Ventricular Fibrillation in Emergency Medicine Clinical Presentation
- Author: Keith A Marill, MD; Chief Editor: David FM Brown, MD more...
History
- Ventricular fibrillation (VF) often occurs without forewarning. The following symptoms, while not necessarily specific for sudden cardiac death or VF, may develop before any major cardiac event:
- Chest pain and other angina equivalents
- Dyspnea
- Easy fatigue
- Palpitations
- Syncope
- Immediately preceding acute cardiac arrest, possible increase in heart rate, presence of premature ventricular contractions (PVCs), or period of VT
Physical
Physical examination findings may include the following:
- No pulse or respiration
- Patients in cardiac arrest have no pulse. However, both lay rescuers and healthcare providers may have difficulty determining pulselessness. Current AHA guidelines do not recommend that lay rescuers check for a pulse. Healthcare providers should take no more than 10 seconds to check for a pulse. If no pulse is found, the provider should proceed with chest compressions.
- Patients in cardiac arrest have absent or abnormal (gasping) respirations. Adults who are unresponsive or have been witnessed to collapse, and have absent or abnormal respirations are likely to be in cardiac arrest. AHA guidelines recommend activating the emergency response system (call 911) and initiating CPR.
- Unconsciousness
- Wide and chaotic QRS complexes on cardiac monitor
Causes
- Cardiac, structural heart disease
- Myocardial ischemia or infarction due to coronary artery disease: Coronary atherosclerosis and its consequences are responsible for approximately 80% of sudden cardiac deaths in the United States.
- Cardiomyopathy: Dilated and hypertrophic cardiomyopathies are the second most important cardiac causes of sudden death. The degree of functional and physiologic left ventricular impairment is correlated with the risk of sudden death: dilated, hypertrophic, or arrhythmogenic right ventricular cardiomyopathy or dysplasia.
- Aortic stenosis
- Aortic dissection
- Pericardial tamponade
- Congenital heart disease
- Myocarditis
- Cardiac, no structural heart disease
- Catecholaminergic polymorphic ventricular tachycardia and right ventricular outflow tract tachycardia
- Mechanical (commotio cordis)[4] or electrical accidents
- Preexcitation (including Wolff-Parkinson-White syndrome)
- Heart block
- Drug-induced QT prolongation with torsades de pointes
- Channelopathies: long QT syndrome, short QT syndrome, or Brugada syndrome
- Noncardiac respiratory
- Bronchospasm
- Aspiration
- Sleep apnea
- Primary pulmonary hypertension
- Pulmonary embolism
- Tension pneumothorax
- Metabolic or toxic
- Electrolyte disturbances and acidosis
- Medications or drug ingestion
- Environmental poisoning
- Sepsis
- Neurologic
- Seizure
- Cerebrovascular accident - Intracranial hemorrhage or ischemic stroke
- Drowning
Menegazzi JJ, Callaway CW, Sherman LD. Ventricular Fibrillation Scaling Exponent Can Guide Timing of Defibrillation and Other Therapies. Circulation. 2004;109(7):926-31. [Medline].
Valenzuela TD, Roe DJ, Nichol G. Outcomes of rapid defibrillation by security officers after cardiac arrest in casinos. N Engl J Med. 2000;343(17):1206-9. [Medline].
Becker LB, Ostrander MP, Barrett J, Kondos GT. Outcome of CPR in a large metropolitan area--where are the survivors?. Ann Emerg Med. Apr 1991;20(4):355-61. [Medline].
Link MS, Wang PJ, Pandian N. An experimental model of sudden death due to low-energy chest-wall impact (commotio cordis). N Engl J Med. 1998;338(25):1805-11. [Medline].
Bobrow BJ, Clark LL, Ewy GA, Chikani V, Sanders AB, Berg RA. Minimally interrupted cardiac resuscitation by emergency medical services for out-of-hospital cardiac arrest. JAMA. Mar 12 2008;299(10):1158-65. [Medline].
Cardiopulmonary resuscitation by bystanders with chest compression only (SOS-KANTO): an observational study. Lancet. Mar 17 2007;369(9565):920-6. [Medline].
Field JM, Hazinski MF, Sayre MR, Chameides L, Schexnayder SM, Hemphill R. Part 1: executive summary: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. Nov 2 2010;122(18 Suppl 3):S640-56. [Medline].
