Hiccups Treatment & Management
- Author: Garry Wilkes, MBBS, FACEM; Chief Editor: Steven C Dronen, MD, FAAEM more...
Generations of physicians have failed to discover a definitive cure for hiccups. The following statement from the Mayo Clinic, though made in 1932, still describes the situation perfectly: "The amount of knowledge on any subject such as this can be considered as being in inverse proportion to the number of different treatments suggested and tried for it."
Patients rarely present to the emergency department (ED) after cessation of a brief episode of hiccups. If this occurs, the possibility of another reason for the presentation (eg, depression) should be considered first.
Supportive care is administered as indicated by the causative pathology (eg, oxygen for the patient whose hiccups may be secondary to pneumonia). Therapy is directed first toward at the cause of the hiccups (if identified) and then toward the hiccups themselves (if necessary).
Gastroesophageal reflux is associated closely with hiccups but may be either a cause or an effect. Acid perfusion studies should be done to confirm the inducibility of hiccups before antireflux surgery is performed to cure hiccups.
Treatment may be pharmacologic or nonpharmacologic. Surgical phrenic nerve ablation has been advocated for intractable cases that are unresponsive to other treatment. This drastic approach may be associated with considerable morbidity and is not universally successful. A Cochrane review concluded that the available evidence was insufficient to guide treatment of persistent or intractable hiccups by either pharmacologic or nonpharmacologic means.
Consultation is rarely necessary unless the cause of the hiccups calls for the participation of a specialist.
Various agents have been reported to cure hiccups. In a 2015 systematic review of pharmacologic therapy for persistent/intractable hiccups in 341 patients in 15 studies, Steger et al noted that treatment of the underlying condition was the most successful, but there were no high-quality data to allow for pharmacologic treatment recommendations. However, on the basis of the limited data available, the investigators indicated that, owing to their lower risk of adverse effects over long-term therapy compared to traditional neuroleptic agents, baclofen and gabapentin may be considered as first-line therapy for persistent/intractable hiccups, with metoclopramide and chlorpromazine in reserve.
Chlorpromazine is the most thoroughly studied medication and appears to be the drug of choice in many reports. Regimens in the range of 25-50 mg intravenously (IV) or intramuscularly (IM) are effective in 80% of cases. To prevent or minimize hypotension caused by this agent, preloading the patient with 500-1000 mL of IV fluid is advised.
Another major tranquilizer, haloperidol, is effective in doses of 2-5 mg. Metoclopramide has been used successfully in a dosage of 10 mg every 8 hours. Indeed, a study by Wang and Wang provided evidence of the usefulness of metoclopramide against intractable hiccups. In the double-blind, randomized, controlled pilot study, 34 patients with intractable hiccups received either 10 mg of metoclopramide or placebo, three times per day for 15 days. The efficacy of metoclopramide with regard to cessation or improvement of hiccups was greater in the metoclopramide patients than in the placebo group; the drug was associated with no serious adverse effects.
Several anticonvulsant agents have been used to treat intractable hiccups. Phenytoin, valproic acid, and carbamazepine have all been effective when used in typical anticonvulsant doses. Gabapentin has been shown to be effective in patients with central nervous system (CNS) lesions and in some other etiologic groups.[16, 17, 18]
Of the anesthetic agents, ketamine has been the most successful in a dose of 0.4 mg/kg (one fifth of the usual anesthetic dose). The centrally acting muscle relaxant baclofen, in a dosage of 10 mg orally every 6 hours, is particularly useful in patients for whom other agents are contraindicated (eg, those with renal impairment). IV lidocaine, in a loading dose of 1 mg/kg followed by an infusion of 2 mg/min, has cured patients after other agents were unsuccessful. Oral lidocaine was reported to be successful in 4 cancer patients with hiccups.
Other agents reported to be beneficial are as follows:
Analgesics (eg, orphenadrine, amitriptyline, chloral hydrate, and morphine)
Stimulants (eg, ephedrine, methylphenidate, amphetamine, and nikethamide)
Miscellaneous agents (eg, edrophonium, dexamethasone, amantadine,  and nifedipine)
Benzodiazepines exacerbate or precipitate hiccups and should be avoided.
