eMedicine Specialties > Emergency Medicine > Environmental

Hypothermia: Follow-up

Author: Jamie Alison Edelstein, MD, Staff Physician, Department of Emergency Medicine, State University of New York, Kings County Hospital Center
Coauthor(s): James Li, MD, Former Assistant Professor, Division of Emergency Medicine, Harvard Medical School; Board of Directors, Remote Medicine; Mark A Silverberg, MD, FACEP, MMB, Assistant Professor, Assistant Residency Director, Department of Emergency Medicine, State University of New York Downstate College of Medicine; Consulting Staff, Department of Emergency Medicine, Staten Island University Hospital, Kings County Hospital, University Hospital, State University of New York Downstate at Brooklyn; Wyatt Decker, MD, Chair and Program Director, Department of Emergency Medicine, Mayo Clinic
Contributor Information and Disclosures

Updated: Oct 29, 2009

Follow-up

Further Inpatient Care

  • Medical complications from hypothermia often result and necessitate admission to the hospital in moderate and severe hypothermia. Severely hypothermic patients should be admitted to an intensive care unit where their respiratory and cardiac function and temperature may be closely monitored.
    • Acute pulmonary edema should be treated with oxygen, empirical antibiotics for aspiration pneumonia, and diuretics as necessary.
    • Frostbite and other localized cold injuries result in deep tissue damage. Surgical exploration and debridement may be necessary. Affected body parts may have to be amputated if gangrene develops. Such a procedure is usually performed at some delayed time interval once a line of demarkation has declared itself days to weeks later
    • The development of rhabdomyolysis should be monitored.

Deterrence/Prevention

  • Preparation is key to avoiding accidental hypothermia.
  • Appropriate cold weather clothing and survival bags are a necessity if walking or climbing in a cold climate.
  • Persons should avoid alcohol if anticipating exposure to cold because alcohol can disrupt temperature homeostasis by causing vasodilation.
  • Individuals should remain alert to early symptoms and initiate preventive measures (eg, drinking warm fluids).
  • Adequate heat in the home should be maintained.
  • Patients should be referred to a social service agency for help with adequate housing, heat, and/or clothing.

Complications

  • Complications of hypothermia
    • Cardiac arrhythmias at temperatures below 30-32°C
    • Infection
    • Aspiration pneumonia
    • Pulmonary edema
    • Pancreatitis
    • Bleeding diathesis
    • Bladder atony
    • Frostbite
    • Electrolyte (hyperkalemia, hypoglycemia), hematocrit, coagulation study abnormalities
  • Complications of treatment of hypothermia
    • Rewarming shock, or hypotension secondary to marked vasodilatation of rewarming
    • Rewarming acidosis due to recirculation of pooled lactic acid in the peripheral circulation
    • Rewarming electrolyte disturbances, in particular hypocalcemia and hypomagnesemia, indicate a poor prognosis
    • Aspiration pneumonia
    • Pulmonary edema
    • Pancreatitis 
    • Burns to cold and vasoconstricted skin secondary to application of hot water bottles and heating pads
    • Neutropenia, thrombocytopenia, and infection
    • Iatrogenic hyperthermia  
    • Ventricular fibrillation
    • Peritonitis
    • GI bleeding
    • Acute tubular necrosis
    • Intravascular thrombosis
    • Metabolic acidosis
    • Rhabdomyolysis
    • Gangrene
    • Compartment syndrome

Prognosis

  • The risk of morbidity and mortality depends on the severity of the degree of hypothermia and the underlying cause.
  • Recovery is usually complete for previously healthy individuals with mild or moderate hypothermia (mortality rate <5%).
  • The mortality rate for patients with severe hypothermia, especially with preexisting illness, may be higher than 50%.

Patient Education

Miscellaneous

Medicolegal Pitfalls

  • The major medical/legal pitfall is misdiagnosis by failing to check or document a patient's core temperature.
  • Treating a patient for hypothermia but failing to treat for a secondary cause or an underlying comorbid condition, such as sepsis or drug overdose, is another potential pitfall.
  • Always consider the possibility of trauma, especially to the head and abdomen, in patients with severe hypothermia who are unable to give a reliable history.

