eMedicine Specialties > Radiology > Vascular/Interventional

Uterine Fibroid Embolization

Gary P Siskin, MD, Associate Professor, Department of Radiology, Albany Medical College; Chief, Division of Vascular and Interventional Radiology, Department of Radiology, Albany Medical Center

Updated: May 7, 2009

Clinical Background

Uterine leiomyomas, better known as uterine fibroids, are benign smooth muscle tumors of the uterus. The most common tumor found in the female reproductive system, uterine fibroids are seen in 20-25% of all women and are estimated to occur in 40% of menstruating women older than 50 years. In addition, uterine fibroids occur twice as frequently in black women as in either white or Asian women. Uterine fibroids can occur at any time between menarche and menopause but are most common in women 35-49 years of age. They typically resolve after menopause.

Nonselective pelvic angiogram demonstrating the tortuous and dilated uterine arteries supplying a hypervascular uterine fibroid.

Selective angiogram of the left uterine artery prior to embolization.

Selective angiogram of the right uterine artery prior to embolization.

Nonselective angiogram of the pelvis after embolization demonstrating occlusion of both the right and left uterine arteries.

• Submucosal fibroids are the least common. Because they are in the submucosa and near the endometrial cavity, they are associated with heavy and prolonged menstrual periods and an increased miscarriage rate. Submucosal fibroids may be pedunculated and may prolapse into the cervix.
• Intramural fibroids grow within the uterine wall. Their growth may be associated with mass-related symptoms such as abdominal distention due to mass or urinary frequency due to bladder compression.
• Subserosal fibroids develop in the outer portion of the uterus. They may be pedunculated, can potentially grow into the abdomen or in the ligaments of the uterus, and are associated with bladder compression and abdominal distention.

Most patients are asymptomatic. Fibroids typically are discovered incidentally during routine gynecologic examination. Presenting symptoms most commonly include the following:

• Abnormal uterine bleeding
• Pelvic pain, possibly resulting from intramural degeneration, torsion of a pedunculated fibroid, or uterine contractions
• Pelvic pressure
• Abdominal distention
• Genitourinary dysfunction, which may manifest as the following:
  • Increased urinary frequency resulting from bladder compression
  • Flank pain resulting from ureteral compression and hydronephrosis
• Infertility
• Rarely, lower extremity edema, constipation, or intestinal obstruction

For excellent patient education resources, visit eMedicine's Women's Health Center. Also, see eMedicine's patient education articles Fibroids and Amenorrhea.

Rationale

The rationale for the use of uterine artery embolization, or uterine fibroid embolization (UFE), to treat uterine fibroids can be traced to several known indications for embolotherapy.

• As a palliative treatment for end-stage cancer patients, embolotherapy successfully addresses tumor-related symptoms (eg, bone pain from bony metastases of renal cell carcinoma,¹ abdominal pain from inoperable liver tumors² ). This includes symptoms caused by mass effect.
• Embolotherapy reduces the vascularity of tumors (eg, renal cell carcinomas, spinal tumors³ ) prior to surgical excision or resection, thereby reducing intraoperative blood loss.
• Embolotherapy controls tumor-related bleeding throughout the body (eg, bleeding secondary to renal cell carcinoma, bladder tumors, angiomyolipoma, hepatic adenomas⁴ ).
• Embolotherapy controls abnormal uterine bleeding caused by gynecologic malignancies, postpartum hemorrhage, bleeding from an ectopic pregnancy, and bleeding caused by congenital arteriovenous malformations.

In light of the success of embolization in reducing solid tumors and diminishing associated symptoms, UFE is performed to reduce uterine as well as fibroid volume and their associated symptoms.

Preprocedure Evaluation

Imaging

Prior to embolization, it is important to document the presence of fibroids. This can be accomplished using either pelvic ultrasound (US) or MRI. While US may be effective for confirming enlargement of the uterus and demonstrating the presence of fibroids or other pathology that can explain the patient's presenting symptoms, its efficacy depends on the equipment used and the body habitus of the patient. MRI is preferred because of its greater ability to demonstrate individual fibroids and denote their size, location, and number within the uterus. MRI also allows easier determination of the internal characteristics of individual fibroids as well as their vascularity.

