Hymenoptera Stings Treatment & Management

  • Author: Carrie de Moor, MD; Chief Editor: Scott H Plantz, MD, FAAEM   more...
 
Updated: Apr 26, 2010
 

Prehospital Care

Prehospital care must assess severity immediately and provide immediate appropriate treatment, because the most endangered patients die within 30 minutes of a sting.

Local reactions can be life threatening if swelling occludes the airway. Initiate invasive measures to secure the airway if this occurs. Otherwise, the following local care measures suffice.

  • Provide supplemental oxygen
  • Diphenhydramine limits the size of the local reaction.
  • Clean the wound and remove the stinger if present.
  • Apply ice or cool packs.
  • Elevate the extremity to limit edema.

Manage generalized reactions similarly to anaphylaxis, even in the absence of shock. Increased vascular permeability in anaphylaxis may result in transfer of 50% of the intravascular fluid into the extravascular space within 10 minutes.[1] Check airway and ventilatory status. Treatment should include an initial intravenous (IV) bolus of 10-20 mL/kg isotonic crystalloids in addition to diphenhydramine and epinephrine.

If the patient has not removed the stinger, it should be removed as soon as possible by the first caregiver on the scene. Delay increases venom load, so the fastest removal technique is the best. Pinching and traction is an acceptable technique.

EMT or self-administration of intramuscular or subcutaneous epinephrine should be initiated immediately in the event of severe reaction. Intramuscular epinephrine injections into the lateral thigh provide more rapid absorption and higher plasma epinephrine levels than intramuscular or subcutaneous injections administered in the arm.[1]

Next

Emergency Department Care

  • Corticosteroids should be administered in severe cases to prevent recurrent or prolonged anaphylaxis, although acutely, they are not likely to improve symptoms.
  • H2 blockers such as ranitidine and cimetidine may be given intravenously. Administration of one of these medications combined with diphenhydramine is superior to diphenhydramine alone.[1]
  • In cases of refractory anaphylaxis, glucagon may be helpful if concomitant beta-blockers are preventing adequate response to epinephrine treatment.[1]
  • Vasopressors such as dopamine can be used to provide vascular support.
  • Patients developing respiratory arrest require ventilatory support.
  • Blood products may be required in the event of disseminated intravascular coagulation (DIC).
  • Repeated doses of epinephrine may be indicated for severe cases.
  • In the event of cardiopulmonary arrest due to anaphylaxis, intravenous epinephrine should be administered as a first-line agent.[1]
Previous
Next

Consultations

  • Refer all patients with generalized reactions to an allergist as soon as possible, because risk of fatal reaction is inversely related to length of time since the last sting.
Previous
Proceed to Medication
 
 
Contributor Information and Disclosures
Author

Carrie de Moor, MD  Adjunct Faculty, John Peter Smith Hospital, Emergency Medicine; Attending Physician, 24 Hour Emergency Room, Centennial Medical Center, Del Sol Emergency Department

Carrie de Moor, MD is a member of the following medical societies: American Medical Association and Texas Medical Association

Disclosure: Nothing to disclose.

Coauthor(s)

Hemant H Vankawala, MD  Attending Physician, 24 Hour Emergency Room, Houston and Dallas; Attending Physician, Baylor University Medical Center; Medical Director, Big Bend National Park; Medical Director, Terlingua Fire and EMS; Medical Director, MedCare Ambulance Company

Hemant H Vankawala, MD is a member of the following medical societies: American College of Emergency Physicians, American Medical Association, Emergency Medicine Residents Association, Society for Academic Emergency Medicine, and Texas Medical Association

Disclosure: Nothing to disclose.

Randy Park, MD  Chair, Associate Professor, Department of Emergency Medicine, Denton Regional Medical Center

Disclosure: Nothing to disclose.

Specialty Editor Board

Dan Danzl, MD  Chair, Department of Emergency Medicine, Professor, University of Louisville Hospital

Dan Danzl, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, Kentucky Medical Association, Society for Academic Emergency Medicine, and Wilderness Medical Society

Disclosure: Nothing to disclose.

John T VanDeVoort, PharmD  Regional Director of Pharmacy, Sacred Heart & St. Joseph's Hospitals

John T VanDeVoort, PharmD is a member of the following medical societies: American Society of Health-System Pharmacists

Disclosure: Nothing to disclose.

