Approach Considerations
Most gastrointestinal and surgical societies advocate anoscopy and/or flexible sigmoidoscopy to evaluate any bright-red rectal bleeding. Colonoscopy should be considered in the evaluation of any rectal bleeding that is not typical of hemorrhoids such as in the presence of strong risk factors for colonic malignancy or in the setting of rectal bleeding with a negative anorectal examination.
Hematologic Tests
A complete blood cell (CBC) count may be useful as a marker for infection. Anemia due to hemorrhoidal bleeding is possible,[3] albeit rare (0.5 cases per 100,000 patients), and its presence should raise suspicion of an alternate diagnosis. Hematocrit testing is suggested if excessive bleeding with concomitant anemia is suspected.
Coagulation studies are indicated if the history and physical examination suggest coagulopathy.
Anoscopy and Flexible Sigmoidoscopy
Anoscopy is mandatory for viewing internal hemorrhoids. The anoscope should be a side-viewing one. When angled well by the examiner, the side-viewing anoscope allows the soft hemorrhoidal tufts to fill the beveled end of the scope and to be appropriately evaluated. Prolapse can be observed when the patient performs a Valsalva maneuver.
Flexible sigmoidoscopy is performed to exclude proximal disease. Having a patient strain while sitting on a toilet may reproduce prolapse most accurately; in addition, examining patients while they sit on a toilet can be very helpful in indeterminate cases.
Other Diagnostic Imaging Studies
Proctoscopy may be performed to supplement anoscopy, and proctography may be indicated in rectal prolapse.
Colonoscopy, virtual colonoscopy, and barium enema are reserved for cases of bleeding without an identified anal source. These symptoms are not attributable to hemorrhoids and are considered to be non–outlet-type bleeding. Barium enema study or virtual colonoscopy is also suggested if proximal colonic and intestinal diseases must be excluded and if endoscopy is not helpful.
Full evaluation of the large bowel with colonoscopy is recommended for patients with significant abdominal symptoms, weight loss, change in bowel habits, age older than 50 years, or other risk factors for colonic malignancy.
Histologic Features
Routine histologic examination of hemorrhoidal tissue is usually unrewarding, especially if it is grossly examined by an experienced anorectal surgeon. Any suspicious tissue must be sent for microscopic evaluation. External hemorrhoids are classified by the underlying pathology and symptoms, which include thrombosed veins, bleeding from eroded blood clots, and skin tags causing hygiene problems.
Marx JA, Hockberger RS, Walls RM, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 6th ed. Philadelphia, Pa: Elsevier; 2006:1509-12.
Tintinalli JE, Kelen GD, Stapczynski JS, eds. Emergency Medicine: A Comprehensive Study Guide. 6th ed. New York, NY: McGraw Hill; 2004:540-1.
Ibrahim AM, Hackford AW, Lee YM, Cave DR. Hemorrhoids can be a source of obscure gastrointestinal bleeding that requires transfusion: report of five patients. Dis Colon Rectum. Aug 2008;51(8):1292-4. [Medline].
Grucela A, Salinas H, Khaitov S, Steinhagen RM, Gorfine SR, Chessin DB. Prospective analysis of clinician accuracy in the diagnosis of benign anal pathology: comparison across specialties and years of experience. Dis Colon Rectum. Jan 2010;53(1):47-52. [Medline].
Gibbons CP, Bannister JJ, Read NW. Role of constipation and anal hypertonia in the pathogenesis of haemorrhoids. Br J Surg. Jul 1988;75(7):656-60. [Medline].
Johanson JF, Sonnenberg A. The prevalence of hemorrhoids and chronic constipation. An epidemiologic study. Gastroenterology. Feb 1990;98(2):380-6. [Medline].
Johanson JF, Sonnenberg A. Constipation is not a risk factor for hemorrhoids: a case-control study of potential etiological agents. Am J Gastroenterol. Nov 1994;89(11):1981-6. [Medline].
Bernstein WC. What are hemorrhoids and what is their relationship to the portal venous system?. Dis Colon Rectum. Dec 1983;26(12):829-34. [Medline].
Hosking SW, Smart HL, Johnson AG, Triger DR. Anorectal varices, haemorrhoids, and portal hypertension. Lancet. Feb 18 1989;1(8634):349-52. [Medline].