In a preliminary report, Jha et al attached prognostic significance to both the location and vascularity of fibroids.⁵ Mizukami et al also have reported a possible prognostic value for preprocedural MRI by demonstrating better response to embolization in patients with intermediate or high-signal intensity within their fibroids on T2-weighted images.⁶

Pelvic MRI also can determine whether coexisting pathology is present within the uterus. For example, menorrhagia and other symptoms commonly associated with uterine fibroids may be similar to those of patients with adenomyosis. Adenomyosis, a benign uterine disease, is characterized by the ectopic growth of endometrial glands and stroma into the myometrium and by diffuse enlargement of the uterus. MRI is the best imaging tool for the diagnosis of adenomyosis; diagnostic criteria include diffuse or focal widening of the junctional zone, as well as bright foci or linear striations within the myometrium on T2-weighted images.⁷ On MRI, a focal adenomyoma may appear as a localized low-signal myometrial mass with poorly defined margins that often contain high-signal foci.

MRI is also helpful in assessing the results of embolization several months after the procedure.

Technically, the radiologist should obtain measurements of the uterus and of each fibroid in 3 planes, then calculate the volume measurements using the formula for the volume of a sphere (length × width × height × 0.5233). These measurements provide a baseline for determining the degree of postprocedural reduction in fibroid and uterine volume. After embolization, the signal intensity of the fibroids usually decreases on both T1-weighted and T2-weighted images. Embolization seems to have little effect on the volume or enhancement characteristics of normal myometrium and endometrium.

Other testing

In addition to pelvic MRI, the pre-embolization workup includes evaluation of the patient's renal function (ie, blood urea nitrogen and creatinine levels) and coagulation profile (ie, platelet count, prothrombin time, partial thromboplastin time). At the author's institution, a normal Papanicolaou (Pap) smear is required within 6 months before embolization, and an endometrial biopsy is recommended within 12 months for all patients presenting with menorrhagia. These tests evaluate the patient for both endometrial hyperplasia and endometrial malignancy.

Other procedures

Gonadotropin-releasing hormone (GnRH) agonists often are used as a medical treatment for uterine fibroids, most often before myomectomy or hysterectomy to reduce the potential morbidity of these procedures.⁸ Withhold GnRH agonist therapy before patients undergo the procedure, since these medications can lead to constriction of the arteries supplying the uterus, which can add to the technical difficulty of the uterine fibroid embolization (UFE) procedure. Since fibroids have been shown to return to their previous size within 12 weeks of the cessation of GnRH agonist therapy, UFE should be performed after GnRH agonists have been stopped for at least 12 weeks.

Technique

Prior to embolization, an intravenous (IV) line and Foley catheter are placed in all patients. Prophylactic antibiotics usually are given prior to the procedure. The choice of agent for prophylaxis may vary: at the author's institution, patients receive 1 g cefazolin (Ancef) IV unless they have a history of penicillin allergy, in which case they receive 500 mg of vancomycin. Other premedications that may be used include corticosteroids, antiemetics, and analgesics.

Nonselective pelvic angiogram demonstrating the tortuous and dilated uterine arteries supplying a hypervascular uterine fibroid.

Selective angiogram of the left uterine artery prior to embolization.

Selective angiogram of the right uterine artery prior to embolization.

Nonselective angiogram of the pelvis after embolization demonstrating occlusion of both the right and left uterine arteries.

