eMedicine Specialties > Urology > Stones

Pregnancy and Urolithiasis: Follow-up

Author: Robert O Wayment, MD, Resident Physician, Division of Urology, Southern Illinois University School of Medicine
Coauthor(s): Bradley Fields Schwartz, DO, FACS, Professor of Urology, Director, Center for Laparoscopy and Endourology, Department of Surgery, Southern Illinois University School of Medicine
Contributor Information and Disclosures

Updated: Mar 19, 2009

Follow-up

Deterrence/Prevention

See Diet.

Complications

  • Symptomatic urolithiasis does not appreciably worsen pregnancy outcome. Occurring in about 10-20% of patients, urinary tract infection is the most common nonobstetric complication of urolithiasis in pregnancy. Premature labor associated with renal colic is rare but can occur. In the past, spontaneous abortion has been associated with a history of urolithiasis but is extremely rare today.
  • Complications secondary to surgical interventions are more common in the pregnant population; however, they are becoming increasingly infrequent with increased experience and improved technology.
  • Physiologic changes of pregnancy are associated with an increase in perioperative risk. Complications of any surgical procedure may include the following:
    • Aspiration
    • Deep vein thrombosis
    • Pulmonary embolism
    • Premature delivery
  • Complications of internal stent placement may include the following:
    • Stent incrustation, which may be accelerated in pregnancy and require change every 3-4 weeks8
    • Infection
    • Sepsis
    • Stent migration
  • Complications of percutaneous nephrostomy may include the following:
    • Recurrent obstruction necessitating frequent flushing or replacement
    • Infection or sepsis secondary to tube obstruction
    • Fetal harm secondary to prolonged anesthesia requirements and ionizing radiation
    • Premature delivery42
    • Risk of bleeding caused by nephrostomy tube placement, tube dislodgement, and erosion
  • According to recent studies, complications of ureteroscopy and intracorporeal lithotripsy in pregnancy are rare in experienced hands.18,17,30 The risk of complications may be mildly increased because of the anatomic changes of pregnancy; however, the possible complications do not differ from those in the general population. These types of risks include the following:
    • Ureteral injury
    • Perforation
    • Subsequent stricture formation
  • Complications of open surgery include an increased risk of premature delivery. The rate of premature delivery after surgery is 6.5% during the first trimester, 8.6% during the second trimester, and 11.9% during the third trimester. Intrauterine growth restriction or premature birth (complication of receiving general anesthesia during pregnancy) is more likely.

Prognosis

  • Diagnosis and treatment of urolithiasis in pregnancy is complex. However, advances in technology and experience allow urologists to provide accurate evaluation and succeed with either temporizing or definitive treatments. These can be accomplished safely, with little risk to the mother or fetus. With prompt evaluation and expeditious treatment, the prognosis is excellent.

Patient Education

Miscellaneous

Medicolegal Pitfalls

  • Spontaneous abortion
  • Premature labor
  • Urosepsis
 
Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous author, Jong M. Choe, MD, FACS, and previous coauthor Rajesh Prasad, MD, to the development and writing of this article.



More on Pregnancy and Urolithiasis

Overview: Pregnancy and Urolithiasis
Differential Diagnoses & Workup: Pregnancy and Urolithiasis
Treatment & Medication: Pregnancy and Urolithiasis
Follow-up: Pregnancy and Urolithiasis
Multimedia: Pregnancy and Urolithiasis
References

References

  1. Folger GK. Pain and pregnancy; treatment of painful states complicating pregnancy, with particular emphasis on urinary calculi. Obstet Gynecol. Apr 1955;5(4):513-8. [Medline].

  2. Rodriguez PN, Klein AS. Management of urolithiasis during pregnancy. Surg Gynecol Obstet. Feb 1988;166(2):103-6. [Medline].

  3. Drago JR, Rohner TJ, Chez RA. Management of urinary calculi in pregnancy. Urology. Dec 1982;20(6):578-81. [Medline].

  4. Biyani CS, Joyce AD. Urolithiasis in pregnancy. II: management. BJU Int. May 2002;89(8):819-23. [Medline].

  5. Swanson SK, Heilman RL, Eversman WG. Urinary tract stones in pregnancy. Surg Clin North Am. Feb 1995;75(1):123-42. [Medline].

  6. Parulkar BG, Hopkins TB, Wollin MR, Howard PJ Jr, Lal A. Renal colic during pregnancy: a case for conservative treatment. J Urol. Feb 1998;159(2):365-8. [Medline].