Special Concerns

  • Controversy surrounds the issue of pronouncing death in a hypothermic patient.
  • A reasonable approach is to initiate resuscitation on all hypothermic patients unless a patient presents with a frozen chest or other obvious nonsurvivable injuries. A patient can be warmed aggressively and resuscitated until the core temperature rises above 32°C. At that juncture, if no signs of life are present and the patient is not responding to advanced cardiac life support measures, termination of resuscitation may be indicated.
  • Individual clinical judgment is paramount in these settings, and variables, such as the patient's age and any comorbid conditions, must be taken into account. Serum potassium levels may be useful in determining when to cease resuscitation; patients with potassium levels of 10 mmol/L or higher have very poor outcomes. However, the recovery rate is based on retrospective or observational studies in survivors after potassium levels greater than 10 have been reported.
  • Clearly, profound hypothermia can mimic clinical death. However, patients with profound hypothermia can be resuscitated successfully with good neurologic outcomes. The adage that "a patient is not dead until they are warm and dead" is of some use.
  • Spending prolonged periods to bring a patient with no signs of life to a normal body temperature can, in some instances, be unwarranted. If a patient's chest is frozen, resuscitative efforts are not necessary.
 


More on Hypothermia

Overview: Hypothermia
Differential Diagnoses & Workup: Hypothermia
Treatment & Medication: Hypothermia
Follow-up: Hypothermia
Multimedia: Hypothermia
References

References

  1. Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. Jul 2009;37(7 Suppl):S186-202. [Medline].

  2. Long WB 3rd, Edlich RF, Winters KL, Britt LD. Cold injuries. J Long Term Eff Med Implants. 2005;15(1):67-78. [Medline].

  3. Sessler DI. Thermoregulatory defense mechanisms. Crit Care Med. Jul 2009;37(7 Suppl):S203-10. [Medline].

  4. McCullough L, Arora S. Diagnosis and treatment of hypothermia. Am Fam Physician. Dec 15 2004;70(12):2325-32. [Medline].

  5. Laniewicz M, Lyn-Kew K, Silbergleit R. Rapid endovascular warming for profound hypothermia. Ann Emerg Med. Feb 2008;51(2):160-3. [Medline].

  6. Abella BS, Rhee JW, Huang KN, Vanden Hoek TL, Becker LB. Induced hypothermia is underused after resuscitation from cardiac arrest: a current practice survey. Resuscitation. Feb 2005;64(2):181-6. [Medline].

  7. Alam HB, Rhee P, Honma K, et al. Does the rate of rewarming from profound hypothermic arrest influence the outcome in a swine model of lethal hemorrhage?. J Trauma. Jan 2006;60(1):134-46. [Medline].

  8. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. Feb 21 2002;346(8):557-63. [Medline][Full Text].

  9. Biancolini CA, Del Bosco CG, Jorge MA, Poderoso JJ, Capdevila AA. Active core rewarming in neurologic, hypothermic patients: effects on oxygen-related variables. Crit Care Med. Aug 1993;21(8):1164-8. [Medline].

  10. Biem J, Koehncke N, Classen D, Dosman J. Out of the cold: management of hypothermia and frostbite. CMAJ. Feb 4 2003;168(3):305-11. [Medline].

  11. Britt LD, Dascombe WH, Rodriguez A. New horizons in management of hypothermia and frostbite injury. Surg Clin North Am. Apr 1991;71(2):345-70. [Medline].

  12. Brunette DD, Sterner S, Robinson EP, Ruiz E. Comparison of gastric lavage and thoracic cavity lavage in the treatment of severe hypothermia in dogs. Ann Emerg Med. Nov 1987;16(11):1222-7. [Medline].

  13. Buckley JJ, Bosch OK, Bacaner MB. Prevention of ventricular fibrillation during hypothermia with bretylium tosylate. Anesth Analg. Jul-Aug 1971;50(4):587-93. [Medline].

  14. Casas F, Alam H, Reeves A, Chen Z, Smith WA. A portable cardiopulmonary bypass/extracorporeal membrane oxygenation system for the induction and reversal of profound hypothermia: feasibility study in a Swine model of lethal injuries. Artif Organs. Jul 2005;29(7):557-63. [Medline].