1. A sheath is placed into either the right or left common femoral artery.
2. Under fluoroscopic guidance, a flush catheter is advanced into the abdominal aorta.
3. A pelvic angiogram is performed to identify the right and left uterine arteries. Ovarian, lumbar, or other collateral parasitic supplies to a large myomatous uterus may be seen (see Image 1). The uterine arteries, which typically arise from the anterior division of the internal iliac artery, are responsible for most of the uterine blood supply. A selective arteriogram of the uterine artery reveals the terminal branches, known as the spiral arteries, which dilate and uncoil in response to changes in hormonal levels and endometrial thickness. In the presence of fibroids, arteriography of the uterine arteries shows these vessels as dilated, tortuous, and laterally displaced (see Images 2-3). One can confirm the hypervascular nature of the fibroid by noting the extensive network of intrinsic arteries within the fibroid.
4. Once identified, the uterine arteries should be selectively catheterized.
5. An embolic agent, such as polyvinyl alcohol (PVA) or Embospheres, is injected directly into the uterine arteries to induce thrombosis. Both uterine arteries should be embolized because the spiral arteries arising from them anastomose across the midline. Unilateral embolization caused one of the earliest reported cases of a UFE treatment failure. In some patients, a 4 Fr or 5 Fr catheter may be occlusive within one or both uterine arteries. If this occurs, a coaxial microcatheter may be used to administer the embolic agent. If a microcatheter is used, some difficulty may be encountered if 500-710 micron PVA is used as the embolic agent. Diluting the agent appropriately along with frequent catheter flushing may minimize the risk of catheter occlusion in this setting.
6. After embolization of both uterine arteries, a complete angiogram (see Image 4) should be performed to confirm that arterial occlusion has occurred. It will also allow a search for collateral vessels (eg, ovarian arteries, vaginal arteries) that may represent a significant source of collateral blood supply to the fibroids.

Polyvinyl alcohol

PVA is the most commonly used embolic agent for UFE. The biocompatibility of PVA was established prior to its first medical use in 1949 as a filling material following pneumonectomy.⁹ The first successful use of PVA as an embolic agent was reported by Tadavarthy et al in 2 studies that included patients with cervical carcinoma, hemangiosarcoma of the liver, hemangioendothelioma of the neck and forehead, and arteriovenous malformation of the spine.^10,11 Since then, PVA has been used for embolization in patients with abnormal bleeding caused by arteriovenous malformations,¹² tumors, and other disorders such as hemoptysis due to cystic fibrosis.¹³

The desired level of occlusion (ie, proximal, distal) determines the particle size selection for each embolization procedure. Generally, using small particles results in a more distal occlusion, increasing the risk for end-organ infarction. However, the tendency of PVA particles to clump often makes the effective size larger than that of individual particles, which may account for the proximal occlusion often seen during PVA embolization. The optimum particle size for UFE is not established; most centers use particles measuring 350-500 or 500-710 micrometers in diameter.

Histologically, PVA particles adhere to the vessel wall, causing slow flow within that vessel. The result is intraluminal thrombus formation, inflammatory reaction, foreign-body reaction, and focal angionecrosis of the vessel wall. The foreign-body reaction induced by PVA is reported to persist up to 28 months after embolization.

PVA is not biodegradable and thus is considered by many to be a "permanent" embolic agent; however, the reported duration of PVA-induced vascular occlusion has varied. Persistent occlusion will occur with organization of the thrombus, disappearance of the inflammatory infiltrate, and ingrowth of connective tissue into the particles, resulting in fibrosis. Luminal recanalization has been reported and may be caused by angioneogenesis and capillary regrowth either because of vascular proliferation inside the organized thrombus or resorption of the thrombus found between clumps of PVA.

Recovery

Uterine fibroid embolization (UFE) postembolization syndrome is similar to solid tumor postembolization syndrome. It affects most patients undergoing UFE and lasts approximately 2-7 days. Signs and symptoms may include the following:

• Pelvic pain and cramping
• Nausea and vomiting
• Low-grade fever
• General malaise

Most patients experience these features to some degree; however, the variation in severity has prompted the development of different strategies to increase patient comfort during recovery. Regimens involve oral, IV, epidural, and/or patient-controlled analgesia in both an inpatient and outpatient setting. Reports suggest that most centers admit patients for 1-2 days to aggressively manage these constitutional symptoms. At the author's institution, the outpatient protocol includes the following medication regimen:

