Annulare and Pyogenic Granuloma Medication
- Author: Richard Lichenstein, MD; Chief Editor: Steven C Dronen, MD, FAAEM more...
Medication Summary
Granuloma annulare
Medical treatments such as corticosteroids, potassium iodide, dapsone, niacinamide, chlorambucil, and isotretinoin have been tried, but none has been shown efficacious. Other treatments include liquid nitrogen cryotherapy, oral and topical PUVA photochemotherapy, UVA1 phototherapy, and cyclosporin. Isotretinoin should be reserved for patients with disseminated or refractory GA because of potential serious toxicity.[5] Disseminated granuloma, which may be resistant to therapy, was responsive to low-dose fumaric acid esters in 63% of a series reported.[6] Moreover, adalimumab has been shown to be potentially promising to treat interstitial granuloma annulare.[7]
Corticosteroids
Class Summary
Used for their potent anti-inflammatory activity.
Triamcinolone acetonide (Aristospan)
Treats inflammatory lesions that are responsive to steroids. Decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability.
Retinoids
Class Summary
Isotretinoin may have proliferative and inhibitory effects on collagen synthesis that may ameliorate symptoms associated with GA.
Isotretinoin (Amnesteem, Claravis, Sotret)
Has been used as chemoprophylaxis of skin cancers
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