  15. Centers for Disease Control and Prevention (CDC). Hypothermia-related deaths--United States, 2003-2004. MMWR Morb Mortal Wkly Rep. Feb 25 2005;54(7):173-5. [Medline].

  16. Danzl DF, Pozos RS. Accidental hypothermia. N Engl J Med. Dec 29 1994;331(26):1756-60. [Medline].

  17. Danzl DF, Pozos RS, Auerbach PS, et al. Multicenter hypothermia survey. Ann Emerg Med. Sep 1987;16(9):1042-55. [Medline].

  18. Danzl DF, Pozos RS, Hamlet MP. Accidental hypothermia. In: Wilderness Medicine. 51-103.

  19. [Guideline] ECC Committee, Subcommittees and Task Forces of the American Heart Association. 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. Dec 13 2005;112(24 Suppl):IV1-203. [Medline].

  20. Elbaz G, Etzion O, Delgado J, Porath A, Talmor D, Novack V. Hypothermia in a desert climate: severity score and mortality prediction. Am J Emerg Med. Jul 2008;26(6):683-8. [Medline].

  21. Fildes J, Sheaff C, Barrett J. Very hot intravenous fluid in the treatment of hypothermia. J Trauma. Nov 1993;35(5):683-6; discussion 686-7. [Medline].

  22. Gentilello LM, Cobean RA, Offner PJ, Soderberg RW, Jurkovich GJ. Continuous arteriovenous rewarming: rapid reversal of hypothermia in critically ill patients. J Trauma. Mar 1992;32(3):316-25; discussion 325-7. [Medline].

  23. Hall KN, Syverud SA. Closed thoracic cavity lavage in the treatment of severe hypothermia in human beings. Ann Emerg Med. Feb 1990;19(2):204-6. [Medline].

  24. Headdon WG, Wilson PM, Dalton HR. The management of accidental hypothermia. BMJ. Jun 10 2009;338:b2085. [Medline].

  25. Jurkovich GJ. Environmental cold-induced injury. Surg Clin North Am. Feb 2007;87(1):247-67, viii. [Medline].

  26. Kanzenbach TL, Dexter WW. Cold injuries. Protecting your patients from the dangers of hypothermia and frostbite. Postgrad Med. Jan 1999;105(1):72-8. [Medline].

  27. Keatinge WR. Hypothermia: dead or alive?. BMJ. Jan 5 1991;302(6767):3-4. [Medline].

  28. Ko CS, Alex J, Jeffries S, Parmar JM. Dead? Or just cold: profoundly hypothermic patient with no signs of life. Emerg Med J. Sep 2002;19(5):478-9. [Medline][Full Text].

  29. Launay JC, Savourey G. Cold adaptations. Ind Health. Jul 2009;47(3):221-7. [Medline].

  30. Mechem CC. Accidental Hypothermia. www.uptodate.com.

  31. Murphy K, Nowak RM, Tomlanovich MC. Use of bretylium tosylate as prophylaxis and treatment in hypothermic ventricular fibrillation in the canine model. Ann Emerg Med. Oct 1986;15(10):1160-6. [Medline].

  32. Plaisier BR. Thoracic lavage in accidental hypothermia with cardiac arrest--report of a case and review of the literature. Resuscitation. Jul 2005;66(1):99-104. [Medline].

  33. Romet TT, Hoskin RW. Temperature and metabolic responses to inhalation and bath rewarming protocols. Aviat Space Environ Med. Jul 1988;59(7):630-4. [Medline].

  34. Savard GK, Cooper KE, Veale WL, Malkinson TJ. Peripheral blood flow during rewarming from mild hypothermia in humans. J Appl Physiol. Jan 1985;58(1):4-13. [Medline].

  35. Schewe JC, Heister U, Fischer M, Hoeft A. [Accidental urban hypothermia. Severe hypothermia of 20.7 degrees C]. Anaesthesist. Oct 2005;54(10):1005-11. [Medline].

  36. Spencer SM, Roeseler J, Verschuren F, Reynaert M, Thys F. Metabolism study in an 88-year-old woman with severe hypothermia during rewarming procedures. Am J Emerg Med. Oct 2007;25(8):986.e1-3. [Medline].