• Opioid analgesics (eg, oxycodone [OxyContin], acetaminophen and oxycodone [Percocet], meperidine, hydrocodone with acetaminophen): Currently, the authors administer OxyContin at 10-20 mg orally every 12 hours, with 1-2 tabs of Percocet 5/235 orally every 6 hours for pain not relieved with OxyContin.
• Nonsteroidal anti-inflammatory medications (eg, ketorolac, celecoxib [Celebrex], ibuprofen): Currently, the authors administer celecoxib at 100 mg orally every 12 hours for the first 7 days after embolization, followed by ibuprofen at 200 mg every 4-6 hours as needed.
• Antinausea medications (eg, prochlorperazine): Supply the patient with 25-mg suppositories for relief of nausea associated with embolization and the medications provided above for pain relief.

At the author's institution, patients are offered the opportunity to recover at home following the embolization procedure. In the author's experience, most patients are best managed at home when the following conditions are met:

• Patients are provided with the medication regimen detailed above.
• Patients are ambulated as soon as possible (to prevent potential pulmonary embolus).
• Patients are given adequate education.
• Patients receive diligent follow-up care.
• The care provider is readily available to the patient.
• Family or friends can provide home support.

Once discharged, recommend patient activity as follows:

• On the day of the procedure, the patient should observe bedrest with only limited activity.
• The next day, the patient may engage in limited activity around her home.
• After 2 days, normal activity is permitted. At this point, individual tolerance for activity and reliance on pain medication are the best indicators of the patient's capabilities.
• After 6-10 days, most of the author's patients are able to return to work.

Results

Clinical Results

Embolization was first used by Ravina et al in patients with fibroids to reduce operative blood loss during myomectomy.¹⁴ As of 2004, it is estimated that 13,000-14,000 UFE procedures are performed annually in the US.¹⁵ The procedure is not considered investigational and is reimbursed by most insurance companies.

Goodwin et al were the first to publish experience with UFE in the United States, in 1997.¹⁶  Goodwin et al subsequently conducted a prospective, multicenter study of the short- and long-term outcomes of UFE, the Fibroid Registry for Outcomes Data (FIBROID) for Uterine Embolization. In the FIBROID registry, mean symptom scores in 1,278 patients showed normalization of health-related quality-of-life; 9.79% of patients subsequently underwent hysterectomy, 2.82% underwent myomectomy, and 1.83% underwent repeat UFE.¹⁷  

Gabriel-Cox et al studied 5-year outcomes of UFE in 562 women from 1997-2001: overall, the rate of subsequent hysterectomy was 19.7%. However, the rate in women who had had unilateral UFE was 39.2%; this was the only identified factor that predicted subsequent hysterectomy.²²

Treatment failure can be defined as the absence of demonstrable clinical benefit after successful embolization of both right and left uterine arteries. Possible explanations for treatment failure include the following:

• Incomplete embolization
• Luminal recanalization
• Extremely large uterine fibroids
• Presence of uterine leiomyosarcoma
• Presence of a coexisting disorder (eg, adenomyosis)
• Persistence of collateral sources of arterial blood supply to fibroids (eg, ovarian artery, round ligament artery)

Preprocedure imaging is routinely performed to assess the true size of the uterus and fibroids and to determine the presence of a coexisting disorder. While success has been observed after UFE in patients with large fibroids and in patients with adenomyosis, the potential for persistent postembolization symptoms must be discussed with these patients. Suspect the possibility of a leiomyosarcoma if the expected decrease in fibroid or uterine volume is not observed after embolization.

Pathologic results

Siskin et al, Aziz et al, and McLucas et al specifically studied the histologic effects observed after UFE with PVA particles.^23,24,25 Administration of PVA into the lumen of the uterine arteries initiates a foreign-body reaction, which leads to platelet aggregation and thrombus formation within the intraluminal PVA particles. Thrombus formation results in arterial occlusion and, ultimately, leads to interstitial edema within the fibroid, followed by ischemic necrosis and hyalinization. The myometrium adjacent to a fibroid embolized with PVA particles has been noted to be viable but edematous and chronically inflamed.