Johansen K, Bardin J, Orloff MJ. Massive bleeding from hemorrhoidal varices in portal hypertension. JAMA. Nov 7 1980;244(18):2084-5. [Medline].
Chawla Y, Dilawari JB. Anorectal varices--their frequency in cirrhotic and non-cirrhotic portal hypertension. Gut. Mar 1991;32(3):309-11. [Medline]. [Full Text].
Katz JA, Rubin RA, Cope C, Holland G, Brass CA. Recurrent bleeding from anorectal varices: successful treatment with a transjugular intrahepatic portosystemic shunt. Am J Gastroenterol. Jul 1993;88(7):1104-7. [Medline].
El Nakeeb AM, Fikry AA, Omar WH, Fouda EM, El Metwally TA, Ghazy HE, et al. Rubber band ligation for 750 cases of symptomatic hemorrhoids out of 2200 cases. World J Gastroenterol. Nov 14 2008;14(42):6525-30. [Medline]. [Full Text].
Raahave D, Jepsen LV, Pedersen IK. Primary and repeated stapled hemorrhoidopexy for prolapsing hemorrhoids: follow-up to five years. Dis Colon Rectum. Mar 2008;51(3):334-41. [Medline].
Jayaraman S, Colquhoun PH, Malthaner RA. Stapled hemorrhoidopexy is associated with a higher long-term recurrence rate of internal hemorrhoids compared with conventional excisional hemorrhoid surgery. Dis Colon Rectum. Sep 2007;50(9):1297-305. [Medline].
Ceci F, Picchio M, Palimento D, Calì B, Corelli S, Spaziani E. Long-term outcome of stapled hemorrhoidopexy for Grade III and Grade IV hemorrhoids. Dis Colon Rectum. Jul 2008;51(7):1107-12. [Medline].
Moesgaard F, Nielsen ML, Hansen JB, Knudsen JT. High-fiber diet reduces bleeding and pain in patients with hemorrhoids: a double-blind trial of Vi-Siblin. Dis Colon Rectum. Jul-Aug 1982;25(5):454-6. [Medline].
Gorfine SR. Treatment of benign anal disease with topical nitroglycerin. Dis Colon Rectum. May 1995;38(5):453-6; discussion 456-7. [Medline].
Perrotti P, Antropoli C, Molino D, De Stefano G, Antropoli M. Conservative treatment of acute thrombosed external hemorrhoids with topical nifedipine. Dis Colon Rectum. Mar 2001;44(3):405-9. [Medline].
Yuksel BC, Armagan H, Berkem H, Yildiz Y, Ozel H, Hengirmen S. Conservative management of hemorrhoids: a comparison of venotonic flavonoid micronized purified flavonoid fraction (MPFF) and sclerotherapy. Surg Today. 2008;38(2):123-9. [Medline].
Faucheron JL, Gangner Y. Doppler-guided hemorrhoidal artery ligation for the treatment of symptomatic hemorrhoids: early and three-year follow-up results in 100 consecutive patients. Dis Colon Rectum. Jun 2008;51(6):945-9. [Medline].
Johanson JF, Rimm A. Optimal nonsurgical treatment of hemorrhoids: a comparative analysis of infrared coagulation, rubber band ligation, and injection sclerotherapy. Am J Gastroenterol. Nov 1992;87(11):1600-6. [Medline].
Saleeby RG Jr, Rosen L, Stasik JJ, Riether RD, Sheets J, Khubchandani IT. Hemorrhoidectomy during pregnancy: risk or relief?. Dis Colon Rectum. Mar 1991;34(3):260-1. [Medline].
BLAISDELL PC. Prevention of massive hemorrhage secondary to hemorrhoidectomy. Surg Gynecol Obstet. Apr 1958;106(4):485-8. [Medline].
BARRON J. Office ligation treatment of hemorrhoids. Dis Colon Rectum. Mar-Apr 1963;6:109-13. [Medline].
Jutabha R, Jensen DM, Chavalitdhamrong D. Randomized prospective study of endoscopic rubber band ligation compared with bipolar coagulation for chronically bleeding internal hemorrhoids. Am J Gastroenterol. Aug 2009;104(8):2057-64. [Medline].
