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Thoracic Outlet Syndrome
Updated: Jan 25, 2010
Introduction
Background
Thoracic outlet syndrome (TOS) is a broad term that refers to compression of the neurovascular structures in the area just above the first rib and behind the clavicle that results in upper extremity symptoms. It represents a constellation of symptoms. The cause, diagnosis, and treatment are controversial. The brachial plexus (95%), subclavian vein (4%), and subclavian artery (1%) are affected such that TOS is usually classified into neurogenic, venous, and arterial forms.1 Most presentations to the emergency department (ED) are nonemergent and require only symptomatic treatment and referral.
Pathophysiology
The brachial plexus trunks and subclavian vessels are subject to compression or irritation as they course through 3 narrow passageways from the base of the neck toward the axilla and the proximal arm. The most important of these passageways is the interscalene triangle, which is also the most proximal. This triangle is bordered by the anterior scalene muscle anteriorly, the middle scalene muscle posteriorly, and the medial surface of the first rib inferiorly. This area may be small at rest and may become even smaller with certain provocative maneuvers. Anomalous structures, such as fibrous bands, cervical ribs, and anomalous muscles, may constrict this triangle further. Repetitive trauma to the plexus elements, particularly the lower trunk and C8-T1 spinal nerves, is thought to play an important role in the pathogenesis of thoracic outlet syndrome (TOS).
The second passageway is the costoclavicular triangle, which is bordered anteriorly by the middle third of the clavicle, posteromedially by the first rib, and posterolaterally by the upper border of the scapula.
The last passageway is the subcoracoid space beneath the coracoid process just deep to the pectoralis minor tendon.
Frequency
United States
Because no objective confirmatory test is available for thoracic outlet syndrome (TOS), there is much disagreement with regards to its true incidence, with reported figures ranging from 3-80 cases per 1000 people.
Sex
The sex ratio varies depending on the type of thoracic outlet syndrome (TOS) (eg, neurologic, venous, arterial). Overall, the entity is approximately 3 times more common in women than in men.
- Neurologic - Female-to-male ratio approximately 3.5:1
- Venous - More common in males than in females
- Arterial - No gender predilection
Age
The onset of symptoms usually occurs in persons aged 20-50 years.
Clinical
History
- Neurologic symptoms occur in 95% of cases of thoracic outlet syndrome. The lower 2 nerve roots of the brachial plexus, C8 and T1, are most commonly (90%) involved, producing pain and paresthesias in the ulnar nerve distribution.
- The second most common anatomic pattern involves the upper 3 nerve roots of the brachial plexus, C5, C6, and C7, with symptoms referred to the neck, ear, upper chest, upper back, and outer arm in the radial nerve distribution.
- Neurologic - Symptoms are most often those of nerve irritation.
- Pain, particularly in the medial aspect of the arm, forearm, and the ring and small digits
- Paresthesias, often nocturnal, awakening the patient with pain or numbness. Most often involves all 5 fingers but usually most noticeable in the fourth and fifth fingers and the ulnar forearm.
- Weakness
- Cold intolerance
- Neck pain, pain over the trapezium, anterior chest wall pain, and occipital headache may also occur.
- Raynaud phenomenon, hand coldness, and color changes may also be seen, usually due to an overactive sympathetic nervous system as opposed to ischemia.
- Most have a history of neck trauma preceding their symptoms, most commonly from auto accidents and repetitive stress at work.
- Venous - Symptoms are those of an obstructed vein.
- Swelling of the arm
- Cyanosis
- Paresthesias in the fingers and hand (may be secondary to swelling as opposed to nerve compression)
- Pain, often in younger men and often preceded by excessive activity in the arms
- Arterial - Symptoms are those of digital and hand ischemia.
- Pain
- Pallor
- Coldness
- Paresthesias
- Often in young adults with a history of vigorous arm activity
- Symptoms usually develop spontaneously from arterial emboli.
Physical
In most cases, the physical examination findings of thoracic outlet syndrome (TOS) are completely normal. Other times, the examination is difficult because the patient may guard the extremity and exhibit giveaway-type weakness. The sensory examination is often unreliable.