Potential Complications

Immediate complications

• Complications related to iodinated contrast material administration (not unique to uterine fibroid embolization [UFE] and therefore familiar to most practicing interventional radiologists)
• Complications related to femoral arterial catheterization (not unique to UFE and therefore familiar to most practicing interventional radiologists)
• Complications related to postembolization syndrome (see Recovery)
• Complications related to nontarget or inadvertent embolization of vessels other than the uterine artery. Branches of the anterior division of the internal iliac artery are at risk for nontarget embolization during UFE. In particular, inadvertent embolization of the vesical artery, which sometimes arises from a common trunk with the uterine artery, may increase the risk of bladder necrosis. It may be possible to prevent nontarget embolization by performing the following:
  • Ensure a thorough knowledge of pelvic arterial anatomy and potential variants.
  • Proceed carefully, using an angiographic technique that includes the following:
    • Position the catheter into the descending segment of the uterine artery and confirm this position with an arteriogram prior to embolization.
    • Inject embolic materials under fluoroscopic guidance to prevent reflux into other arteries.
    • Flush the embolization catheter before performing additional arteriograms.
• A fatal pulmonary embolus, which occurred 20 hours after UFE, was reported in a 65-year-old patient.²⁶ The source of the thrombus was believed to be the deep pelvic veins, and it may have occurred either secondary to the mass effect of the fibroid or from diminished arterial flow after embolization, which resulted in stasis and thrombosis within pelvic veins. To reduce the risk of PE after UFE, patients should ambulate as soon as possible to prevent the development of lower extremity diverticulitis (DVT) and possible pulmonary embolism (PE). In addition, compression stockings have been recommended for patients with a history of smoking or oral contraceptive use since these patients are at increased for thrombotic events. While these measures are important to reduce the risk of DVT and PE in many patients, they will not help if the source of a PE is from the pelvic veins.
• Inadvertent end-organ damage (ie, uterus) can result in ischemic injury or infection, both of which may require hysterectomy for treatment.
• Infection or, more specifically, pyometrium with acute endometritis was one of the earliest reported complications of UFE. High fever and persistent pain led to hysterectomy in an early case report. Since then, infection has been reported in less than 1% of patients. Some infected patients have been successfully treated with antibiotics, while others required hysterectomy. In one patient, infection resulted in multiorgan failure and death. All patients with prolonged fever (>7-10 d) should be evaluated for possible uterine infection. Diagnosis may be aided by the performance of a pelvic examination, lab tests (including CBC, blood and urine cultures), and pelvic CT scan.
• Ischemic injury of the uterus is reported in less than 1% of patients. These patients present with pelvic pain persisting several weeks beyond the expected postembolization syndrome. Classic teaching states that the uterus receives approximately two thirds of its blood supply from the uterine arteries and approximately one third from the ovarian arteries, which originate from the abdominal aorta distal to the renal arteries. One possible explanation for this complication is that embolization of the uterine arteries places the uterus at risk for ischemic injury and infarction in cases in which there is potentially inadequate collateral blood flow from the ovarian arteries. Patients experiencing this complication may require further treatment (eg, hysterectomy) to relieve associated pain and discomfort.
• Submucosal fibroids, particularly if pedunculated, are at increased risk for expulsion from the uterus after embolization-induced infarction. This particular complication has been reported in approximately 1-2% of patients. While this may occur spontaneously without clinically significant sequelae, a hysteroscopic resection or other treatment may be required to remove tissue retained within the uterus to prevent subsequent infection.

Technical failure

Technical failure in UFE can be defined as an inability to successfully catheterize and embolize both right and left uterine arteries. While not considered a true complication by some, an inability to successfully complete this procedure is certain to be perceived as a complication by both the patient and referring gynecologist, since it will likely necessitate surgical intervention for definitive treatment. Based on published and presented reports, the technical failure rate for UFE is 1-2%.