  7. Stothers L, Lee LM. Renal colic in pregnancy. J Urol. Nov 1992;148(5):1383-7. [Medline].

  8. Denstedt JD, Razvi H. Management of urinary calculi during pregnancy. J Urol. Sep 1992;148(3 Pt 2):1072-4; discussion 1074-5. [Medline].

  9. Glowacki LS, Beecroft ML, Cook RJ, Pahl D, Churchill DN. The natural history of asymptomatic urolithiasis. J Urol. Feb 1992;147(2):319-21. [Medline].

  10. Gregory MC, Mansell MA. Pregnancy and cystinuria. Lancet. Nov 19 1983;2(8360):1158-60. [Medline].

  11. Boridy IC, Maklad N, Sandler CM. Suspected urolithiasis in pregnant women: imaging algorithm and literature review. AJR Am J Roentgenol. Oct 1996;167(4):869-75. [Medline].

  12. Waltzer WC. The urinary tract in pregnancy. J Urol. Mar 1981;125(3):271-6. [Medline].

  13. Wolff JM, Jung PK, Adam G, Jakse G. Non-traumatic rupture of the urinary tract during pregnancy. Br J Urol. Nov 1995;76(5):645-8. [Medline].

  14. Loughlin KR, McAleer SJ. Management of Urological Problems in Pregnancy: A Rationale and Strategy. AUA Update Series. 2005;24: Lesson 5.

  15. American College of Obstetricians and Gynecologists (ACOG). ACOG Committee Opinion. Number 299, September 2004 (replaces No. 158, September 1995). Guidelines for diagnostic imaging during pregnancy. Obstet Gynecol. Sep 2004;104(3):647-51. [Medline].

  16. Srirangam SJ, Hickerton B, Van Cleynenbreugel B. Management of urinary calculi in pregnancy: a review. J Endourol. May 2008;22(5):867-75. [Medline].

  17. Lifshitz DA, Lingeman JE. Ureteroscopy as a first-line intervention for ureteral calculi in pregnancy. J Endourol. Feb 2002;16(1):19-22. [Medline].

  18. Lemos GC, El Hayek OR, Apezzato M. Rigid ureteroscopy for diagnosis and treatment of ureteral calculi during pregnancy. Int Braz J Urol. Jul-Aug 2002;28(4):311-5; discussion 316. [Medline].

  19. Ulvik NM, Bakke A, Høisaeter PA. Ureteroscopy in pregnancy. J Urol. Nov 1995;154(5):1660-3. [Medline].

  20. Laing FC, Benson CB, DiSalvo DN, Brown DL, Frates MC, Loughlin KR. Distal ureteral calculi: detection with vaginal US. Radiology. Aug 1994;192(2):545-8. [Medline].

  21. Loughlin KR, Ker LA. The current management of urolithiasis during pregnancy. Urol Clin North Am. Aug 2002;29(3):701-4. [Medline].

  22. Shokeir AA, Abdulmaaboud M. Resistive index in renal colic: a prospective study. BJU Int. Mar 1999;83(4):378-82. [Medline].

  23. White WM, Zite NB, Gash J, Waters WB, Thompson W, Klein FA. Low-dose computed tomography for the evaluation of flank pain in the pregnant population. J Endourol. Nov 2007;21(11):1255-60. [Medline].

  24. Rittenberg MH, Bagley DH. Ureteroscopic diagnosis and treatment of urinary calculi during pregnancy. Urology. Nov 1988;32(5):427-8. [Medline].

  25. Scarpa RM, De Lisa A, Usai E. Diagnosis and treatment of ureteral calculi during pregnancy with rigid ureteroscopes. J Urol. Mar 1996;155(3):875-7. [Medline].

  26. Houshiar AM, Ercole CJ. Urinary calculi during pregnancy. When are they cause for concern?. Postgrad Med. Oct 1996;100(4):131-8. [Medline].

  27. Barron WM. Medical evaluation of the pregnant patient requiring nonobstetric surgery. Clin Perinatol. Oct 1985;12(3):481-96. [Medline].

  28. Lipkin M, Shah O. The use of alpha-blockers for the treatment of nephrolithiasis. Rev Urol. 2006;8 Suppl 4:S35-42. [Medline].

  29. Parsons JK, Hergan LA, Sakamoto K, Lakin C. Efficacy of alpha-blockers for the treatment of ureteral stones. J Urol. Mar 2007;177(3):983-7; discussion 987. [Medline].

  30. Watterson JD, Girvan AR, Beiko DT, Nott L, Wollin TA, Razvi H. Ureteroscopy and holmium:YAG laser lithotripsy: an emerging definitive management strategy for symptomatic ureteral calculi in pregnancy. Urology. Sep 2002;60(3):383-7. [Medline].

