Updated: Nov 20, 2009
Perirectal and perianal abscess are commonly encountered ED problems. Timely and appropriate treatment is needed to prevent serious morbidity and mortality.
This article focuses on perirectal abscess and provides some discussion of perianal abscess. These entities are distinct, with potentially different ED evaluation and different treatment and disposition. Differentiation of the more complex perirectal abscess from the more simple perianal abscess is crucial.
Perirectal abscess arises from infection of the mucus-secreting anal glands, which drain into the anal crypts. Blockage of the duct is believed to be the initiating cause of infection. The abscess can then progress to involve the potential spaces filled with fatty areolar tissue, which have little resistance to infection. These spaces include the perianal, intersphincteric, ischiorectal, deep postanal space (connecting the ischiorectal space on each side posteriorly), and supralevator spaces. These spaces may become infected alone or in combination with one another.
Perirectal abscess is usually an aerobic and anaerobic polymicrobial infection. Bacteroides fragilis is the predominant anaerobe. Other common bacteria include Escherichia coli and those of the genera Proteus, Bacteroides, and Streptococcus. Sources of bacteria are skin, bowel, and, rarely, the vagina.1
A variety of disease states is associated with the development of an abscess; these include Crohn disease, carcinoma, radiation fibrosis, trauma, Hodgkin disease, and immunocompromised states. Associated infectious causes include Chlamydia, Actinomyces, Gonococcus, Streptococcus, Bacteroides, and Proteus species; Staphylococcus aureus and Escherichia coli; and herpes, tuberculosis, and lymphogranuloma venereum.
In contradistinction to perirectal abscess, perianal abscess is easily palpable and is not accompanied by fever, leukocytosis, and sepsis in the immunocompetent patient.
In rare instances, inappropriately treated perirectal abscess may result in death.
No racial predilection has been found.
Men are affected more frequently than women, with a male-to-female predominance of 2:1 to 3:1.
Perirectal abscess occurs in all age groups, from infants to elderly persons. The peak incidence is in the third and fourth decades of life.
The history is critical in leading the physician to consider the diagnosis.
The physical examination findings may be normal, but a history that raises suspicion of a perirectal abscess should lead the physician to continue to pursue the diagnosis.
The cause of perirectal abscess is believed to be blockage of the perianal gland duct with resultant infection, rupture, and abscess formation. Risk factors are as follows:
| Abdominal Pain in Elderly Persons | Proctitis |
| Anal Fistulas and Fissures | Rectal Prolapse |
| Hemorrhoids | |
| Inflammatory Bowel Disease | |
| Necrotizing Fasciitis |
Perianal abscess
The isolated perianal abscess that is not associated with deeper, perirectal abscesses is the only type of anorectal abscess that can be adequately treated in an ED setting and is very rare.
Perirectal abscess must be treated in the operating suite, where optimal anesthesia can be achieved and the abscess and any fistula or other complication may be treated definitively. The "point" of a deep abscess must not be mistaken for a superficial perianal abscess. Inadequate ED debridement of a perirectal abscess may result in increased morbidity and even mortality. ED debridement of perirectal abscesses should not be performed. Because the ED lacks adequate anesthesia, ED treatment of perirectal abscesses is inhumane.
A simple (and, by definition, superficial) perianal abscess may be incised and drained in the ED. Adequate analgesia should be obtained by using the steps discussed in Procedures. Conscious sedation may be considered for pain control and to make the procedure as humane as possible. The patient may be discharged home after appropriate wound care with instructions for Sitz baths and routine follow-up care.
Superficial perianal abscesses are uncommon; thus, the provider should err on the side of assuming a deeper process exists if the diagnosis is in doubt.
Antibiotics are unnecessary in otherwise healthy individuals. The practitioner should provide appropriate empiric intravenous antibiotic coverage for patients who are elderly or immunosuppressed, patients who have comorbidities, patients with a heart valve abnormality or prosthetic valve likely to benefit from antibiotic prophylaxis, or those in whom infection has become systemic. Predisposing or comorbid factors may guide empiric antibiotic selection.
Analgesia is necessary for pain control and may be given orally or via an intravenous route, in conjunction with anesthetics if needle aspiration or I&D of an abscess is performed.
Anxiolytics may help certain patients who are apprehensive about needle aspiration, I&D, imaging studies, or surgery.
Appropriate antibiotic coverage should be given intravenously preoperatively and postoperatively, either based on Gram stain or an empiric basis, as a preventive measure, for elderly patients, patients with immunosuppression, patients with heart valve abnormality or prosthesis, and those with comorbid states.
Drug combination of beta-lactamase inhibitor with ampicillin. Interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms. Alternative to amoxicillin when unable to take medication PO.
Covers skin, enteric flora, and anaerobes. Not ideal for nosocomial pathogens.
