eMedicine Specialties > Emergency Medicine > Endocrine & Metabolic

Hypoglycemia: Follow-up

Author: Frank C Smeeks lll, MD, Chief Medical Officer, Frye Regional Medical Center
Contributor Information and Disclosures

Updated: Nov 26, 2008

Follow-up

Further Inpatient Care

  • Patients with no known cause or no previous episodes of hypoglycemia must be admitted for further evaluation.
    • For overdose, accidental ingestion, or therapeutic misadventures with oral hypoglycemics, little correlation exists between the amount of oral hypoglycemic agent ingested and the length or depth of coma. These patients require admission.
    • Inadequate data are available to predict the extent or the time course of hypoglycemia in children.
  • Chlorpropamide has demonstrated refractory hypoglycemia for up to 6 days after ingestion. Asymptomatic patients who have ingested hypoglycemic agents should be observed for the development of hypoglycemia, because the onset of action and the half-life are extremely variable. The length of observation is based on the ingested agent.
  • Admission criteria
    • No obvious cause
    • Oral hypoglycemic agent
    • Long-acting insulin
    • Persistent neurologic deficits
  • Discharge may be considered after a high carbohydrate meal in the following situations:
    • Obvious cause is found and treated.
    • Episode is reversed rapidly.

Further Outpatient Care

  • For patients on either short-acting insulin or hypoglycemic agents who have not eaten and have had their hypoglycemia reversed rapidly, a high carbohydrate meal prior to discharge is recommended.
  • A competent adult who has been directed to monitor fingerstick glucose measurements closely during the remainder of the day should accompany the patient after discharge.

Deterrence/Prevention

  • Patients must be counseled as to the causes and the early signs and symptoms of hypoglycemia. This counseling is particularly important for those patients who have a history of prior episodes of hypoglycemia or who are newly diagnosed diabetics.
  • General outpatient diabetic education or inpatient diabetic teaching is indicated.

Complications

  • Prolonged hypoglycemia may cause permanent neurologic deficit or death.
  • Unrecognized infection causing hypoglycemia in diabetic patients may result in recurrent hypoglycemic spells or progression of the infection.

Prognosis

  • The prognosis for this condition is excellent if detected and treated early.

Patient Education

  • Diabetic patients with episodes of hypoglycemia need education in nutrition, checking glucose levels at home, and early signs and symptoms of hypoglycemia.
  • Recognition of early symptoms is paramount for self-treatment.
  • For excellent patient education resources, see eMedicine's Diabetes Center. Also, visit eMedicine's patient education article, Low Blood Sugar.

Miscellaneous

Medicolegal Pitfalls

  • Discharging a patient following a hypoglycemic episode that is likely the result of a long-acting oral hypoglycemic medication is a potential pitfall. Any patient for whom the cause is not identified readily may have a recurrence of hypoglycemia with resultant sequelae.
 


More on Hypoglycemia

Overview: Hypoglycemia
Differential Diagnoses & Workup: Hypoglycemia
Treatment & Medication: Hypoglycemia
Follow-up: Hypoglycemia
References

References

  1. Altuntas Y, Bilir M, Ucak S, Gundogdu S. Reactive hypoglycemia in lean young women with PCOS and correlations with insulin sensitivity and with beta cell function. Eur J Obstet Gynecol Reprod Biol. Apr 1 2005;119(2):198-205. [Medline].

  2. Bourcigaux N, Arnault-Ouary G, Christol R, et al. Treatment of hypoglycemia using combined glucocorticoid and recombinant human growth hormone in a patient with a metastatic non-islet cell tumor hypoglycemia. Clin Ther. Feb 2005;27(2):246-51. [Medline].

  3. Ellenhorn MJ, Barceloux DG. Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 1988:440-61.

  4. Goldfrank LR. Goldfrank's Toxicologic Emergencies. 1994:577-88.

  5. Haddad LM, Winchester JF. Clinical Management of Poisoning and Drug Overdose. 2nd ed. 1990:1475-6.

  6. Hoffman RS, Goldfrank LR. The poisoned patient with altered consciousness. Controversies in the use of a 'coma cocktail'. JAMA. Aug 16 1995;274(7):562-9. [Medline].

  7. Kahn RC, Shechter Y. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. In: Goodman and Gilman's: The Pharmacologic Basis of Therapeutics. 8th ed. 1993:1463-84.

  8. Leiken JB, Palouchek FP. Poisoning and Toxicology Handbook. 1996-1997.

  9. Martin FI, Hansen N, Warne GL. Attempted suicide by insulin overdose in insulin-requiring diabetics. Med J Aust. Jan 15 1977;1(3):58-60. [Medline].

  10. McEvoy GK. Drug Information. 1986.

  11. Paterson KR, Paice BJ, Lawson DH. Undesired effects of biguanide therapy. Adverse Drug React Acute Poisoning Rev. 1984;3(3):173-82. [Medline].

  12. Patrick AW, Williams G. Adverse effects of exogenous insulin. Clinical features, management and prevention. Drug Saf. Jun 1993;8(6):427-44. [Medline].

  13. Ragland G. Hypoglycemia. In: Tintinalli J, et al, eds. Emergency Medicine: A Comprehensive Study Guide. 1996:939-46.

Further Reading

Keywords

hypoglycemia, low blood sugar, low glucose, glucopenia, decrease in the blood glucose level, insulinoma, coma, cardiac dysrhythmia, confusion, convulsions, diabetes, non–insulin-dependent diabetes, oral hypoglycemics, islet cell tumor, extrapancreatic tumor,insulin, palpitations, nausea, sweating, anxiety, diabetes mellitus type 1, diabetes mellitus type 2

Contributor Information and Disclosures

Author

Frank C Smeeks lll, MD, Chief Medical Officer, Frye Regional Medical Center
Frank C Smeeks lll, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, American College of Emergency Physicians, American College of Physician Executives, American Medical Association, and North Carolina Medical Society
Disclosure: Nothing to disclose.

Medical Editor

Robin R Hemphill, MD, MPH, Associate Professor, Director, Disaster Preparedness, Department of Emergency Medicine, Vanderbilt University Medical Center
Robin R Hemphill, MD, MPH is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: Nothing to disclose.

Managing Editor

Howard A Bessen, MD, Professor of Medicine, Department of Emergency Medicine, UCLA School of Medicine; Program Director, Harbor-UCLA Medical Center
Howard A Bessen, MD is a member of the following medical societies: American College of Emergency Physicians
Disclosure: Nothing to disclose.

CME Editor

John D Halamka, MD, MS, Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center
John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Chief Editor

Rick Kulkarni, MD, Medical Director, Assistant Professor of Surgery, Section of Emergency Medicine, Yale-New Haven Hospital
Rick Kulkarni, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
Disclosure: WebMD Salary Employment

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.