Aufderheide TP, Sigurdsson G, Pirrallo RG, Yannopoulos D, McKnite S, von Briesen C, et al. Hyperventilation-induced hypotension during cardiopulmonary resuscitation. Circulation. Apr 27 2004;109(16):1960-5. [Medline].
Ewy GA, Kern KB. Recent advances in cardiopulmonary resuscitation: cardiocerebral resuscitation. J Am Coll Cardiol. Jan 13 2009;53(2):149-57. [Medline].
Bardy GH, Lee KL, Mark DB, Poole JE, Toff WD, Tonkin AM, et al. Home use of automated external defibrillators for sudden cardiac arrest. N Engl J Med. Apr 24 2008;358(17):1793-804. [Medline].
Forcina MS, Farhat AY, O'Neil WW, Haines DE. Cardiac arrest survival after implementation of automated external defibrillator technology in the in-hospital setting. Crit Care Med. Apr 2009;37(4):1229-36. [Medline].
Chan PS, Krumholz HM, Spertus JA, Jones PG, Cram P, Berg RA, et al. Automated external defibrillators and survival after in-hospital cardiac arrest. JAMA. Nov 17 2010;304(19):2129-36. [Medline].
Truong JH, Rosen P. Current concepts in electrical defibrillation. J Emerg Med. May-Jun 1997;15(3):331-8. [Medline].
Schneider T, Martens PR, Paschen H. Multicenter, randomized, controlled trial of 150-J biphasic shocks compared with 200- to 360-J monophasic shocks in the resuscitation of out-of-hospital cardiac arrest victims. Circulation. 2000;102(15):1780-7. [Medline].
Stiell IG, Walker RG, Nesbitt LP, Chapman FW, Cousineau D, Christenson J, et al. BIPHASIC Trial: a randomized comparison of fixed lower versus escalating higher energy levels for defibrillation in out-of-hospital cardiac arrest. Circulation. Mar 27 2007;115(12):1511-7. [Medline].
Wik L, Hansen T, Fylling F. Delaying Defibrillation to Give Basic Cardiopulmonary Resuscitation to Patients With Out-of-Hospital Ventricular Fibrillation. A Randomized Trial. JAMA. 2003;289(11):1389-95. [Medline].
Gertsch M, Hottinger S, Hess T. Serial chest thumps for the treatment of ventricular tachycardia in patients with coronary artery disease. Clin Cardiol. Mar 1992;15(3):181-8. [Medline].
[Guideline] American Heart Association. 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. Dec 13 2005;112(24 Suppl):IV1-203. [Medline].
Shin TG, Choi JH, Jo IJ, Sim MS, Song HG, Jeong YK, et al. Extracorporeal cardiopulmonary resuscitation in patients with inhospital cardiac arrest: A comparison with conventional cardiopulmonary resuscitation. Crit Care Med. Jan 2011;39(1):1-7. [Medline].
Kellum MJ, Kennedy KW, Barney R, Keilhauer FA, Bellino M, Zuercher M, et al. Cardiocerebral resuscitation improves neurologically intact survival of patients with out-of-hospital cardiac arrest. Ann Emerg Med. Sep 2008;52(3):244-52. [Medline].
Weisfeldt ML, Becker LB. Resuscitation after cardiac arrest: a 3-phase time-sensitive model. JAMA. Dec 18 2002;288(23):3035-8. [Medline].
Gueugniaud PY, Mols P, Goldstein P. A comparison of repeated high doses and repeated standard doses of epinephrine for cardiac arrest outside the hospital. N Engl J Med. 1998;339(22):1595-1601. [Medline].
Wenzel V, Krismer AC, Arntz R. A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation. N Engl J Med. 2004;350(2):105-16. [Medline].
[Best Evidence] Callaway CW, Hostler D, Doshi AA. Usefulness of Vasopressin Administered With Epinephrine During Out-of-Hospital Cardiac Arrest. Am J Cardiol. 2006;98(10):1316-21. [Medline].
Kudenchuk PJ, Cobb LA, Copass MK, et al. Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation. N Engl J Med. Sep 16 1999;341(12):871-8. [Medline].
Dorian P, Cass D, Schwartz B. Amiodarone as compared with Lidocaine for Shock-Resistant Ventricular Fibrillation. N Engl J Med. 2002;346(12):884-90. [Medline].