1.5 (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6-8h; not to exceed 4 g/d sulbactam or 8 g/d ampicillin
Not established
Probenecid and disulfiram elevate ampicillin levels; allopurinol decreases ampicillin effects and has additive effects on ampicillin rash; may decrease effects of PO contraceptives
Documented hypersensitivity
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Adjust dose in renal failure; evaluate rash and differentiate from hypersensitivity reaction
Should be used for more severely ill ICU patients empirically. Pus and/or blood culture and sensitivity results, once available, should guide antibiotic selection. Predisposing and comorbid diseases may also guide empiric antibiotic selection.
Base initial dose on severity of infection, and administer in equally divided doses; dose may range from 250-500 mg q6h IV; 3-4 g/d maximum
Alternatively, 500-750 mg IM q12h or intra-abdominally
Not established
Coadministration with cyclosporine may increase CNS side effects of both agents; coadministration with ganciclovir may result in generalized seizures
Documented hypersensitivity
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Adjust dose in renal insufficiency (adult adjustments)
CrCl (mL/min) 80-50: 0.5 g q6-8h
CrCl 50-10: 0.5 g q8-12h
Hemodialysis (HD): 0.25-0.5 g after HD, then q12h
Adjust dose in renal insufficiency; avoid use in children <12 y
Broad-spectrum penicillin. Interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms. Alternative to amoxicillin when unable to take medication PO.
Those with prosthetic heart valves at risk for endocarditis should receive IV prophylactic antibiotics prior to any procedure. Ampicillin IV should be used, unless the patient is penicillin allergic, in which case cefazolin or clindamycin are appropriate choices.
250-500 mg PO q6h
500 mg to 1.5 g IM q4-6h
500 mg to 3 g IV q4-6h; not to exceed 12 g/d
Not established
Probenecid and disulfiram elevate ampicillin levels; allopurinol decreases ampicillin effects and has additive effects on ampicillin rash; may decrease effects of PO contraceptives
Documented hypersensitivity
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Adjust dose in renal failure; evaluate rash and differentiate from hypersensitivity reaction
First-generation semisynthetic cephalosporin that by binding to 1 or more penicillin-binding proteins arrests bacterial cell wall synthesis and inhibits bacterial replication. Poor capacity to cross blood-brain barrier. Primarily active against skin flora, including S aureus. Typically used alone for skin and skin-structure coverage. Regimens for IV and IM dosing are similar. Primarily active against skin flora, including S aureus. Use in penicillin-allergic patients with prosthetic heart valves at risk for endocarditis.
250 mg to 2 g IV/IM q6-12h depending on severity of infection; not to exceed 12 g/d
Not established
Probenecid prolongs effect of cefazolin; coadministration with aminoglycosides may increase renal toxicity; may yield false-positive urine-dip test results for glucose
Documented hypersensitivity
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Adjust dose in severe renal insufficiency (high doses may cause CNS toxicity); superinfections and promotion of nonsusceptible organisms may occur with prolonged use or repeated therapy
Semisynthetic antibiotic produced by 7(S)-chloro-substitution of 7(R)-hydroxyl group of parent compound lincomycin. Inhibits bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest. Widely distributes in the body without penetration of CNS. Protein bound and excreted by the liver and kidneys.
Use in penicillin-allergic patients with prosthetic heart valves at risk for endocarditis.
150-450 mg/dose PO q6-8h; not to exceed 1.8 g/d
600-1200 mg/d IV/IM divided q6-8h depending on degree of infection
Not established
Increases duration of neuromuscular blockade induced by tubocurarine and pancuronium; erythromycin may antagonize effects; antidiarrheals may delay absorption
Documented hypersensitivity; regional enteritis; ulcerative colitis; hepatic impairment; antibiotic-associated colitis
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
Adjust dose in severe hepatic dysfunction; no adjustment necessary in renal insufficiency; associated with severe and possibly fatal colitis by allowing overgrowth of Clostridium difficile
These agents may help to blunt the pain of a diagnostic needle aspiration but is only partially effective.
Decreases permeability to sodium ions in neuronal membranes. This results in the inhibition of depolarization, blocking the transmission of nerve impulses. Ethylene chloride may be used in conjunction with lidocaine to blunt the pain of a diagnostic needle aspiration but is only partially effective. It should be sprayed over the area to be aspirated immediately prior to aspiration.
5-10 mL as a field block at the area of intended aspiration
Not established
None reported
Documented hypersensitivity; avoid use in Adams-Stokes syndrome and Wolff-Parkinson-White syndrome
B - Fetal risk not confirmed in studies in humans but has been shown in some studies in animals
For external or mucous membrane use only; do not use in eyes
Pain control is essential to quality patient care. Analgesics ensure patient comfort, promote pulmonary toilet, and have sedating properties, which are beneficial for patients who experience pain. These agents are used for comfort and sedation and to blunt discomfort of diagnostic needle aspiration.
Analgesic with multiple actions similar to those of morphine; may produce less constipation, smooth muscle spasm, and depression of cough reflex than similar analgesic doses of morphine. May use in combination with promethazine to provide synergistic effect.