  31. Loughlin KR. Management of urologic problems during pregnancy. Urology. Aug 1994;44(2):159-69. [Medline].

  32. Evans HJ, Wollin TA. The management of urinary calculi in pregnancy. Curr Opin Urol. Jul 2001;11(4):379-84. [Medline].

  33. Kavoussi LR, Jackman SV, Bishoff JT. Re: Renal colic during pregnancy: a case for conservative treatment. J Urol. Sep 1998;160(3 Pt 1):837-8. [Medline].

  34. Kavoussi LR, Albala DM, Basler JW, Apte S, Clayman RV. Percutaneous management of urolithiasis during pregnancy. J Urol. Sep 1992;148(3 Pt 2):1069-71. [Medline].

  35. Akpinar H, Tüfek I, Alici B, Kural AR. Ureteroscopy and holmium laser lithotripsy in pregnancy: stents must be used postoperatively. J Endourol. Feb 2006;20(2):107-10. [Medline].

  36. Streem SB. Contemporary clinical practice of shock wave lithotripsy: a reevaluation of contraindications. J Urol. Apr 1997;157(4):1197-203. [Medline].

  37. Kakkar VV. The current status of low-dose heparin in the prophylaxis of thrombophlebitis and pulmonary embolism. World J Surg. Jan 1978;2(1):3-18. [Medline].

  38. Pisegna JR. Switching between intravenous and oral pantoprazole. J Clin Gastroenterol. Jan 2001;32(1):27-32. [Medline].

  39. Li DK, Liu L, Odouli R. Exposure to non-steroidal anti-inflammatory drugs during pregnancy and risk of miscarriage: population based cohort study. BMJ. Aug 16 2003;327(7411):368. [Medline].

  40. Boubred F, Vendemmia M, Garcia-Meric P, Buffat C, Millet V, Simeoni U. Effects of maternally administered drugs on the fetal and neonatal kidney. Drug Saf. 2006;29(5):397-419. [Medline].

  41. Koren G, Florescu A, Costei AM, Boskovic R, Moretti ME. Nonsteroidal antiinflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysis. Ann Pharmacother. May 2006;40(5):824-9. [Medline].

  42. Khoo L, Anson K, Patel U. Success and short-term complication rates of percutaneous nephrostomy during pregnancy. J Vasc Interv Radiol. Dec 2004;15(12):1469-73. [Medline].

  43. Armstrong SJ, Witcombe JB. Calcified hydronephrosis in pregnancy. Br J Radiol. Oct 1991;64(766):966-8. [Medline].

  44. Asgari MA, Safarinejad MR, Hosseini SY. Extracorporeal shock wave lithotripsy of renal calculi during early pregnancy. BJU Int. Oct 1999;84(6):615-7. [Medline].

  45. Butler EL, Cox SM, Eberts EG. Symptomatic nephrolithiasis complicating pregnancy. Obstet Gynecol. Nov 2000;96(5 Pt 1):753-6. [Medline].

  46. Cass AS, Smith CS, Gleich P. Management of urinary calculi in pregnancy. Urology. Nov 1986;28(5):370-2. [Medline].

  47. Fabrizio MD, Gray DS, Feld RI. Placement of ureteral stents in pregnancy using ultrasound guidance. Tech Urol. Fall 1996;2(3):121-5. [Medline].

  48. Fligelstone LJ, Datta SN, Evans C. Problematic renal calculi presenting during pregnancy. Ann R Coll Surg Engl. Mar 1996;78(2):142-5. [Medline].

  49. Gana BM, Taube M. Extracorporeal shock wave lithotripsy of renal calculi during early pregnancy. BJU Int. Feb 2000;85(3):384. [Medline].

  50. Gorton E, Whitfield HN. Renal calculi in pregnancy. Br J Urol. Jul 1997;80 Suppl 1:4-9. [Medline].

  51. Hendricks SK, Ross SO, Krieger JN. An algorithm for diagnosis and therapy of management and complications of urolithiasis during pregnancy. Surg Gynecol Obstet. Jan 1991;172(1):49-54. [Medline].

  52. Horowitz E, Schmidt JD. Renal calculi in pregnancy. Clin Obstet Gynecol. Jun 1985;28(2):324-38. [Medline].

  53. Kroovand RL. Stones in pregnancy and in children. J Urol. Sep 1992;148(3 Pt 2):1076-8. [Medline].

  54. Leslie S. Increasing urinary volume. Personal communication. Used with permission. 2001.

  55. Leslie S. The IRS plan for increasing urinary volume. In: Savitz G, Leslie S, eds. The Kidney Stones Handbook. 2nd ed. Roseville, Calif: Four Geez Press; 1999:141-4.