Possible explanations for technical failure include the following:

• Anatomic variation
• Anatomic deviation secondary to the mass effect produced by large uterine fibroids
• Operator inexperience
• Persistent effects of GnRH agonist (eg, leuprolide acetate) at the time of embolization (as described below)

Hormonal changes

Postprocedure amenorrhea has been reported in approximately 2-14% of patients. Transient amenorrhea may occur in the presence of normal hormone levels secondary to endometrial atrophy. Often, a spontaneous return to normal menstruation occurs within 3-6 months.

• The existence of collateral pathways between the uterine and ovarian arteries also makes it possible for the embolic materials injected into a uterine artery to enter ovarian arterial circulation.
• Aziz et al found that PVA particles may be found in the mesovarium and mesosalpinx after UFE.²⁴ This may contribute to potential ovarian and tubal dysfunction by reducing blood flow to the adnexa. This may result in thrombosis of the ovarian artery, ovarian ischemia, or ovarian infarction.
• Early menopause after UFE has been described. In a randomized trial in premenopausal women who underwent either UFE or hysterectomy for menorrhagia from uterine fibroids, Hehenkamp et al found increased levels of follicle-stimulating hormone and decreased levels of anti-Mullerian hormone (a reliable marker of ovarian reserve in some patients. For older women with less ovarian reserve, these hormonal changes might hasten the onset of menopause; in younger women, the changes might affect fertility.²⁷
• These events provide one possible explanation for permanent amenorrhea after UFE. However, most women do not demonstrate a change in their basal follicle-stimulating hormone levels and, in the absence of this change, the true cause-and-effect relationship between UFE and permanent amenorrhea remains unproved.Fibroids depend on ovarian steroids such as estrogen for growth. GnRH agonists act at the level of the pituitary gland to down-regulate GnRH receptors. This results in a decrease in luteinizing hormone and follicle-stimulating hormone levels, which in turn induces a hypoestrogenic state. With a reduction in serum estrogen levels, hyaline degeneration is induced and leads to a reduction in the uterus of 52-77% after 3 months of therapy. Doppler US studies of uterine and fibroid blood flow have documented a decrease in arterial blood flow and an increase in the arterial resistance index after several months of GnRH agonist therapy.

In addition, a decrease in arterial size and an increase in atherosclerotic changes are seen in uterine and fibroid vessels after therapy. Since a decrease in uterine vasculature is associated with GnRH agonist therapy, the effectiveness of embolization therapy may be diminished during therapy because of decreased particle delivery to the distal uterine vasculature.

Within 3 months after discontinuing GnRH agonist therapy, the uterus returns to 88% of pretreatment size.

To avoid potential UFE failure in patients on GnRH agonist therapy, patients should have their GnRH agonist therapy withheld for a minimum of 3 months before undergoing UFE.

Fertility

The ideal candidate for UFE is a woman who is premenopausal but has no interest in subsequent childbearing. Nevertheless, for younger women, preservation of childbearing ability may be an important feature of UFE. However, 2 studies from the CzechRepublic suggest possible adverse effects of UFE in this respect. A prospective multicenter study by Holub et al found that the risk of spontaneous abortion was significantly increased after UFE, as compared with laparoscopic uterine artery occlusion.²⁸ In a comparison study of UFE with myomectomy in 118 patients, Mara et al reported that although UFE is less invasive than myomectomy and as effective for controlling symptoms, reproductive outcomes appear to be superior in myomectomy patients.²⁹

Alternative Radiologic Treatment

The Food and Drug Administration has approved a system that uses focused ultrasound to target and destroy uterine fibroids.³⁰ In this technique, focused, converging ultrasound beams cause coagulative necrosis of fibroids through the local generation of heat. MRI is used to visualize and map the fibroid tissue, as well as to monitor the temperature of the uterine tissue after heating. The procedure can take as long as 3 hours. A 24-month follow-up study on the 359 women in all clinical trials of this system found durable symptom relief and a low incidence of adverse effects; however, the risk of additional procedures was high for women who received minimal treatment.³¹

Multimedia

Media file 1: Nonselective pelvic angiogram demonstrating the tortuous and dilated uterine arteries supplying a hypervascular uterine fibroid.

