Lizard Envenomation Workup

  • Author: Robert L Norris, MD; Chief Editor: Rick Kulkarni, MD   more...
 
Updated: Dec 14, 2011
 

Laboratory Studies

The most common CBC count finding is an elevation in the WBC count. In rare severe cases, a drop in the platelet count may occur.

Measure serum electrolyte levels, particularly if there is a history of significant underlying disease.

Helodermatid venoms do not appear to have any anticoagulant fractions. However, very rarely, reports of abnormal coagulation studies with severe bites have been documented. These rare coagulopathies are likely secondary to hemostatic changes occurring as a result of severe endothelial cell damage.

It is reasonable to obtain a prothrombin time, an activated partial thromboplastin time, a fibrinogen level, and a measure of fibrin degradation products.

Perform a urinalysis and look for any evidence of blood or casts.

A cardiac panel, including a CK-MB, myoglobin, and troponin should be obtained if the victim has evidence of hemodynamic instability, chest pain, or an abnormal ECG result.

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Imaging Studies

A chest radiograph should be obtained if the victim is experiencing chest pain, shortness of breath, or has significant comorbidities.

Soft tissue radiographs may be obtained to look for retained teeth, although the sensitivity of such studies is low.

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Other Tests

Obtaining an ECG is reasonable because several reports of transient abnormalities have been reported in the literature.

T-wave abnormalities, conduction disturbances, and 2 cases of acute myocardial infarction (one in a young patient without chest pain who had a possible history of cocaine use but no other cardiac risk factors) have been reported.

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Contributor Information and Disclosures
Author

Robert L Norris, MD  Professor, Department of Surgery, Chief, Division of Emergency Medicine, Stanford University Medical Center

Robert L Norris, MD is a member of the following medical societies: American College of Emergency Physicians, American Medical Association, California Medical Association, International Society of Toxinology, Society for Academic Emergency Medicine, and Wilderness Medical Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Mark S Slabinski, MD, FACEP, FAAEM  Vice President, EMP Medical Group

Mark S Slabinski, MD, FACEP, FAAEM is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, and Ohio State Medical Association

Disclosure: Nothing to disclose.

John T VanDeVoort, PharmD  Regional Director of Pharmacy, Sacred Heart and St Joseph's Hospitals

John T VanDeVoort, PharmD is a member of the following medical societies: American Society of Health-System Pharmacists

Disclosure: Nothing to disclose.

A Antoine Kazzi  MD, Deputy Chief of Staff, American University of Beirut Medical Center; Associate Professor, Department of Emergency Medicine, American University of Beirut, Lebanon

A Antoine Kazzi is a member of the following medical societies: American Academy of Emergency Medicine

Disclosure: Nothing to disclose.

John D Halamka, MD, MS  Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center

John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine

Disclosure: Nothing to disclose.

Chief Editor

Rick Kulkarni, MD  Attending Physician, Department of Emergency Medicine, Cambridge Health Alliance, Division of Emergency Medicine, Harvard Medical School

Rick Kulkarni, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine

Disclosure: WebMD Salary Employment

References
  1. Mebs D. Clinical toxicology of Helodermatidae lizard bites. In: Handbook of Clinical Toxicology of Animal Venoms and Poisons. 1995: 361-366.

  2. Piacentine J, Curry SC, Ryan PJ. Life-threatening anaphylaxis following gila monster bite. Ann Emer Med. 1986;15:959-961. [Medline].

  3. Bou-Abboud CF, Kardassakis DG. Acute myocardial infarction following a Gila monster (Heloderma suspectum cinctum) bite. West J Med. 1988;148(5):577-579. [Medline].

  4. Preston CA. Hypotension, myocardial infarction, an coagulopathy following gila monster bite. J Emer Med. 1989;7:37-40. [Medline].

  5. Brown DE, Carmony NB. Gila Monster: Facts and Folklore of America's Aztec Lizard. 1991;1-126.

  6. Cantrell FL. Envenomation by the Mexican beaded lizard: a case report. J Toxicol Clin Toxicol. 2003;41(3):241-4. [Medline].

  7. Hooker KR, Caravati EM. Gila monster envenomation. Ann Emerg Med. 1994;24(4):731-735. [Medline].

  8. Kunkel DB. Bites of venomous reptiles. Emerg Med Clin North Am. Aug 1984;2(3):563-77. [Medline].

  9. Kunkel DB, Curry SC, Vance MV, Ryan PJ. Reptile envenomations. J Toxicol Clin Toxicol. 1983-84;21(4-5):503-26. [Medline].

  10. McNally J, Boesen K, Boyer L. Toxicologic information resources for reptile envenomations. Vet Clin North Am Exot Anim Pract. May 2008;11(2):389-401, viii. [Medline].

  11. Miller MF. Gila monster envenomation. Ann Emerg Med. May 1995;25(5):720. [Medline].

  12. Russell FE. Snake Venom Poisoning. Scholium International, Inc;1983:1-562.

  13. Stahnke HL, Heffron WA, Lewis DL. Bite of the Gila monster. Rocky Mt Med J. Sep 1970;67(9):25-30. [Medline].

  14. Streiffer RH. Bite of the venomous lizard, the Gila monster. Postgrad Med. Feb 1 1986;79(2):297-9, 302. [Medline].

  15. Strimple PD, Tomassoni AJ, Otten EJ. Report on envenomation by a Gila monster (Heloderma suspectum) with a discussion of venom apparatus, clinical findings, and treatment. Wilderness Environ Med. May 1997;8(2):111-6. [Medline].

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A Gila monster (Heloderma suspectum). Photo by Holly McNally.
Close-up of the head of a Gila monster. Clearly evident is the bulging musculature of the jaws, which gives this animal a tenacious bite. Photo by Holly McNally.
The dentition of a Gila monster. The grooved surfaces of the teeth are evident. These grooves allow for venom movement from the venom glands into the victim's tissues. Photo by Michael Cardwell.
A Gila monster (Heloderma suspectum). Photo by Michael Cardwell.
 
 
 
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