  56. Powell CR, Stoller ML, Schwartz BF. Impact of body weight on urinary electrolytes in urinary stone formers. Urology. Jun 2000;55(6):825-30. [Medline].

  57. Rosenfeld JA. Renal disease and pregnancy. Am Fam Physician. Apr 1989;39(4):209-12. [Medline].

  58. Savitz G, Leslie S. Water, Water Everywhere. In: Savitz G, Leslie S, eds. The Kidney Stones Handbook. 2nd ed. Roseville, Calif: Four Geez Press; 1999:131-40.

  59. Shokeir AA, Mahran MR, Abdulmaaboud M. Renal colic in pregnant women: role of renal resistive index. Urology. Mar 2000;55(3):344-7. [Medline].

  60. Thompson T, Kelly JD, Keane PF. Problematic renal calculi presenting during pregnancy. Ann R Coll Surg Engl. Jul 1996;78(4):399. [Medline].

  61. Wolf MC, Hollander JB, Salisz JA. A new technique for ureteral stent placement during pregnancy using endoluminal ultrasound. Surg Gynecol Obstet. Dec 1992;175(6):575-6. [Medline].

Further Reading

Keywords

urolithiasis in pregnancy, kidney stones, ureteral stones, bladder stones, urolithiasis, calculi, calculus, urosepsis, urinary tract infection, stone formation, uric acid stone disease, calcium stone disease, cystinuria, uric acid stone formation, calcium oxalate stone formation, calcium phosphate stone formation, crystalluria, struvite stones, renal calculi, nephrolithiasis, hypercalcemia, hypercalciuria, hydroureteronephrosis

Contributor Information and Disclosures

Author

Robert O Wayment, MD, Resident Physician, Division of Urology, Southern Illinois University School of Medicine
Robert O Wayment, MD is a member of the following medical societies: American Medical Association and American Urological Association
Disclosure: Nothing to disclose.

Coauthor(s)

Bradley Fields Schwartz, DO, FACS, Professor of Urology, Director, Center for Laparoscopy and Endourology, Department of Surgery, Southern Illinois University School of Medicine
Bradley Fields Schwartz, DO, FACS is a member of the following medical societies: American College of Surgeons, American Urological Association, Association of Military Osteopathic Physicians and Surgeons, Endourological Society, Society of Laparoendoscopic Surgeons, and Society of University Urologists
Disclosure: Nothing to disclose.

Medical Editor

Jeffrey B Garris, MD, Chief, Assistant Professor, Department of Obstetrics and Gynecology, Division of Urogynecology and Reconstructive Pelvic Surgery, Tulane University School of Medicine
Jeffrey B Garris, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Institute of Ultrasound in Medicine, American Medical Association, American Urological Association, Association of Professors of Gynecology and Obstetrics, Louisiana State Medical Society, Royal Society of Medicine, and Sigma Xi
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Eleanor Lederer, MD, Consulting Staff, Louisville VA Hospital; Professor of Medicine, Director of Nephrology Training Program, Kidney Disease Program, University of Louisville School of Medicine; Director, Metabolic Stone Clinic
Eleanor Lederer, MD is a member of the following medical societies: American Association for the Advancement of Science, American Federation for Medical Research, American Society for Biochemistry and Molecular Biology, American Society for Bone and Mineral Research, American Society of Nephrology, American Society of Transplantation, International Society of Nephrology, Kentucky Medical Association, National Kidney Foundation, and Phi Beta Kappa
Disclosure: Nothing to disclose.

CME Editor

J Stuart Wolf Jr, MD, FACS, David A Bloom Professor of Urology, Director of Division of Minimally Invasive Urology, Department of Urology, University of Michigan
J Stuart Wolf Jr, MD, FACS is a member of the following medical societies: American College of Surgeons, American Urological Association, Catholic Medical Association, Endourological Society, Society for Urology and Engineering, Society of Laparoendoscopic Surgeons, Society of University Urologists, and Society of Urologic Oncology
Disclosure: Terumo Corporation Consulting fee Consulting; Omeros Corporation Consulting fee Consulting

Chief Editor

Bradley Fields Schwartz, DO, FACS, Professor of Urology, Director, Center for Laparoscopy and Endourology, Department of Surgery, Southern Illinois University School of Medicine
Bradley Fields Schwartz, DO, FACS is a member of the following medical societies: American College of Surgeons, American Urological Association, Association of Military Osteopathic Physicians and Surgeons, Endourological Society, Society of Laparoendoscopic Surgeons, and Society of University Urologists
Disclosure: Nothing to disclose.

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.