Many of the traditional nonpharmacologic remedies used in the ED have a sound physiologic basis, in that they have an effect on components of the hiccup reflex. The following are examples:
Stimulation of the nasopharynx by applying forcible traction to the tongue, swallowing granulated sugar, gargling with water, sipping ice water, drinking from the far side of a glass, biting on a lemon, or inhaling noxious agents (eg, ammonia)
C3-5 dermatome stimulation by tapping or rubbing the back of the neck, coolant sprays, or acupuncture
Direct pharyngeal stimulation by a nasal or oral catheter (90% effective)
Direct uvular stimulation by a spoon or cotton-tip applicator
Removal of gastric contents by means of emetics or a nasogastric tube
The following remedies lead to vagal stimulation (only one should be used at any given time):
Iced gastric lavage
Carotid sinus massage (performed only by experienced personnel after exclusion of contraindications)
Digital ocular globe pressure (performed only by experienced personnel after exclusion of contraindications)
Digital rectal massage
Various techniques are used that interfere with normal respiratory function, such as the following:
Gasping (as in fright)
Breathing into a paper bag (which increases arterial carbon dioxide tension [PaCO 2])
Pulling the knees up to the chest and leaning forward
Using continuous positive airway pressure
Rebreathing 5% carbon dioxide
Mental distraction sometimes works. For example, the patient may be asked to "think of a loved one remembering you." An inventive naval doctor achieved success by offering $10 if the patient could continue to hiccup immediately.
The following nonpharmacologic approaches have also been tried:
Behavioral conditioning (including other members of the family unit)
Acupuncture (including near-infrared irradiation of acupoints) [21, 22, 23, 24]
Phrenic nerve or diaphragmatic pacing – Incidental cure of hiccups during cardioversion has been reported
Prayer - One patient, after 8 years of hiccupping and more than 60,000 suggested treatments, finally obtained relief after praying to St Jude, the Catholic patron saint of lost causes
The final and most drastic treatment for hiccups is phrenic nerve ablation. Fluoroscopic examination may reveal unilateral involvement, which allows directed therapy. Initially, temporary blockade is advisable. Bilateral phrenic nerve interruption may lead to significant respiratory complications and may not always cure hiccups, because other respiratory muscles are involved. All other treatments must be explored before this step is embarked on.
Microvascular decompression of the vagus nerve has been reported to be successful in case reports.[25, 26]
Wang T, Wang D. Metoclopramide for patients with intractable hiccups: a multicentre, randomised, controlled pilot study. Intern Med J. 2014 Dec. 44(12a):1205-9. [Medline].
Lee GW, Kim RB, Go SI, et al. Gender differences in hiccup patients: analysis of published case reports and case-control studies. J Pain Symptom Manage. 2015 Nov 17. [Medline].
Vanamoorthy P, Kar P, Prabhakar H. Intractable hiccups as a presenting symptom of Chiari I malformation. Acta Neurochir (Wien). 2008 Nov. 150(11):1207-8; discussion 1208. [Medline].
Krysiak W, Szabowski S, Stepien M, Krzywkowska K, Krzywkowski A, Marciniak P. Hiccups as a myocardial ischemia symptom. Pol Arch Med Wewn. 2008 Mar. 118(3):148-51. [Medline].
Morinaka S. Herpes zoster laryngitis with intractable hiccups. Auris Nasus Larynx. 2009 Oct. 36(5):606-8. [Medline].
Yeatman CF 2nd, Minoshima S. F-18 fluorodeoxyglucose PET/CT findings in active hiccups. Clin Nucl Med. 2009 Mar. 34(3):197-8. [Medline].
Celik T, Kose S, Bugan B, Iyisoy A, Akgun V, Cingoz F. Hiccup as a result of late lead perforation: report of two cases and review of the literature. Europace. 2009 Jul. 11(7):963-5. [Medline].
Zugel NP, Kox M, Lang RA, Huttl TP. Laparoscopic resection of an intradiaphragmatic bronchogenic cyst. JSLS. 2008 Jul-Sep. 12(3):318-20. [Medline].
