such complications as the development of ascites and pleural effusions. When only polyvinyl alcohol embolization is performed, as in cases of hepatic carcinoid, postembolization CT scans demonstrate only tumor necrosis. [15]  In patients with hepatocellular carcinoma (HCC), if the embolization procedure is successful, the postprocedural CT scan will show a lipiodol uptake of greater than 50% in necrotic tumor. In these cases, the embolization is repeated in 6-8 weeks. If the lipiodol uptake is less than 50%, the authors repeat the CT scan in 6-8 weeks. [16, 17, 18]

Contrast-enhanced, axial CT scan through the liver Contrast-enhanced, axial CT scan through the liver, obtained 10 days after chemoembolization, shows intensely concentrated lipiodol within the hepatocellular carcinoma. Note the considerable central tumor necrosis.

 

Previous
Next:

MRI

MRI and radionuclide scanning are useful in confirming a diagnosis, particularly the diagnosis of benign lesions, such as hemangiomas and focal nodular hyperplasia. These lesions are increasingly encountered in the setting of malignant disease. The multiplanar capability of MRI is particularly helpful in determining the exact anatomic location of the lesions. In the setting of hepatocellular carcinoma, a protocol similar to that used for liver metastasis is performed. [19, 20]

Previous
Next:

Angiography

Angiography is an essential part of the workup performed prior to embolization or chemoembolization, although most centers proceed to the embolization procedure if no contraindications are present. Angiography is usually performed by placing a 5F to 6F catheter through a sheath via the right or left femoral artery. The catheter should be able to accept the insertion of a 3F coaxial microcatheter. A celiac-axis and superior mesenteric angiogram is first obtained to identify common variations in the blood supply to the liver and to check for patency of the portal vein.

Angiograms obtained prior to and after chemoembolization are seen below.

Arterial/early capillary phase of a celiac-axis an Arterial/early capillary phase of a celiac-axis angiogram shows extensive neovascularity in the mass, with stretching of the vessels around the mass.
Portal venous phase of a celiac-axis angiogram (sa Portal venous phase of a celiac-axis angiogram (same patient as in the previous image) shows patent splenic and portal veins; therefore, the patient is a suitable candidate for chemoembolization.
Selective hepatic angiogram obtained after chemoem Selective hepatic angiogram obtained after chemoembolization shows a complete shutdown of the neovascularity and pruning of the stretched peripheral vessels.

Embolization of parasitized extrahepatic arteries (EHAs) to reestablish intrahepatic arterial inflow to hepatic tumors was found to be safe and effective in a retrospective analysis of 201 patients. [21] The procedure successfully delivered yttrium-90 microspheres to tumors previously perfused by parasitized EHAs.

Previous