Cnidaria Envenomation Medication
- Author: G Patrick Daubert, MD; Chief Editor: Scott H Plantz, MD, FAAEM more...
Medication Summary
Analgesics and local anesthetics can be used to ameliorate pain associated with these bites. Antivenom exists for box jellyfish (C fleckeri). Chironex antivenom will cross react with Chiropsalmus species venom to prevent neurotoxic and myotoxic effects. However, it has not prevented cardiovascular effects in vivo. Antivenom is available in Australia and is produced by Commonwealth Serum Laboratories.
Antivenom
Class Summary
These agents neutralize toxins.
Box Jellyfish Antivenom
Box jellyfish antivenom is ovine-based concentrated immunoglobulins. Each ampule contains sufficient activity to neutralize 20,000 IV mouse doses of C fleckeri venom. Chironex antivenom will cross react with Chiropsalmus species venom to prevent neurotoxic and myotoxic effects. However, it has not prevented cardiovascular effects in vivo. Box jellyfish antivenom is available from Commonwealth Serum Laboratory in Melbourne, Australia.
O'Reilly GM, Isbister GK, Lawrie PM, et al. Prospective study of jellyfish stings from tropical Australia, including the major box jellyfish Chironex fleckeri. Med J Aust. Dec 3-17 2001;175(11-12):652-5. [Medline].
Bengtson K, Nichols MM, Schnadig V, et al. Sudden death in a child following jellyfish envenomation by Chiropsalmus quadrumanus. Case report and autopsy findings. JAMA. Sep 11 1991;266(10):1404-6. [Medline].
Auerbach PS. Marine envenomations. N Engl J Med. Aug 15 1991;325(7):486-93. [Medline].
Bailey PM, Little M, Jelinek GA, et al. Jellyfish envenoming syndromes: unknown toxic mechanisms and unproven therapies. Med J Aust. Jan 6 2003;178(1):34-7. [Medline].
Brown CK, Shepherd SM. Marine trauma, envenomations, and intoxications. Emerg Med Clin North Am. May 1992;10(2):385-408. [Medline].
Brush DE. Marine envenomations. In: Flomembaum N, Goldfrank LR, Howland MA, Lewin NA, Hoffman RS, Nelson LS. Goldfrank's Toxicologic Emergencies. 8th ed. New York, NY: McGraw-Hill; 2006:1629-1642.
Burnett JW, Calton GJ. Jellyfish envenomation syndromes updated. Ann Emerg Med. Sep 1987;16(9):1000-5. [Medline].
Burnett JW, Gable WD. A fatal jellyfish envenomation by the Portuguese man-o'war. Toxicon. 1989;27(7):823-4. [Medline].
Currie BJ. Marine antivenoms. J Toxicol Clin Toxicol. 2003;41(3):301-8. [Medline].
Currie BJ, Jacups SP. Prospective study of Chironex fleckeri and other box jellyfish stings in the "Top End" of Australia's Northern Territory. Med J Aust. Dec 5-19 2005;183(11-12):631-6. [Medline].
Fenner PJ, Hadok JC. Fatal envenomation by jellyfish causing Irukandji syndrome. Med J Aust. Oct 7 2002;177(7):362-3. [Medline].
Fenner PJ, Williamson J, Callanan VI, et al. Further understanding of, and a new treatment for, "Irukandji" (Carukia barnesi) stings. Med J Aust. Dec 1-15 1986;145(11-12):569, 572-4. [Medline].
Fenner PJ, Williamson JA. Worldwide deaths and severe envenomation from jellyfish stings. Med J Aust. Dec 2-16 1996;165(11-12):658-61. [Medline].
Fenner PJ, Williamson JA, Burnett JW, et al. The "Irukandji syndrome" and acute pulmonary oedema. Med J Aust. Aug 1 1988;149(3):150-6. [Medline].
Freudenthal AR, Joseph PR. Seabather's eruption. N Engl J Med. Aug 19 1993;329(8):542-4. [Medline].
Giordano AR, Vito L, Sardella PJ. Complication of a Portuguese man-of-war envenomation to the foot: a case report. J Foot Ankle Surg. Jul-Aug 2005;44(4):297-300. [Medline].
Flomembaum N, Goldfrank LR, Howland MA, Lewin NA, Hoffman RS, Nelson LS. Goldfrank's Toxicologic Emergencies. 8th ed. 2006.
Haddad L, Lee L. Toxic marine life. In: Clinical Management of Poisoning and Drug Overdose. 3rd ed. WB Saunders Co; 1998:386-399.
Kimball AB, Arambula KZ, Stauffer AR, et al. Efficacy of a jellyfish sting inhibitor in preventing jellyfish stings in normal volunteers. Wilderness Environ Med. Summer 2004;15(2):102-8. [Medline].
Kizer KW. Marine envenomations. J Toxicol Clin Toxicol. 1983-1984;21(4-5):527-55. [Medline].
Little M. Is there a role for the use of pressure immobilization bandages in the treatment of jellyfish envenomation in Australia?. Emerg Med (Fremantle). Jun 2002;14(2):171-4. [Medline].
Lumley J, Williamson JA, Fenner PJ, et al. Fatal envenomation by Chironex fleckeri, the north Australian box jellyfish: the continuing search for lethal mechanisms. Med J Aust. May 16 1988;148(10):527-34. [Medline].
McGoldrick J, Marx JA. Marine envenomations. Part 2: Invertebrates. J Emerg Med. Jan-Feb 1992;10(1):71-7. [Medline].
Mizuno M, Nozaki M, Morine N, et al. A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a severe renal injury with predominant glomerular endothelial damage. Am J Pathol. Aug 2007;171(2):402-14. [Medline].
Nimorakiotakis B, Winkel KD. Marine envenomations. Part 1--Jellyfish. Aust Fam Physician. Dec 2003;32(12):969-74. [Medline].
Pearn J. The sea, stingers, and surgeons: the surgeon's role in prevention, first aid, and management of marine envenomations. J Pediatr Surg. Jan 1995;30(1):105-10. [Medline].
Perkins RA, Morgan SS. Poisoning, envenomation, and trauma from marine creatures. Am Fam Physician. Feb 15 2004;69(4):885-90. [Medline].
Stein MR, Marraccini JV, Rothschild NE, et al. Fatal Portuguese man-o'-war (Physalia physalis) envenomation. Ann Emerg Med. Mar 1989;18(3):312-5. [Medline].
Tibballs J. Australian venomous jellyfish, envenomation syndromes, toxins and therapy. Toxicon. Dec 1 2006;48(7):830-59. [Medline].
Watters MR, Stommel EW. Marine Neurotoxins: Envenomations and Contact Toxins. Curr Treat Options Neurol. Mar 2004;6(2):115-123. [Medline].
Weisman R. Marine animals. In: Goldfrank LR. Goldfranks's Toxicologic Emergencies. 5th ed. Appleton & Lange; 1994:1327-1332.