50-100 mg IV/IM with 25 mg promethazine IV/IM
Not established
Monitor for increased respiratory and CNS depression with coadministration of cimetidine; hydantoins may decrease effects of meperidine; avoid with protease inhibitors
Documented hypersensitivity; MAOIs; upper airway obstruction or significant respiratory depression; during labor when delivery of premature infant is anticipated
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
Caution in patients with head injuries because may increase respiratory depression and CSF pressure (use only if absolutely necessary); caution postoperatively and with history of pulmonary disease (suppresses cough reflex); increased dosing levels, because of tolerance, may aggravate or cause seizures (even without prior history); adjust dose in renal insufficiency (do not use in severe renal dysfunction); normeperidine metabolite accumulation may induce CNS toxicity; monitor closely for morphine-induced seizure activity if prior seizure history
These agents are used to treat emesis.
Antidopaminergic agent effective in treating emesis. Blocks postsynaptic mesolimbic dopaminergic receptors in brain and reduces stimuli to brainstem reticular system. May use in combination with meperidine to provide synergistic effect.
25 mg IV/IM with 50-100 mg meperidine IM/IV
Not established
May have additive effects when used concurrently with other CNS depressants or anticonvulsants; coadministration with epinephrine may cause hypotension
Documented hypersensitivity; children <2 y (incidences of death due to respiratory depression)
C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to fetus
Caution in cardiovascular disease, impaired liver function, seizures, sleep apnea, and asthma
By binding to specific receptor sites these agents appear to potentiate the effects of γ -aminobutyric acid (GABA) and to facilitate inhibitory GABA neurotransmission and other inhibitory transmitters. Benzodiazepines are anxiolytics that may help patients apprehensive about needle aspiration, imaging studies, or surgery. Conscious sedatives may be considered by the emergency physician with equipment and experience necessary to manage the patient's airway if spontaneous ventilation become compromised.
Shorter-acting benzodiazepine sedative-hypnotic useful in patients who require acute and/or short-term sedation. Midazolam is also useful for its amnestic effects.
1 mg IV slowly q2-3min up to 10 mg with the endpoint being slurred speech as an indicator of the desired hypnotic effect
Not established
Sedative effects of midazolam may be antagonized by theophyllines; narcotics and erythromycin may accentuate sedative effects of midazolam due to decreased clearance
Documented hypersensitivity; preexisting hypotension; narrow-angle glaucoma
D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
Caution in congestive heart failure, pulmonary disease, renal impairment, and hepatic failure
Sedative hypnotic with short onset of effects and relatively long half-life.
By increasing the action of GABA, which is a major inhibitory neurotransmitter in the brain, may depress all levels of CNS, including limbic and reticular formation.
When patient needs to be sedated for longer than 24-h period, this medication is excellent.
0.5-2 mg IV q6h prn anxiety
Not established
Toxicity of benzodiazepines in CNS increases when used concurrently with alcohol, phenothiazines, barbiturates, and MAOIs
Documented hypersensitivity; preexisting CNS depression; hypotension; narrow-angle glaucoma
D - Fetal risk shown in humans; use only if benefits outweigh risk to fetus
Caution in renal or hepatic impairment, myasthenia gravis, organic brain syndrome, or Parkinson disease
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perirectal abscess, perianal abscess, perirectal abscess treatment, perirectal abscess symptoms, perirectal abscess diagnosis, infection of the mucus-secreting anal glands, anorectal abscess
Drew Evan Fenton, MD, Hospitalist, Our Health Care Consultants
Drew Evan Fenton, MD is a member of the following medical societies: American Academy of Emergency Medicine
Disclosure: Nothing to disclose.
Michael S Beeson, MD, MBA, FACEP, Professor of Emergency Medicine, Northeastern Ohio Universities College of Medicine and Pharmacy; Attending Faculty, Summa Health System
Michael S Beeson, MD, MBA, FACEP is a member of the following medical societies: American College of Emergency Physicians, Council of Emergency Medicine Residency Directors, National Association of EMS Physicians, and Society for Academic Emergency Medicine
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Francisco Talavera, PharmD, PhD, Senior Pharmacy Editor, eMedicine
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Eugene Hardin, MD, FAAEM, FACEP, Former Chair and Associate Professor, Department of Emergency Medicine, Charles Drew University of Medicine and Science; Former Chair, Department of Emergency Medicine, Martin Luther King Jr/Drew Medical Center
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John D Halamka, MD, MS, Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center; Chief Information Officer, CareGroup Healthcare System and Harvard Medical School; Attending Physician, Division of Emergency Medicine, Beth Israel Deaconess Medical Center
John D Halamka, MD, MS is a member of the following medical societies: American College of Emergency Physicians, American Medical Informatics Association, Phi Beta Kappa, and Society for Academic Emergency Medicine
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Steven C Dronen, MD, FAAEM, Director of Emergency Services, Director of Chest Pain Center, Department of Emergency Medicine, Ft Sanders Sevier Medical Center
Steven C Dronen, MD, FAAEM is a member of the following medical societies: American Academy of Emergency Medicine and Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.
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