James Steven Walker, DO, MS  Clinical Professor of Surgery, Department of Surgery, University of Oklahoma Health Sciences Center

James Steven Walker, DO, MS is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American College of Osteopathic Emergency Physicians, and American Osteopathic Association

Disclosure: Nothing to disclose.

John D Halamka, MD, MS  Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center

John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Chief Editor

Scott H Plantz, MD, FAAEM  Associate Clinical Professor of Emergency Medicine, Rosalind Franklin University of Medicine and Science, Chicago Medical School; Medical Director, WeCare Med, Inc

Scott H Plantz, MD, FAAEM is a member of the following medical societies: American Academy of Emergency Medicine

Disclosure: Nothing to disclose.

References
  1. [Guideline] The diagnosis and management of anaphylaxis: an updated practice parameter. J Allergy Clin Immunol. Mar 2005;115(3 Suppl 2):S483-523. [Medline].

  2. Galera C, Soohun N, Zankar N, Caimmi S, Gallen C, Demoly P. Severe anaphylaxis to bee venom immunotherapy: efficacy of pretreatment and concurrent treatment with omalizumab. J Investig Allergol Clin Immunol. 2009;19(3):225-9. [Medline].

  3. Hernandez M, Gonzalez S, Galindo G, Iaz A, Rodriguez P. University Hospital, et al. Reactions to hymenoptera sting in adult patients: experience in a clinical allergy/immunology service in Monterrey Mexico. World Allergy Organization Journal. 2007/11;S216-S217.

  4. Langley RL. Animal-related fatalities in the United States-an update. Wilderness Environ Med. 2005;16(2):67-74. [Medline].

  5. Rhoades RB, Stafford CT, James FK Jr. Survey of fatal anaphylactic reactions to imported fire ant stings. Report of the Fire Ant Subcommittee of the American Academy of Allergy and Immunology. J Allergy Clin Immunol. Aug 1989;84(2):159-62. [Medline].

  6. Visscher PK, Vetter RS, Camazine S. Removing bee stings. Lancet. Aug 3 1996;348(9023):301-2. [Medline].

  7. Rekik S, Andrieu S, Aboukhoudir F, Barnay P, Quaino G, Pansieri M, et al. ST Elevation Myocardial Infarction with No Structural Lesions after a Wasp Sting. J Emerg Med. Mar 26 2009;[Medline].

  8. Vachvanichsanong P, Dissaneewate P. Acute renal failure following wasp sting in children. Eur J Pediatr. Jan 16 2009;[Medline].

  9. Agarwal V, Singh R, Chauhan S. Parkinsonism following a honeybee sting. Indian J Med Sci. Jan 2006;60(1):24-5. [Medline].

  10. Agarwal V, Singh R, Chauhan S, D'Cruz S, Thakur R. Parkinsonism following a honeybee sting. Indian J Med Sci. Jan 2006;60(1):24-5. [Medline].

  11. Agostinucci W, Cardoni AA, Rosenberg P. Effect of papain of bee venom toxicity. Toxicon. 1981;19(6):851-5. [Medline].

  12. Ariue BK. Multiple Africanized bee stings in a child. Pediatrics. Jul 1994;94(1):115-7. [Medline].

  13. Awai LE, Mekori YA. Insect sting anaphylaxis and beta-adrenergic blockade: a relative contraindication. Ann Allergy. Jul 1984;53(1):48-9. [Medline].

  14. Betten DP, Richardson WH, Tong TC. Massive honey bee envenomation-induced rhabdomyolysis in an adolescent. Pediatrics. Jan 2006;117(1):231-5. [Medline].

  15. Brown SG, Wiese MD, Blackman KE, Heddle RJ. Ant venom immunotherapy: a double-blind, placebo-controlled, crossover trial. Lancet. Mar 22 2003;361(9362):1001-6. [Medline].

  16. Charpin D, Birnbaum J, Vervloet D. Epidemiology of hymenoptera allergy. Clin Exp Allergy. Nov 1994;24(11):1010-5. [Medline].

  17. Chen CJ, Richardson CD. Bee sting-induced ocular changes. Ann Ophthalmol. Oct 1986;18(10):285-6. [Medline].

  18. Cohen SG, Bianchine PJ. Hymenoptera, hypersensitivity, and history: a prologue to current day concepts and practices in the diagnosis, treatment, and prevention of insect sting allergy. Ann Allergy Asthma Immunol. Mar 1995;74(3):198-217; quiz 217-21. [Medline].

