Outcome and Prognosis
In a retrospective record review of 76 patients diagnosed with enterovesical fistula over a 12-year period, the complication rate in those treated with single-stage repair was not statistically different from that in patients who underwent multistage repair.65
In general, the overall outcome and prognosis are excellent in patients with non–radiation-induced or cancer-induced fistulae. Such patients usually respond well to resection of the diseased colon and have no significant urinary sequelae.
The prognosis in patients with colon carcinoma and fistulization is less favorable because the involvement of the bladder usually heralds a more aggressive tumor that often is metastatic at the time of detection.
Radiation-induced fistulae are more likely to recur, but the long-term patient prognosis may be better if the malignancy for which the radiation was administered has been controlled.
Future and Controversies
Future treatment of typical enterovesical fistulae may focus on development and refinement of minimally invasive surgical techniques, such as laparoscopic and robotic, to shorten recovery time and to potentially decrease hospital stay. The benefit and complications of preoperative ureteral stenting for intraoperative identification of the ureter may become a particular area of interest for clinical study. As of the latest review of this article, there is little clinical data to demonstrate the benefit of ureteral stents in preventing ureteral injury.
New modalities in neoadjuvant chemotherapy may allow further bladder preservation strategies. Trends in radiation oncology that permit minimization of collateral organ damage (eg, conformal external beam radiotherapy) and the use of tumor-specific radiosensitizing agents may be highly useful in preventing radiation-induced fistulae.
Improved surgical techniques, including laparoscopic procedures that greatly enhance visualization of the operative field, hold promise for fewer fistula-related complications of gynecologic and urologic procedures.
Advancements in molecular biology and the development of medications to manipulate inflammatory mediators may eventually produce more specifically targeted therapies to decrease the risk of fistula formation in inflammatory conditions, particularly Crohn disease.
Given the low incidence of colovesical fistula, the development of and recruitment for prospective randomized studies is difficult.
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Further Reading
Keywords
enterovesical fistula, enterovesical fistulae, colovesical fistula, colovesical fistulae, intestinovesical fistula, vesicocolic fistula, rectovesical fistula, ileovesical fistula, appendicovesical fistula, pneumaturia, fecaluria, urinary tract infections, UTIs, bowel disease, vesicoenteric fistula, rectourethral fistula, diverticular disease, Crohn disease, appendicitis, imperforate anus, diverticulitis, Crohn colitis, Meckel diverticulum, genitourinary coccidioidomycosis, pelvic actinomycosis, colorectal cancer, prostatectomy, laparoscopic inguinal hernia repair, Gouverneur syndrome, sigmoid diverticular disease
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