- Provocative tests, such as the Adson, costoclavicular, and hyperabduction maneuvers, are unreliable. Approximately 92% of asymptomatic patients have variation in the strength of the radial pulse during positional changes.
- The elevated arm stress test (EAST) is of debatable use, but it may be the most reliable screening test. It evaluates all 3 types of thoracic outlet syndrome (TOS).
- To perform this test, the patient sits with the arms abducted 90 degrees from the thorax and the elbows flexed 90 degrees. The patient then opens and closes the hands for 3 minutes.
- Patients with TOS cannot continue this for 3 minutes because of reproduction of symptoms. Patients with carpal tunnel syndrome experience dysesthesias in the fingers, but do not have shoulder or arm pain.
- The upper limb tension test of Elvey may be helpful
- This test serially puts tension on the brachial plexus similar to straight leg raising in the lower extremity.
- Neurologic
- A typical patient is a young, thin female with a long neck and drooping shoulders.
- A positive EAST test result and the presence of a radial pulse are strong indicators of neurologic involvement of the brachial plexus.
- Supraclavicular tenderness may be present.
- Usually, no evidence of muscle atrophy is present, although the classic finding is known as the Gilliatt-Sumner hand, with the most dramatic atrophy in the abductor pollicis brevis, with lesser involvement of the interossei and hypothenar muscles.
- Paresthesias/sensory loss is restricted to the ulnar aspect of the hand and forearm.
- Weakness (usually subtle) of affected limb may be noted.
- Venous
- Edema of the upper extremity
- Cyanosis of the upper extremity
- Distended superficial veins of the shoulder and chest
- Arterial
- Pallor and pulselessness
- Coolness on the affected upper extremity
- Lower blood pressure in affected arm of greater than 20 mm Hg (a reliable indicator of arterial involvement)
- Rarely can produce multiple small infarcts on the hand and fingers (embolization)
Causes
Listed below are common etiologies for each anatomic form of thoracic outlet syndrome (TOS):
- Neurogenic TOS: Etiology is most often a hyperextension neck injury, such as whiplash after a motor vehicle accident or a fall.2 Other causes include repetitive injury most often form sitting at a keyboard for long hours.
- Venous TOS: Etiology is obstruction of the subclavian vein, either thrombotic or nonthrombotic.2 The cause is a combination of predisposing and precipitating factors. The predisposition is congenital anatomic narrowing at the point where the subclavian and jugular veins join to form the innominate vein. The precipitating factor that leads to thrombosis is excessive activity of the arm such as throwing a baseball, swimming, weight lifting, or working with the arms elevated. Coagulopathies can also be a precipitating cause.
- Arterial TOS: Etiology is subclavian artery stenosis or aneurysm with thrombus formation and distal emboli usually due to a cervical rib or anomalous first rib.2 The aneurysm and stenosis are usually asymptomatic until embolization occurs.
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| Follow-up: Thoracic Outlet Syndrome |
| References |
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References
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Aufderheide TP. Peripheral arteriovascular disease. Emerg Med: Concepts and Clinical Practice. 1998;2:1844-7.
Hood DB, Kuehne J, Yellin AE, Weaver FA. Vascular complications of thoracic outlet syndrome. Am Surg. Oct 1997;63(10):913-7. [Medline].
Oates SD, Daley RA. Thoracic outlet syndrome. Hand Clin. Nov 1996;12(4):705-18. [Medline].
Plewa MC, Delinger M. The false-positive rate of thoracic outlet syndrome shoulder maneuvers in healthy subjects. Acad Emerg Med. Apr 1998;5(4):337-42. [Medline].
Sanders RJ, Hammond SL, Rao NM. Thoracic outlet syndrome: a review. Neurologist. Nov 2008;14(6):365-73. [Medline].
Weber RJ, Lebduskin S. Rehabilitation issues in plexopathies. Phys Med Rehabil. 1988;996-8.
Further Reading
Keywords
thoracic outlet syndrome, nerve compression syndrome, thoracic outlet syndrome causes, thoracic outlet syndrome symptoms, TOS, vascular thoracic outlet syndrome, neurologic thoracic outlet syndrome, arterial thoracic outlet syndrome, venous thoracic outlet syndrome, compression of neurovascular structures, neurovascular entrapment
Overview: Thoracic Outlet Syndrome