Outcome and Prognosis
The outcome of TBI is related to the initial level of injury. While the initial GCS score provides a description of the initial neurologic condition, it does not correlate tightly with outcome. Various methods have been used in an attempt to predict the outcome of TBI, and these are beyond the scope of this discussion. However, one simplified model uses 3 factors, that is, age, motor score of the GCS, and pupillary response (ie, normal, unilateral unresponsive pupil, bilateral unresponsive pupils), to provide a probability of outcome.
The Traumatic Coma Data Bank analyzed 780 patients with head injuries and identified 5 factors that correlated with a poor outcome, as follows: (1) age older than 60 years, (2) initial GCS score of less than 5, (3) presence of a fixed dilated pupil, (4) prolonged hypotension or hypoxia early after injury, and (5) presence of a surgical intracranial mass lesion.
Many methods exist for evaluating the outcome of TBI. A simple and commonly used method is the Glasgow outcome scale. This divides outcome into 5 categories, as follows: (1) good, (2) moderate disability, (3) severe disability, (4) vegetative, and (5) dead. The scale can be divided further into good outcomes (eg, good plus moderate disability) and poor outcomes (eg, severe disability, vegetative, dead).
Future and Controversies
The most significant controversy today in the treatment of TBI is the minimum desirable CPP to achieve in the patient with a head injury. Previously, a CPP of 79 mm Hg was considered the minimum; however, many now believe that a CPP of 60 mm Hg is sufficient. Further controversy also exists as to whether elevated ICP or decreased CPP is a more important prognostic factor. This is an important distinction because it directs the main goals of therapy in severely injured patients. If ICP elevations are considered a more important factor, then efforts may be directed at lowering ICP as a primary goal and improving CPP as a secondary goal. If one considers CPP to be the more important factor, then the primary goal of treatment should be to maintain an appropriate CPP.
The authors and editors of eMedicine gratefully acknowledge the contributions of previous author Scott Shepard, MD, to the development and writing of this article.
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References
[Best Evidence] Maloney-Wilensky E, Gracias V, Itkin A, et al. Brain tissue oxygen and outcome after severe traumatic brain injury: a systematic review. Crit Care Med. Jun 2009;37(6):2057-63. [Medline].
Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet. Mar 1 1975;1(7905):480-4. [Medline].
Marshall LF, Marshall SB, Klauber MR. A new classification of head injury based on computerized tomography. J Neurosurg. 1991;75:S14-20.
Temkin NR, Dikmen SS, Wilensky AJ, et al. A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. N Engl J Med. Aug 23 1990;323(8):497-502. [Medline].
Lundberg N. Continuous Recording and Control of Ventricular Fluid Pressure in Neurosurgical Practice. Acta Psychiatr Neurol Scand. 1960;36:148-93.
Benzel EC, Mashburn JP, Conrad S, et al. Apnea testing for the determination of brain death: a modified protocol. Technical note. J Neurosurg. Jun 1992;76(6):1029-31. [Medline].
Bernat JL, Culver CM, Gert B. On the definition and criterion of death. Arch Intern Med. Mar 1981;94(3):389-94. [Medline].
Brandt MM, Ahrns KS, Corpron CA, et al. Hospital cost is reduced by motorcycle helmet use. J Trauma. Sep 2002;53(3):469-71. [Medline].
Choi SC, Narayan RK, Anderson RL, et al. Enhanced specificity of prognosis in severe head injury. J Neurosurg. Sep 1988;69(3):381-5. [Medline].
Crippen DW, Whetstine LM. Ethics review: dark angels--the problem of death in intensive care. Crit Care. 2007;11(1):202. [Medline].
Darwin MG, Leaf JD, Hixon H. Neuropreservation of Alcor patient A-1068. From Cryonics, February & March, 1986. Available at http://www.alcor.org/Library/html/casereport8504.html#part2.
Guidelines for the determination of death. Report of the medical consultants on the diagnosis of death to the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. JAMA. Nov 13 1981;246(19):2184-6. [Medline].
Guidelines for the management of severe head injury. Brain Trauma Foundation, American Association of Neurological Surgeons, Joint Section on Neurotrauma and Critical Care. J Neurotrauma. Nov 1996;13(11):641-734. [Medline].
Horn P, Munch E, Vajkoczy P, et al. Hypertonic saline solution for control of elevated intracranial pressure in patients with exhausted response to mannitol and barbiturates. Neurol Res. Dec 1999;21(8):758-64. [Medline].
Kraus JF, Peek C, McArthur DL, et al. The effect of the 1992 California motorcycle helmet use law on motorcycle crash fatalities and injuries. JAMA. Nov 16 1994;272(19):1506-11. [Medline].
Morenski JD, Oro JJ, Tobias JD, et al. Determination of death by neurological criteria. J Intensive Care Med. Jul-Aug 2003;18(4):211-21. [Medline].
Rosenberg WS, Harsh GR. Penetrating cerebral trauma. In: Grossman GR, Loftus CM, eds. Principles of Neurosurgery. 2nd ed. Philadelphia: Lippincott-Raven; 1999:173-82.
Rosner MJ, Rosner SD, Johnson AH. Cerebral perfusion pressure: management protocol and clinical results. J Neurosurg. Dec 1995;83(6):949-62. [Medline].
Sumas ME, Narayan RK. Head injury. In: Grossman GR, Loftus CM, eds. Principles of Neurosurgery. 2nd ed. Philadelphia: Lippincott-Raven; 1999:117-71.
Vivien B, Paqueron X, Le Cosquer P, et al. Detection of brain death onset using the bispectral index in severely comatose patients. Intensive Care Med. Apr 2002;28(4):419-25. [Medline].
Whetstine L, Streat S, Darwin M, Crippen D. Pro/con ethics debate: when is dead really dead?. Crit Care. 2005;9(6):538-42. [Medline].
Further Reading
Keywords
head injury, traumatic brain injury, TBI, brain trauma, brain injury, closed head injury, primary brain injury, secondary brain injury, cerebral injury, penetrating head injury, brain herniation, cerebral herniation, transtentorial herniation, subfalcine herniation, central herniation, upward herniation, cerebellar herniation, tonsillar herniation, Glasgow Coma Scale
Follow-up: Head Trauma