  19. Davis K. Africanized honey bees. 1997.

  20. De Soto H, Turk P. Cimetidine in anaphylactic shock refractory to standard therapy. Anesth Analg. Aug 1989;69(2):264-5. [Medline].

  21. Fitzgerald KT, Flood AA. Hymenoptera stings. Clin Tech Small Anim Pract. Nov 2006;21(4):194-204. [Medline].

  22. Freye HB, Ehrlich B. Acute myocardial infarction following hymenoptera envenomation. Allergy Proc. Mar-Apr 1989;10(2):119-26. [Medline].

  23. Goldstein NP, Rucker CW, Klass DW. Encephalopathy and papilledema after bee sting. JAMA. 1964;188:1083-1084. [Medline].

  24. Hay SM, Hay FA, Austwick DH. Case report. Bee sting brachial block. Arch Emerg Med. Dec 1992;9(4):369-72. [Medline].

  25. Hiran S, Pande TK, Pani S, Gupta R, Vishwanathan KA. Rhabdomyolysis due to multiple honey bee stings. Postgrad Med J. Dec 1994;70(830):937. [Medline].

  26. Hur W, Ahn SK, Lee SH, Kang WH. Cutaneous reaction induced by retained bee stinger. J Dermatol. Dec 1991;18(12):736-9. [Medline].

  27. Janik JE, Wania-Galicia L, Kalauokalani D. Bee stings--a remedy for postherpetic neuralgia? A case report. Reg Anesth Pain Med. Nov-Dec 2007;32(6):533-5. [Medline].

  28. Karamloo F, Schmid-Grendelmeier P, Kussebi F. Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes. Eur J Immunol. Nov 2005;35(11):3268-76. [Medline].

  29. McDougle L, Klein GL, Hoehler FK. Management of hymenoptera sting anaphylaxis: a preventive medicine survey. J Emerg Med. Jan-Feb 1995;13(1):9-13. [Medline].

  30. Patrick A, Roberts L, Poon-King P, Jeelal V. Acute renal failure due to multiple stings by Africanised bees. Report of the first case in Trinidad. West Indian Med J. Mar 1987;36(1):43-4. [Medline].

  31. Pucci S, Antonicelli L, Bilo MB. Shortness of interval between two stings as risk factor for developing Hymenoptera venom allergy. Allergy. Dec 1994;49(10):894-6. [Medline].

  32. Reisman RE. Unusual reactions to insect stings. Curr Opin Allergy Clin Immunol. Aug 2005;5(4):355-8. [Medline].

  33. Roll A, Schmid-Grendelmeier P. Ultrarush immunotherapy in a patient with occupational allergy to bumblebee venom (Bombus terrestris). J Investig Allergol Clin Immunol. 2005;15(4):305-7. [Medline].

  34. Schmidt JO. Let's not forget crawling Hymenoptera. Clin Exp Allergy. Jun 1994;24(6):511-4. [Medline].

  35. Schumacher MJ, Tveten MS, Egen NB. Rate and quantity of delivery of venom from honeybee stings. J Allergy Clin Immunol. May 1994;93(5):831-5. [Medline].

  36. Shimizu T, Hori T, Tokuyama K, et al. Clinical and immunologic surveys of Hymenoptera hypersensitivity in Japanese forestry workers. Ann Allergy Asthma Immunol. 1995;74(6):495-500. [Medline].

  37. Stablein JJ, Lockey RF. Adverse reactions to ant stings. Clin Rev Allergy. May 1987;5(2):161-75. [Medline].

  38. Stafford CT, Hutto LS, Rhoades RB, et al. Imported fire ant as a health hazard. South Med J. Dec 1989;82(12):1515-9. [Medline].

  39. Valentine MD. Allergy to stinging insects. Ann Allergy. Jun 1993;70(6):427-32. [Medline].

  40. Valkanas MA, Bowman S, Dailey MW. Electrocardiographic myocardial infarction without structural lesion in the setting of acute hymenoptera envenomation. Am J Emerg Med. Nov 2007;25(9):1082.e5-8. [Medline].

  41. Vetter RS, Visscher PK, Camazine S. Mass envenomations by honey bees and wasps. West J Med. Apr 1999;170(4):223-7. [Medline].

Previous
Next
 
Two fire ant stings that are 24 hours old (Randy Park, MD)
A paper wasp (Randy Park, MD)
A paper wasp (Randy Park, MD)
A paper wasp (Randy Park, MD)
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2012 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.