Media file 2: Selective angiogram of the left uterine artery prior to embolization.

Media file 3: Selective angiogram of the right uterine artery prior to embolization.

Media file 4: Nonselective angiogram of the pelvis after embolization demonstrating occlusion of both the right and left uterine arteries.

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Keywords

uterine fibroid embolization, uterine fibroid, uterus fibroid, uterine leiomyoma, uterine tumor, tumor of the uterus, uterine artery embolization, UFE

Contributor Information and Disclosures

Author

Gary P Siskin, MD, Associate Professor, Department of Radiology, Albany Medical College; Chief, Division of Vascular and Interventional Radiology, Department of Radiology, Albany Medical Center
Gary P Siskin, MD is a member of the following medical societies: American Heart Association and Radiological Society of North America
Disclosure: Nothing to disclose.

Medical Editor

Harris L Cohen, MD, FACR, Vice Chairman/Associate Chairman (Research Activities), Director, Division of Body Imaging, Professor of Radiology, Stony Brook School of Medicine; Visiting Professor of Radiology, Johns Hopkins School of Medicine
Harris L Cohen, MD, FACR is a member of the following medical societies: American College of Radiology, American Institute of Ultrasound in Medicine, Association of Program Directors in Radiology, Radiological Society of North America, Society for Pediatric Radiology, and Society of Radiologists in Ultrasound
Disclosure: Nothing to disclose.

Pharmacy Editor

Bernard D Coombs, MB, ChB, PhD, Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand
Disclosure: Nothing to disclose.

Managing Editor

Douglas M Coldwell, MD, PhD,, Principal, Coldwell Associates. Interventional Radiologist, Jane Phillips Medical Center, Bartlesville, OK
Douglas M Coldwell, MD, PhD, is a member of the following medical societies: American Association for Cancer Research, American College of Radiology, American Heart Association, American Physical Society, American Roentgen Ray Society, Society of Cardiovascular and Interventional Radiology, Southwest Oncology Group, and Special Operations Medical Association
Disclosure: Sirtex, Inc. Consulting fee Speaking and teaching

CME Editor

Robert M Krasny, MD, Consulting Staff, Department of Radiology, Resolution Imaging Medical Corporation
Robert M Krasny, MD is a member of the following medical societies: American Roentgen Ray Society and Radiological Society of North America
Disclosure: Nothing to disclose.

Chief Editor

Kyung J Cho, MD, FACR, William Martel Professor of Radiology, Interventional Radiology Fellowship Director, University of Michigan Health System
Kyung J Cho, MD, FACR is a member of the following medical societies: American College of Radiology, American Heart Association, American Medical Association, American Roentgen Ray Society, Association of University Radiologists, and Radiological Society of North America
Disclosure: Nothing to disclose.

Related eMedicine topics

Leiomyoma, Uterus (Fibroid)

Hysterectomy

Radical Hysterectomy

Clinical guidelines

Patient care and uterine artery embolization for leiomyomata. Society of Interventional Radiology - Medical Specialty Society.  2004 Feb.  6 pages.  NGC:003697

Alternatives to hysterectomy in the management of leiomyomas. American College of Obstetricians and Gynecologists - Medical Specialty Society.  2000 May (revised 2008 Aug).  14 pages.  NGC:006762

Clinical trials

A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE)

Comparison Study in the Treatment of Uterine Fibroids Uterine Fibroid Embolization Using BeadBlock™ Embolic Agent

Laparoscopic Occlusion of Uterine Vessels Compared to Uterine Fibroid Embolization for Treatment of Uterine Fibroids

Pilot Study of MRI-Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids

Laparoscopic Radiofrequency Ablation of Symptomatic Uterine Fibroids

The Benefits and Limits of Laparoscopic Surgery for Uterine Fibroids

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