Senapati A, Nicholls RJ. A randomised trial to compare the results of injection sclerotherapy with a bulk laxative alone in the treatment of bleeding haemorrhoids. Int J Colorectal Dis. Jun 1988;3(2):124-6. [Medline].
Thornton SC. Sclerotherapy of hemorrhoids. Selected Topics in Colon and Rectal Surgery. Vol 5. Norwalk, Conn: Konsyl Pharmaceuticals; 1992:72-5..
Gupta PJ, Kalaskar S. Radiowave ablation and mucopexy for prolapsing hemorrhoids--a pilot study. Int J Surg. Jun 2009;7(3):223-7. [Medline].
American Gastroenterological Association medical position statement: Diagnosis and treatment of hemorrhoids. Gastroenterology. May 2004;126(5):1461-2. [Medline].
Cataldo P, Ellis CN, Gregorcyk S, Hyman N, Buie WD, Church J, et al. Practice parameters for the management of hemorrhoids (revised). Dis Colon Rectum. Feb 2005;48(2):189-94. [Medline].
Leff EI. Hemorrhoidectomy--laser vs. nonlaser: outpatient surgical experience. Dis Colon Rectum. Aug 1992;35(8):743-6. [Medline].
Corman M. Hemorrhoid. In: Corman M. Colon and Rectal Surgery. Philadelphia, Pa: Lippincott-Raven; 1998:154-6.
Mazier WP. Hemorrhoids: surgery of the colon. In: Maxier WP, Levm DH, Luchtefeld. MA, Senagore AJ, eds. Rectum and Anus. Philadelphia, Pa: WB Saunders; 1995:229-54.
Esser S, Khubchandani I, Rakhmanine M. Stapled hemorrhoidectomy with local anesthesia can be performed safely and cost-efficiently. Dis Colon Rectum. Jul 2004;47(7):1164-9. [Medline].
Ho YH, Cheong WK, Tsang C, Ho J, Eu KW, Tang CL, et al. Stapled hemorrhoidectomy--cost and effectiveness. Randomized, controlled trial including incontinence scoring, anorectal manometry, and endoanal ultrasound assessments at up to three months. Dis Colon Rectum. Dec 2000;43(12):1666-75. [Medline].
Senagore AJ, Singer M, Abcarian H, Fleshman J, Corman M, Wexner S, et al. A prospective, randomized, controlled multicenter trial comparing stapled hemorrhoidopexy and Ferguson hemorrhoidectomy: perioperative and one-year results. Dis Colon Rectum. Nov 2004;47(11):1824-36. [Medline].
Behboo R, Zanella S, Ruffolo C, Vafai M, Marino F, Scarpa M. Stapled haemorrhoidopexy: extent of tissue excision and clinical implications in the early postoperative period. Colorectal Dis. Jun 2011;13(6):697-702. [Medline].
Pattana-arun J, Wesarachawit W, Tantiphlachiva K, Atithansakul P, Sahakitrungruang C, Rojanasakul A. A comparison of early postoperative results between urgent closed hemorrhoidectomy for prolapsed thrombosed hemorrhoids and elective closed hemorrhoidectomy. J Med Assoc Thai. Dec 2009;92(12):1610-5. [Medline].
Bove A, Bongarzoni G, Palone G, Chiarini S, Calisesi EM, Corbellini L. Effective treatment of haemorrhoids: early complication and late results after 150 consecutive stapled haemorrhoidectomies. Ann Ital Chir. Jul-Aug 2009;80(4):299-303. [Medline].
Perrotti P, Dominici P, Grossi E, Cerutti R, Antropoli C. Topical nifedipine with lidocaine ointment versus active control for pain after hemorrhoidectomy: results of a multicentre, prospective, randomized, double-blind study. Can J Surg. Feb 2010;53(1):17-24. [Medline]. [Full Text].
Halverson A. Hemorrhoids. Clin Colon Rectal Surg. May 2007;20(2):77-85. [Medline]. [Full Text].
Koning MV, Loffeld RJ. Rectal bleeding in patients with haemorrhoids. Coincidental findings in colon and rectum. Fam Pract. Jun 2010;27(3):260-2. [Medline].