Wilcox SK, Garry A, Johnson MJ. Novel use of amantadine: to treat hiccups. J Pain Symptom Manage. 2009 Sep. 38(3):460-5. [Medline].
Salanitri S, Goncalves AJ, Helene A Jr, Lopes FH. Surgical complications in hair transplantation: a series of 533 procedures. Aesthet Surg J. 2009 Jan-Feb. 29(1):72-6. [Medline].
Doshi H, Vaidyalingam R, Buchan K. Atrial pacing wires: an uncommon cause of postoperative hiccups. Br J Hosp Med (Lond). 2008 Sep. 69(9):534. [Medline].
Uldum B, Hallonsten AL, Poulsen S. Midazolam conscious sedation in a large Danish municipal dental service for children and adolescents. Int J Paediatr Dent. 2008 Jul. 18(4):256-61. [Medline].
Moretto EN, Wee B, Wiffen PJ, Murchison AG. Interventions for treating persistent and intractable hiccups in adults. Cochrane Database Syst Rev. 2013 Jan 31. 1:CD008768. [Medline].
Steger M, Schneemann M, Fox M. Systemic review: the pathogenesis and pharmacological treatment of hiccups. Aliment Pharmacol Ther. 2015 Nov. 42 (9):1037-50. [Medline].
Moretti R, Torre P, Antonello RM, Ukmar M, Cazzato G, Bava A. Gabapentin as a drug therapy of intractable hiccup because of vascular lesion: a three-year follow up. Neurologist. 2004 Mar. 10(2):102-6. [Medline].
Ong AM, Tan CS, Foo MW, Kee TY. Gabapentin for intractable hiccups in a patient undergoing peritoneal dialysis. Perit Dial Int. 2008 Nov-Dec. 28(6):667-8. [Medline].
Marinella MA. Diagnosis and management of hiccups in the patient with advanced cancer. J Support Oncol. 2009 Jul-Aug. 7(4):122-7, 130. [Medline].
Turkyilmaz A, Eroglu A. Use of baclofen in the treatment of esophageal stent-related hiccups. Ann Thorac Surg. 2008 Jan. 85(1):328-30. [Medline].
Neuhaus T, Ko YD, Stier S. Successful treatment of intractable hiccups by oral application of lidocaine. Support Care Cancer. 2012 Nov. 20(11):3009-11. [Medline].
Chang CC, Chang ST, Lin JC, Li TY, Chiang SL, Tsai KC. Resolution of intractable hiccups after near-infrared irradiation of relevant acupoints. Am J Med Sci. Aug 2006. 332(2):93-6. [Medline].
Chang CC, Chang YC, Chang ST, et al. Efficacy of near-infrared irradiation on intractable hiccup in custom-set acupoints: evidence-based analysis of treatment outcome and associated factors. Scand J Gastroenterol. 2008. 43(5):538-44. [Medline].
Dietzel J, Grundling M, Pavlovic D, Usichenko TI. Acupuncture for persistent postoperative hiccup. Anaesthesia. 2008 Sep. 63(9):1021-2. [Medline].
Choi TY, Lee MS, Ernst E. Acupuncture for cancer patients suffering from hiccups: a systematic review and meta-analysis. Complement Ther Med. 2012 Dec. 20(6):447-55. [Medline].
Farin A, Chakrabarti I, Giannotta SL, Vaynman S, Samudrala S. Microvascular decompression for intractable singultus: technical case report. Neurosurgery. 2008 May. 62(5):E1180-1; discussion E1181. [Medline].
Johnson DL. Intractable hiccups: treatment by microvascular decompression of the vagus nerve. Case Report. J Neurosurg. 1993 May. 78(5):813-6. [Medline].
Naro A, Bramanti P, Calabro RS. Successful use of tetrabenazine in a patient with intractable hiccups after stroke. Pharmacotherapy. 2014 Dec. 34 (12):e345-8. [Medline].
Thompson AN, Ehret Leal J, Brzezinski WA. Olanzapine and baclofen for the treatment of intractable hiccups. Pharmacotherapy. 2014 Jan. 34 (1):e4-8. [Medline].