Urticaria Follow-up

  • Author: M Scott Linscott, MD, FACEP; Chief Editor: Pamela L Dyne, MD   more...
 
Updated: Apr 2, 2010
 

Further Inpatient Care

  • In general, patients with urticaria can be cared for on an outpatient basis unless their urticaria is severe and does not respond to antihistamine therapy or if they progress to laryngeal angioedema and/or anaphylactic shock, or have comorbidities that require inpatient therapy.
Next

Further Outpatient Care

  • Most patients with urticaria can be treated at home on H1 antihistamines (ie, diphenhydramine 50 mg q6h or hydroxyzine 50 mg q6h for 24-48 h) or, in refractory cases, use a combination of H1 and H2 antihistamines plus oral glucocorticoids.
  • If the patient has angioedema that is treated successfully in the ED, the patient should be sent home with an EpiPen prescription and told to keep it with him or her at all times and to use it if swelling of the lips, tongue, face develops or if his or her voice acutely become hoarse.
  • Consultation with or referral to a dermatologist, allergist, immunologist, or rheumatologist may be appropriate in cases of suspected urticarial vasculitis and in cases of chronic or recurrent urticaria.
Previous
Next

Deterrence/Prevention

  • Patients with urticaria should avoid any medication, food, or other allergen that has precipitated urticaria or other serious allergic reaction previously.
Previous
Next

Prognosis

  • The prognosis in acute urticaria is excellent, with most cases resolving within 1-4 days.
  • The prognosis in chronic urticaria is more guarded and depends upon the comorbid disease causing the urticaria as well as the response to therapy.
Previous
Next

Patient Education

Previous
 
Contributor Information and Disclosures
Author

M Scott Linscott, MD, FACEP  Professor, Division of Emergency Medicine, Professor of Surgery (Clinical), University of Utah School of Medicine

M Scott Linscott, MD, FACEP is a member of the following medical societies: American College of Emergency Physicians, Society for Academic Emergency Medicine, and Utah Medical Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Steven A Conrad, MD, PhD  Chief, Department of Emergency Medicine; Chief, Multidisciplinary Critical Care Service, Professor, Department of Emergency and Internal Medicine, Louisiana State University Health Sciences Center

Steven A Conrad, MD, PhD is a member of the following medical societies: American College of Chest Physicians, American College of Critical Care Medicine, American College of Emergency Physicians, American College of Physicians, International Society for Heart and Lung Transplantation, Louisiana State Medical Society, Shock Society, Society for Academic Emergency Medicine, and Society of Critical Care Medicine

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD  Senior Pharmacy Editor, eMedicine

Disclosure: eMedicine Salary Employment

Mark W Fourre, MD  Program Director, Department of Emergency Medicine, Maine Medical Center; Associate Clinical Professor, Department of Surgery, University of Vermont School of Medicine

Disclosure: Nothing to disclose.

John D Halamka, MD, MS  Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center

John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Chief Editor

Pamela L Dyne, MD  Professor of Clinical Medicine/Emergency Medicine, David Geffen School of Medicine at UCLA; Attending Physician, Department of Emergency Medicine, Olive View-UCLA Medical Center

Pamela L Dyne, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

References
  1. Najib U, Sheikh J. An update on acute and chronic urticaria for the primary care provider. Postgrad Med. Jan 2009;121(1):141-51. [Medline].

  2. Poonawalla T, Kelly B. Urticaria : a review. Am J Clin Dermatol. 2009;10(1):9-21. [Medline].

  3. Frigas E, Park MA. Acute urticaria and angioedema: diagnostic and treatment considerations. Am J Clin Dermatol. 2009;10(4):239-50. [Medline].

  4. Brown NA, Carter JD. Urticarial vasculitis. Curr Rheumatol Rep. Aug 2007;9(4):312-9. [Medline].

  5. Zuberbier T, Maurer M. Urticaria: current opinions about etiology, diagnosis and therapy. Acta Derm Venereol. 2007;87(3):196-205. [Medline].

  6. Kaplan AP, Joseph K, Maykut RJ, Geba GP, Zeldin RK. Treatment of chronic autoimmune urticaria with omalizumab. J Allergy Clin Immunol. Sep 2008;122(3):569-73. [Medline].

  7. Viola M, Quaratino D, Gaeta F, Rumi G, Caruso C, Romano A. Cross-reactive reactions to nonsteroidal anti-inflammatory drugs. Curr Pharm Des. 2008;14(27):2826-32. [Medline].

  8. [Guideline] Magerl M, Borzova E, Gimrnez-Arnau A, Grattan CE, Lawlor F, Mathelier-Fusade P, et al. The definition and diagnostic testing of physical and cholinergic urticarias--EAACI/GA2LEN/EDF/UNEV consensus panel recommendations. Allergy. Dec 2009;64(12):1715-21. [Medline].

  9. Tong LJ, Balakrishnan G, Kochan JP, Kinét JP, Kaplan AP. Assessment of autoimmunity in patients with chronic urticaria. J Allergy Clin Immunol. Apr 1997;99(4):461-5. [Medline].

  10. Konstantinou GN, Asero R, Maurer M, Sabroe RA, Schmid-Grendelmeier P, Grattan CE. EAACI/GA(2)LEN task force consensus report: the autologous serum skin test in urticaria. Allergy. Sep 2009;64(9):1256-68. [Medline].