Nowak RM, Bodnar TJ, Dronen S. Bretylium tosylate as initial treatment for cardiopulmonary arrest: randomized comparison with placebo. Ann Emerg Med. 1981;10(8):404-7. [Medline].
Kovoor P, Love A, Hall J. Randomized double-blind trial of sotalol versus lignocaine in out-of-hospital refractory cardiac arrest due to ventricular tachyarrhythmias. Intern Med J. 2005;35(9):518-25. [Medline].
Spaulding CM, Joly LM, Rosenberg A. Immediate coronary angiography in survivors of out-of-hospital cardiac arrest. N Engl J Med. 1997;336(23):1629-33. [Medline].
Sunde K, Pytte M, Jacobsen D, Mangschau A, Jensen LP, Smedsrud C, et al. Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest. Resuscitation. Apr 2007;73(1):29-39. [Medline].
Hypothermia after Cardiac Arrest Study Group. Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest. N Engl J Med. 2002;346(8):549-56. [Medline].
Bernard SA, Gray TW, Buist MD. Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia. N Engl J Med. 2002;346(8):557-63. [Medline].
Young KD, Gausche-Hill M, McClung CD. A prospective, population-based study of the epidemiology and outcome of out-of-hospital pediatric cardiopulmonary arrest. Pediatrics. 2004;114(1):157-64. [Medline].
Swor RA, Jackson RE, Tintinalli JE. Does advanced age matter in outcomes after out-of-hospital cardiac arrest in community-dwelling adults?. Acad Emerg Med. 2000;7(7):762-8. [Medline].
Mosier J, Itty A, Sanders A, Mohler J, Wendel C, Poulsen J, et al. Cardiocerebral resuscitation is associated with improved survival and neurologic outcome from out-of-hospital cardiac arrest in elders. Acad Emerg Med. Mar 2010;17(3):269-75. [Medline].
Robinson SM, Mackenzie-Ross S, Campbell Hewson GL. Psychological effect of witnessed resuscitation on bereaved relatives. Lancet. 1998;352(9128):614-7. [Medline].
Angelos MG, Menegazzi JJ, Callaway CW. Bench to Bedside: Resuscitation from Prolonged Ventricular Fibrillation. Acad Emerg Med. 2001;8(9):909-24. [Medline].
Bossaert LL. Fibrillation and defibrillation of the heart. Br J Anaesth. Aug 1997;79(2):203-13. [Medline].
Cohen TJ. Innovative emergency defibrillation methods for refractory ventricular fibrillation in a variety of hospital settings. Am Heart J. Oct 1993;126(4):962-8. [Medline].
Cummins RO, Eisenberg MS, Litwin PE, et al. Automatic external defibrillators used by emergency medical technicians. A controlled clinical trial. JAMA. Mar 27 1987;257(12):1605-10. [Medline].
Eisenberg MS, Mengert TJ. Cardiac resuscitation. N Engl J Med. 2001;344(17):1304-1313. [Medline].
Huikuri HV, Castellanos A, Myerburg RJ. Sudden death due to cardiac arrhythmias. N Engl J Med. 2001;345(20):1473-82. [Medline].
Mogayzel C, Quan L, Graves JR, et al. Out-of-hospital ventricular fibrillation in children and adolescents: causes and outcomes. Ann Emerg Med. Apr 1995;25(4):484-91. [Medline].
Mols P, Beaucarne E, Bruyninx J, et al. Early defibrillation by EMTs: the Brussels experience. Resuscitation. Mar 1994;27(2):129-36. [Medline].
Weaver WD, Cobb LA, Copass MK, Hallstrom AP. Ventricular defibrillation -- a comparative trial using 175-J and 320-J shocks. N Engl J Med. Oct 28 1982;307(18):1101-6. [Medline].
Weiss JN, Garfinkel A, Karagueuzian HS. Chaos and the Transition to Ventricular Fibrillation: a new approach to antiarrhythmic drug evaluation. Circulation. 1999;99(21):2819-26. [Medline].
White RD, Russell JK. Refibrillation, resuscitation and survival in out-of-hospital sudden cardiac arrest victims treated with biphasic automated external defibrillators. Resuscitation. Oct 2002;55(1):17-23. [Medline].