  37. Ulrich AS, Rathlev NK. Hypothermia and localized cold injuries. Emerg Med Clin North Am. May 2004;22(2):281-98. [Medline].

  38. Vachiery JL, Reuse C, Blecic S, Contempre B, Vincent JL. Bretylium tosylate versus lidocaine in experimental cardiac arrest. Am J Emerg Med. Nov 1990;8(6):492-5. [Medline].

  39. Walpoth BH, Walpoth-Aslan BN, Mattle HP, et al. Outcome of survivors of accidental deep hypothermia and circulatory arrest treated with extracorporeal blood warming. N Engl J Med. Nov 20 1997;337(21):1500-5. [Medline].

  40. Webb P. Afterdrop of body temperature during rewarming: an alternative explanation. J Appl Physiol. Feb 1986;60(2):385-90. [Medline].

  41. Wilkerson JA. Hypothermia, Frostbite, and other Cold Injuries. 1986.

  42. Zachary L, Kucan JO, Robson MC, Frank DH. Accidental hypothermia treated with rapid rewarming by immersion. Ann Plast Surg. Sep 1982;9(3):238-41. [Medline].

Further Reading

Keywords

hypothermia, environmental exposure, accidental hypothermia, intentional hypothermia, primary hypothermia, secondary hypothermia, atrial arrhythmia, ventricular arrhythmia, ventricular fibrillation, core temperature drop, decreased heat production, increased heat loss, impaired thermoregulation, mild hypothermia, moderate hypothermia, severe hypothermia

Contributor Information and Disclosures

Author

Jamie Alison Edelstein, MD, Staff Physician, Department of Emergency Medicine, State University of New York, Kings County Hospital Center
Disclosure: Nothing to disclose.

Coauthor(s)

James Li, MD, Former Assistant Professor, Division of Emergency Medicine, Harvard Medical School; Board of Directors, Remote Medicine
Disclosure: Nothing to disclose.

Mark A Silverberg, MD, FACEP, MMB, Assistant Professor, Assistant Residency Director, Department of Emergency Medicine, State University of New York Downstate College of Medicine; Consulting Staff, Department of Emergency Medicine, Staten Island University Hospital, Kings County Hospital, University Hospital, State University of New York Downstate at Brooklyn
Mark A Silverberg, MD, FACEP, MMB is a member of the following medical societies: American College of Emergency Physicians, American Medical Association, Council of Emergency Medicine Residency Directors, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Wyatt Decker, MD, Chair and Program Director, Department of Emergency Medicine, Mayo Clinic
Wyatt Decker, MD is a member of the following medical societies: American College of Emergency Physicians
Disclosure: Nothing to disclose.

Medical Editor

Dan Danzl, MD, Chair, Department of Emergency Medicine, Professor, University of Louisville Hospital
Dan Danzl, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, Kentucky Medical Association, Society for Academic Emergency Medicine, and Wilderness Medical Society
Disclosure: Nothing to disclose.

Pharmacy Editor

Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
Disclosure: eMedicine Salary Employment

Managing Editor

James Steven Walker, DO, MS, Clinical Professor of Surgery, Department of Surgery, University of Oklahoma Health Sciences Center
James Steven Walker, DO, MS is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American College of Osteopathic Emergency Physicians, and American Osteopathic Association
Disclosure: Nothing to disclose.

CME Editor

John D Halamka, MD, MS, Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center
John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

Chief Editor

Jonathan Adler, MD, Attending Physician, Department of Emergency Medicine, Massachusetts General Hospital; Division of Emergency Medicine, Harvard Medical School
Jonathan Adler, MD is a member of the following medical societies: American Academy of Emergency Medicine and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.

 
 
HONcode

We subscribe to the
HONcode principles of the
Health On the Net Foundation

All material on this website is protected by copyright, Copyright© 1994- by Medscape.
This website also contains material copyrighted by 3rd parties.

DISCLAIMER: The content of this Website is not influenced by sponsors. The site is designed primarily for use by qualified physicians and other medical professionals. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with a physician if you suspect you are ill.