  11. Philpott H, Kette F, Hissaria P, Gillis D, Smith W. Chronic urticaria: the autoimmune paradigm. Intern Med J. Nov 2008;38(11):852-7. [Medline].

  12. Hossler EW. Caterpillars and moths: Part I. Dermatologic manifestations of encounters with Lepidoptera. J Am Acad Dermatol. Jan 2010;62(1):1-10; quiz 11-2. [Medline].

  13. Kaplan AP, Greaves M. Pathogenesis of chronic urticaria. Clin Exp Allergy. Jun 2009;39(6):777-87. [Medline].

  14. Vonakis BM, Saini SS. New concepts in chronic urticaria. Curr Opin Immunol. Dec 2008;20(6):709-16. [Medline].

  15. Guldbakke KK, Khachemoune A. Etiology, classification, and treatment of urticaria. Cutis. Jan 2007;79(1):41-9. [Medline].

  16. Bains SN, Hsieh FH. Current approaches to the diagnosis and treatment of systemic mastocytosis. Ann Allergy Asthma Immunol. Jan 2010;104(1):1-10; quiz 10-2, 41. [Medline].

  17. Goldfinger S. The inherited autoinflammatory syndrome: a decade of discovery. Trans Am Clin Climatol Assoc. 2009;120:413-8. [Medline].

  18. Nichols KM, Cook-Bolden FE. Allergic skin disease: major highlights and recent advances. Med Clin North Am. Nov 2009;93(6):1211-24. [Medline].

  19. Brodell LA, Beck LA. Differential diagnosis of chronic urticaria. Ann Allergy Asthma Immunol. Mar 2008;100(3):181-8; quiz 188-90, 215. [Medline].

  20. Botto NC, Warshaw EM. Solar urticaria. J Am Acad Dermatol. Dec 2008;59(6):909-20; quiz 921-2. [Medline].

  21. Irinyi B, Szeles G, Gyimesi E, Tumpek J, Heredi E, Dimitrios G, et al. Clinical and laboratory examinations in the subgroups of chronic urticaria. Int Arch Allergy Immunol. 2007;144(3):217-25. [Medline].

  22. Simons FE. Anaphylaxis. J Allergy Clin Immunol. Feb 2010;125(2 Suppl 2):S161-81. [Medline].

  23. [Guideline] Zuberbier T, Asero R, Bindslev-Jensen C, Walter Canonica G, Church MK, Giménez-Arnau AM, et al. EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria. Allergy. Oct 2009;64(10):1427-43. [Medline].

  24. Sype JW, Khan IA. Prolonged QT interval with markedly abnormal ventricular repolarization in diphenhydramine overdose. Int J Cardiol. Mar 18 2005;99(2):333-5. [Medline].

  25. Lin RY, Curry A, Pesola GR, Knight RJ, Lee HS, Bakalchuk L, et al. Improved outcomes in patients with acute allergic syndromes who are treated with combined H1 and H2 antagonists. Ann Emerg Med. Nov 2000;36(5):462-8. [Medline].

  26. Jauregui I, Ferrer M, Montoro J, Davila I, Bartra J, del Cuvillo A, et al. Antihistamines in the treatment of chronic urticaria. J Investig Allergol Clin Immunol. 2007;17 Suppl 2:41-52. [Medline].

  27. Smith PF, Corelli RL. Doxepin in the management of pruritus associated with allergic cutaneous reactions. Ann Pharmacother. May 1997;31(5):633-5. [Medline].

  28. Pollack CV Jr, Romano TJ. Outpatient management of acute urticaria: the role of prednisone. Ann Emerg Med. Nov 1995;26(5):547-51. [Medline].

  29. Bluestein HM, Hoover TA, Banerji AS, Camargo CA Jr, Reshef A, Herscu P. Angiotensin-converting enzyme inhibitor-induced angioedema in a community hospital emergency department. Ann Allergy Asthma Immunol. Dec 2009;103(6):502-7. [Medline].

  30. Simons FE. H1-Antihistamines: more relevant than ever in the treatment of allergic disorders. J Allergy Clin Immunol. Oct 2003;112(4 Suppl):S42-52. [Medline].

  31. Balaraman B, Bergstrom KG. Beyond antihistamines: treating chronic urticaria. J Drugs Dermatol. Nov 2009;8(11):1043-8. [Medline].

  32. Sicherer SH, Leung DY. Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009. J Allergy Clin Immunol. Jan 2010;125(1):85-97. [Medline].

  33. [Best Evidence] Wan KS. Efficacy of leukotriene receptor antagonist with an anti-H1 receptor antagonist for treatment of chronic idiopathic urticaria. J Dermatolog Treat. 2009;20(4):194-7. [Medline].

  34. Serhat Inaloz H, Ozturk S, Akcali C, Kirtak N, Tarakcioglu M. Low-dose and short-term cyclosporine treatment in patients with chronic idiopathic urticaria: a clinical and immunological evaluation. J Dermatol. May 2008;35(5):276-82. [Medline].

  35. Kessel A, Toubi E. Low-dose cyclosporine is a good option for severe chronic urticaria. J Allergy Clin Immunol. Apr 2009;123(4):970; author reply 970-1. [Medline].

  36. Bailey E, Shaker M. An update on childhood urticaria and angioedema. Curr Opin Pediatr. Aug 2008;20(4):425-30. [Medline].

Previous
Next
 
Urticaria developed after bites from an imported fire ant.
Urticaria associated with a drug reaction.
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.